Best TWAS P=8.42e-09 · Best GWAS P=1.23e-08 conditioned to 0.0626
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | ROSMAP | Brain Pre-frontal Cortex | WBP11 | 0.10 | 0.05 | lasso | 4 | 0.06 | 1.2e-08 | -4.5 | 5.8 | 8.4e-09 | -0.61 | 0.08 | 0.92 | TRUE |
| 2 | GTEx | Brain Cortex | RP11-695J4.2 | 0.41 | 0.04 | lasso | 14 | 0.09 | 1.7e-03 | 3.0 | 5.5 | 3.1e-08 | -0.39 | 0.03 | 0.36 | TRUE |
| 3 | GTEx | Skin Sun Exposed Lower leg | C12orf60 | 0.09 | 0.06 | enet | 11 | 0.05 | 4.0e-05 | 4.7 | 5.8 | 9.0e-09 | -0.72 | 0.04 | 0.96 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | C12orf60 | 0.16 | 0.16 | enet | 10 | 0.18 | 1.3e-17 | 4.6 | 5.7 | 1.1e-08 | -0.66 | 0.21 | 0.78 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C12orf60 | 0.10 | 0.04 | enet | 7 | 0.05 | 2.0e-06 | -5.7 | 5.4 | 5.4e-08 | -0.85 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C12orf60 | 0.12 | 0.07 | enet | 8 | 0.07 | 5.4e-05 | 4.6 | 5.3 | 1.1e-07 | -0.65 | 0.12 | 0.69 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | WBP11 | 0.03 | 0.03 | blup | 57 | 0.02 | 2.3e-03 | -5.1 | 5.2 | 1.9e-07 | -0.70 | 0.03 | 0.76 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | C12orf60 | 0.28 | 0.25 | lasso | 4 | 0.24 | 2.0e-29 | 4.7 | 5.2 | 2.5e-07 | -0.55 | 0.19 | 0.80 | FALSE |