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chr19:43,370,213-44,769,974

Best TWAS P=7.43e-09 · Best GWAS P=2.42e-08 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ZNF575	0.38	0.48	lasso	5	0.48	1.3e-43	5.6	5.5	3.6e-08	1.00	0.00	1.00	FALSE
2	GTEx	Adipose Visceral Omentum	ZNF575	0.25	0.21	lasso	6	0.26	4.8e-14	5.6	5.3	9.6e-08	0.94	0.00	1.00	FALSE
3	GTEx	Adipose Visceral Omentum	PINLYP	0.17	0.10	lasso	6	0.09	1.8e-05	5.3	-5.7	1.2e-08	-0.95	0.01	0.99	FALSE
4	GTEx	Artery Aorta	ZNF575	0.39	0.43	lasso	5	0.42	1.1e-24	5.6	5.6	2.3e-08	1.00	0.00	1.00	FALSE
5	GTEx	Artery Coronary	ZNF575	0.25	0.18	enet	12	0.17	2.5e-06	5.6	5.4	7.1e-08	0.98	0.01	0.99	FALSE
6	GTEx	Artery Tibial	ZNF575	0.20	0.23	lasso	6	0.24	1.6e-18	5.6	5.4	5.4e-08	0.96	0.00	0.99	FALSE
7	GTEx	Brain Cerebellar Hemisphere	PINLYP	0.33	0.20	lasso	10	0.18	2.3e-05	5.1	-5.3	1.0e-07	-0.94	0.01	0.98	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	PINLYP	0.26	0.15	lasso	2	0.13	2.1e-04	5.3	-5.3	1.3e-07	-0.98	0.01	0.89	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	ZNF575	0.19	0.11	lasso	7	0.05	7.5e-03	5.6	5.5	3.4e-08	0.97	0.01	0.96	FALSE
10	GTEx	Cells Transformed fibroblasts	ZNF575	0.38	0.38	enet	37	0.39	1.4e-30	5.6	5.4	5.4e-08	0.95	0.00	1.00	FALSE
11	GTEx	Colon Sigmoid	ZNF575	0.20	0.10	lasso	6	0.09	4.5e-04	4.5	5.3	1.2e-07	0.93	0.01	0.97	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	ZNF575	0.23	0.18	lasso	7	0.16	1.4e-06	5.6	5.4	6.0e-08	0.99	0.01	0.99	FALSE
13	GTEx	Esophagus Mucosa	PINLYP	0.23	0.17	lasso	6	0.16	4.1e-11	5.6	-5.2	1.8e-07	-0.99	0.01	0.99	FALSE
14	GTEx	Heart Atrial Appendage	ZNF575	0.21	0.29	lasso	3	0.28	3.4e-13	5.6	5.6	2.6e-08	1.00	0.01	0.99	FALSE
15	GTEx	Lung	ZNF575	0.23	0.26	enet	19	0.26	6.9e-20	5.6	5.4	6.0e-08	0.95	0.00	1.00	FALSE
16	GTEx	Muscle Skeletal	ZNF575	0.07	0.05	enet	10	0.03	8.0e-04	5.6	5.7	1.2e-08	0.91	0.00	0.99	FALSE
17	GTEx	Nerve Tibial	ZNF575	0.36	0.41	lasso	12	0.44	9.1e-34	5.6	5.5	4.2e-08	0.96	0.01	0.99	FALSE
18	GTEx	Nerve Tibial	PINLYP	0.33	0.12	lasso	4	0.26	4.0e-18	5.2	-5.2	2.5e-07	-0.80	0.01	0.99	FALSE
19	GTEx	Ovary	ZNF575	0.57	0.46	lasso	3	0.46	1.1e-12	5.3	5.4	8.5e-08	0.98	0.01	0.99	FALSE
20	GTEx	Pancreas	ZNF575	0.28	0.20	lasso	3	0.16	2.7e-07	5.6	5.6	2.6e-08	1.00	0.01	0.99	FALSE
21	GTEx	Pituitary	ZNF575	0.44	0.44	lasso	7	0.45	1.0e-12	5.6	5.6	2.3e-08	0.98	0.01	0.99	FALSE
22	GTEx	Prostate	ZNF575	0.31	0.19	lasso	5	0.13	4.3e-04	5.3	5.5	3.9e-08	1.00	0.01	0.93	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	ZNF575	0.14	0.14	enet	13	0.16	6.1e-09	5.6	5.4	6.6e-08	0.87	0.00	1.00	FALSE
24	GTEx	Skin Sun Exposed Lower leg	ZNF575	0.16	0.20	enet	8	0.21	5.2e-17	5.6	5.5	4.5e-08	0.97	0.00	1.00	FALSE
25	GTEx	Spleen	ZNF575	0.32	0.22	lasso	7	0.31	1.2e-08	5.3	5.5	3.2e-08	0.90	0.01	0.99	FALSE
26	GTEx	Testis	XRCC1	0.39	0.39	lasso	10	0.43	1.3e-20	5.3	5.4	6.0e-08	0.96	0.01	0.99	FALSE
27	GTEx	Testis	ZNF575	0.31	0.30	lasso	10	0.29	2.3e-13	5.6	5.6	2.8e-08	1.00	0.01	0.99	FALSE
28	GTEx	Thyroid	ZNF575	0.28	0.25	enet	28	0.30	5.0e-23	5.6	5.2	2.5e-07	0.88	0.00	1.00	FALSE
29	GTEx	Vagina	ZNF575	0.30	0.26	lasso	9	0.20	2.7e-05	5.6	5.6	2.2e-08	0.99	0.01	0.98	FALSE
30	YFS	Blood	ZNF575	0.05	0.05	lasso	2	0.05	8.3e-15	5.1	5.1	2.8e-07	0.93	0.02	0.98	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF575	0.08	0.12	lasso	8	0.12	2.8e-23	5.6	5.6	2.3e-08	0.99	0.00	1.00	FALSE
32	The Cancer Genome Atlas	Esophageal Carcinoma	XRCC1	0.14	0.01	blup	76	0.02	8.3e-02	5.1	5.2	2.3e-07	0.87	0.01	0.74	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF575	0.08	0.08	lasso	4	0.08	4.8e-09	5.3	5.3	1.1e-07	0.99	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF575	0.15	0.16	lasso	6	0.19	1.1e-20	5.3	5.3	1.3e-07	0.93	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	XRCC1	0.04	0.03	enet	5	0.04	4.0e-05	5.5	5.3	1.4e-07	0.91	0.00	0.98	FALSE
36	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF575	0.09	0.10	lasso	5	0.11	1.4e-12	5.6	5.7	1.2e-08	0.99	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZNF575	0.04	0.05	blup	66	0.04	8.4e-06	5.5	5.5	2.9e-08	0.91	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ZNF575	0.27	0.18	blup	65	0.19	1.5e-08	5.3	5.4	5.6e-08	0.90	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ZNF575	0.17	0.13	blup	66	0.12	2.4e-05	5.6	5.5	4.1e-08	0.90	0.01	0.98	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF575	0.21	0.20	lasso	6	0.19	1.1e-19	5.5	5.8	7.4e-09	0.98	0.00	1.00	TRUE
41	The Cancer Genome Atlas	Soft Tissue Sarcoma	ZNF575	0.09	0.09	lasso	4	0.06	1.5e-04	5.2	5.3	1.4e-07	0.97	0.01	0.98	FALSE
42	The Cancer Genome Atlas	Stomach Adenocarcinoma	PHLDB3	0.07	0.05	lasso	1	0.04	9.0e-04	5.6	5.6	2.4e-08	1.00	0.00	0.97	FALSE
43	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZNF575	0.05	0.06	lasso	2	0.04	4.7e-04	5.5	5.5	2.9e-08	1.00	0.01	0.97	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF575	0.23	0.22	blup	66	0.25	1.7e-24	5.6	5.6	1.7e-08	0.88	0.01	0.99	FALSE