TWAS hub - ASPSCR1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.227	0.0530	4.6e-06	0.150	NA	0.094	NA	0.070	1.5e-11	NA	1.2e-07	NA	4.9e-06
2	YFS	Blood	0.113	0.0258	2.2e-13	0.066	0.051	0.063	0.059	0.063	1.0e-20	2.9e-16	1.0e-19	1.1e-18	7.9e-20

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Forced expiratory volume in 1-second (FEV1), Best measure	17.9	57.2	65.0	7.0	8.1
Forced expiratory volume in 1-second (FEV1)	16.8	56.6	62.4	7.1	7.9
Peak expiratory flow (PEF)	16.6	38.5	46.2	5.5	6.8
Forced vital capacity (FVC), Best measure	16.0	58.5	66.1	7.1	8.1
Forced vital capacity (FVC)	12.6	48.6	53.6	6.6	7.3
Lung FVC	11.2	56.8	60.4	7.8	7.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	10.3	21.8	22.1	4.7	4.6
Sitting height	8.9	63.0	77.1	7.0	8.8
Birth weight of first child	8.9	16.1	19.8	3.5	4.4
HbA1C	8.4	9.4	14.5	-3.8	-2.1
Gout (self-reported)	6.8	9.3	10.0	-3.2	-2.9
Waist Hip Ratio (WHR)	6.7	30.2	32.8	-5.2	-5.7
Number of full brothers	6.7	8.4	9.4	3.1	2.7
Ever smoked	6.7	11.8	13.4	-3.2	-3.7
Tinnitus: Yes, now most or all of the time	6.0	7.0	7.1	2.7	2.6
Frequency of tenseness / restlessness in last 2 weeks	5.9	9.2	10.7	2.8	3.3
Smoking Status	5.7	13.6	14.6	-3.6	-3.8
Number of live births	5.4	7.7	8.4	2.9	2.6
Hearing difficulty/problems with background noise	4.7	7.5	8.5	2.6	2.9
Fractured/broken bones in last 5 years	4.7	6.1	7.3	2.2	2.7
Medication: Omeprazole	4.5	5.4	7.2	2.7	1.9
Eye problems/disorders: Diabetes related eye disease	4.3	4.7	5.1	-2.3	-2.1
Medication: Co-codamol	4.3	5.0	5.1	2.2	2.3
Birth weight	4.3	9.3	14.4	2.1	3.8
Comparative height size at age 10	4.3	23.7	31.2	4.0	5.6
Medication: Lisinopril	4.3	5.6	7.1	-2.7	-2.0
Alzheimer’s Disease (including proxy)	4.2	6.1	7.9	-2.8	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	4.2	9.5	10.0	-3.0	-3.2
Heart disease (mother)	4.2	5.2	5.9	2.4	2.1
Unable to work because of sickness or disability	4.2	5.5	6.2	2.2	2.5
Cholesterol lowering medication	4.2	6.2	8.1	-2.1	-2.8
Blood Red Count	4.0	38.8	43.6	6.6	5.8
Heel T-Score	3.9	31.3	32.8	-5.5	-5.7
Prostate Cancer	3.8	5.3	6.9	-2.6	-1.9
Alcohol usually taken with meals	3.8	6.1	6.2	2.5	2.4
Pack years of smoking	3.7	5.4	5.8	-2.4	-2.2
Pack years adult smoking proportion	3.6	5.5	6.4	-2.5	-2.2
Medication: Simvastatin	3.6	5.3	6.8	-2.0	-2.6
Illness, injury, bereavement, stress in last 2 years	3.6	4.4	5.9	-2.4	-1.7
Height	3.5	67.6	80.8	7.4	9.0
Supplements: Vitamin C	3.4	4.0	4.1	2.0	2.0
Pain experienced in last month	3.4	5.6	7.7	-1.9	-2.8
Chest pain or discomfort	3.3	4.7	5.2	2.0	2.3
High cholesterol (Self-reported)	3.3	5.8	6.1	-2.3	-2.5
Past tobacco smoking	3.2	5.9	7.9	2.0	2.8
Handedness (chirality/laterality): Left-handed	3.2	3.8	5.2	-1.6	-2.3
Chronic bronchitis/emphysema (father)	3.0	3.5	3.6	-1.9	-1.8
Alzheimer’s Disease (in mother)	2.9	3.4	5.7	-2.4	-1.1
Hair Pigment	2.9	83.1	92.0	9.6	8.6
Friendships satisfaction	2.9	3.6	4.8	-2.2	-1.6
Depression (self-reported)	2.8	3.3	4.2	1.5	2.1
Financial difficulties in last 2 years	2.7	3.7	3.7	1.9	1.9
Number of children fathered	2.7	3.1	3.1	1.8	1.7
Standing height	2.6	25.9	38.6	3.6	6.2
Forced expiratory volume in 1-second (FEV1), predicted	2.6	5.3	8.0	1.6	2.8
Heel bone mineral density (BMD) T-score, automated (left)	2.5	5.6	6.1	-2.3	-2.5
Back pain experienced in last month	2.5	3.6	3.9	2.0	1.8
Body Mass Index (BMI) (2010)	2.4	3.3	6.6	0.0	-2.6
Mood swings	2.4	4.3	5.2	2.3	1.8
Hearing difficulty/problems: Yes	2.3	3.5	4.1	1.7	2.0
Ever had bowel cancer screening	2.3	2.7	3.5	-1.4	-1.9
LDL Cholesterol	2.2	3.5	7.0	0.0	-2.6
Serious illness, injury or assault to yourself	2.2	2.7	3.8	1.9	1.3
Worry too long after embarrassment	2.2	3.7	3.8	-1.9	-2.0
Pulse wave Arterial Stiffness index	2.1	2.4	2.8	1.4	1.7
Medication: Seretide 50 evohaler	2.1	2.4	3.0	1.4	1.7
Eye problems/disorders: Glaucoma	2.1	2.5	4.1	2.0	0.9
Number of operations (self-reported)	2.1	3.2	3.5	1.7	1.9
Alzheimer’s Disease (in father)	2.0	2.1	3.1	-1.1	-1.7
Systolic blood pressure, automated reading	2.0	5.9	6.9	2.2	2.6
Vitamin and mineral supplements	2.0	2.7	3.0	-1.7	-1.5
Pulse rate, automated reading	2.0	6.5	8.2	2.9	2.2
Systolic Blood Pressure	1.9	9.3	11.0	2.7	3.3
Age when periods started (menarche)	1.9	4.5	5.0	-2.2	-2.0
Fluid intelligence score	1.9	4.0	4.6	1.9	2.2
Hair/balding pattern: Pattern 3	1.9	2.8	3.6	1.9	1.4
Medication: Aspirin	1.9	2.4	3.9	-1.0	-2.0
Smoking status: Current	1.9	3.0	3.4	-1.6	-1.8
Hip circumference	1.8	7.9	10.1	2.4	3.2
Impedance of arm (left)	1.8	8.4	8.6	2.9	2.9
Medication: Amlodipine	1.8	2.6	3.7	-1.2	-1.9
Pain type(s) experienced in last month: Hip pain	1.8	2.2	3.1	1.2	1.7
Supplements: Zinc	1.7	1.8	3.3	0.6	1.8
Current tobacco smoking	1.7	2.8	3.2	-1.5	-1.8
Medication: Ramipril	1.7	2.2	2.7	-1.3	-1.7
Smoking status: Previous	1.7	2.6	4.1	-1.1	-2.0
Medication for cholesterol	1.7	2.6	3.0	1.5	1.7
Impedance of arm (right)	1.6	7.5	7.5	2.7	2.7
Glaucoma (self-reported)	1.6	1.9	2.7	1.6	1.0
Hearing aid user	1.6	1.8	2.6	1.6	1.0
Nervous feelings	1.5	2.9	3.9	2.0	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	2.6	1.5	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	2.8	-1.7	-0.9
Diabetes diagnosed by doctor	1.5	2.5	3.7	-1.1	-1.9
Average weekly champagne plus white wine intake	1.5	2.0	3.1	-1.7	-1.0
Verbal and Numeric Reasoning (VNR)	1.4	3.3	4.2	1.6	2.0
Medication: Metformin	1.4	1.9	2.3	-1.2	-1.5
Maternal smoking around birth	1.4	2.0	2.0	-1.4	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.7	1.7	1.3	1.3
Medication: Cholesterol lowering	1.4	2.1	2.4	-1.3	-1.6
Medication: Ventolin 100micrograms inhaler	1.4	1.8	3.2	0.7	1.8
Medication: Aspirin	1.4	1.9	3.1	-0.8	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	2.5	1.6	0.9
Average weekly beer plus cider intake	1.4	2.0	2.8	-1.1	-1.7
Alcohol intake frequency.	1.3	3.0	3.7	1.9	1.5
Family relationship satisfaction	1.3	1.6	2.7	-1.6	-0.7
Medication: Atorvastatin	1.3	1.6	2.4	-1.5	-1.0
Intelligence (Savage-Jansen 2018)	1.2	3.6	4.7	1.6	2.2
Ovarian Cancer	1.2	1.6	1.9	-1.4	-1.1
Type 2 Diabetes (T2D) (2018)	1.2	2.2	3.6	-0.9	-1.9
Emphysema/chronic bronchitis	1.2	1.3	1.8	-0.9	-1.3
Medication: Allopurinol	1.2	1.6	2.2	-1.5	-0.9
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.3	-0.9	-1.5
Impedance of whole body	1.2	5.9	7.6	2.8	2.0
Qualifications: None of the above	1.1	2.3	3.0	-1.7	-1.2
Diabetes (self-reported)	1.1	1.7	2.1	-1.1	-1.4
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.4	1.6	0.7
Pulse wave peak to peak time	1.1	1.3	1.3	-1.1	-1.2
Medication: Blood pressure	1.1	1.9	2.3	-1.5	-1.2
Number of full sisters	1.1	1.3	2.1	0.7	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.1	0.4	1.5
Wears glasses or contact lenses	1.1	1.3	1.7	-0.9	-1.3
Medication for hormone replacement therapy	1.0	1.1	1.9	-0.6	-1.4
Falls in the last year	1.0	1.4	1.9	1.4	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	1.7	-1.3	-0.8
Shortness of breath walking on level ground	1.0	1.2	1.3	1.1	1.1
Migraine (self-reported)	1.0	1.2	1.6	1.3	0.9
Age at last live birth	1.0	1.4	2.5	0.6	1.6
Schizophrenia (2018)	0.9	1.9	3.9	0.0	-2.0
Crohns Disease (2017)	0.9	2.0	3.0	-1.7	-1.0
Frequency of depressed mood in last 2 weeks	0.9	1.3	1.5	1.2	1.0
Length of working week for main job	0.9	0.9	1.6	0.5	1.3
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	2.9	-0.7	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.5	0.9	1.2
Illnesses of father: High blood pressure	0.9	1.2	1.6	0.8	1.3
Depressed Affect (Nagel 2018)	0.8	1.6	1.7	1.3	1.2
Lung FEV1/FVC ratio	0.8	4.2	5.1	1.8	2.3
Sensitivity / hurt feelings	0.8	1.3	2.0	-0.8	-1.4
Trunk fat percentage	0.8	3.2	3.7	1.9	1.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	0.9	1.0	0.8
Happiness	0.8	1.0	1.8	-1.3	-0.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	1.6	0.9	1.3
Leg fat-free mass (right)	0.8	4.5	8.1	0.9	2.8
Commuting to job workplace: Walk	0.8	0.9	1.0	1.0	0.8
Breast cancer (self-reported)	0.8	0.9	1.3	-0.8	-1.1
Leg predicted mass (right)	0.8	4.3	7.9	0.9	2.8
Mother’s age at death	0.8	0.9	1.0	-0.9	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	1.3	1.2	0.7
Neuroticism (2016)	0.7	1.1	1.1	1.1	1.0
Leg fat-free mass (left)	0.7	3.6	6.6	0.8	2.6
Multivitamins +/- minerals	0.7	0.9	1.0	1.0	0.9
Leg predicted mass (left)	0.7	3.7	6.7	0.8	2.6
Trunk fat mass	0.7	3.2	3.8	1.6	1.9
Allergy	0.7	1.7	1.9	-1.4	-1.2
Eye problems/disorders: None of the above	0.7	0.8	1.1	0.7	1.0
Suffer from ‘nerves’	0.7	1.2	1.9	1.4	0.6
Osteoporosis (self-reported)	0.7	0.8	1.6	1.3	-0.1
Bipolar Disorder or Schizophrenia	0.6	1.4	2.8	0.0	-1.7
Triglycerides	0.6	1.0	2.0	0.0	-1.4
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.5	1.2	0.3
Diabetes (father)	0.6	0.7	1.2	1.1	0.5
Severe depression (siblings)	0.6	0.7	0.8	0.9	0.7
Townsend deprivation index at recruitment	0.6	0.8	1.2	-1.1	-0.6
Medication: Atenolol	0.6	0.7	0.9	0.9	0.7
Mouth/teeth dental problems	0.6	0.9	1.0	-1.0	-0.9
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	1.2	1.1	0.5
Weight	0.6	2.7	4.2	1.1	2.1
Asthma	0.6	1.2	1.3	1.1	1.1
Asthma (self-reported)	0.6	1.3	1.4	1.1	1.2
Commuting to job workplace: Public transport	0.6	0.7	0.8	-0.9	-0.7
Diastolic blood pressure, automated reading	0.6	1.9	2.7	1.1	1.6
Chronotype (morning person)	0.5	1.2	1.6	-0.8	-1.3
Ever had hysterectomy (womb removed)	0.5	0.6	0.6	-0.8	-0.8
Supplements: Glucosamine	0.5	0.6	1.1	0.3	1.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.7	-0.7	-0.9
Worrier / anxious feelings	0.5	0.9	1.1	-0.8	-1.0
Hair/balding pattern: Pattern 4	0.5	1.1	2.0	1.4	0.6
Loud music exposure frequency	0.5	0.5	0.6	-0.7	0.8
Whole body fat-free mass	0.5	2.7	5.3	0.3	2.3
Long-standing illness, disability or infirmity	0.5	0.8	1.0	1.0	0.8
Whole body water mass	0.5	2.6	5.1	0.3	2.2
Basal metabolic rate	0.5	3.0	5.7	0.6	2.4
Blood Eosinophil Count	0.4	3.0	4.5	2.1	1.2
Hypothyroidism (self reported)	0.4	1.0	1.9	0.1	-1.4
Relative age of first facial hair	0.4	0.8	1.0	0.8	1.0
Taking other prescription medications	0.4	0.6	1.1	0.2	-1.1
Waist circumference	0.4	1.3	1.6	-1.3	-1.0
Had other major operations	0.4	0.5	1.0	1.0	0.0
Trunk fat-free mass	0.4	2.1	4.1	-0.1	2.0
Alcohol intake versus 10 years previously	0.4	0.6	0.8	0.9	0.5
Pulse rate	0.4	0.7	1.1	1.0	0.5
Trunk predicted mass	0.4	2.1	4.3	0.0	2.1
Headache pain in last month	0.4	0.6	0.6	0.8	0.8
Exposure to tobacco smoke outside home	0.4	0.5	0.8	0.4	0.9
Average weekly red wine intake	0.4	0.6	1.2	0.1	1.1
Number of self-reported non-cancer illnesses	0.4	0.6	0.8	0.7	0.9
Risk taking	0.4	0.5	1.0	-0.0	1.0
Alcohol drinker status: Previous	0.4	0.5	0.9	-0.9	-0.3
Ulcerative Colitis (UC)	0.3	0.6	0.7	0.7	0.8
Reaction Time	0.3	0.5	1.0	0.0	1.0
Schizophrenia (2014)	0.3	0.7	1.4	0.0	-1.2
Hand grip strength (right)	0.3	0.7	1.0	1.0	0.7
Relative age voice broke	0.3	0.5	0.5	-0.7	-0.6
Impedance of leg (left)	0.3	1.7	2.6	1.6	0.9
Had menopause	0.3	0.4	0.8	-0.3	-0.9
Heart attack	0.3	0.4	0.6	0.8	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.8	0.1	0.9
Lung cancer (father)	0.3	0.3	0.5	-0.4	-0.7
Arm fat-free mass (right)	0.3	1.4	2.8	0.1	1.7
Mean time to correctly identify matches	0.3	0.5	1.0	0.1	1.0
Arm predicted mass (right)	0.3	1.4	2.8	0.1	1.7
Knee pain experienced in last month	0.3	0.4	0.8	0.0	0.9
Illnesses of father: Heart disease	0.3	0.5	0.5	0.6	0.7
Osteoarthritis (self-reported)	0.3	0.3	0.5	-0.7	0.4
Medication: Gliclazide	0.3	0.3	0.4	-0.6	-0.5
Ever taken oral contraceptive pill	0.3	0.4	0.7	0.3	0.8
Arm fat-free mass (left)	0.3	1.6	2.9	0.5	1.7
Ever depressed for a whole week	0.3	0.3	0.5	0.3	0.7
Supplements: Calcium	0.3	0.3	0.5	0.7	0.2
Heart disease (siblings)	0.3	0.3	0.5	0.5	-0.7
Arm predicted mass (left)	0.3	1.6	3.0	0.5	1.7
Depression (Nagel 2018)	0.2	0.2	0.4	0.6	0.2
Age at First Birth	0.2	0.3	0.5	-0.7	-0.3
Mean Putamen Volume	0.2	0.2	0.3	0.4	0.6
Lupus	0.2	0.3	0.3	-0.6	-0.6
Respiratory disease	0.2	0.5	0.7	0.8	0.5
Neuroticism	0.2	0.5	1.0	1.0	-0.3
Impedance of leg (right)	0.2	1.1	1.9	1.4	0.6
Stomach or abdominal pain in last month	0.2	0.2	0.4	-0.6	0.1
Medication: Levothyroxine sodium	0.2	0.3	0.5	0.2	-0.7
Hair/balding pattern: Pattern 2	0.2	0.3	0.4	-0.6	0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.3	0.4	0.6
Breastfed as a baby	0.2	0.3	0.6	-0.8	-0.1
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.5	0.7	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.6	-0.2
Age at first live birth	0.2	0.3	0.6	0.1	0.8
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	0.6	0.3
Whole body fat mass	0.2	0.8	1.1	0.7	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	0.7	-0.2
Mineral and other dietary supplements	0.2	0.3	0.4	0.3	0.7
Miserableness	0.2	0.3	0.6	0.8	-0.2
Medication: Bendroflumethiazide	0.2	0.3	0.7	-0.1	0.8
Alcohol drinker status: Never	0.2	0.3	0.5	0.3	0.7
Age started oral contraceptive pill	0.2	0.2	0.3	0.6	-0.3
Basal cell carcinoma (self-reported)	0.2	0.3	0.5	0.2	-0.7
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	0.6	0.2
Bipolar Disorder (2018)	0.1	0.1	0.2	0.0	-0.4
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	-0.7	0.2
Breast Cancer	0.1	0.3	0.4	0.6	0.4
Fasting Glucose	0.1	0.1	0.1	0.3	0.3
HDL Cholesterol	0.1	0.2	0.5	0.0	0.7
Primary Biliary Cirrhosis	0.1	0.2	0.3	-0.6	-0.2
Rheumatoid Arthritis	0.1	0.1	0.2	0.0	0.4
Ulcerative Colitis	0.1	0.2	0.4	0.0	0.6
BMI	0.1	0.6	0.8	-0.9	-0.6
Allergy or Eczema	0.1	0.3	0.5	0.7	0.3
Number of treatments/medications taken	0.1	0.1	0.2	0.4	-0.2
Average weekly spirits intake	0.1	0.2	0.3	-0.1	0.6
Average weekly fortified wine intake	0.1	0.1	0.2	0.1	-0.5
Fed-up feelings	0.1	0.2	0.4	0.6	0.0
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	0.3	0.2
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.4	0.7	0.4
Body mass index (BMI)	0.1	0.4	0.6	-0.6	-0.8
Number of incorrect matches in round	0.1	0.1	0.1	0.2	0.4
Illnesses of siblings	0.1	0.2	0.2	-0.4	-0.4
Neuroticism score	0.1	0.3	0.3	0.6	-0.4
Time employed in main current job	0.1	0.1	0.2	0.2	0.5
Noisy workplace	0.1	0.1	0.1	0.3	0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	-0.0	0.6
Prospective memory result	0.1	0.1	0.2	-0.4	-0.0
Arm fat mass (right)	0.1	0.4	0.6	0.4	0.8
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.1	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.6	-0.2
Pulse wave reflection index	0.1	0.1	0.1	-0.2	-0.3
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.3	0.6	-0.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.2	0.4	-0.4
Blood clot in the leg (DVT)	0.1	0.2	0.3	0.5	0.2
Medication: Paracetamol	0.1	0.1	0.2	-0.2	-0.5
Body fat percentage	0.1	0.5	0.8	0.9	0.4
Leg fat percentage (right)	0.1	0.5	0.9	-0.1	-1.0
Wheeze or whistling in the chest in last year	0.1	0.3	0.5	0.7	0.2
Health satisfaction	0.1	0.1	0.2	-0.4	-0.3
Qualifications: College or University degree	0.1	0.3	0.5	0.3	0.7
Medication: Ibuprofen	0.1	0.1	0.3	0.1	0.5
Leg pain on walking	0.1	0.1	0.2	-0.1	-0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.2	-0.5	0.3
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.5	-0.1
Loneliness, isolation	0.1	0.1	0.2	-0.5	-0.1
Qualifications: nursing, teaching	0.1	0.2	0.4	-0.0	-0.6
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	-0.5	-0.3
Arm fat mass (left)	0.1	0.4	0.6	0.5	0.8
Guilty feelings	0.1	0.2	0.2	0.4	0.5
Financial situation satisfaction	0.1	0.1	0.3	-0.5	0.1
Leg fat percentage (left)	0.1	0.3	0.5	0.1	-0.7
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	0.1
Neuroticism (Nagel 2018)	0.0	0.0	0.0	0.1	-0.1
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	0.0	0.1	0.1	0.4	-0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.1	0.1	0.0	-0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.1	0.2	0.2	0.4
Blood White Count	0.0	0.3	0.4	-0.7	-0.4
Cardiovascular Disease	0.0	0.0	0.1	-0.2	0.1
Tanning	0.0	0.4	0.6	-0.4	0.8
Hand grip strength (left)	0.0	0.0	0.0	0.0	0.0
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	0.2	-0.0
Angina	0.0	0.0	0.0	0.1	0.0
Diabetes (mother)	0.0	0.0	0.0	0.2	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.1	0.3	-0.3
Qualifications: CSEs or equivalent	0.0	0.0	0.1	0.2	-0.2
High blood pressure	0.0	0.0	0.0	-0.2	0.0
High blood pressure (mother)	0.0	0.0	0.0	-0.1	0.2
Pain all over the body in last month	0.0	0.0	0.0	0.1	0.2
Arm fat percentage (right)	0.0	0.1	0.2	0.4	0.2
Father’s age at death	0.0	0.0	0.0	0.1	-0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	0.2	-0.4
Medication: Lansoprazole	0.0	0.0	0.1	-0.2	0.2
Illnesses of mother	0.0	0.1	0.1	0.1	0.3
Tense / ‘highly strung’	0.0	0.1	0.1	0.1	-0.4
High blood pressure (siblings)	0.0	0.0	0.0	-0.2	0.1
Comparative body size at age 10	0.0	0.1	0.1	-0.3	-0.4
Medication for pain relief, constipation, heartburn	0.0	0.0	0.0	-0.1	0.1
Neck or shoulder pain in last month	0.0	0.0	0.1	0.2	0.1
Angina (self-reported)	0.0	0.0	0.0	-0.1	0.1
Leg fat mass (right)	0.0	0.0	0.0	0.0	-0.0
Overall health rating	0.0	0.1	0.1	0.2	0.2
Had major operations	0.0	0.0	0.1	-0.2	-0.1
Hypertension (Self-reported)	0.0	0.0	0.0	-0.1	0.0
Arm fat percentage (left)	0.0	0.1	0.1	0.4	0.3
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.0	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	-0.3	-0.1
Medication: Blood pressure	0.0	0.0	0.0	-0.2	0.0
Medication: Paracetamol	0.0	0.0	0.0	0.1	-0.1
Irritability	0.0	0.1	0.1	-0.2	-0.3
Commuting to job workplace: Cycle	0.0	0.0	0.0	-0.0	0.0
Myopia	0.0	0.0	0.0	-0.2	-0.1
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.0	-0.0	-0.2
Leg fat mass (left)	0.0	0.0	0.0	0.2	0.2

Hub : Genes

ASPSCR1

Models

Trait associations