Best TWAS P=5.5e-26 · Best GWAS P=9.01e-26 conditioned to 0.0156
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | TBX2 | 0.19 | 0.04 | lasso | 4 | 0.10 | 1.0e-05 | 8.0 | 6.3 | 3.9e-10 | 0.47 | 0.05 | 0.74 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | RP11-332H18.4 | 0.22 | 0.07 | lasso | 7 | 0.05 | 9.0e-04 | 8.0 | 9.6 | 1.2e-21 | 0.89 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Artery Tibial | RP11-332H18.4 | 0.18 | 0.15 | lasso | 1 | 0.14 | 4.5e-11 | 8.0 | 8.0 | 1.7e-15 | 0.70 | 0.94 | 0.06 | FALSE |
| 4 | GTEx | Brain Frontal Cortex BA9 | TBX2 | 0.29 | 0.01 | lasso | 3 | 0.02 | 7.7e-02 | 5.8 | 5.2 | 1.7e-07 | 0.15 | 0.03 | 0.36 | FALSE |
| 5 | GTEx | Brain Frontal Cortex BA9 | RP11-332H18.4 | 0.40 | 0.05 | lasso | 16 | 0.07 | 6.4e-03 | 5.8 | 6.5 | 5.8e-11 | 0.31 | 0.05 | 0.59 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | RP11-332H18.4 | 0.19 | 0.16 | lasso | 4 | 0.14 | 1.7e-10 | 8.0 | 8.5 | 1.6e-17 | 0.76 | 0.42 | 0.58 | FALSE |
| 7 | GTEx | Esophagus Mucosa | RP11-332H18.4 | 0.19 | 0.09 | lasso | 4 | 0.04 | 9.6e-04 | 8.0 | 8.3 | 1.3e-16 | 0.73 | 0.03 | 0.95 | FALSE |
| 8 | GTEx | Lung | RP11-332H18.4 | 0.10 | 0.04 | enet | 3 | 0.07 | 6.8e-06 | 8.0 | 6.9 | 6.1e-12 | 0.65 | 0.04 | 0.94 | FALSE |
| 9 | GTEx | Testis | TBX2 | 0.20 | 0.18 | lasso | 3 | 0.15 | 4.8e-07 | 8.0 | 8.1 | 5.6e-16 | 0.70 | 0.49 | 0.46 | FALSE |
| 10 | GTEx | Testis | RP11-332H18.4 | 0.19 | 0.19 | lasso | 2 | 0.16 | 1.6e-07 | 7.9 | 8.4 | 4.7e-17 | 0.73 | 0.31 | 0.68 | FALSE |
| 11 | GTEx | Thyroid | TBX2 | 0.10 | 0.09 | lasso | 2 | 0.06 | 1.7e-05 | 8.0 | 8.0 | 1.4e-15 | 0.71 | 0.07 | 0.92 | FALSE |
| 12 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C17orf82 | 0.03 | 0.02 | blup | 42 | 0.00 | 1.3e-01 | 10.4 | -10.5 | 5.5e-26 | -0.90 | 0.00 | 0.96 | TRUE |