Best TWAS P=4.2e-18 · Best GWAS P=1.16e-28 conditioned to 3.16e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ADAMTS17 | 0.14 | 0.00 | enet | 19 | 0.02 | 5.0e-03 | 8.0 | -7.6 | 3.8e-14 | -0.27 | 0.23 | 0.03 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | CTD-3076O17.1 | 0.22 | 0.05 | lasso | 6 | 0.04 | 2.9e-04 | -4.1 | -6.1 | 9.0e-10 | -0.01 | 0.80 | 0.01 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | ADAMTS17 | 0.20 | 0.00 | enet | 20 | 0.05 | 2.2e-03 | -6.0 | -8.6 | 8.6e-18 | -0.55 | 0.10 | 0.26 | TRUE |
| 4 | GTEx | Adipose Visceral Omentum | CTD-3076O17.1 | 0.21 | 0.00 | lasso | 6 | 0.00 | 6.2e-01 | -5.6 | -8.7 | 4.2e-18 | -0.15 | 0.10 | 0.20 | TRUE |
| 5 | GTEx | Breast Mammary Tissue (Female) | CTD-3076O17.1 | 0.29 | -0.01 | lasso | 5 | 0.00 | 3.2e-01 | -5.8 | -5.5 | 4.9e-08 | 0.06 | 0.07 | 0.05 | FALSE |
| 6 | GTEx | Colon Sigmoid | CTD-3076O17.1 | 0.25 | 0.15 | lasso | 5 | 0.09 | 3.5e-04 | -5.7 | -5.2 | 1.8e-07 | 0.06 | 0.23 | 0.05 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | ADAMTS17 | 0.22 | 0.00 | lasso | 4 | 0.09 | 9.6e-05 | -4.9 | -7.0 | 2.1e-12 | -0.19 | 0.11 | 0.17 | FALSE |
| 8 | GTEx | Heart Atrial Appendage | CTD-3076O17.1 | 0.25 | 0.11 | enet | 24 | 0.17 | 3.8e-08 | -4.7 | -6.0 | 1.6e-09 | -0.06 | 0.71 | 0.02 | FALSE |
| 9 | GTEx | Lung | CTD-3076O17.1 | 0.15 | 0.09 | enet | 13 | 0.09 | 2.8e-07 | -5.6 | -5.8 | 8.1e-09 | 0.06 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Pancreas | CTD-3076O17.1 | 0.24 | 0.11 | enet | 6 | 0.11 | 2.7e-05 | -5.5 | -5.7 | 1.0e-08 | 0.06 | 0.53 | 0.02 | FALSE |
| 11 | GTEx | Testis | ADAMTS17 | 0.30 | 0.24 | lasso | 2 | 0.22 | 6.7e-10 | -5.6 | -5.7 | 1.2e-08 | 0.06 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Testis | CTD-3076O17.1 | 0.45 | 0.17 | enet | 19 | 0.14 | 1.0e-06 | -5.6 | -5.4 | 7.0e-08 | 0.05 | 0.90 | 0.00 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LRRK1 | 0.07 | 0.05 | lasso | 3 | 0.04 | 1.3e-05 | -5.5 | -6.0 | 1.7e-09 | 0.02 | 0.00 | 1.00 | TRUE |