TWAS
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Traits
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Traits
:
Comparative height size at age 10
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chr5:138,053,059-140,120,953
Best TWAS P=1.93e-12 · Best GWAS P=2.66e-16 conditioned to 1.77e-05
138M
138.5M
139M
139.5M
140M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
5
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
UBE2D2
0.05
0.02
enet
6
0.03
4.4e-04
5.1
7.0
1.9e-12
0.91
0.01
0.97
TRUE
3
GTEx
Esophagus Gastroesophageal Junction
DNAJC18
0.17
0.01
lasso
10
0.04
2.0e-02
4.0
5.7
9.8e-09
0.77
0.07
0.65
FALSE
2
GTEx
Cells EBV-transformed lymphocytes
DNAJC18
0.26
0.09
lasso
2
0.12
9.7e-05
3.7
5.5
4.0e-08
0.77
0.03
0.87
FALSE
4
GTEx
Esophagus Mucosa
TMEM173
0.10
0.03
enet
20
0.10
1.8e-07
7.1
-5.4
5.8e-08
-0.39
0.16
0.24
FALSE
1
CommonMind
Brain Pre-frontal Cortex
NRG2
0.04
0.01
lasso
5
0.01
1.0e-02
3.7
-5.3
1.0e-07
-0.44
0.03
0.80
FALSE