TWAS hub - LRRC45

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0860	0.0260	9.4e-06	0.097	0.053	0.095	0.088	0.092	7.2e-12	4.2e-07	1.2e-11	7.6e-11	2.6e-11
2	GTEx	Adipose Subcutaneous	0.2340	0.1040	4.1e-03	0.061	NA	0.004	NA	0.047	1.0e-05	NA	1.4e-01	NA	1.0e-04
3	GTEx	Adipose Visceral Omentum	0.1780	0.0630	4.2e-03	0.031	NA	0.098	NA	0.045	1.0e-02	NA	9.0e-06	NA	2.1e-03
4	GTEx	Artery Coronary	0.1790	0.0790	7.1e-03	0.004	NA	-0.002	NA	-0.007	2.3e-01	NA	3.8e-01	NA	6.4e-01
5	GTEx	Artery Tibial	0.0891	0.0384	4.0e-03	0.069	NA	0.035	NA	0.044	4.3e-06	NA	8.8e-04	NA	2.0e-04
6	GTEx	Cells Transformed fibroblasts	0.0840	0.0360	1.8e-03	0.080	NA	0.076	NA	0.065	1.4e-06	NA	2.6e-06	NA	1.2e-05
7	GTEx	Heart Atrial Appendage	0.1900	0.0600	5.5e-04	0.063	NA	0.117	NA	0.093	8.7e-04	NA	6.7e-06	NA	5.5e-05
8	YFS	Blood	0.0109	0.0076	3.1e-02	0.003	0.002	-0.001	0.003	0.004	2.6e-02	8.4e-02	9.7e-01	3.0e-02	1.3e-02
9	TCGA	Colon Adenocarcinoma	0.0810	0.0380	6.6e-04	0.074	0.033	0.041	NA	0.044	4.3e-05	5.3e-03	2.1e-03	NA	1.4e-03
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0225	0.0133	7.2e-03	0.026	0.022	0.016	NA	0.020	5.2e-04	1.5e-03	5.7e-03	NA	2.2e-03
11	TCGA	Brain Lower Grade Glioma	0.0518	0.0218	6.0e-07	0.073	0.049	0.051	NA	0.064	1.1e-08	2.5e-06	1.6e-06	NA	9.5e-08
12	TCGA	Pheochromocytoma and Paraganglioma	0.0980	0.0530	7.2e-03	0.021	0.043	0.015	NA	0.018	4.8e-02	8.1e-03	8.3e-02	NA	6.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Peak expiratory flow (PEF)	13.1	30.3	38.4	5.8	6.0	5.4	4.2	6.1	6.2	6.2	1.9	4.6	6.0	6.1	6.0
Forced expiratory volume in 1-second (FEV1), Best measure	12.7	40.5	52.9	6.7	7.3	6.0	3.8	7.3	7.2	7.2	3.9	4.3	7.0	6.9	7.2
Forced expiratory volume in 1-second (FEV1)	10.4	35.0	49.4	6.1	6.9	5.2	3.4	6.8	6.5	7.0	4.6	3.3	6.7	6.2	6.5
Forced vital capacity (FVC), Best measure	10.1	37.1	54.5	6.2	7.4	5.3	3.0	7.0	6.6	7.2	5.7	2.7	6.8	6.1	6.7
Sitting height	9.4	66.6	87.8	8.9	9.4	7.6	6.0	8.7	9.1	8.9	4.4	6.1	9.2	8.7	9.1
Ever smoked	7.3	12.8	18.5	-3.6	-3.7	-3.1	-3.1	-3.8	-4.0	-3.7	-0.9	-3.3	-4.3	-4.1	-4.0
Forced vital capacity (FVC)	6.9	26.6	42.0	5.1	6.4	4.1	2.4	6.0	5.4	6.5	5.8	1.5	5.9	4.9	5.3
Waist Hip Ratio (WHR)	6.3	28.5	37.9	-5.8	-5.8	-5.1	-4.1	-6.1	-5.8	-6.2	-2.6	-3.7	-6.0	-5.7	-5.7
Heel T-Score	6.0	47.9	73.4	-7.6	-7.9	-6.5	-5.7	-6.6	-8.0	-6.5	-2.6	-5.9	-7.2	-7.8	-8.6
Mood swings	6.0	10.9	20.6	3.5	3.6	2.9	3.6	2.8	3.6	2.2	1.6	3.2	3.5	3.6	4.5
Height	5.7	109.2	139.2	11.6	10.8	10.8	8.0	11.7	11.7	10.5	0.7	10.7	11.3	11.8	10.6
Birth weight of first child	5.6	10.2	25.9	2.7	3.7	2.0	1.5	3.9	2.8	3.3	5.1	0.4	4.3	2.6	3.0
Past tobacco smoking	5.5	10.0	14.7	3.6	3.6	2.6	2.6	3.0	3.8	3.0	0.4	3.1	3.5	3.8	3.5
Medication: Simvastatin	5.1	7.5	13.0	-3.2	-3.0	-2.6	-0.1	-2.7	-3.2	-2.4	-1.1	-2.6	-3.6	-3.2	-3.2
Supplements: Vitamin C	4.9	5.8	9.4	2.8	2.6	2.5	1.4	2.3	2.9	2.0	0.7	2.5	2.8	3.1	2.3
Standing height	4.7	46.1	61.0	7.7	7.2	6.5	5.8	7.2	7.6	6.6	1.1	6.7	7.8	7.5	7.1
Smoking Status	4.6	11.1	18.5	-3.3	-3.5	-3.3	-2.7	-3.1	-3.7	-3.2	-1.3	-3.3	-3.5	-3.7	-4.3
Depression (self-reported)	4.4	5.3	7.9	2.2	2.1	2.6	2.3	2.1	2.5	2.1	-0.1	2.8	2.2	2.5	2.8
Heel bone mineral density (BMD) T-score, automated (right)	4.3	9.9	13.8	-3.5	-3.7	-3.0	-2.4	-3.5	-3.6	-3.1	-1.3	-1.9	-3.4	-3.5	-3.6
High cholesterol (Self-reported)	4.3	7.7	10.9	-3.3	-3.1	-2.9	-0.4	-3.2	-3.1	-2.9	-0.5	-2.4	-3.3	-3.1	-2.9
Birth weight	4.2	9.2	14.8	3.4	3.5	2.5	3.4	3.4	3.1	3.3	1.6	1.6	3.9	3.1	2.5
Number of live births	4.0	5.6	8.9	2.5	3.0	1.9	0.7	2.9	2.5	2.5	2.1	1.3	3.0	2.4	2.5
Emphysema/chronic bronchitis	3.9	4.4	6.7	-2.0	-1.7	-2.4	-1.8	-2.5	-2.2	-2.2	1.1	-2.6	-2.3	-2.4	-1.7
Comparative height size at age 10	3.9	21.6	31.9	4.8	4.5	4.8	2.5	5.4	5.1	5.7	0.7	4.9	5.1	4.9	5.1
Smoking status: Previous	3.8	5.7	9.2	-2.9	-2.9	-1.8	-2.3	-2.0	-3.0	-2.1	-0.2	-2.2	-2.4	-3.0	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.7	7.8	13.6	2.6	3.0	2.9	-0.0	3.2	3.1	3.7	2.0	1.7	2.9	2.9	3.6
Financial difficulties in last 2 years	3.6	4.8	7.4	2.4	2.2	2.6	0.9	2.1	2.3	2.4	-0.3	2.7	2.1	2.4	2.5
Age at last live birth	3.5	5.1	8.5	2.7	2.2	2.9	0.8	2.4	2.5	1.9	-1.9	2.7	2.1	2.7	1.4
Cholesterol lowering medication	3.5	5.2	7.0	-2.6	-2.4	-2.2	-1.4	-2.4	-2.6	-2.5	-0.0	-2.5	-2.4	-2.6	-2.1
Lung FVC	3.4	17.1	88.5	2.1	4.5	1.7	-1.0	4.0	2.7	4.9	9.4	-2.5	4.0	1.9	3.8
Gout (self-reported)	3.4	4.7	9.5	-1.6	-1.9	-2.4	-1.4	-2.6	-2.0	-3.1	-1.7	-1.8	-2.4	-1.9	-2.5
Length of working week for main job	3.3	3.7	5.8	2.4	1.9	1.9	1.8	2.2	2.2	1.5	-1.5	1.7	1.9	2.3	1.4
Number of full brothers	3.3	4.2	8.2	1.6	2.1	1.7	2.6	1.9	1.9	2.2	2.9	0.3	2.4	1.8	2.0
Medication: Co-codamol	3.2	3.7	7.4	1.8	2.1	2.1	-1.2	1.9	1.8	2.7	2.2	1.1	2.1	1.7	1.8
Heel bone mineral density (BMD) T-score, automated (left)	3.0	6.8	11.4	-2.9	-3.1	-2.3	-2.2	-2.6	-3.0	-2.3	-1.5	-1.7	-2.9	-2.9	-3.4
Hair Pigment	2.9	81.3	144.0	9.3	10.2	8.9	5.3	10.1	9.5	12.0	6.3	4.1	10.7	9.2	9.2
Alcohol usually taken with meals	2.9	4.7	6.6	2.2	2.3	2.4	0.2	2.5	2.6	2.4	0.2	2.4	2.2	2.5	2.2
Mouth/teeth dental problems: Loose teeth	2.9	3.5	6.1	2.4	2.0	2.1	-0.5	1.7	2.1	1.9	-1.0	2.5	1.5	2.2	1.5
Medication for cholesterol	2.9	4.3	7.1	2.7	2.2	1.7	1.7	1.7	2.6	1.6	-0.7	2.5	1.9	2.6	2.1
Medication: Lisinopril	2.9	3.8	10.0	-1.6	-1.8	-2.0	-1.9	-1.6	-2.2	-1.5	-0.6	-2.4	-1.4	-2.0	-3.2
Alzheimer’s Disease (in father)	2.8	3.1	5.3	-1.9	-1.8	-1.7	-1.7	-1.6	-1.8	-1.4	0.4	-2.3	-1.8	-1.9	-2.0
Vitamin and mineral supplements	2.8	3.8	5.9	-1.9	-1.7	-2.4	-1.1	-2.0	-2.0	-1.9	-0.3	-2.4	-2.4	-2.1	-1.8
Chronic bronchitis/emphysema (father)	2.7	3.1	7.2	-1.6	-1.2	-2.2	-0.2	-1.4	-2.0	-2.0	1.2	-2.7	-0.9	-1.9	-2.4
Frequency of tenseness / restlessness in last 2 weeks	2.7	4.2	9.2	1.5	1.5	2.0	2.4	1.5	2.1	2.2	1.1	2.2	2.2	2.1	3.0
Hearing difficulty/problems with background noise	2.7	4.3	7.5	2.0	2.0	2.1	0.9	2.2	2.3	2.1	0.5	1.8	2.7	2.4	2.6
Wears glasses or contact lenses	2.7	3.1	5.2	-2.0	-1.7	-1.8	-2.1	-1.2	-2.1	-1.3	0.1	-2.1	-1.8	-2.3	-1.7
Pain type(s) experienced in last month: Hip pain	2.7	3.4	4.8	1.9	1.9	1.8	2.0	2.0	2.0	1.6	0.3	1.6	2.2	2.0	2.1
Pain experienced in last month	2.7	4.5	7.5	-1.9	-2.1	-1.7	-2.7	-2.2	-2.3	-1.9	-1.3	-1.5	-2.5	-2.3	-2.4
Friendships satisfaction	2.5	3.1	5.5	-1.9	-1.9	-2.3	0.6	-2.0	-1.8	-2.4	-1.6	-0.8	-1.9	-1.7	-1.6
Lung FEV1/FVC ratio	2.4	12.3	24.7	3.6	2.4	4.0	3.6	3.2	3.6	2.9	-2.8	5.0	3.0	4.0	3.2
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.9	7.5	1.8	2.0	1.2	2.5	1.3	2.1	1.5	1.3	1.9	2.4	2.2	2.7
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	5.9	-1.5	-1.4	-1.8	-1.8	-1.5	-1.9	-1.5	0.7	-1.8	-1.4	-1.9	-2.4
Age at first live birth	2.4	4.3	10.1	2.0	1.1	2.7	2.0	1.6	1.9	1.3	-3.2	2.9	1.4	2.3	1.0
Forced expiratory volume in 1-second (FEV1), predicted	2.4	4.9	5.9	2.4	2.4	1.9	2.4	2.3	2.4	2.4	1.3	1.6	2.4	2.4	2.2
Tinnitus: Yes, now most or all of the time	2.4	2.8	4.8	1.6	2.0	1.8	1.1	2.1	1.6	2.2	1.4	0.6	1.7	1.4	1.6
Pack years of smoking	2.4	3.6	6.1	-1.7	-1.6	-2.5	-0.2	-1.9	-1.9	-2.0	-0.7	-2.1	-2.2	-1.9	-2.4
Pack years adult smoking proportion	2.3	3.5	6.6	-1.7	-1.6	-2.6	-0.2	-1.9	-1.9	-2.0	-0.6	-2.1	-2.1	-2.0	-2.4
Hip circumference	2.3	9.8	14.7	3.1	3.8	2.4	2.5	3.8	3.1	3.2	3.8	1.0	3.7	2.7	3.2
Number of full sisters	2.3	2.8	6.6	1.7	2.2	0.0	2.2	1.3	1.5	0.6	2.6	-0.5	2.3	1.4	1.6
Mouth/teeth dental problems: Bleeding gums	2.2	2.9	4.7	1.8	1.9	1.8	1.2	2.0	1.9	1.0	0.5	1.5	2.2	1.9	1.9
Medication: Amlodipine	2.2	3.1	7.1	-1.5	-1.1	-2.3	-1.1	-1.7	-1.7	-1.3	2.0	-2.7	-1.3	-1.8	-2.0
Handedness (chirality/laterality): Left-handed	2.2	2.6	5.0	-1.4	-1.5	-1.1	-1.8	-2.1	-1.4	-2.2	-1.5	-1.0	-1.8	-1.3	-1.6
Severe depression (siblings)	2.1	2.4	6.2	1.6	2.0	0.9	0.9	1.6	1.5	1.2	2.2	0.4	2.5	1.4	0.8
Chest pain or discomfort	2.1	3.0	5.6	1.4	1.9	1.2	2.4	2.0	1.6	1.3	2.1	0.4	1.8	1.4	2.4
Blood Red Count	2.0	19.2	38.7	4.0	5.0	4.7	2.2	6.2	4.7	5.5	2.6	2.5	4.7	4.5	4.2
Hearing difficulty/problems: Yes	2.0	3.0	5.8	1.8	1.9	1.7	0.9	1.9	1.9	1.5	0.5	1.6	2.4	2.0	1.8
Medication: Blood pressure	2.0	3.5	6.0	-2.0	-2.3	-1.8	-1.4	-2.1	-1.8	-1.7	-1.8	-0.9	-2.5	-1.8	-1.9
Leg fat-free mass (right)	2.0	10.5	16.2	3.8	4.0	2.4	3.4	3.6	3.6	3.0	2.1	1.8	3.8	3.3	3.2
Leg predicted mass (right)	2.0	10.5	16.2	3.8	4.0	2.4	3.4	3.6	3.6	3.0	2.0	1.8	3.8	3.3	3.2
Unable to work because of sickness or disability	2.0	2.6	5.2	1.1	1.3	1.7	2.0	1.8	1.4	1.8	1.9	1.0	1.6	1.3	2.3
Type 2 Diabetes (T2D) (2018)	1.9	3.5	6.1	-2.0	-1.5	-1.7	-1.9	-2.2	-2.1	-1.4	0.7	-2.5	-1.4	-2.1	-2.3
Medication for hormone replacement therapy	1.9	2.1	5.2	-1.5	-1.2	-1.2	-2.3	-0.7	-1.7	-0.6	0.8	-1.6	-1.2	-1.7	-1.9
Fluid intelligence score	1.9	3.9	6.6	2.2	2.5	1.3	-0.3	1.9	2.3	1.9	1.6	1.2	2.6	2.2	2.4
Medication: Cholesterol lowering	1.9	2.9	5.7	-1.8	-2.0	-1.5	0.2	-1.6	-1.8	-1.4	-1.7	-1.1	-2.4	-1.8	-2.2
Medication: Aspirin	1.9	2.5	4.7	-2.2	-1.9	-1.8	-0.2	-1.5	-1.9	-1.6	0.1	-1.2	-1.6	-2.0	-1.5
Ever taken oral contraceptive pill	1.9	2.1	13.8	-0.0	-1.1	1.4	-0.2	-0.0	0.3	0.4	-3.7	2.7	-0.8	0.6	0.1
Serious illness, injury or assault to yourself	1.8	2.2	4.5	1.5	1.6	1.8	0.1	1.3	1.7	1.6	0.5	1.5	1.2	1.7	2.1
Fractured/broken bones in last 5 years	1.8	2.3	4.6	1.4	2.1	1.4	0.0	1.9	1.6	2.0	1.6	0.8	1.3	1.4	1.5
Leg fat-free mass (left)	1.7	9.0	14.1	3.5	3.8	2.0	3.2	3.3	3.3	2.7	2.3	1.5	3.5	3.0	3.0
Leg predicted mass (left)	1.7	9.3	14.4	3.5	3.8	2.1	3.2	3.4	3.3	2.8	2.3	1.5	3.6	3.0	3.1
Exposure to tobacco smoke at home	1.7	1.9	3.7	-1.9	-1.6	-1.5	-0.4	-1.0	-1.7	-0.8	1.5	-1.6	-1.0	-1.7	-1.1
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	6.8	-1.2	-1.3	-1.8	-0.2	-1.2	-1.4	-1.6	-0.6	-1.5	-1.0	-1.4	-2.6
HbA1C	1.6	1.7	7.0	-0.5	-1.5	-1.4	0.4	-1.8	-1.5	-1.9	-2.6	0.0	0.0	0.0	0.0
Time employed in main current job	1.6	1.9	4.5	-1.4	-1.2	-1.7	-0.5	-0.9	-1.4	-0.5	1.7	-2.1	-1.2	-1.5	-1.5
Heart disease (mother)	1.6	1.9	6.4	0.9	1.6	1.0	0.6	1.7	1.0	2.0	2.5	-0.4	1.6	0.9	0.8
Whole body fat-free mass	1.6	9.1	13.4	3.6	3.7	2.3	3.3	3.5	3.3	2.8	1.3	1.9	3.6	3.1	2.7
Whole body water mass	1.6	9.1	13.7	3.7	3.7	2.3	3.2	3.5	3.4	2.8	1.3	1.9	3.6	3.2	2.8
Average weekly champagne plus white wine intake	1.6	2.2	15.3	-0.3	-1.3	0.0	-0.8	-0.7	-0.3	-1.2	-3.9	1.8	-1.5	-0.1	-0.8
Basal metabolic rate	1.6	8.8	13.5	3.5	3.7	2.1	3.2	3.5	3.2	2.7	2.0	1.6	3.5	3.0	2.8
Crohns Disease (2017)	1.5	3.2	4.7	-1.9	-2.0	-2.0	-0.5	-2.2	-1.7	-2.1	-0.5	-1.7	-2.1	-1.6	-2.1
Hand grip strength (right)	1.5	4.2	8.6	1.9	1.2	2.5	2.9	1.9	2.0	2.2	-1.1	2.7	1.6	2.1	1.8
Trunk fat-free mass	1.5	8.5	13.3	3.6	3.4	2.4	3.3	3.3	3.2	2.6	0.5	2.1	3.5	3.1	2.4
Falls in the last year	1.5	2.0	3.9	1.2	0.8	1.8	-0.1	1.6	1.2	1.8	-0.1	2.0	1.2	1.3	2.0
Trunk predicted mass	1.5	8.6	13.3	3.6	3.4	2.4	3.2	3.4	3.3	2.7	0.5	2.2	3.5	3.1	2.5
Leg fat percentage (right)	1.5	5.3	12.4	-2.7	-1.4	-2.4	-1.4	-1.1	-2.5	-1.4	3.5	-3.5	-1.6	-2.8	-1.7
Medication: Omeprazole	1.5	1.8	5.2	0.7	0.9	1.9	0.4	1.1	1.1	1.6	1.2	1.5	1.2	1.0	2.3
Medication: Seretide 50 evohaler	1.5	1.8	3.4	1.2	1.3	1.8	0.7	1.2	1.2	1.4	0.8	1.4	1.5	1.2	1.8
Ovarian Cancer	1.4	1.9	3.6	-1.2	-1.4	-1.0	-1.5	-1.3	-1.3	-1.2	-1.9	-0.8	-1.9	-1.2	-1.6
Supplements: Glucosamine	1.4	1.8	4.6	1.5	1.2	1.1	1.3	1.4	1.5	1.1	-0.1	1.4	2.1	1.6	0.6
Medication: Aspirin	1.4	1.8	3.5	-1.9	-1.6	-1.5	0.2	-1.2	-1.7	-1.2	0.5	-1.1	-1.2	-1.8	-1.3
Illnesses of father: High blood pressure	1.4	1.7	3.1	1.3	1.3	1.6	0.3	1.4	1.3	1.2	0.5	1.4	1.8	1.4	1.3
Leg fat percentage (left)	1.4	5.0	12.8	-2.5	-1.2	-2.2	-1.3	-1.0	-2.3	-1.2	3.6	-3.6	-1.5	-2.7	-1.7
Number of operations (self-reported)	1.4	2.0	3.4	1.4	1.2	1.8	-0.2	1.6	1.5	1.5	-0.2	1.8	1.6	1.5	1.5
Ever had bowel cancer screening	1.3	1.6	3.7	-0.8	-0.9	-1.2	-1.1	-1.1	-1.2	-1.9	-1.1	-1.4	-1.3	-1.2	-1.4
Osteoarthritis (self-reported)	1.3	1.7	4.6	-1.1	-0.9	-1.2	-1.5	0.0	-1.4	-0.5	0.6	-2.1	-0.7	-1.5	-2.1
Arm predicted mass (left)	1.3	6.4	9.3	2.9	3.0	1.9	2.8	3.0	2.7	2.4	1.5	1.4	3.0	2.5	2.5
Prostate Cancer	1.2	1.6	4.0	-1.0	-1.1	-1.4	-0.2	-1.3	-1.4	-1.3	-1.3	-1.0	-1.2	-1.4	-2.0
Neuroticism (2016)	1.2	1.7	4.9	1.0	1.3	0.8	2.2	0.9	1.4	0.4	0.7	1.1	1.1	1.4	2.0
Hand grip strength (left)	1.2	3.0	6.6	1.7	1.0	1.9	2.6	1.7	1.6	1.5	-2.0	2.4	1.1	1.8	0.8
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.6	-0.8	-1.2	-1.1	0.4	-1.6	-1.1	-1.4	-1.1	-0.8	-1.4	-1.0	-1.3
Medication: Metformin	1.2	1.7	3.2	-1.3	-1.5	-1.0	-0.3	-1.4	-1.4	-0.8	-1.6	-1.0	-1.7	-1.3	-1.8
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	4.9	0.8	1.0	0.8	2.2	1.6	1.0	0.9	-0.1	0.9	1.3	1.0	0.6
Mouth/teeth dental problems	1.2	1.9	8.2	-1.3	-2.1	-0.1	0.2	-1.2	-1.2	-0.5	-2.9	0.2	-1.6	-0.9	-1.4
Asthma	1.2	2.3	5.2	1.6	1.5	1.3	1.2	1.4	1.7	1.5	0.4	1.5	1.3	1.7	2.3
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	3.8	1.6	1.8	1.2	0.1	1.8	1.4	1.3	1.4	0.4	1.9	1.3	1.4
Arm fat-free mass (right)	1.2	6.0	9.3	3.0	3.0	1.7	2.7	2.9	2.6	2.2	1.6	1.3	2.9	2.4	2.3
Migraine (self-reported)	1.2	1.5	3.1	1.1	1.2	1.1	1.3	0.7	1.2	0.9	1.5	0.7	1.6	1.2	1.8
Arm predicted mass (right)	1.2	6.2	9.6	3.0	3.1	1.8	2.6	3.0	2.7	2.2	1.6	1.3	2.9	2.4	2.4
Diabetes diagnosed by doctor	1.2	1.9	3.9	-1.3	-1.2	-0.9	-2.0	-1.5	-1.5	-1.2	-0.3	-1.2	-1.3	-1.5	-1.8
Arm fat-free mass (left)	1.2	5.9	8.7	2.8	3.0	1.8	2.6	2.9	2.6	2.2	1.8	1.2	2.9	2.4	2.3
Risk taking	1.2	1.7	3.0	1.4	1.2	1.1	1.2	0.9	1.5	1.1	-0.5	1.7	1.5	1.6	1.4
Intelligence (Savage-Jansen 2018)	1.1	3.2	5.2	1.9	2.2	1.8	0.6	1.8	2.3	1.6	-0.2	1.6	2.0	2.3	2.0
Alzheimer’s Disease (including proxy)	1.1	1.5	4.2	-0.7	-1.3	-1.1	-1.4	-0.9	-1.0	-1.6	-2.1	-0.5	-1.0	-0.7	-1.7
BMI	1.1	6.2	18.6	-2.4	-1.1	-3.0	-0.9	-1.4	-2.4	-1.3	3.7	-4.3	-1.7	-2.8	-2.4
Frequency of depressed mood in last 2 weeks	1.1	1.6	5.0	1.0	1.0	1.3	0.9	0.3	1.3	0.7	0.3	2.2	0.7	1.3	2.2
Relative age of first facial hair	1.1	2.3	4.3	1.7	1.6	1.3	1.5	1.1	1.5	1.4	0.2	1.3	1.9	1.5	2.1
Supplements: Zinc	1.1	1.2	2.7	1.6	1.3	0.8	0.8	1.2	1.4	0.8	0.4	0.6	1.5	1.6	0.2
Stomach or abdominal pain in last month	1.1	1.4	2.8	-1.7	-1.5	-1.2	0.9	-1.3	-1.4	-1.1	-0.3	-1.1	-0.9	-1.3	-0.6
Headache pain in last month	1.1	1.9	7.4	0.9	0.7	1.2	2.7	0.5	1.3	0.5	-0.1	2.0	0.9	1.4	1.9
Worry too long after embarrassment	1.1	1.9	3.7	-1.1	-0.9	-1.9	0.6	-1.6	-1.4	-1.9	1.3	-1.6	-1.1	-1.5	-1.1
Shortness of breath walking on level ground	1.1	1.3	2.9	1.0	0.9	1.3	0.9	1.0	1.2	1.0	-0.9	1.5	0.8	1.2	1.7
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.2	1.5	0.8	1.4	0.0	1.0	1.2	1.1	-0.7	1.3	1.1	1.3	0.8
Verbal and Numeric Reasoning (VNR)	1.0	2.5	4.5	1.9	2.1	0.9	-0.8	1.6	1.9	1.5	1.1	0.8	2.0	1.8	1.8
Qualifications: None of the above	1.0	2.1	4.5	-1.3	-0.9	-1.9	0.1	-1.7	-1.5	-2.1	1.3	-1.8	-0.9	-1.6	-1.2
Mouth/teeth dental problems: Dentures	1.0	1.6	11.1	0.0	0.9	-1.0	-1.3	0.2	-0.1	-0.3	3.3	-2.0	0.4	-0.6	-0.1
Breastfed as a baby	1.0	1.2	2.2	-1.1	-1.2	-1.1	-0.5	-1.0	-1.2	-0.8	-0.9	-1.0	-1.3	-1.2	-1.5
Glaucoma (self-reported)	1.0	1.2	2.7	0.8	0.9	1.3	-0.0	0.8	1.3	1.2	-0.5	1.7	0.5	1.4	1.5
Knee pain experienced in last month	1.0	1.6	2.7	1.5	1.1	0.9	1.2	1.1	1.5	0.6	-1.0	1.7	1.6	1.6	1.0
Commuting to job workplace: Walk	1.0	1.1	2.3	0.8	1.1	0.7	1.1	1.0	1.2	0.9	1.1	1.1	0.8	1.1	1.5
Asthma (self-reported)	1.0	2.0	5.1	1.5	1.3	1.2	1.0	1.2	1.6	1.4	0.2	1.6	1.1	1.6	2.2
Average weekly beer plus cider intake	1.0	1.4	2.7	-1.2	-1.1	-1.4	-0.2	-1.6	-1.2	-1.5	-0.6	-1.0	-1.7	-1.3	-0.9
Age at First Birth	0.9	1.3	7.9	0.6	-0.0	1.1	-0.2	0.6	0.5	0.5	-2.8	2.1	-0.1	0.9	-0.2
Average weekly fortified wine intake	0.9	1.1	3.0	1.1	0.7	1.1	0.2	0.7	1.1	0.4	-0.9	1.7	0.8	1.3	1.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.1	-1.3	-1.3	-1.5	-0.8	-1.1	-1.1	-0.9	-0.3	-1.1	-0.9	-1.1	-0.6
Medication: Ramipril	0.9	1.2	4.0	-1.1	-1.3	-0.8	-0.9	-1.7	-1.0	-2.0	0.3	-0.1	-0.9	-0.9	-0.5
Weight	0.9	4.3	11.4	1.9	2.6	1.1	1.9	2.5	1.9	1.9	3.4	0.1	2.4	1.5	2.0
Pulse wave Arterial Stiffness index	0.9	1.0	2.2	1.0	1.0	1.0	1.1	1.4	1.0	1.5	-0.0	0.6	0.6	0.9	1.1
Impedance of arm (left)	0.9	4.3	8.4	1.9	2.0	2.2	0.5	1.7	2.3	1.9	0.8	2.7	2.4	2.3	2.9
Number of children fathered	0.9	1.0	2.6	1.1	1.3	1.3	0.2	1.6	1.0	1.2	0.3	-0.2	0.8	1.0	0.6
Qualifications: College or University degree	0.9	2.9	13.8	0.7	-0.2	1.9	1.4	0.5	1.1	1.0	-3.7	3.1	0.7	1.5	0.9
Alzheimer’s Disease (in mother)	0.8	0.9	7.7	0.4	-0.3	-0.1	-0.7	-0.2	0.1	-1.0	-2.8	0.8	-0.0	0.4	-0.8
Chronotype (morning person)	0.8	1.9	5.0	-1.3	-0.7	-1.5	-1.8	-0.8	-1.3	-0.9	2.2	-1.8	-1.0	-1.5	-0.8
Nervous feelings	0.8	1.6	10.9	-0.2	0.8	-0.7	0.8	0.2	0.3	-0.1	3.3	-1.2	0.9	0.1	1.9
Happiness	0.8	1.0	2.5	-0.9	-0.8	-0.9	0.6	-1.2	-0.7	-1.6	-1.4	-0.0	-1.1	-0.7	-0.9
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.8	1.1	0.4	0.9	0.8	0.8	1.1	0.8	-0.5	1.7	0.3	1.1	1.5
Had major operations	0.8	0.9	2.0	-0.9	-1.4	-0.5	-0.9	-1.2	-1.0	-0.6	-1.0	-0.3	-1.3	-0.9	-1.1
Qualifications: nursing, teaching	0.8	1.2	4.3	0.4	-0.2	1.2	1.5	0.2	0.7	0.6	-2.1	1.9	-0.2	0.9	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.9	1.0	1.0	0.6	0.9	1.2	0.8	1.3	1.0	0.0	1.4	0.8	0.7
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.5	-1.0	-1.4	-0.4	0.3	-1.3	-1.0	-1.1	-1.6	0.4	-1.1	-0.8	-0.7
Age started oral contraceptive pill	0.8	1.0	2.1	-1.4	-1.3	-0.4	-1.4	-0.6	-1.3	-0.0	0.0	-0.9	-0.9	-1.2	-1.0
Reaction Time	0.7	1.4	3.8	1.1	0.7	0.7	1.3	1.0	1.2	0.5	-0.3	1.8	1.0	1.3	2.0
Maternal smoking around birth	0.7	1.0	2.1	-0.6	-0.3	-1.4	-1.2	-0.8	-1.0	-0.7	0.4	-1.5	-0.8	-1.2	-1.4
Qualifications: CSEs or equivalent	0.7	1.0	4.5	-0.6	-0.1	-0.9	-1.2	-0.2	-0.7	-0.2	2.1	-1.8	-0.3	-0.8	-0.6
Body mass index (BMI)	0.7	3.1	9.4	-1.7	-0.7	-1.9	-0.7	-0.8	-1.6	-1.1	3.1	-3.0	-1.1	-2.0	-1.2
Waist circumference	0.7	2.5	5.3	-1.6	-0.9	-1.8	-0.8	-1.1	-1.6	-1.6	1.6	-2.3	-1.4	-1.9	-1.5
Heart attack	0.7	0.9	2.2	0.9	0.7	1.4	0.2	1.5	0.8	1.2	-0.4	1.1	0.6	0.8	0.9
Impedance of arm (right)	0.7	3.3	6.5	1.6	1.7	1.9	0.5	1.4	2.0	1.6	0.8	2.4	2.3	2.0	2.5
Worrier / anxious feelings	0.7	1.3	2.2	-1.3	-0.9	-1.5	1.1	-1.1	-1.2	-1.3	0.9	-1.1	-1.0	-1.3	-0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.5	9.6	0.5	-0.1	0.9	0.6	-0.1	0.7	0.1	-3.1	2.3	-0.4	0.9	0.5
Medication: Paracetamol	0.7	1.2	2.1	-0.8	-0.7	-1.2	-1.0	-1.2	-1.0	-1.2	0.9	-1.4	-1.3	-1.0	-1.2
Alcohol intake frequency.	0.7	1.6	6.6	0.9	1.4	0.7	0.7	0.8	1.2	0.6	2.6	0.0	1.4	1.1	1.8
Smoking status: Current	0.7	1.2	2.4	-1.0	-1.0	-1.0	-0.6	-1.3	-1.0	-1.2	-0.6	-1.1	-1.6	-1.1	-1.2
Hearing aid user	0.7	0.8	3.9	0.5	0.4	1.3	0.3	1.0	0.5	2.0	0.6	0.5	0.9	0.4	0.7
Eye problems/disorders: Glaucoma	0.7	0.9	2.5	0.6	0.8	0.9	-0.9	0.8	1.0	1.6	0.1	0.8	0.3	1.0	1.4
Commuting to job workplace: Cycle	0.7	0.8	5.7	0.6	-0.1	0.7	-0.8	-0.2	0.5	-0.0	-2.4	1.2	0.2	0.7	0.6
Depressed Affect (Nagel 2018)	0.6	1.4	5.5	0.7	1.0	0.6	1.3	0.5	1.2	0.4	1.1	1.5	0.8	1.1	2.4
Average weekly spirits intake	0.6	0.8	2.7	-1.0	-1.1	-0.1	0.4	-0.3	-0.9	0.2	-1.6	-0.2	-0.7	-0.7	-1.4
Sensitivity / hurt feelings	0.6	1.0	4.5	-0.6	0.1	-1.3	-0.1	-0.5	-0.7	-1.2	2.1	-1.3	-0.8	-1.0	-0.3
Current tobacco smoking	0.6	1.1	2.1	-0.9	-0.8	-1.0	-0.7	-1.3	-0.9	-1.1	-0.2	-1.2	-1.4	-1.0	-1.0
Trunk fat mass	0.6	2.5	15.6	0.6	1.7	0.3	0.9	1.7	0.8	1.2	3.9	-0.8	1.5	0.4	1.5
Diabetes (self-reported)	0.6	0.9	1.9	-0.9	-0.9	-0.4	-1.3	-1.0	-1.1	-0.7	-0.7	-0.4	-0.8	-1.1	-1.4
Arm fat percentage (right)	0.6	2.5	12.9	-1.5	-0.3	-1.5	-0.8	-0.5	-1.3	-0.6	3.6	-2.6	-0.6	-1.7	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.9	0.4	0.4	1.2	-0.1	1.4	0.7	1.1	-0.6	0.6	0.1	0.6	1.3
Lung cancer (father)	0.6	0.7	6.2	0.3	-0.1	0.5	-0.4	0.2	0.1	0.0	-2.5	1.1	-0.5	0.1	-0.7
Body fat percentage	0.6	2.5	15.8	-1.4	-0.1	-1.3	-0.8	-0.1	-1.1	-0.4	4.0	-2.5	-0.4	-1.5	-0.2
Neck or shoulder pain in last month	0.6	0.8	1.8	0.9	0.9	0.5	1.3	0.6	0.8	0.8	0.9	0.2	1.2	0.8	1.0
Family relationship satisfaction	0.6	0.7	4.9	0.3	-0.1	-0.3	1.1	-0.2	0.2	-1.0	-2.2	0.9	-0.0	0.2	-0.2
Arm fat percentage (left)	0.6	2.4	13.7	-1.4	-0.1	-1.4	-0.6	-0.4	-1.1	-0.6	3.7	-2.5	-0.5	-1.6	-0.4
Long-standing illness, disability or infirmity	0.6	0.9	1.6	0.9	0.9	1.1	0.8	0.8	1.0	0.9	0.9	0.9	0.9	1.0	1.3
Osteoporosis (self-reported)	0.6	0.8	1.3	0.8	0.8	1.1	-0.6	0.8	1.0	1.0	0.6	0.9	0.8	1.0	1.1
Miserableness	0.6	1.0	2.7	1.0	1.4	0.2	0.8	0.5	1.1	0.1	1.3	0.9	0.7	1.0	1.6
Mother’s age at death	0.6	0.7	2.0	-0.7	-0.7	-1.0	-0.2	-0.7	-1.0	-1.1	-0.5	-0.8	-0.7	-0.9	-1.4
Alcohol drinker status: Previous	0.6	0.7	1.6	-0.8	-1.3	-0.5	-0.3	-1.0	-0.9	-1.0	-1.1	0.0	-0.7	-0.7	-1.0
Ever had hysterectomy (womb removed)	0.5	0.5	1.8	-0.9	-0.8	-0.6	-1.4	-0.6	-0.8	-0.6	0.0	-0.6	-0.7	-0.8	-0.3
Systolic blood pressure, automated reading	0.5	1.4	3.1	0.7	1.2	1.2	1.2	1.5	1.0	1.8	1.1	0.6	1.1	0.9	1.4
Diabetes (father)	0.5	0.6	1.0	0.5	0.6	0.9	1.0	0.9	0.8	1.0	-0.3	0.8	0.4	0.8	0.8
Trunk fat percentage	0.5	2.0	17.6	-0.2	1.0	-0.1	0.0	1.0	0.1	0.7	4.2	-1.3	0.8	-0.3	1.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	0.7	0.6	0.8	1.1	0.6	0.9	0.2	-0.8	1.1	0.7	0.9	0.6
Prospective memory result	0.5	0.6	2.2	-0.7	-0.5	-0.4	-1.5	-0.9	-0.6	-1.0	0.9	-0.5	-0.7	-0.8	-0.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	4.5	-0.5	0.2	-0.6	0.4	0.4	-0.2	-0.2	2.1	-1.2	0.5	-0.3	0.2
Medication: Allopurinol	0.5	0.7	2.2	-0.2	-0.5	-0.8	-0.6	-0.9	-0.4	-1.5	-1.4	-0.1	-1.1	-0.3	-0.6
Hypertension (Self-reported)	0.5	1.3	2.5	-1.6	-1.6	-1.0	-1.3	-1.3	-1.1	-0.5	-0.8	-0.4	-1.3	-1.1	-0.8
Medication: Paracetamol	0.5	0.7	2.6	-0.4	-0.3	-0.7	-1.1	-0.6	-0.7	-0.6	1.6	-1.2	-0.6	-0.8	-0.8
Irritability	0.5	0.8	6.2	0.5	0.6	0.4	2.5	0.3	0.6	-0.4	0.3	0.3	1.0	0.7	0.7
Basal cell carcinoma (self-reported)	0.5	0.6	2.9	-0.7	-0.4	-0.7	-1.7	-0.5	-0.7	-0.7	0.4	-1.1	-0.4	-0.6	-0.9
Worry (Nagel 2018)	0.4	0.8	1.6	-1.1	-0.4	-1.0	0.8	-0.6	-0.8	-0.9	1.3	-1.3	-0.3	-0.9	0.4
Mean Putamen Volume	0.4	0.5	1.2	1.0	0.8	0.8	-0.0	1.1	0.6	0.7	-0.2	0.8	0.7	0.6	0.5
Systolic Blood Pressure	0.4	2.0	4.8	0.9	1.2	1.3	1.3	1.4	1.4	2.2	1.0	1.1	1.2	1.4	2.0
Fed-up feelings	0.4	0.8	3.5	0.1	0.6	0.1	1.6	0.0	0.7	-0.0	0.7	1.3	0.1	0.6	1.9
Multivitamins +/- minerals	0.4	0.5	1.2	0.5	0.4	1.0	0.0	0.7	0.6	0.7	0.5	1.1	1.0	0.5	0.6
Hair/balding pattern: Pattern 3	0.4	0.5	2.8	0.1	0.6	0.5	-0.5	0.7	0.5	1.0	1.7	-0.5	0.5	0.5	0.3
Illnesses of mother	0.4	0.5	1.6	-0.9	-0.8	-0.2	-0.5	-1.1	-0.7	-0.5	-0.4	-0.3	-1.3	-0.8	0.1
Tense / ‘highly strung’	0.4	0.6	3.3	0.3	0.5	0.1	1.8	0.2	0.7	-0.3	0.5	0.6	1.0	0.8	1.0
High blood pressure (siblings)	0.4	0.6	1.8	0.7	1.1	0.4	-1.3	1.0	0.3	0.6	1.4	-0.1	0.7	0.2	-0.2
Wheeze or whistling in the chest in last year	0.4	0.7	3.5	0.6	0.8	0.4	-0.0	0.8	0.6	0.8	1.9	-0.3	0.6	0.4	1.1
Medication for pain relief, constipation, heartburn	0.4	0.7	1.4	0.9	0.7	1.2	0.2	0.8	0.9	0.8	-0.6	0.9	0.8	1.0	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	3.8	-0.1	-0.5	-0.1	0.5	-0.2	-0.2	-0.6	-1.9	0.2	-0.3	-0.0	-1.0
Whole body fat mass	0.4	1.6	13.1	-0.0	1.0	-0.4	0.4	0.9	0.1	0.4	3.6	-1.5	0.7	-0.3	0.7
Leg fat mass (right)	0.4	1.7	10.0	-1.0	-0.0	-1.3	-0.1	0.0	-0.9	-0.4	3.2	-2.2	-0.3	-1.2	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.2	0.1	0.5	1.0	0.5	0.5	0.4	0.9	0.9	-0.0	0.2	0.3	1.1
Illnesses of father: Heart disease	0.4	0.5	2.5	0.5	0.3	1.6	0.1	0.9	0.5	1.2	-0.4	0.8	0.3	0.5	0.1
Loneliness, isolation	0.4	0.6	4.3	0.2	0.1	0.0	2.1	-0.1	0.4	-0.4	-0.7	1.1	0.1	0.4	0.9
Back pain experienced in last month	0.4	0.6	1.3	0.3	0.7	0.8	-0.1	1.1	0.6	1.1	1.0	0.3	0.7	0.5	0.9
Breast cancer (self-reported)	0.4	0.5	2.0	-0.4	-0.5	-0.7	-1.4	-0.5	-0.5	-0.9	0.2	-0.8	-0.6	-0.5	-0.4
Arm fat mass (left)	0.4	1.6	13.9	-0.1	0.9	-0.7	0.4	0.7	-0.0	0.2	3.7	-1.8	0.6	-0.5	0.4
Alcohol drinker status: Never	0.4	0.5	1.1	0.7	0.5	0.4	1.0	0.6	0.8	0.4	-0.5	1.0	0.7	0.8	1.0
Myopia	0.4	0.5	3.1	0.3	0.5	-0.4	0.7	0.2	0.1	-0.3	1.8	-1.3	0.8	0.0	-0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.6	0.6	0.4	1.2	0.1	1.3	0.6	1.0	-0.6	0.8	0.3	0.6	0.7
Impedance of whole body	0.4	2.0	4.8	1.0	1.1	1.6	-0.2	1.0	1.4	1.4	0.7	2.0	1.7	1.5	2.2
Leg fat mass (left)	0.4	1.5	10.4	-0.8	0.2	-1.1	0.1	0.2	-0.7	-0.3	3.2	-2.1	-0.1	-1.1	-0.2
Depression (Nagel 2018)	0.3	0.5	2.6	0.3	0.4	0.4	0.3	-0.4	0.6	-0.0	0.0	1.5	0.1	0.6	1.6
Neuroticism (Nagel 2018)	0.3	0.7	3.4	-0.4	0.2	-0.9	1.3	-0.5	-0.1	-0.9	1.8	-0.5	0.1	-0.2	1.0
Ulcerative Colitis (UC)	0.3	0.5	1.4	1.0	1.2	0.3	-0.1	0.6	0.9	0.6	0.8	0.0	0.7	0.8	0.3
Lupus	0.3	0.4	2.6	0.1	0.1	-0.3	0.8	-0.1	0.0	-0.4	-1.6	-0.8	-0.1	0.1	-0.8
Cardiovascular Disease	0.3	0.9	1.9	-1.3	-1.0	-1.4	0.8	-1.1	-0.9	-0.6	1.0	-1.0	-0.6	-1.0	-0.4
Hypothyroidism (self reported)	0.3	0.6	1.8	-1.1	-1.0	-0.6	0.8	-1.3	-0.6	-1.0	0.1	-0.0	-0.9	-0.5	-0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	0.3	0.6	0.5	0.4	0.7	0.6	0.9	0.8	0.2	0.7	0.5	0.9
High blood pressure	0.3	0.9	1.8	-1.3	-1.3	-0.8	-1.2	-1.0	-0.9	-0.2	-0.9	-0.4	-1.2	-0.9	-0.7
Medication: Levothyroxine sodium	0.3	0.5	2.5	0.4	0.3	0.5	1.0	0.3	0.6	-0.1	-1.6	0.9	-0.4	0.6	0.1
Allergy	0.3	0.7	1.9	-0.6	-0.7	-0.8	0.3	-1.4	-0.6	-1.3	-1.1	-0.5	-0.6	-0.5	-0.9
Illnesses of siblings	0.3	0.4	2.2	-0.4	-0.7	-0.4	0.5	-0.7	-0.1	-0.7	-1.5	0.5	-0.6	-0.1	0.2
Neuroticism score	0.3	0.5	2.4	-0.2	0.4	-0.5	1.4	-0.2	0.1	-0.6	1.5	0.0	0.1	0.0	1.1
Pulse rate	0.3	0.5	1.6	0.6	0.8	0.4	0.8	0.6	0.6	0.9	1.3	-0.3	0.8	0.6	0.8
Medication: Lansoprazole	0.3	0.3	0.9	-0.6	-0.8	-0.5	-0.4	-0.9	-0.5	-0.5	0.4	-0.3	-0.3	-0.5	0.4
Arm fat mass (right)	0.3	1.3	10.9	-0.2	0.7	-0.6	0.4	0.6	-0.1	0.2	3.3	-1.6	0.5	-0.5	0.3
Exposure to tobacco smoke outside home	0.3	0.4	4.0	-0.3	-0.2	-0.1	2.0	-0.2	-0.1	-0.4	0.6	-0.2	0.5	-0.0	0.5
Health satisfaction	0.3	0.4	1.4	-0.8	-0.7	-0.0	0.6	-0.3	-0.4	-0.6	-1.2	0.5	-0.5	-0.4	0.2
Eye problems/disorders: None of the above	0.3	0.4	0.9	0.5	0.5	0.9	0.3	0.9	0.5	0.7	0.4	0.5	0.6	0.5	0.7
Mean time to correctly identify matches	0.3	0.7	1.8	0.8	0.6	0.5	0.7	1.0	0.9	0.4	-0.3	1.4	0.8	0.9	1.1
Pulse rate, automated reading	0.3	1.1	8.7	-0.4	0.5	0.0	0.8	0.3	0.1	1.1	3.0	-1.1	0.2	-0.1	1.0
Suffer from ‘nerves’	0.3	0.5	2.1	-0.3	0.4	-0.2	1.3	-0.1	0.2	-0.5	1.4	-0.5	0.1	0.1	1.2
Illnesses of father: None of the above (group 1)	0.3	0.3	1.3	-0.2	-0.2	-1.1	-0.1	-0.9	-0.2	-1.0	-0.3	-0.1	-0.5	-0.3	-0.3
Financial situation satisfaction	0.3	0.4	1.5	-0.3	-0.4	-0.4	0.8	-0.6	-0.4	-0.5	-1.2	0.2	-0.8	-0.3	-0.9
Commuting to job workplace: Public transport	0.3	0.3	0.8	-0.4	-0.8	-0.3	-0.0	-0.4	-0.4	-0.6	-0.8	0.9	-0.6	-0.4	-0.2
Medication: Atorvastatin	0.3	0.3	1.2	-0.4	-0.6	-0.7	-0.5	-0.5	-0.5	-1.1	0.2	-0.6	-0.1	-0.5	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.9	-0.2	-0.2	0.8	0.2	0.0	0.1	0.4	0.7	1.0	0.4	0.1	1.4
Heart disease (siblings)	0.3	0.3	0.9	-0.9	-0.9	0.0	-0.2	-0.5	-0.7	-0.3	0.5	-0.1	-0.6	-0.7	-0.2
Bipolar Disorder or Schizophrenia	0.2	0.4	4.2	0.0	-2.0	0.0	0.0	0.0	0.0	0.0	-0.9	0.0	0.0	0.0	0.0
Irritable Bowel Disease (IBD)	0.2	0.4	1.3	-0.2	-0.2	-0.9	-0.0	-0.8	-0.2	-0.8	0.2	-0.7	-0.6	-0.1	-1.1
Rheumatoid Arthritis	0.2	0.3	1.4	0.2	0.7	-0.2	0.2	0.7	0.4	0.3	1.2	-0.4	0.6	0.3	0.0
Blood White Count	0.2	1.6	6.7	-0.7	-0.2	-1.4	-1.7	-1.1	-0.8	-0.8	1.8	-2.6	-0.6	-0.9	-1.0
Allergy or Eczema	0.2	0.6	1.9	-0.8	-1.1	0.4	-1.4	-0.1	-0.5	0.2	-1.1	0.4	-1.0	-0.3	-0.1
Neuroticism	0.2	0.4	1.5	-0.6	-0.1	-0.6	0.9	-0.5	-0.2	-0.7	1.2	-0.1	-0.3	-0.3	1.0
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.2	-0.6	-0.3	-0.1	-0.7	-0.2	-0.6	0.1	1.1	-0.6	-0.2	-0.6	-0.4
Townsend deprivation index at recruitment	0.2	0.3	0.9	-0.3	-0.1	-1.0	-0.2	-0.5	-0.6	-0.6	0.7	-0.5	-0.5	-0.8	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.4	-0.0	0.1	0.3	0.8	-0.5	0.3	-0.4	-0.3	1.1	-0.1	0.3	1.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.9	0.2	0.2	0.3	-1.0	0.6	0.2	0.4	-0.6	0.7	0.2	0.3	0.5
Had menopause	0.2	0.3	0.6	-0.8	-0.8	0.1	-0.6	-0.1	-0.8	-0.2	-0.6	-0.1	-0.4	-0.7	-0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.5	0.4	0.7	0.3	-0.2	0.3	0.6	0.1	1.2	0.1	0.3	0.5	0.6
Noisy workplace	0.2	0.3	1.0	-0.4	-0.3	0.0	1.0	0.5	-0.5	0.6	0.0	-0.7	-0.1	-0.5	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	1.2	0.2	0.3	-0.3	1.1	0.1	0.1	-0.1	0.4	0.1	0.7	0.2	-0.3
Pulse wave reflection index	0.2	0.3	1.6	0.2	-0.1	0.5	0.2	0.5	-0.1	0.6	-1.3	0.4	-0.6	-0.1	-0.6
Loud music exposure frequency	0.2	0.2	1.7	0.1	-0.3	-0.5	1.3	0.1	-0.0	0.2	-0.6	0.2	0.3	0.1	-0.6
Blood clot in the leg (DVT)	0.2	0.3	1.8	0.1	0.4	0.2	-0.0	0.7	0.0	0.5	1.3	-0.5	0.5	-0.1	-0.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	-0.7	-0.6	-0.7	0.7	-0.9	-0.5	-1.1	-0.1	-0.2	-0.8	-0.4	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	1.0	-0.4	-0.2	0.2	-0.0	-0.8	0.1	-0.0	0.6	0.5	-0.0	0.1	1.0
Pulse wave peak to peak time	0.2	0.3	1.0	-0.4	-0.4	-0.5	-0.7	-0.9	-0.4	-1.0	0.2	-0.1	0.1	-0.3	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.7	0.0	0.4	-0.4	-0.8	0.2	0.0	0.2	0.8	-0.7	-0.2	-0.1	-0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.6	0.7	0.6	0.3	-0.1	0.7	0.2	0.6	0.1	-0.8	0.6	0.3	-0.5
Illnesses of siblings: Diabetes	0.2	0.2	1.0	0.1	0.2	-0.2	0.1	0.1	-0.3	0.1	0.4	-0.9	-0.2	-0.4	-1.0
Average weekly red wine intake	0.2	0.3	2.0	0.2	0.0	0.3	-1.4	0.6	0.1	0.6	0.0	0.4	0.6	0.1	-0.2
Guilty feelings	0.2	0.3	2.8	0.2	0.4	0.2	1.7	-0.3	0.4	0.1	0.7	-0.1	0.4	0.4	0.2
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.6	-0.5	-0.7	-0.2	0.1	-0.6	0.2	0.4	-0.8	-0.2	-0.7	-0.8
Ever depressed for a whole week	0.2	0.2	0.9	-0.0	-0.1	0.4	0.6	-0.1	0.2	-0.2	-1.0	0.7	-0.1	0.2	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.2	1.1	1.1	0.4	0.4	0.5	0.7	-0.1	0.8	0.2	0.9	0.7	0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	1.5	-0.0	0.2	0.1	-0.2	0.5	-0.1	0.3	1.2	-0.5	0.4	-0.2	-0.1
Bipolar Disorder (2018)	0.1	0.1	1.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.2	0.0	0.0	0.0	0.0
Breast Cancer	0.1	0.2	0.4	-0.5	-0.4	0.2	-0.6	-0.2	-0.4	0.0	0.6	-0.6	0.1	-0.4	-0.3
Fasting Glucose	0.1	0.2	0.7	-0.4	0.0	-0.0	-0.8	-0.1	-0.0	0.2	0.7	0.6	-0.2	-0.2	0.0
Primary Biliary Cirrhosis	0.1	0.1	1.2	0.3	0.3	-0.2	1.1	0.1	0.1	-0.1	-0.0	-0.2	0.3	0.1	0.1
Ulcerative Colitis	0.1	0.1	1.6	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.3	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.1	0.8	4.2	0.5	0.1	1.2	-1.4	0.8	0.5	2.0	0.4	0.5	0.7	0.7	0.4
Blood Platelet Count	0.1	0.9	5.9	0.5	0.9	0.1	2.4	0.4	0.6	0.8	1.3	0.2	0.6	0.4	0.6
Respiratory disease	0.1	0.2	1.0	0.3	0.1	0.6	0.5	-0.0	0.4	0.7	-0.3	0.3	-0.0	0.5	1.0
Tanning	0.1	0.7	3.5	0.7	0.4	0.8	0.2	0.8	0.6	0.3	-1.9	1.0	0.5	0.7	-0.5
Number of treatments/medications taken	0.1	0.1	0.5	-0.4	-0.4	0.3	0.3	-0.1	-0.1	0.0	-0.4	0.7	-0.5	-0.1	0.4
Angina	0.1	0.1	0.7	0.0	-0.3	-0.2	0.9	0.2	0.0	-0.1	-0.3	0.1	-0.2	0.1	0.4
Diabetes (mother)	0.1	0.2	0.9	-0.0	0.1	-0.0	1.0	0.2	0.2	0.4	0.8	-0.1	0.4	0.3	0.0
Impedance of leg (right)	0.1	0.3	1.4	-0.2	-0.4	0.6	-0.8	0.1	0.0	0.3	-0.3	1.2	0.3	0.2	0.6
Relative age voice broke	0.1	0.1	0.3	0.2	0.1	-0.5	0.0	0.0	-0.3	-0.6	0.2	-0.6	0.3	-0.3	-0.3
Taking other prescription medications	0.1	0.2	0.6	-0.1	0.0	0.6	0.4	0.2	0.1	-0.0	-0.5	0.7	-0.3	0.1	0.8
Age when periods started (menarche)	0.1	0.2	0.8	0.2	-0.0	-0.7	0.8	-0.3	-0.3	-0.5	-0.5	-0.2	0.4	-0.3	-0.9
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.4	-0.2	-0.3	0.5	-0.6	0.6	-0.0	0.6	-0.0	0.5	-0.3	-0.1	0.4
Medication: Atenolol	0.1	0.2	0.4	-0.6	-0.5	0.2	0.2	-0.0	-0.3	0.3	-0.6	0.3	-0.4	-0.3	0.7
High blood pressure (mother)	0.1	0.1	0.6	0.2	0.0	0.1	0.1	0.4	0.1	0.3	0.8	-0.1	0.7	0.2	0.4
Impedance of leg (left)	0.1	0.3	1.4	-0.0	-0.1	0.9	-0.6	0.2	0.2	0.5	-0.1	1.2	0.6	0.4	0.6
Number of incorrect matches in round	0.1	0.1	1.2	0.0	-0.1	0.1	-1.1	0.1	-0.2	0.0	0.3	0.2	0.2	-0.3	-0.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.3	0.2	-0.3	0.5	-0.1	0.0	-0.1	-0.1	-0.3	0.4	0.0	-0.3
Had other major operations	0.1	0.1	0.7	-0.3	0.3	0.3	-0.8	0.2	0.0	-0.3	0.7	-0.2	0.2	-0.1	0.3
Pain all over the body in last month	0.1	0.1	1.2	0.0	0.4	-0.2	0.2	0.2	-0.0	-0.1	1.1	-0.3	0.0	-0.1	0.2
Alcohol intake versus 10 years previously	0.1	0.2	1.6	0.1	0.4	0.2	0.4	-0.1	0.2	-0.2	1.3	-0.4	0.1	0.1	0.3
Father’s age at death	0.1	0.1	0.6	0.2	-0.2	0.5	-0.2	-0.1	0.1	-0.4	-0.6	0.4	0.3	0.3	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	1.2	-0.5	-0.4	-0.2	-0.1	-1.1	-0.1	-0.5	0.2	0.0	-0.6	-0.1	0.2
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	0.3	0.3	0.4	-0.2	1.0	0.5	0.8	0.6	-0.3	0.5	0.5	0.5
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.5	-0.1	-0.2	-0.2	-0.1	-0.3	0.0	0.6	-0.5	-0.3	-0.3	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.7	0.2	-0.0	0.6	-0.5	0.4	0.1	0.3	-0.8	0.7	0.3	0.2	-0.1
Medication: Ibuprofen	0.1	0.1	0.4	0.5	0.4	0.0	0.4	0.4	0.3	-0.0	-0.1	0.4	0.6	0.3	-0.3
Overall health rating	0.1	0.3	1.5	-0.2	0.3	-0.2	0.8	0.4	0.0	-0.3	1.2	-0.2	0.4	-0.1	0.5
Leg pain on walking	0.1	0.1	0.3	-0.0	0.1	0.5	0.5	0.2	0.1	0.2	-0.4	0.5	-0.2	0.1	0.2
Mineral and other dietary supplements	0.1	0.2	0.8	0.1	0.4	-0.0	-0.2	0.5	0.0	0.5	0.8	-0.9	-0.1	-0.2	0.3
Medication: Gliclazide	0.1	0.1	0.6	-0.0	-0.1	-0.3	0.4	-0.3	-0.2	-0.3	-0.6	-0.2	-0.2	-0.2	-0.8
Number of self-reported non-cancer illnesses	0.1	0.2	0.3	0.1	0.2	0.6	0.6	0.5	0.4	0.5	-0.6	0.4	-0.2	0.4	0.5
Medication: Blood pressure	0.1	0.2	0.5	-0.5	-0.4	-0.1	-0.6	0.1	-0.5	-0.1	0.4	-0.7	0.2	-0.5	-0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.5	-0.3	-0.1	-0.4	-0.4	-0.2	-0.3	-0.1	0.7	-0.7	-0.2	-0.3	-0.0
Diastolic blood pressure, automated reading	0.1	0.2	0.8	0.0	0.3	0.4	-0.0	0.5	0.1	0.9	0.9	0.2	0.1	-0.0	0.3
Supplements: Calcium	0.1	0.1	0.7	-0.3	-0.3	0.4	-0.8	-0.1	0.0	-0.2	-0.3	0.3	-0.4	0.1	-0.0
Schizophrenia (2018)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.2	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.7	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.1	0.9	0.0	-1.0	0.0	0.0	0.0	0.0	0.0	-0.2	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Comparative body size at age 10	0.0	0.1	0.3	0.3	0.5	0.2	-0.4	0.5	0.4	0.1	-0.4	0.2	-0.3	0.2	-0.5
Angina (self-reported)	0.0	0.1	0.3	-0.1	-0.3	-0.4	0.5	0.1	-0.1	-0.3	0.1	-0.2	-0.2	-0.1	0.2
Eye problems/disorders: Cataract	0.0	0.0	0.2	-0.0	-0.2	0.1	-0.2	-0.4	0.1	-0.2	-0.1	0.3	-0.0	0.0	0.3
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.3	0.2	0.5	-0.5	0.3	-0.2	0.1	-0.2	-0.0	-0.1	0.3	0.1	0.3

Hub : Genes

LRRC45

Models

Trait associations