Best TWAS P=7.13e-11 · Best GWAS P=1.85e-10 conditioned to 0.0986
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FAM160A1 | 0.04 | 0.04 | blup | 436 | 0.06 | 1.8e-07 | -5.0 | 5.2 | 2.4e-07 | 0.80 | 0.52 | 0.48 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | SH3D19 | 0.28 | 0.22 | lasso | 5 | 0.20 | 9.3e-06 | 6.2 | -6.3 | 3.9e-10 | -0.97 | 0.02 | 0.97 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | RP11-164P12.4 | 0.47 | 0.44 | enet | 18 | 0.35 | 6.6e-10 | 6.2 | 6.2 | 5.9e-10 | 0.92 | 0.02 | 0.98 | FALSE |
4 | GTEx | Brain Cerebellum | RP11-164P12.3 | 0.21 | 0.02 | enet | 19 | 0.03 | 3.4e-02 | 6.0 | 5.1 | 2.7e-07 | 0.77 | 0.03 | 0.88 | FALSE |
5 | GTEx | Brain Cerebellum | RP11-164P12.4 | 0.48 | 0.40 | lasso | 17 | 0.49 | 2.2e-16 | -5.2 | 5.6 | 2.0e-08 | 0.89 | 0.03 | 0.97 | FALSE |
6 | GTEx | Brain Cortex | PET112 | 0.11 | 0.13 | enet | 22 | 0.12 | 4.1e-04 | -4.8 | 5.7 | 1.4e-08 | 0.79 | 0.15 | 0.68 | FALSE |
7 | GTEx | Heart Atrial Appendage | PET112 | 0.20 | 0.11 | enet | 24 | 0.18 | 2.1e-08 | -5.3 | 6.2 | 6.9e-10 | 0.73 | 0.17 | 0.82 | FALSE |
8 | GTEx | Nerve Tibial | RP11-164P12.3 | 0.08 | 0.14 | lasso | 6 | 0.14 | 8.3e-10 | -4.8 | 5.2 | 2.4e-07 | 0.78 | 0.88 | 0.12 | FALSE |
9 | GTEx | Spleen | RP11-164P12.4 | 0.36 | 0.26 | lasso | 10 | 0.20 | 5.8e-06 | 6.2 | 6.2 | 5.6e-10 | 0.92 | 0.02 | 0.97 | FALSE |
10 | NTR | Blood | FAM160A1 | 0.03 | 0.02 | enet | 26 | 0.02 | 1.4e-07 | -5.8 | 6.5 | 7.1e-11 | 0.84 | 0.03 | 0.97 | TRUE |
11 | ROSMAP | Brain Pre-frontal Cortex | PET112 | 0.04 | 0.02 | bslmm | 410 | 0.04 | 5.2e-06 | -4.9 | 5.2 | 2.3e-07 | 0.68 | 0.68 | 0.19 | FALSE |
12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FAM160A1 | 0.04 | 0.02 | blup | 99 | 0.02 | 1.2e-05 | 6.2 | 5.6 | 2.2e-08 | 0.79 | 0.02 | 0.97 | FALSE |
13 | The Cancer Genome Atlas | Colon Adenocarcinoma | FAM160A1 | 0.06 | 0.05 | lasso | 3 | 0.04 | 1.8e-03 | -5.8 | 6.1 | 1.2e-09 | 0.81 | 0.04 | 0.74 | FALSE |
14 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FAM160A1 | 0.08 | 0.05 | blup | 99 | 0.05 | 2.9e-03 | -5.0 | 5.9 | 3.2e-09 | 0.81 | 0.04 | 0.71 | FALSE |
15 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PET112L | 0.09 | 0.04 | blup | 76 | 0.07 | 1.0e-03 | -4.4 | 5.1 | 2.9e-07 | 0.71 | 0.05 | 0.83 | FALSE |
16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FAM160A1 | 0.09 | 0.10 | lasso | 2 | 0.10 | 3.3e-10 | 6.4 | 6.4 | 1.6e-10 | 1.00 | 0.01 | 0.99 | FALSE |
17 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | FAM160A1 | 0.16 | 0.14 | enet | 33 | 0.11 | 6.6e-04 | 6.2 | 6.0 | 1.7e-09 | 0.88 | 0.03 | 0.97 | FALSE |