Best TWAS P=2.46e-09 · Best GWAS P=5.73e-08 conditioned to 0.638
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | TSPAN3 | 0.14 | 0.07 | lasso | 5 | 0.10 | 1.6e-08 | 5.4 | -6.0 | 2.5e-09 | -0.88 | 0.01 | 0.99 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | SNUPN | 0.03 | 0.03 | enet | 8 | 0.02 | 9.9e-04 | 4.4 | 5.6 | 2.6e-08 | -0.01 | 0.00 | 0.83 | TRUE |
| 5 | GTEx | Nerve Tibial | TSPAN3 | 0.13 | 0.08 | lasso | 2 | 0.07 | 9.0e-06 | 5.4 | -5.5 | 4.6e-08 | -0.98 | 0.00 | 0.99 | FALSE |
| 6 | GTEx | Nerve Tibial | IMP3 | 0.08 | 0.00 | enet | 14 | 0.00 | 5.5e-01 | -2.4 | -5.5 | 4.7e-08 | -0.10 | 0.01 | 0.08 | FALSE |
| 3 | GTEx | Esophagus Muscularis | RP11-797A18.4 | 0.07 | 0.09 | lasso | 3 | 0.09 | 6.3e-06 | 5.4 | -5.4 | 6.8e-08 | -0.99 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TSPAN3 | 0.05 | 0.01 | blup | 43 | 0.01 | 1.5e-02 | 5.2 | -5.4 | 7.3e-08 | -0.79 | 0.01 | 0.45 | FALSE |
| 7 | GTEx | Testis | PSTPIP1 | 0.10 | 0.03 | lasso | 3 | 0.02 | 4.1e-02 | 5.3 | -5.3 | 9.2e-08 | -0.94 | 0.01 | 0.94 | FALSE |
| 4 | GTEx | Heart Left Ventricle | RP11-797A18.4 | 0.16 | 0.09 | enet | 12 | 0.08 | 3.3e-05 | 5.4 | -5.3 | 1.1e-07 | -0.95 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Brain Cortex | RP11-797A18.4 | 0.47 | 0.28 | enet | 14 | 0.34 | 3.3e-10 | 5.3 | -5.2 | 1.6e-07 | -0.92 | 0.01 | 0.99 | FALSE |