Best TWAS P=6.42e-09 · Best GWAS P=4.1e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | SYTL2 | 0.14 | 0.03 | lasso | 5 | 0.05 | 1.1e-04 | -5.6 | 5.8 | 6.5e-09 | -0.93 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CCDC89 | 0.06 | 0.07 | lasso | 4 | 0.05 | 8.3e-05 | -5.6 | -5.5 | 4.8e-08 | 0.78 | 0.03 | 0.96 | FALSE |
| 3 | GTEx | Muscle Skeletal | SYTL2 | 0.10 | 0.11 | lasso | 5 | 0.10 | 2.2e-10 | -5.3 | 5.7 | 1.3e-08 | -0.85 | 0.04 | 0.96 | FALSE |
| 4 | GTEx | Nerve Tibial | SYTL2 | 0.05 | 0.03 | enet | 9 | 0.02 | 2.4e-02 | -5.6 | 5.5 | 2.9e-08 | -0.86 | 0.03 | 0.93 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SYTL2 | 0.04 | 0.03 | lasso | 4 | 0.03 | 1.9e-04 | -5.6 | 5.8 | 6.4e-09 | -0.95 | 0.01 | 0.98 | TRUE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | SYTL2 | 0.01 | 0.03 | lasso | 3 | 0.02 | 6.3e-04 | -5.1 | 5.3 | 9.0e-08 | -0.74 | 0.06 | 0.66 | FALSE |