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chr12:27,587,038-30,229,606

Best TWAS P=1.07e-37 · Best GWAS P=7.24e-34 conditioned to 0.00222

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
40	GTEx	Skin Not Sun Exposed Suprapubic	CCDC91	0.26	0.05	lasso	15	0.04	4.1e-03	-12.1	-12.8	1.1e-37	0.85	0.07	0.93	TRUE
14	GTEx	Breast Mammary Tissue (Male)	RP11-996F15.2	0.52	0.28	lasso	9	0.23	4.1e-06	7.3	7.5	6.0e-14	0.05	0.00	0.98	TRUE
19	GTEx	Cells Transformed fibroblasts	RP11-967K21.1	0.07	0.07	lasso	2	0.07	3.7e-06	-11.8	12.3	1.2e-34	-0.96	0.12	0.88	FALSE
59	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCDC91	0.09	0.11	lasso	2	0.12	2.3e-05	-12.1	-12.1	8.4e-34	1.00	0.03	0.96	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCDC91	0.04	0.04	lasso	3	0.03	1.8e-06	-11.8	-11.8	2.9e-32	0.98	0.09	0.91	FALSE
29	GTEx	Heart Atrial Appendage	RP11-967K21.1	0.08	0.09	lasso	1	0.08	2.3e-04	-11.8	11.8	3.4e-32	-0.92	0.08	0.84	FALSE
28	GTEx	Heart Atrial Appendage	CCDC91	0.10	0.06	lasso	8	0.04	4.4e-03	-11.5	-11.8	3.9e-32	0.84	0.08	0.83	FALSE
18	GTEx	Cells Transformed fibroblasts	CCDC91	0.10	0.10	lasso	5	0.09	5.5e-07	-11.5	-11.8	5.2e-32	0.84	0.06	0.93	FALSE
42	GTEx	Skin Sun Exposed Lower leg	CCDC91	0.09	0.01	enet	8	0.01	2.6e-02	-11.8	-11.6	4.7e-31	0.87	0.07	0.88	FALSE
32	GTEx	Muscle Skeletal	RP11-967K21.1	0.04	0.01	lasso	9	0.00	2.9e-01	-11.6	11.0	4.4e-28	-0.88	0.07	0.79	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CCDC91	0.08	0.06	lasso	6	0.07	9.4e-09	-11.7	10.0	1.7e-23	-0.92	0.10	0.90	FALSE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	CCDC91	0.09	0.01	blup	170	0.02	1.0e-03	-12.0	-9.9	3.0e-23	0.80	0.07	0.87	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC91	0.40	0.12	blup	175	0.14	4.9e-13	-11.9	-9.8	1.8e-22	0.65	0.08	0.92	FALSE
22	GTEx	Colon Transverse	CCDC91	0.11	0.01	lasso	6	0.00	4.6e-01	-11.6	-9.6	1.1e-21	0.81	0.07	0.80	FALSE
7	GTEx	Artery Aorta	RP11-967K21.1	0.07	0.02	lasso	7	0.01	7.9e-02	4.5	9.1	6.9e-20	-0.85	0.05	0.85	FALSE
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCDC91	0.06	0.02	blup	174	0.04	2.9e-05	3.2	-9.0	1.9e-19	0.82	0.33	0.65	FALSE
48	GTEx	Thyroid	CCDC91	0.15	0.12	enet	42	0.12	2.9e-09	-12.0	-8.7	4.7e-18	0.83	0.06	0.94	FALSE
52	NTR	Blood	CCDC91	0.01	0.01	blup	648	0.00	9.0e-03	2.4	-8.3	8.7e-17	0.77	0.18	0.58	FALSE
37	GTEx	Pituitary	RP11-967K21.1	0.20	0.04	lasso	7	0.04	4.4e-02	3.4	8.3	1.2e-16	-0.64	0.06	0.54	FALSE
6	GTEx	Artery Aorta	CCDC91	0.16	0.00	enet	37	0.02	4.1e-02	-12.0	-7.5	4.8e-14	0.55	0.08	0.79	FALSE
13	GTEx	Breast Mammary Tissue	RP11-996F15.2	0.45	0.35	lasso	8	0.31	1.2e-16	7.3	7.4	1.5e-13	0.05	0.00	1.00	FALSE
25	GTEx	Esophagus Mucosa	CCDC91	0.18	0.04	enet	36	0.03	3.1e-03	4.5	-7.3	2.0e-13	0.57	0.09	0.79	FALSE
44	GTEx	Small Intestine Terminal Ileum	RP11-996F15.2	0.60	0.51	lasso	5	0.46	7.1e-12	7.3	7.3	2.1e-13	0.04	0.00	1.00	FALSE
5	GTEx	Adrenal Gland	RP11-996F15.2	0.62	0.55	lasso	7	0.55	3.0e-23	7.3	7.3	3.1e-13	0.04	0.00	1.00	FALSE
51	GTEx	Whole Blood	RP11-996F15.2	0.20	0.18	enet	11	0.18	9.2e-17	7.3	7.3	3.2e-13	0.07	0.00	1.00	FALSE
15	GTEx	Breast Mammary Tissue (Female)	RP11-996F15.2	0.42	0.38	lasso	1	0.35	3.5e-11	7.3	7.3	3.3e-13	0.04	0.00	1.00	FALSE
23	GTEx	Colon Transverse	RP11-996F15.2	0.31	0.32	lasso	1	0.31	3.5e-15	7.3	7.3	3.3e-13	0.04	0.00	1.00	FALSE
12	GTEx	Brain Cerebellum	RP11-996F15.2	0.25	0.15	lasso	4	0.10	7.6e-04	7.3	7.2	4.4e-13	0.04	0.01	0.94	FALSE
26	GTEx	Esophagus Mucosa	RP11-996F15.2	0.39	0.43	lasso	7	0.45	6.2e-33	7.3	7.2	4.8e-13	0.05	0.00	1.00	FALSE
36	GTEx	Pancreas	RP11-996F15.2	0.56	0.46	enet	22	0.48	1.8e-22	7.3	7.2	4.8e-13	0.03	0.00	1.00	FALSE
33	GTEx	Muscle Skeletal	RP11-996F15.2	0.24	0.26	lasso	11	0.25	9.3e-25	7.3	7.2	4.9e-13	0.05	0.00	1.00	FALSE
56	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ERGIC2	0.04	0.03	lasso	2	0.03	1.3e-04	7.3	-7.2	5.4e-13	-0.03	0.00	0.99	FALSE
46	GTEx	Stomach	RP11-996F15.2	0.35	0.41	lasso	3	0.40	1.4e-20	7.3	7.2	5.5e-13	0.03	0.00	1.00	FALSE
31	GTEx	Lung	RP11-996F15.2	0.50	0.46	lasso	5	0.46	1.9e-39	7.3	7.2	6.2e-13	0.04	0.00	1.00	FALSE
49	GTEx	Thyroid	RP11-996F15.2	0.54	0.54	lasso	8	0.55	9.1e-50	7.3	7.2	7.0e-13	0.04	0.00	1.00	FALSE
43	GTEx	Skin Sun Exposed Lower leg	RP11-996F15.2	0.50	0.48	enet	21	0.50	1.5e-47	7.3	7.2	8.3e-13	0.04	0.00	1.00	FALSE
10	GTEx	Artery Tibial	RP11-996F15.2	0.44	0.40	enet	28	0.44	1.2e-37	7.3	7.2	8.5e-13	0.06	0.00	1.00	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	RP11-996F15.2	0.50	0.42	lasso	8	0.42	1.4e-16	7.3	7.1	1.1e-12	0.05	0.00	1.00	FALSE
8	GTEx	Artery Aorta	RP11-996F15.2	0.35	0.28	lasso	4	0.28	1.5e-15	7.3	7.1	1.3e-12	0.04	0.00	1.00	FALSE
47	GTEx	Testis	RP11-996F15.2	0.28	0.35	lasso	2	0.37	2.7e-17	7.3	7.1	1.3e-12	0.03	0.00	1.00	FALSE
20	GTEx	Cells Transformed fibroblasts	RP11-996F15.2	0.34	0.33	lasso	7	0.34	7.3e-26	7.3	7.1	1.6e-12	0.04	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	RP11-996F15.2	0.46	0.38	lasso	10	0.38	4.1e-33	7.3	7.1	1.7e-12	0.04	0.00	1.00	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	RP11-996F15.2	0.21	0.22	lasso	7	0.24	5.1e-30	7.3	7.1	1.7e-12	0.05	0.00	1.00	FALSE
45	GTEx	Spleen	RP11-996F15.2	0.53	0.49	lasso	5	0.46	1.7e-13	7.3	7.0	1.8e-12	0.06	0.00	1.00	FALSE
38	GTEx	Pituitary	RP11-996F15.2	0.54	0.42	lasso	8	0.32	7.7e-09	7.3	7.0	2.0e-12	0.05	0.00	1.00	FALSE
27	GTEx	Esophagus Muscularis	RP11-996F15.2	0.56	0.45	enet	31	0.47	1.3e-31	7.3	7.0	2.5e-12	0.02	0.00	1.00	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	RP11-996F15.2	0.27	0.24	lasso	4	0.23	6.0e-08	7.3	7.0	2.8e-12	0.04	0.00	1.00	FALSE
39	GTEx	Prostate	RP11-996F15.2	0.49	0.36	enet	32	0.39	6.0e-11	7.3	7.0	2.8e-12	0.04	0.00	1.00	FALSE
34	GTEx	Nerve Tibial	RP11-996F15.2	0.52	0.53	lasso	5	0.56	3.3e-47	7.3	7.0	3.2e-12	0.05	0.00	1.00	FALSE
41	GTEx	Skin Not Sun Exposed Suprapubic	RP11-996F15.2	0.44	0.28	enet	55	0.28	1.1e-15	7.3	7.0	3.4e-12	0.02	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC91	0.22	0.00	enet	16	0.04	2.5e-05	8.0	-6.9	3.9e-12	0.44	0.02	0.12	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-996F15.2	0.40	0.34	enet	12	0.33	7.9e-18	7.3	6.9	4.4e-12	0.03	0.00	1.00	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	ERGIC2	0.19	0.10	blup	62	0.11	1.1e-10	6.3	-6.9	6.1e-12	-0.04	0.01	0.99	FALSE
4	GTEx	Adrenal Gland	CCDC91	0.16	0.01	lasso	16	0.03	3.5e-02	4.1	-6.8	1.2e-11	0.39	0.08	0.51	FALSE
21	GTEx	Colon Sigmoid	RP11-996F15.2	0.42	0.27	lasso	7	0.29	7.7e-11	7.3	6.7	2.4e-11	0.05	0.00	1.00	FALSE
11	GTEx	Brain Cerebellar Hemisphere	RP11-996F15.2	0.30	0.11	enet	24	0.17	3.7e-05	7.3	6.6	4.5e-11	0.04	0.01	0.98	FALSE
17	GTEx	Cells Transformed fibroblasts	ERGIC2	0.12	0.03	enet	23	0.05	1.4e-04	7.3	-6.6	4.9e-11	-0.02	0.00	0.99	FALSE
35	GTEx	Ovary	RP11-996F15.2	0.50	0.46	enet	22	0.54	1.1e-15	6.3	6.4	1.6e-10	0.06	0.01	0.99	FALSE
50	GTEx	Vagina	RP11-996F15.2	0.44	0.31	enet	23	0.27	5.9e-07	7.3	6.4	1.9e-10	0.05	0.00	0.99	FALSE
9	GTEx	Artery Coronary	RP11-996F15.2	0.54	0.44	enet	20	0.43	9.0e-16	7.3	6.1	8.1e-10	0.05	0.00	1.00	FALSE
30	GTEx	Lung	CCDC91	0.14	0.00	enet	33	0.06	1.5e-05	-6.6	-5.9	3.7e-09	0.37	0.25	0.20	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	ERGIC2	0.06	0.02	enet	9	0.04	4.8e-05	3.8	-5.3	8.8e-08	-0.08	0.01	0.91	FALSE