Best TWAS P=3.53e-70 · Best GWAS P=9.16e-68 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RAD9A | 0.43 | 0.22 | lasso | 6 | 0.23 | 7.1e-19 | -17.39 | -16.9 | 3.6e-64 | 0.97 | 0.00 | 1.00 | FALSE |
2 | GTEx | Adrenal Gland | RAD9A | 0.46 | 0.08 | lasso | 3 | 0.22 | 2.9e-08 | 2.94 | -6.4 | 1.7e-10 | 0.53 | 0.11 | 0.87 | FALSE |
3 | GTEx | Adrenal Gland | CTD-3074O7.12 | 0.28 | 0.00 | enet | 24 | 0.02 | 4.5e-02 | -3.90 | -5.4 | 7.3e-08 | 0.33 | 0.12 | 0.06 | FALSE |
4 | GTEx | Artery Tibial | RAD9A | 0.39 | 0.26 | lasso | 2 | 0.24 | 3.5e-19 | -17.39 | -17.4 | 9.0e-68 | 1.00 | 0.00 | 1.00 | FALSE |
5 | GTEx | Artery Tibial | AP001266.1 | 0.11 | 0.02 | enet | 9 | 0.09 | 2.8e-07 | -5.67 | -5.1 | 2.9e-07 | 0.22 | 0.67 | 0.11 | TRUE |
6 | GTEx | Breast Mammary Tissue (Male) | GSTP1 | 0.11 | -0.01 | lasso | 2 | -0.01 | 7.7e-01 | -0.96 | 5.1 | 2.7e-07 | -0.40 | 0.02 | 0.42 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | RAD9A | 0.24 | 0.16 | lasso | 3 | 0.16 | 3.6e-12 | -17.39 | -14.8 | 1.1e-49 | 0.92 | 0.00 | 1.00 | FALSE |
8 | GTEx | Colon Sigmoid | CTD-3074O7.12 | 0.11 | 0.01 | lasso | 4 | 0.02 | 4.5e-02 | -5.11 | -5.2 | 2.5e-07 | 0.27 | 0.14 | 0.05 | FALSE |
9 | GTEx | Colon Transverse | RAD9A | 0.40 | 0.16 | lasso | 8 | 0.16 | 7.2e-08 | -17.39 | -14.1 | 4.3e-45 | 0.88 | 0.00 | 1.00 | FALSE |
10 | GTEx | Esophagus Mucosa | CTD-3074O7.12 | 0.10 | 0.04 | lasso | 7 | 0.04 | 1.9e-03 | -4.71 | -5.4 | 6.3e-08 | 0.24 | 0.64 | 0.02 | FALSE |
11 | GTEx | Esophagus Muscularis | TCIRG1 | 0.10 | 0.09 | lasso | 2 | 0.06 | 8.7e-05 | -6.73 | 7.8 | 6.7e-15 | -0.43 | 0.02 | 0.92 | TRUE |
12 | GTEx | Esophagus Muscularis | RAD9A | 0.25 | 0.26 | lasso | 2 | 0.26 | 6.2e-16 | -17.39 | -17.7 | 3.5e-70 | 0.99 | 0.00 | 1.00 | TRUE |
13 | GTEx | Esophagus Muscularis | MRGPRF | 0.09 | 0.01 | lasso | 3 | 0.01 | 1.3e-01 | -6.13 | 6.1 | 1.0e-09 | 0.02 | 0.03 | 0.77 | TRUE |
14 | GTEx | Esophagus Muscularis | RP11-805J14.5 | 0.09 | 0.01 | lasso | 2 | 0.01 | 1.3e-01 | -5.32 | -5.3 | 9.5e-08 | 0.01 | 0.03 | 0.70 | TRUE |
15 | GTEx | Liver | CDK2AP2 | 0.30 | -0.01 | lasso | 7 | -0.01 | 4.9e-01 | -3.00 | -7.8 | 5.0e-15 | 0.46 | 0.02 | 0.47 | TRUE |
16 | GTEx | Lung | NUDT8 | 0.10 | 0.03 | enet | 11 | 0.02 | 1.2e-02 | -2.31 | -5.5 | 4.2e-08 | 0.27 | 0.11 | 0.35 | TRUE |
17 | GTEx | Muscle Skeletal | RAD9A | 0.12 | 0.02 | lasso | 4 | 0.03 | 4.2e-04 | -17.39 | -13.2 | 1.2e-39 | 0.83 | 0.00 | 0.99 | TRUE |
18 | GTEx | Nerve Tibial | RAD9A | 0.53 | 0.24 | lasso | 10 | 0.23 | 5.6e-16 | -17.39 | -17.3 | 3.9e-67 | 0.99 | 0.00 | 1.00 | FALSE |
19 | GTEx | Testis | DPF2 | 0.20 | 0.09 | lasso | 7 | 0.06 | 9.5e-04 | -3.70 | 5.3 | 1.1e-07 | -0.16 | 0.07 | 0.58 | FALSE |
20 | GTEx | Testis | RAD9A | 0.72 | 0.50 | lasso | 4 | 0.49 | 1.1e-24 | -17.39 | -17.2 | 1.6e-66 | 1.00 | 0.00 | 1.00 | FALSE |
21 | GTEx | Testis | BBS1 | 0.07 | 0.10 | lasso | 2 | 0.07 | 6.3e-04 | -4.71 | 5.3 | 1.2e-07 | -0.25 | 0.16 | 0.04 | FALSE |
22 | GTEx | Thyroid | RAD9A | 0.27 | 0.07 | lasso | 6 | 0.20 | 1.8e-15 | -17.39 | -10.6 | 1.8e-26 | 0.70 | 0.00 | 1.00 | FALSE |
23 | METSIM | Adipose | DPP3 | 0.06 | 0.04 | blup | 284 | 0.04 | 2.6e-07 | 4.08 | -5.1 | 2.9e-07 | 0.20 | 1.00 | 0.00 | FALSE |
24 | ROSMAP | Brain Pre-frontal Cortex | GAL | 0.21 | 0.17 | bslmm | 393 | 0.17 | 1.5e-21 | -5.72 | -6.3 | 3.0e-10 | -0.02 | 0.98 | 0.02 | TRUE |
25 | ROSMAP | Brain Pre-frontal Cortex | CDK2AP2 | 0.03 | 0.02 | enet | 11 | 0.03 | 1.6e-04 | -2.89 | 7.9 | 2.4e-15 | -0.48 | 0.27 | 0.60 | FALSE |
26 | ROSMAP | Brain Pre-frontal Cortex | RAD9A | 0.34 | 0.17 | enet | 21 | 0.20 | 1.1e-25 | -17.39 | -15.4 | 1.3e-53 | 0.89 | 0.00 | 1.00 | TRUE |
27 | YFS | Blood | BANF1 | 0.14 | 0.19 | bslmm | 342 | 0.21 | 8.3e-67 | -4.26 | 5.3 | 1.2e-07 | -0.12 | 1.00 | 0.00 | TRUE |
28 | YFS | Blood | BBS1 | 0.02 | 0.02 | lasso | 5 | 0.02 | 1.4e-07 | -4.67 | -5.2 | 2.1e-07 | 0.22 | 1.00 | 0.00 | FALSE |
29 | YFS | Blood | CATSPER1 | 0.02 | 0.01 | blup | 352 | 0.01 | 5.5e-04 | -2.61 | 5.2 | 1.7e-07 | -0.21 | 0.57 | 0.01 | FALSE |
30 | YFS | Blood | RAD9A | 0.08 | 0.02 | lasso | 7 | 0.04 | 5.4e-12 | -17.39 | -11.4 | 4.7e-30 | 0.78 | 0.00 | 1.00 | TRUE |
31 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CAPN1 | 0.03 | 0.02 | blup | 39 | 0.02 | 2.1e-03 | -5.63 | -7.0 | 1.8e-12 | 0.08 | 0.02 | 0.88 | TRUE |
32 | The Cancer Genome Atlas | Soft Tissue Sarcoma | POLA2 | 0.09 | 0.06 | blup | 34 | 0.08 | 1.4e-05 | -5.50 | 5.2 | 1.5e-07 | -0.06 | 0.01 | 0.98 | FALSE |