TWAS hub - WBP11

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1540	0.0550	8.5e-04	0.113	NA	0.094	NA	0.120	1.9e-06	NA	1.4e-05	NA	8.7e-07
2	GTEx	Artery Tibial	0.0887	0.0385	2.8e-03	0.062	NA	0.045	NA	0.055	1.2e-05	NA	1.7e-04	NA	3.8e-05
3	GTEx	Muscle Skeletal	0.0830	0.0339	1.3e-03	0.083	NA	0.075	NA	0.081	1.5e-08	NA	7.7e-08	NA	2.4e-08
4	GTEx	Nerve Tibial	0.1063	0.0414	2.9e-03	0.105	NA	0.063	NA	0.087	7.6e-08	NA	2.8e-05	NA	1.0e-06
5	ROSMAP	Brain Pre-frontal Cortex	0.0964	0.0288	8.9e-07	0.054	0.062	0.059	0.062	0.064	1.6e-07	1.9e-08	3.9e-08	2.1e-08	1.2e-08
6	TCGA	Brain Lower Grade Glioma	0.0289	0.0168	4.8e-03	0.028	0.020	0.011	NA	0.014	3.4e-04	2.3e-03	1.6e-02	NA	9.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Hand grip strength (right)	9.9	27.0	36.6	5.0	5.5	5.2	4.5	6.0	4.8
Hand grip strength (left)	8.9	23.5	35.9	4.5	5.0	4.5	3.9	6.0	5.0
Arm predicted mass (right)	7.2	36.7	52.3	5.1	6.2	5.5	5.4	7.2	6.6
Arm fat-free mass (right)	6.9	35.5	50.8	5.0	6.1	5.3	5.2	7.1	6.7
Arm fat-free mass (left)	6.7	34.1	50.1	4.7	5.9	5.1	5.1	7.1	6.7
Arm predicted mass (left)	6.7	34.1	49.6	4.7	5.9	5.1	5.2	7.0	6.7
Trunk fat-free mass	6.6	38.0	53.2	5.4	6.3	5.6	5.4	7.3	6.8
Trunk predicted mass	6.6	37.8	52.8	5.3	6.3	5.6	5.4	7.3	6.7
Forced expiratory volume in 1-second (FEV1), predicted	6.5	13.5	15.9	3.8	3.8	3.6	3.3	4.0	3.5
Whole body fat-free mass	6.0	34.4	50.6	4.8	5.9	5.1	5.0	7.1	6.8
Whole body water mass	5.7	32.6	47.9	4.7	5.8	5.0	4.9	6.9	6.7
Basal metabolic rate	5.6	31.2	46.4	4.4	5.6	4.8	4.8	6.8	6.7
Forced expiratory volume in 1-second (FEV1)	5.5	18.5	21.6	4.6	4.6	4.5	4.1	4.5	3.3
Forced vital capacity (FVC)	5.4	20.9	23.9	4.7	4.8	4.7	4.4	4.9	3.9
Number of self-reported non-cancer illnesses	5.3	9.2	11.4	-2.5	-3.2	-3.2	-3.2	-3.4	-2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	5.1	6.6	15.5	-1.1	-2.3	-1.5	-2.2	-3.2	-3.9
Forced expiratory volume in 1-second (FEV1), Best measure	4.9	15.6	18.6	4.3	4.3	4.2	3.8	4.0	2.9
Pack years adult smoking proportion	4.6	7.0	10.8	-3.3	-3.0	-2.9	-2.9	-2.2	-0.3
Leg predicted mass (left)	4.6	24.4	40.5	3.6	4.8	4.0	4.1	6.2	6.4
Age started oral contraceptive pill	4.6	5.8	10.8	-1.4	-2.0	-2.0	-2.1	-3.1	-3.3
Pack years of smoking	4.6	6.7	10.2	-3.2	-3.0	-2.8	-2.8	-2.3	-0.4
Leg fat-free mass (left)	4.4	23.3	39.5	3.5	4.7	3.8	3.9	6.0	6.3
Comparative height size at age 10	4.3	23.8	33.2	4.6	4.8	4.5	4.3	5.8	5.2
Leg predicted mass (right)	4.2	22.2	41.8	3.3	4.4	3.5	3.5	6.0	6.5
Leg fat-free mass (right)	4.1	22.0	41.3	3.3	4.4	3.5	3.5	6.0	6.4
Supplements: Glucosamine	4.0	5.2	12.5	-0.4	-2.0	-1.9	-1.4	-2.9	-3.5
Medication: Levothyroxine sodium	4.0	6.8	11.8	-2.5	-2.9	-2.5	-3.4	-2.5	-1.3
Forced vital capacity (FVC), Best measure	4.0	14.7	16.6	4.0	3.9	4.1	3.6	4.0	3.3
Height	3.9	74.9	92.4	9.6	9.1	8.6	7.7	9.5	7.2
Standing height	3.9	38.4	46.4	6.7	6.2	6.0	5.4	6.8	5.9
Sitting height	3.7	26.2	33.1	5.0	5.2	5.0	4.3	5.8	5.2
Had menopause	3.6	4.5	12.5	-0.5	-1.6	-1.2	-1.6	-2.7	-3.5
Relative age voice broke	3.5	5.4	15.3	0.1	-1.7	-1.5	-1.7	-3.0	-3.9
Weight	3.5	17.3	26.0	3.0	4.2	3.4	3.7	5.1	5.1
Hair/balding pattern: Pattern 4	3.2	7.7	10.7	-3.0	-2.5	-2.6	-1.8	-3.3	-3.3
Illnesses of siblings: Diabetes	3.2	3.9	5.3	-1.7	-2.1	-1.9	-2.0	-2.3	-1.9
Medication: Lisinopril	3.2	4.2	6.2	-2.5	-2.4	-2.1	-2.4	-1.7	-0.1
Coronary Artery Disease (CAD)	3.1	3.7	5.2	-1.1	-2.2	-2.3	-1.9	-2.3	-1.6
Medication: Blood pressure	3.1	5.4	7.1	-2.6	-2.5	-2.7	-2.6	-2.3	-0.6
Suffer from ‘nerves’	3.1	4.9	6.1	-2.1	-2.1	-2.2	-2.2	-2.5	-2.1
Pulse wave peak to peak time	3.0	3.6	4.2	2.0	1.7	1.8	1.7	2.0	2.0
Average weekly beer plus cider intake	3.0	4.4	6.9	-2.5	-2.3	-2.6	-1.9	-1.6	-1.4
Fractured/broken bones in last 5 years	2.9	3.7	5.6	-2.4	-2.1	-2.3	-1.6	-1.9	-1.0
Supplements: Vitamin C	2.7	3.1	4.3	-1.6	-1.9	-2.1	-1.7	-1.8	-1.6
Average weekly spirits intake	2.5	3.0	5.2	-1.9	-1.7	-2.3	-1.8	-1.5	-0.9
Ever used hormone-replacement therapy (HRT)	2.5	3.2	6.2	-1.0	-1.4	-1.4	-1.7	-2.3	-2.5
Taking other prescription medications	2.5	3.9	5.2	-1.8	-2.3	-1.9	-2.2	-2.1	-1.4
Hip circumference	2.5	11.0	17.1	2.1	3.5	2.5	3.2	4.1	3.9
Had major operations	2.5	3.0	4.5	-1.8	-2.1	-1.8	-1.9	-1.6	-0.7
Sensitivity / hurt feelings	2.4	4.0	5.1	-2.1	-1.8	-2.1	-1.8	-2.2	-2.0
Ever had hysterectomy (womb removed)	2.4	2.7	5.1	-1.5	-1.6	-0.9	-1.2	-2.3	-2.1
Pulse wave Arterial Stiffness index	2.4	2.8	3.3	-1.8	-1.6	-1.6	-1.6	-1.8	-1.7
Hypothyroidism/myxoedema (self-reported)	2.4	4.6	8.4	-1.9	-2.2	-1.8	-2.9	-2.3	-1.6
Crohns Disease (2012)	2.3	3.6	6.3	1.8	1.8	1.3	1.5	2.3	2.5
Current tobacco smoking	2.3	3.8	5.1	-2.3	-2.2	-2.2	-2.1	-1.7	-0.7
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	4.1	0.6	1.3	1.9	1.3	1.9	2.0
Impedance of arm (right)	2.3	10.5	16.3	-1.9	-3.4	-2.8	-2.9	-4.0	-3.9
Mouth/teeth dental problems: Dentures	2.2	3.8	9.2	-0.9	-1.5	-1.6	-1.5	-2.4	-3.0
Impedance of arm (left)	2.2	10.0	15.8	-1.9	-3.4	-2.8	-2.9	-4.0	-3.6
Handedness (chirality/laterality): Left-handed	2.2	2.7	4.4	-2.1	-1.4	-2.0	-1.5	-1.5	-1.1
Osteoporosis (self-reported)	2.2	2.8	5.6	-2.0	-1.7	-2.4	-1.5	-1.4	-0.5
Vitamin and mineral supplements	2.1	2.9	4.0	1.1	1.6	1.7	1.6	2.0	2.0
Medication: Co-codamol	2.1	2.4	7.1	-2.7	-1.6	-1.5	-1.1	-1.1	-0.0
Serious illness, injury or assault to yourself	2.1	2.5	5.2	-2.3	-1.6	-2.0	-1.5	-0.5	1.0
Length of working week for main job	2.1	2.3	3.2	1.0	1.7	1.4	1.8	1.5	1.5
Medication: Bendroflumethiazide	2.1	3.2	4.2	-1.3	-1.7	-2.1	-1.7	-2.0	-1.8
Chronic bronchitis/emphysema (father)	2.0	2.4	3.1	-1.4	-1.7	-1.6	-1.0	-1.8	-1.7
Peak expiratory flow (PEF)	2.0	4.6	5.9	2.4	2.1	2.0	2.0	2.4	1.9
Medication: Omeprazole	2.0	2.4	4.3	-1.4	-1.7	-1.4	-2.1	-1.7	-0.7
Reaction Time	1.9	3.6	4.7	1.4	2.2	2.0	2.2	1.9	1.5
Mean Putamen Volume	1.9	2.1	2.9	0.6	1.5	1.5	1.7	1.6	1.6
Comparative body size at age 10	1.9	5.4	11.4	1.0	2.0	1.6	1.6	3.3	3.4
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	4.6	-2.1	-1.8	-1.5	-1.6	-0.7	0.8
Waist circumference	1.8	6.5	9.8	1.9	2.7	2.0	2.5	3.1	2.8
Birth weight of first child	1.8	3.3	4.4	1.6	2.1	2.1	1.7	1.9	1.4
Mouth/teeth dental problems: Loose teeth	1.8	2.1	5.3	-0.4	-1.3	-1.4	-1.2	-1.6	-2.3
HDL Cholesterol	1.7	2.8	4.3	1.7	1.7	1.8	2.1	1.6	0.9
Townsend deprivation index at recruitment	1.7	2.5	4.5	-1.9	-1.4	-2.1	-1.4	-1.3	-1.0
Hearing difficulty/problems with background noise	1.6	2.6	3.5	-1.7	-1.6	-1.7	-1.9	-1.6	-1.0
Birth weight	1.6	3.5	10.1	0.6	1.4	1.3	1.1	2.3	3.2
Long-standing illness, disability or infirmity	1.6	2.5	4.2	-1.8	-2.0	-1.5	-1.9	-1.1	0.8
Impedance of whole body	1.6	8.0	14.3	-1.3	-2.9	-2.2	-2.3	-3.7	-3.8
Type 2 Diabetes (T2D) (2012)	1.5	1.7	3.2	-0.6	-1.8	-1.4	-1.2	-1.4	-1.1
Alcohol intake versus 10 years previously	1.5	2.3	3.7	1.2	1.9	1.4	1.9	1.5	0.9
Loud music exposure frequency	1.5	1.7	3.5	1.3	1.5	1.3	1.9	0.9	0.2
Health satisfaction	1.5	2.0	3.5	-1.9	-1.4	-1.5	-1.7	-1.1	-0.1
Loneliness, isolation	1.5	2.0	4.1	-2.0	-1.2	-1.3	-1.3	-1.3	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.7	2.4	1.1	1.2	1.4	1.2	1.6	1.5
Average weekly champagne plus white wine intake	1.5	2.1	3.3	1.2	1.8	1.4	1.8	1.5	0.8
Number of operations (self-reported)	1.5	2.2	3.6	-1.0	-1.9	-1.3	-1.5	-1.8	-1.1
Number of treatments/medications taken	1.4	2.6	4.1	-1.3	-2.0	-1.7	-2.0	-1.5	-0.7
Medication for hormone replacement therapy	1.4	1.5	2.5	-1.0	-1.3	-0.9	-1.6	-1.4	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.1	5.2	1.9	2.0	2.3	1.7	1.7	-0.0
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	3.5	1.9	1.3	1.4	1.6	0.6	-0.3
Leg fat mass (right)	1.4	5.3	7.8	1.4	2.5	1.9	2.4	2.8	2.5
Supplements: Calcium	1.4	1.6	3.0	-0.7	-1.4	-1.3	-1.0	-1.7	-1.1
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	2.3	-1.5	-1.4	-1.1	-1.4	-1.2	-0.8
Falls in the last year	1.3	1.8	3.1	-1.7	-1.0	-1.8	-1.0	-1.4	-0.9
Arm fat mass (right)	1.3	5.2	9.3	1.0	2.3	1.6	2.1	3.0	3.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	5.3	-1.1	-1.1	-0.7	-0.7	-1.6	-2.3
Shortness of breath walking on level ground	1.3	1.6	2.9	-1.7	-1.2	-1.2	-1.4	-1.2	-0.7
Medication: Ibuprofen	1.3	1.5	2.3	0.6	1.0	1.5	1.3	1.4	1.4
Whole body fat mass	1.3	5.4	8.3	1.2	2.4	1.7	2.4	2.9	2.8
Smoking status: Current	1.3	2.1	3.0	-1.6	-1.6	-1.7	-1.5	-1.4	-0.8
Ever depressed for a whole week	1.3	1.6	2.7	1.5	1.3	1.6	1.6	0.6	-0.1
Cholesterol lowering medication	1.3	1.9	2.6	-0.6	-1.4	-1.2	-1.6	-1.6	-1.5
Leg fat mass (left)	1.3	5.0	7.8	1.1	2.4	1.7	2.2	2.8	2.6
Worrier / anxious feelings	1.2	2.2	3.9	-1.9	-1.4	-1.8	-2.0	-0.9	0.3
Age at first live birth	1.2	2.2	7.0	2.6	1.4	1.3	1.4	0.7	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.1	-0.5	-1.1	-1.4	-1.2	-1.4	-1.3
Mineral and other dietary supplements	1.2	1.6	4.3	0.0	1.0	0.9	0.6	1.7	2.1
Risk taking	1.2	1.8	3.7	-0.4	-1.2	-1.2	-0.9	-1.8	-1.9
Respiratory disease	1.1	2.5	3.4	-1.4	-1.6	-1.4	-1.4	-1.8	-1.8
Fed-up feelings	1.1	1.9	5.4	-2.3	-1.2	-1.5	-1.5	-0.6	0.1
Hayfever, allergic rhinitis or eczema	1.1	2.4	3.2	1.7	1.2	1.5	1.1	1.8	1.8
Trunk fat mass	1.1	4.6	6.9	1.3	2.2	1.5	2.2	2.6	2.6
Qualifications: None of the above	1.1	2.4	3.5	-1.8	-1.3	-1.5	-1.0	-1.9	-1.6
Mouth/teeth dental problems	1.1	1.6	4.0	1.0	0.8	1.1	0.8	1.4	2.0
Noisy workplace	1.1	1.4	4.2	-0.4	-0.8	-0.9	-0.4	-1.6	-2.1
Pulse wave reflection index	1.1	1.4	2.4	-0.9	-1.2	-0.9	-1.1	-1.6	-1.3
Overall health rating	1.1	2.5	5.4	-2.3	-1.7	-1.6	-1.7	-1.0	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	2.2	-1.5	-0.7	-1.5	-0.6	-0.9	-0.8
Qualifications: nursing, teaching	1.1	1.7	4.7	1.0	1.0	1.0	0.4	1.5	2.2
Arm fat mass (left)	1.1	4.6	9.1	0.7	2.1	1.4	1.9	2.8	3.0
Eye problems/disorders: Glaucoma	1.1	1.3	4.4	0.8	0.6	0.7	0.4	1.3	2.1
Illnesses of father: High blood pressure	1.1	1.4	2.4	0.1	1.6	1.1	1.3	1.3	1.1
Bipolar Disorder (2018)	1.0	1.5	2.9	1.7	1.1	1.4	1.2	0.9	1.0
HbA1C	1.0	1.1	1.7	-0.8	-1.1	-0.8	-1.3	-1.1	-1.0
Smoking Status	1.0	2.5	3.7	-1.4	-1.6	-1.1	-1.3	-1.9	-1.9
Hearing aid user	1.0	1.1	3.2	-0.1	1.0	1.0	0.5	1.2	1.8
Schizophrenia (2018)	0.9	1.8	6.3	1.6	0.3	0.2	0.8	-1.0	-2.5
Heel T-Score	0.9	6.9	11.1	2.3	3.2	2.7	2.2	3.3	1.7
Allergy or Eczema	0.9	2.4	3.2	1.4	1.3	1.6	1.3	1.8	1.7
Systolic blood pressure, automated reading	0.9	2.5	3.6	-1.5	-1.4	-1.5	-1.3	-1.9	-1.8
Maternal smoking around birth	0.9	1.3	2.8	-1.7	-1.0	-1.1	-1.5	-0.6	-0.1
Impedance of leg (left)	0.9	4.5	12.9	-0.5	-1.7	-1.2	-1.2	-2.8	-3.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.6	1.1	0.9	0.9	0.8	1.3	0.9
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.0	0.9	1.3	1.4	1.1	1.0	0.2
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.0	1.4	1.4	1.4	1.4	0.9	-0.7
Qualifications: College or University degree	0.9	2.9	6.2	2.5	1.2	1.4	0.8	1.9	1.9
Mean time to correctly identify matches	0.9	1.7	2.9	1.4	1.5	1.7	1.6	0.8	0.4
Age at last live birth	0.9	1.3	2.9	1.6	0.8	0.9	0.9	-0.3	-1.7
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.1	-0.7	-1.2	-0.8	-1.5	-1.3	-0.5
Primary Biliary Cirrhosis	0.8	1.1	3.2	0.9	0.6	0.9	0.6	1.1	1.8
Relative age of first facial hair	0.8	1.7	6.2	1.4	0.1	0.0	0.1	-1.3	-2.5
Diabetes (father)	0.8	1.0	2.2	-0.6	-1.3	-1.5	-1.0	-0.9	-0.4
Impedance of leg (right)	0.8	3.6	13.3	-0.1	-1.2	-0.5	-0.6	-2.6	-3.6
Number of live births	0.8	1.2	2.1	-0.8	-1.4	-1.0	-1.2	-1.1	-0.6
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.6	1.2	0.4	0.5	0.7	-0.4	-1.9
Eye problems/disorders: None of the above	0.8	0.9	3.0	-0.7	-0.5	-0.7	-0.3	-1.2	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	3.9	-0.1	0.5	-0.1	0.3	1.3	2.0
Number of full sisters	0.8	1.0	1.8	-0.6	-0.5	-1.1	-0.9	-1.2	-1.4
Ever taken oral contraceptive pill	0.8	0.9	3.0	-0.7	0.5	0.3	0.5	1.0	1.7
Bipolar Disorder or Schizophrenia	0.7	1.8	5.2	2.3	1.0	1.0	1.4	-0.2	-1.3
Worry (Nagel 2018)	0.7	1.4	2.5	-1.0	-0.8	-1.1	-1.1	-1.4	-1.6
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.5	1.4	1.2	1.3	0.6	1.3	1.6
Hypothyroidism (self reported)	0.7	1.6	4.2	-0.7	-1.3	-0.8	-2.0	-1.2	-0.9
Neuroticism	0.7	1.7	2.8	-1.3	-0.9	-1.3	-1.0	-1.5	-1.7
Hearing difficulty/problems: Yes	0.7	1.1	1.5	-1.2	-0.8	-1.2	-1.2	-0.9	-0.7
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.7	-1.3	-1.0	-0.7	-0.8	-1.0	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	2.5	1.3	1.4	1.6	1.0	1.4	0.3
Stomach or abdominal pain in last month	0.7	0.9	2.5	0.6	0.8	0.8	0.3	1.0	1.6
Past tobacco smoking	0.7	1.3	5.8	-0.6	-0.1	-0.1	-0.5	1.2	2.4
Had other major operations	0.7	0.8	1.8	-0.3	-0.7	-0.8	-0.6	-1.3	-1.3
Neuroticism score	0.7	1.5	2.8	-1.7	-0.9	-1.3	-1.0	-1.2	-1.0
Depression (self-reported)	0.7	0.8	1.3	0.4	1.0	1.0	0.6	1.1	1.1
Lung cancer (father)	0.7	0.9	1.4	1.1	1.1	1.0	1.2	0.6	0.2
Headache pain in last month	0.7	1.2	4.0	-0.7	0.7	0.3	0.5	1.4	2.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	3.8	0.1	-0.1	0.2	-0.3	-1.1	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	2.5	1.4	1.3	1.6	1.2	1.0	0.8
Mother’s age at death	0.7	0.9	1.4	-0.5	-1.0	-0.8	-1.0	-1.2	-1.0
Ever smoked	0.7	1.3	5.9	0.3	-0.1	-0.3	0.1	-1.3	-2.4
Irritability	0.7	1.2	1.9	-1.1	-1.0	-1.1	-0.9	-1.4	-1.1
Basal cell carcinoma (self-reported)	0.7	0.9	1.6	-0.9	-0.8	-0.7	-0.7	-1.3	-1.1
Crohns Disease (2017)	0.6	1.3	4.8	0.4	0.9	0.1	0.2	1.3	2.2
Lupus	0.6	1.0	1.8	-1.3	-1.1	-0.9	-1.1	-0.9	-0.2
Rheumatoid Arthritis	0.6	0.8	1.1	0.9	1.0	0.8	1.0	1.1	0.6
Systolic Blood Pressure	0.6	2.8	3.2	-1.8	-1.7	-1.7	-1.7	-1.8	-1.3
Angina	0.6	0.8	2.0	0.1	0.7	1.0	0.5	1.0	1.4
Severe depression (siblings)	0.6	0.7	1.0	-0.7	-0.9	-0.8	-1.0	-0.9	-0.5
Multivitamins +/- minerals	0.6	0.8	1.4	-0.5	-0.7	-0.7	-0.8	-1.1	-1.2
Body mass index (BMI)	0.6	2.7	6.7	-0.0	1.5	0.7	1.3	2.2	2.6
Alcohol usually taken with meals	0.6	1.0	1.9	0.9	1.3	1.2	1.4	0.7	-0.2
Diabetes (self-reported)	0.6	0.9	2.2	0.4	-0.9	-0.7	-0.6	-1.1	-1.5
Pulse rate	0.6	1.0	2.1	-1.1	-0.6	-0.9	-0.8	-1.0	-1.5
Exposure to tobacco smoke at home	0.6	0.6	1.6	-1.3	-0.7	-0.7	-1.0	-0.4	-0.3
Medication: Paracetamol	0.6	0.9	1.5	0.2	0.8	1.1	1.2	1.1	1.1
Worry too long after embarrassment	0.6	1.0	2.7	-1.6	-0.5	-1.3	-0.9	-0.2	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.2	0.8	1.1	0.5	0.9	1.0	0.3
Medication: Allopurinol	0.6	0.8	1.5	0.9	0.7	0.8	0.7	0.8	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.9	-0.1	0.7	0.7	0.6	1.0	1.4
Illnesses of father: Heart disease	0.6	0.9	1.2	0.7	0.9	1.1	0.9	1.1	0.8
Diabetes diagnosed by doctor	0.6	1.0	1.5	-0.0	-1.1	-1.0	-0.8	-1.2	-1.2
Asthma (self-reported)	0.6	1.3	1.7	-0.7	-1.3	-0.9	-1.1	-1.3	-1.2
Osteoarthritis (self-reported)	0.6	0.8	2.7	-0.4	-0.9	-0.2	-0.2	-1.1	-1.6
Unable to work because of sickness or disability	0.6	0.7	3.2	-0.8	-0.0	0.1	0.0	0.9	1.8
Alzheimer’s Disease (in mother)	0.5	0.6	0.8	0.8	0.7	0.9	0.6	0.7	0.8
Age at First Birth	0.5	0.7	1.6	0.7	0.6	0.6	0.4	1.0	1.3
BMI	0.5	3.1	10.4	0.2	1.1	0.4	0.8	2.5	3.2
Tanning	0.5	5.6	7.6	-2.8	-2.6	-2.4	-2.4	-2.5	-1.2
Time employed in main current job	0.5	0.6	1.8	1.3	0.5	0.7	0.4	0.1	-0.8
Hair/balding pattern: Pattern 3	0.5	0.8	2.1	0.7	0.5	0.8	0.5	1.0	1.4
Medication: Cholesterol lowering	0.5	0.8	1.3	-1.0	-1.0	-1.2	-0.8	-0.6	0.5
Prospective memory result	0.5	0.6	0.7	-0.7	-0.7	-0.8	-0.7	-0.9	-0.8
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	3.8	0.1	-0.2	0.3	-0.4	0.9	1.9
Glaucoma (self-reported)	0.5	0.6	1.8	0.9	0.1	0.6	-0.1	0.7	1.3
Number of children fathered	0.5	0.6	1.5	0.7	0.7	1.2	0.9	0.4	0.1
Neck or shoulder pain in last month	0.5	0.7	2.8	-1.7	-0.5	-1.0	-0.3	-0.1	0.2
Angina (self-reported)	0.5	0.7	1.8	0.1	0.7	0.9	0.5	0.9	1.3
Medication: Seretide 50 evohaler	0.5	0.6	0.9	1.0	0.8	0.8	0.7	0.2	-0.9
Average weekly red wine intake	0.5	0.7	1.9	0.9	-0.3	-0.5	-0.5	-1.0	-1.4
Ever had bowel cancer screening	0.5	0.6	1.9	1.4	0.6	1.0	0.3	0.5	-0.1
Medication for cholesterol	0.5	0.8	1.3	0.6	1.0	0.6	1.1	1.0	0.9
Guilty feelings	0.5	0.7	2.0	-1.4	-0.6	-1.0	-0.9	-0.5	0.1
Alcohol drinker status: Previous	0.5	0.6	1.4	1.0	0.4	1.2	0.9	-0.1	-0.6
Neuroticism (Nagel 2018)	0.4	0.9	1.8	-1.4	-0.7	-1.1	-1.0	-0.8	-0.4
Body Mass Index (BMI) (2010)	0.4	0.6	1.3	0.4	0.7	0.5	0.6	1.1	1.0
Fasting Glucose	0.4	0.5	1.9	-0.5	-0.1	-0.1	0.1	0.8	1.4
LDL Cholesterol	0.4	0.7	1.0	0.7	0.9	1.0	0.5	1.0	0.8
Schizophrenia (2014)	0.4	0.9	2.3	1.4	0.2	0.3	0.7	-0.7	-1.5
Triglycerides	0.4	0.7	1.6	-0.4	-0.7	-0.7	-0.7	-0.9	-1.3
Blood Eosinophil Count	0.4	3.3	6.0	0.2	-1.7	-2.2	-1.5	-1.9	-2.4
Chronotype (morning person)	0.4	1.0	5.1	0.7	-0.0	0.1	0.2	-0.7	-2.3
Diabetes (mother)	0.4	0.6	1.4	1.2	0.6	0.9	0.6	0.6	0.1
Medication: Atenolol	0.4	0.5	1.0	0.1	-0.8	-0.6	-0.4	-1.0	-0.9
Number of incorrect matches in round	0.4	0.6	2.2	-0.9	-0.0	-0.1	-0.2	-0.8	-1.5
Nervous feelings	0.4	0.7	2.1	-0.5	-0.3	-0.5	-0.4	-1.0	-1.5
Allergy	0.4	0.9	1.5	-1.2	-0.9	-1.1	-0.8	-0.9	-0.7
Fluid intelligence score	0.4	0.9	2.0	1.1	0.7	0.9	0.1	1.1	1.4
Illnesses of siblings	0.4	0.6	1.6	0.6	0.3	0.8	0.1	0.9	1.2
Father’s age at death	0.4	0.6	1.4	-1.2	-0.7	-0.5	-0.9	-0.7	-0.3
Qualifications: A levels/AS levels or equivalent	0.4	0.9	3.9	0.5	-0.0	0.1	-0.3	1.0	2.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.3	0.5	0.6	1.1	1.1	0.5	0.3
Gout (self-reported)	0.4	0.5	1.2	1.1	0.7	0.6	0.7	0.5	0.4
Emphysema/chronic bronchitis	0.4	0.4	1.5	-1.2	-0.5	-0.2	-0.8	0.0	0.5
Leg pain on walking	0.4	0.5	1.2	0.6	0.5	0.2	0.6	0.9	1.1
Smoking status: Previous	0.4	0.6	2.4	0.5	0.2	0.3	0.5	-0.8	-1.5
Friendships satisfaction	0.4	0.5	1.2	0.6	0.6	0.9	0.1	0.8	1.1
Commuting to job workplace: Walk	0.4	0.5	0.7	-0.7	-0.5	-0.8	-0.6	-0.7	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.9	-1.7	-0.4	-0.4	-0.0	-0.2	0.3
Breast cancer (self-reported)	0.4	0.5	1.9	-0.3	-0.3	0.1	-0.1	0.9	1.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.1	0.1	0.1	0.2	0.6	-0.6	-1.4
Medication: Paracetamol	0.4	0.6	0.9	0.1	0.6	1.0	0.9	0.8	0.7
Medication: Atorvastatin	0.4	0.5	0.8	-0.6	-0.9	-0.5	-0.9	-0.8	-0.5
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.8	0.6	0.8	0.9	0.9	0.6	0.1
Commuting to job workplace: Cycle	0.4	0.5	0.9	-0.7	-0.8	-0.9	-0.7	-0.4	0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	0.6	0.8	0.6	0.8	0.7	0.4	0.3
Irritable Bowel Disease (IBD)	0.3	0.7	2.2	-0.7	-0.1	-0.7	-0.7	0.5	1.5
Ulcerative Colitis (UC)	0.3	0.6	1.7	-1.3	-0.7	-0.9	-0.7	-0.2	0.4
Ulcerative Colitis	0.3	0.5	0.9	-0.9	-0.7	-0.9	-0.8	-0.1	0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.9	0.2	-0.5	-0.5	-0.2	-0.7	-1.4
Lung FEV1/FVC ratio	0.3	1.5	2.3	1.5	1.5	1.5	1.1	0.5	-0.9
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.4	-1.1	0.0	0.1	-0.1	0.3	1.2
Medication: Metformin	0.3	0.4	0.9	-0.1	-0.6	-0.4	-0.3	-0.9	-0.9
Heart attack	0.3	0.3	1.4	-0.7	-0.2	0.2	-0.2	0.2	1.2
Medication: Simvastatin	0.3	0.5	0.8	-0.3	-0.9	-0.7	-0.9	-0.7	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.5	-1.2	-0.5	-0.7	-0.4	-0.3	0.4
Happiness	0.3	0.4	0.7	-0.1	-0.9	-0.5	-0.8	-0.7	-0.4
Asthma	0.3	0.6	0.9	-0.4	-0.9	-0.6	-0.7	-0.9	-1.0
Medication: Lansoprazole	0.3	0.3	0.7	-0.2	-0.6	-0.7	-0.9	-0.6	-0.0
Breastfed as a baby	0.3	0.4	0.5	0.6	0.7	0.6	0.6	0.5	0.7
Tense / ‘highly strung’	0.3	0.5	1.7	0.2	0.6	-0.0	0.8	-0.6	-1.3
Medication for pain relief, constipation, heartburn	0.3	0.5	0.8	-0.5	-0.5	-0.9	-0.8	-0.6	-0.6
Migraine (self-reported)	0.3	0.3	1.4	-0.4	-0.1	-0.0	-0.5	0.3	1.2
Family relationship satisfaction	0.3	0.4	0.7	0.3	0.7	0.9	0.4	0.4	0.7
Hypertension (Self-reported)	0.3	0.9	2.0	-0.5	-0.8	-0.8	-0.6	-1.4	-1.2
Financial situation satisfaction	0.3	0.4	1.0	-1.0	-0.4	-0.4	-0.5	-0.6	-0.7
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.0	0.1	-0.7	-0.5	-0.6	0.4	1.0
Medication: Blood pressure	0.3	0.6	0.9	-0.2	-0.8	-0.7	-0.9	-0.8	-0.9
Myopia	0.3	0.4	2.0	0.0	-0.2	-0.3	-0.2	-0.7	-1.4
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.8	0.3	0.5	0.5	0.4	1.2	1.4
Pain experienced in last month	0.3	0.6	1.6	1.3	0.1	0.6	-0.0	-0.5	-1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.0	-0.8	-0.5	0.0	-0.5	-0.1	1.0
Depression (Nagel 2018)	0.2	0.3	0.7	0.1	0.5	0.9	0.6	0.4	0.3
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.3	1.1	0.6	1.1	0.2	0.4	0.8
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.6	-0.3	-0.7	0.0	-0.4	-0.8
Waist Hip Ratio (WHR)	0.2	0.9	1.7	1.3	1.0	1.2	0.9	0.6	0.2
Lung FVC	0.2	0.8	1.4	1.2	0.9	1.0	0.9	0.9	0.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	0.7	-0.0	0.4	0.1	-0.3	-0.8
High blood pressure	0.2	0.6	1.7	-0.1	-0.4	-0.5	-0.3	-1.2	-1.3
Hair/balding pattern: Pattern 2	0.2	0.2	0.7	0.1	-0.2	-0.7	-0.8	0.2	0.4
Financial difficulties in last 2 years	0.2	0.2	0.5	0.1	0.7	0.4	0.4	0.7	0.4
Pain all over the body in last month	0.2	0.2	0.3	-0.6	-0.6	-0.5	-0.2	-0.3	0.1
Medication: Ramipril	0.2	0.3	0.8	-0.9	-0.3	-0.5	-0.4	-0.1	0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.2	1.0	0.0	-0.2	0.0	-0.0	-0.5	-1.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	1.1	-0.2	-0.1	0.1	-0.2	0.3	1.0
Exposure to tobacco smoke outside home	0.2	0.3	0.6	-0.8	-0.6	-0.4	-0.3	0.2	0.7
Number of full brothers	0.2	0.2	0.7	-0.8	-0.4	-0.4	-0.6	-0.1	0.1
Medication: Gliclazide	0.2	0.3	0.8	0.9	0.1	0.0	0.2	-0.2	-0.8
Wears glasses or contact lenses	0.2	0.2	0.7	-0.1	-0.5	0.0	-0.7	-0.1	0.8
Commuting to job workplace: Public transport	0.2	0.3	1.3	0.1	-0.3	-0.4	0.2	0.2	1.1
Heart disease (siblings)	0.2	0.2	1.1	-0.1	-0.0	0.1	0.1	-0.3	-1.0
Depressed Affect (Nagel 2018)	0.1	0.3	0.9	-1.0	-0.3	-0.5	-0.5	-0.1	0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.1	-0.3	-0.2	-0.2	-0.5	-0.5
Neuroticism (2016)	0.1	0.2	0.7	0.4	-0.0	0.1	-0.1	-0.6	-0.9
Blood Platelet Count	0.1	1.1	3.3	1.5	0.3	0.3	0.8	-0.5	-1.8
Blood Red Count	0.1	0.5	1.3	0.3	1.0	0.3	1.2	0.6	-0.3
Cardiovascular Disease	0.1	0.4	0.8	-0.8	-0.5	-0.9	-0.5	0.1	0.9
Hair Pigment	0.1	4.2	8.5	2.9	1.9	2.4	2.0	1.8	0.4
Supplements: Zinc	0.1	0.1	0.4	0.5	0.3	-0.1	0.2	-0.1	-0.7
Trunk fat percentage	0.1	0.3	0.6	-0.2	0.5	-0.0	0.8	0.7	0.7
Average weekly fortified wine intake	0.1	0.1	0.2	-0.4	-0.4	-0.1	0.1	-0.5	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	0.1	0.5	0.5	0.6	0.0	-0.5
Qualifications: CSEs or equivalent	0.1	0.2	0.4	-0.1	0.3	-0.1	0.2	0.7	0.7
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.5	0.7	0.4	0.4	0.1	0.1	-0.3
Arm fat percentage (right)	0.1	0.5	1.6	-1.3	0.0	-0.6	0.2	0.5	1.0
Illnesses of mother	0.1	0.1	0.4	0.2	0.3	0.6	-0.1	-0.3	-0.2
Medication: Amlodipine	0.1	0.1	0.2	-0.2	-0.3	-0.5	-0.2	-0.3	-0.5
High blood pressure (siblings)	0.1	0.1	0.2	0.0	0.4	0.0	0.5	0.3	0.1
Body fat percentage	0.1	0.3	0.7	-0.4	0.5	-0.0	0.8	0.6	0.7
Leg fat percentage (right)	0.1	0.3	1.1	-0.1	0.7	0.4	1.0	0.5	0.0
Heart disease (mother)	0.1	0.1	0.3	-0.2	0.1	-0.3	-0.1	0.6	0.3
Pulse rate, automated reading	0.1	0.2	0.4	-0.5	0.0	-0.4	-0.4	-0.1	-0.7
Alcohol intake frequency.	0.1	0.3	0.9	0.3	0.3	0.9	0.6	-0.0	-0.4
Chest pain or discomfort	0.1	0.2	0.4	-0.6	-0.2	-0.0	-0.4	-0.2	-0.6
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	-0.4	-0.1	0.2	-0.1	-0.3	-0.6
Medication: Aspirin	0.1	0.2	0.4	0.3	-0.3	-0.2	-0.6	-0.4	-0.6
Knee pain experienced in last month	0.1	0.2	0.3	-0.5	0.3	-0.1	0.6	0.5	0.5
Arm fat percentage (left)	0.1	0.5	1.4	-1.2	0.0	-0.6	0.1	0.5	1.0
Mood swings	0.1	0.2	0.4	0.3	0.7	0.5	0.6	0.4	0.2
Back pain experienced in last month	0.1	0.1	0.6	0.1	-0.1	0.1	-0.0	-0.1	-0.8
Medication: Aspirin	0.1	0.2	0.6	0.8	0.2	0.3	0.0	-0.1	-0.6
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	0.6	0.4	0.5	0.5	0.0	-0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.5	-0.7	-0.2	-0.1	0.0	-0.1	-0.3
Alcohol drinker status: Never	0.1	0.1	0.2	-0.4	-0.3	-0.2	-0.5	0.2	-0.3
Diastolic blood pressure, automated reading	0.1	0.3	0.8	-0.9	-0.1	-0.6	0.5	0.2	0.6
Major Depression (MDD)	0.0	0.1	0.1	0.3	0.0	0.2	0.3	-0.3	-0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.0	0.1	0.2	-0.4	-0.1	-0.4	-0.2	-0.2	-0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.2	0.1	0.2	-0.0	0.4	0.0	-0.0
Blood White Count	0.0	0.3	0.7	-0.0	-0.8	-0.8	-0.1	-0.4	-0.6
Age when periods started (menarche)	0.0	0.1	0.4	0.6	-0.0	0.1	0.1	-0.0	0.2
High blood pressure (mother)	0.0	0.1	0.2	-0.0	-0.3	-0.4	0.2	0.1	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.2	0.2	0.2	0.2	0.2	-0.1	-0.4
Blood clot in the leg (DVT)	0.0	0.0	0.0	-0.1	0.0	-0.0	0.0	0.1	0.0
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	-0.3	-0.1	-0.1	-0.3	-0.2	-0.4
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.2	-0.1	-0.3	-0.1	0.0	-0.1
Miserableness	0.0	0.1	0.2	-0.4	0.1	-0.4	0.1	0.3	0.1
High cholesterol (Self-reported)	0.0	0.1	0.1	0.4	-0.3	-0.4	-0.2	-0.3	-0.1
Leg fat percentage (left)	0.0	0.1	0.3	-0.5	0.3	-0.1	0.5	0.2	0.1
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	0.1	0.1	0.1	0.1	0.2	0.0

Hub : Genes

WBP11

Models

Trait associations