Best TWAS P=7.64e-28 · Best GWAS P=3.35e-34 conditioned to 1.62e-11
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | LOXL1-AS1 | 0.12 | 0.11 | enet | 19 | 0.12 | 2.4e-09 | -10.5 | 7.6 | 3.9e-14 | -0.49 | 0.95 | 0.04 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | PML | 0.14 | 0.02 | lasso | 4 | 0.02 | 1.9e-02 | -7.4 | 7.1 | 1.6e-12 | 0.05 | 0.29 | 0.03 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | LOXL1-AS1 | 0.28 | 0.09 | lasso | 6 | 0.17 | 1.7e-12 | 4.7 | 8.9 | 7.2e-19 | -0.64 | 0.84 | 0.16 | FALSE |
| 4 | GTEx | Esophagus Mucosa | LOXL1-AS1 | 0.30 | 0.03 | enet | 37 | 0.05 | 2.0e-04 | 2.0 | 5.7 | 1.2e-08 | -0.37 | 0.16 | 0.17 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | ISLR | 0.08 | 0.00 | enet | 14 | 0.03 | 2.8e-03 | 2.5 | 5.9 | 4.2e-09 | -0.12 | 0.14 | 0.09 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | LOXL1-AS1 | 0.11 | 0.05 | enet | 11 | 0.10 | 7.3e-09 | 1.4 | 7.4 | 1.8e-13 | -0.41 | 0.82 | 0.09 | FALSE |
| 7 | GTEx | Testis | LOXL1-AS1 | 0.36 | 0.15 | lasso | 10 | 0.13 | 2.4e-06 | -10.5 | -10.9 | 7.6e-28 | 0.58 | 0.47 | 0.16 | TRUE |
| 8 | GTEx | Thyroid | C15orf59 | 0.23 | 0.12 | lasso | 7 | 0.11 | 6.7e-09 | 5.3 | 5.7 | 1.1e-08 | -0.19 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Thyroid | LOXL1-AS1 | 0.15 | 0.03 | enet | 40 | 0.03 | 2.6e-03 | -10.5 | 10.6 | 2.8e-26 | -0.33 | 0.12 | 0.25 | FALSE |
| 10 | GTEx | Whole Blood | LOXL1-AS1 | 0.10 | 0.00 | enet | 33 | 0.00 | 5.8e-01 | 8.9 | 5.9 | 4.4e-09 | -0.21 | 0.05 | 0.12 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC283731 | 0.02 | 0.01 | blup | 15 | 0.01 | 1.9e-03 | -4.7 | -5.8 | 4.8e-09 | 0.20 | 0.01 | 0.64 | TRUE |