Best TWAS P=1.08e-09 · Best GWAS P=2.7e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MYADML2 | 0.52 | 0.43 | enet | 15 | 0.45 | 3.6e-60 | -6.3 | -6.1 | 1.1e-09 | 0.97 | 0.00 | 1.00 | TRUE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NOTUM | 0.06 | 0.02 | enet | 2 | 0.02 | 4.7e-03 | -5.6 | -6.0 | 1.6e-09 | 0.92 | 0.01 | 0.41 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PYCR1 | 0.02 | 0.01 | blup | 9 | 0.01 | 1.1e-02 | -6.3 | 5.9 | 2.9e-09 | -0.94 | 0.00 | 0.76 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | LRRC45 | 0.19 | 0.06 | enet | 9 | 0.12 | 6.7e-06 | -4.0 | 5.7 | 1.6e-08 | -0.82 | 0.01 | 0.98 | FALSE |
| 4 | YFS | Blood | ASPSCR1 | 0.11 | 0.07 | lasso | 9 | 0.06 | 7.9e-20 | -5.4 | 5.6 | 2.3e-08 | -0.69 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MYADML2 | 0.03 | 0.03 | blup | 10 | 0.03 | 1.1e-04 | -5.8 | -5.4 | 5.2e-08 | 0.93 | 0.01 | 0.96 | FALSE |
| 2 | GTEx | Artery Tibial | LRRC45 | 0.09 | 0.07 | lasso | 4 | 0.04 | 2.0e-04 | -4.6 | 5.4 | 6.8e-08 | -0.68 | 0.10 | 0.89 | FALSE |