Best TWAS P=8.35e-16 · Best GWAS P=7.51e-16 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Skin Sun Exposed Lower leg | VPS13C | 0.09 | 0.09 | lasso | 2 | 0.08 | 1.8e-07 | 6.2 | 6.3 | 3.5e-10 | -0.82 | 0.39 | 0.61 | FALSE |
| 2 | GTEx | Spleen | VPS13C | 0.27 | 0.19 | lasso | 7 | 0.12 | 6.6e-04 | 5.4 | 5.9 | 3.5e-09 | -0.79 | 0.33 | 0.42 | FALSE |
| 3 | GTEx | Whole Blood | VPS13C | 0.09 | 0.00 | enet | 35 | 0.00 | 1.9e-01 | -6.8 | 5.2 | 2.2e-07 | -0.58 | 0.12 | 0.67 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C2CD4A | 0.03 | 0.01 | blup | 59 | 0.02 | 7.2e-03 | -7.3 | -5.8 | 7.1e-09 | 0.82 | 0.02 | 0.72 | FALSE |
| 5 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C2CD4A | 0.09 | 0.11 | lasso | 1 | 0.08 | 9.4e-04 | -8.0 | -8.1 | 8.3e-16 | 1.00 | 0.01 | 0.90 | TRUE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | VPS13C | 0.07 | 0.03 | enet | 15 | 0.03 | 5.3e-04 | -8.1 | 6.6 | 5.1e-11 | -0.74 | 0.02 | 0.93 | FALSE |