Hub : Genes

NRG2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.038 0.020 0.0220 0.012 0.008 0.012 0.012 0.012 0.01 0.034 0.0120 0.012 0.010
2 GTEx Esophagus Mucosa 0.088 0.043 0.0095 0.002 NA 0.026 NA 0.015 0.24 NA 0.0075 NA 0.032

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.1 1.7 2.5 -1.6 0.9
Bipolar Disorder or Schizophrenia 0.6 1.5 2.4 -1.5 0.8
Depressed Affect (Nagel 2018) 1.2 2.4 3.2 -1.3 1.8
Depression (Nagel 2018) 0.8 1.2 1.6 -1.3 0.9
Intelligence (Savage-Jansen 2018) 1.1 3.3 6.4 -2.5 0.5
Neuroticism (Nagel 2018) 0.3 0.7 0.9 -0.9 0.7
Schizophrenia (2018) 0.1 0.3 0.5 -0.7 0.2
Schizophrenia vs Biploar Disorder 0.3 0.4 0.7 0.2 -0.8
Worry (Nagel 2018) 0.0 0.1 0.1 0.1 -0.4
Alzheimer’s Disease (in mother) 0.2 0.2 0.4 0.3 0.6
Alzheimer’s Disease (in father) 0.3 0.3 0.6 0.1 -0.7
Alzheimer’s Disease (including proxy) 0.4 0.5 0.5 0.7 -0.7
Crohns Disease (2017) 1.1 2.4 3.7 1.0 -1.9
Irritable Bowel Disease (IBD) 0.5 1.2 2.1 0.5 -1.4
Ulcerative Colitis (UC) 0.2 0.3 0.3 -0.5 -0.6
Major Depression (MDD) 0.4 0.4 0.9 -0.1 -0.9
Reaction Time 0.8 1.6 3.0 -1.7 -0.4
Verbal and Numeric Reasoning (VNR) 0.9 2.2 4.0 -2.0 0.6
Breast Cancer 0.3 0.6 1.2 -0.1 1.1
Ovarian Cancer 0.9 1.2 2.0 -0.5 1.4
Prostate Cancer 0.4 0.6 0.9 1.0 0.5
Age at First Birth 0.5 0.8 1.5 -1.2 0.2
Bipolar Disorder (2011) 1.5 1.4 2.9 -1.7 0.0
Body Mass Index (BMI) (2010) 0.0 0.0 0.1 0.1 -0.2
Coronary Artery Disease (CAD) 0.4 0.5 0.8 -0.6 0.9
Crohns Disease (2012) 0.3 0.5 0.9 1.0 -0.4
Mean Putamen Volume 0.6 0.7 0.8 -0.8 -0.9
Fasting Glucose 0.6 0.7 1.0 -1.0 -0.7
HbA1C 0.6 0.7 1.3 0.1 -1.1
HDL Cholesterol 0.1 0.2 0.2 -0.5 -0.5
LDL Cholesterol 0.1 0.1 0.2 -0.5 -0.1
Lupus 0.4 0.7 0.8 -0.7 0.9
Neuroticism (2016) 0.4 0.5 0.9 0.3 -1.0
Primary Biliary Cirrhosis 0.3 0.5 0.7 -0.8 -0.5
Rheumatoid Arthritis 1.1 1.5 2.8 1.7 -0.3
Schizophrenia (2014) 0.2 0.5 0.9 -1.0 0.1
Triglycerides 0.3 0.6 1.1 -1.0 0.1
Type 2 Diabetes (T2D) (2012) 1.0 1.1 1.4 1.2 0.9
Ulcerative Colitis 0.3 0.5 0.8 -0.9 -0.4
Blood Eosinophil Count 0.0 0.0 0.0 0.0 -0.0
Blood Platelet Count 0.8 9.0 15.5 3.9 -1.6
Blood Red Count 0.0 0.1 0.2 0.0 -0.4
Blood White Count 0.3 2.6 5.2 2.3 0.0
Heel T-Score 0.3 2.4 4.1 2.0 -0.8
BMI 1.1 6.3 12.5 0.3 -3.5
Height 1.5 29.0 42.8 -6.5 3.9
Waist Hip Ratio (WHR) 1.3 6.0 7.0 2.6 -2.2
Systolic Blood Pressure 1.0 5.1 8.4 2.9 -1.3
Smoking Status 0.7 1.8 2.2 1.2 -1.5
Allergy or Eczema 0.3 0.7 0.9 -0.7 -0.9
Cardiovascular Disease 0.5 1.7 2.8 1.7 -0.8
Hypothyroidism (self reported) 0.6 1.3 1.7 1.3 -1.0
Respiratory disease 0.1 0.1 0.2 -0.2 0.4
Type 2 Diabetes (T2D) (2018) 1.5 2.8 5.4 2.3 0.5
Lung FEV1/FVC ratio 0.3 1.3 1.6 1.0 -1.3
Lung FVC 0.7 3.6 6.5 -0.9 -2.6
Neuroticism 0.6 1.4 2.7 -1.6 0.3
Chronotype (morning person) 0.4 0.9 1.8 -1.3 -0.1
Hair Pigment 0.0 1.0 1.6 1.3 -0.7
Tanning 0.3 4.3 8.1 0.6 2.9
Hand grip strength (left) 0.2 0.6 0.8 -0.6 -0.9
Number of treatments/medications taken 0.4 0.8 1.5 1.2 0.1
Average weekly spirits intake 0.7 0.9 1.0 1.0 -0.9
Sensitivity / hurt feelings 0.7 1.1 2.2 -1.5 0.2
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.2 -1.1 0.7
Hearing difficulty/problems: Yes 0.7 1.1 1.7 -1.3 0.7
Relative age of first facial hair 0.5 1.1 2.0 0.5 -1.4
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 1.7 0.6 1.3
Ever used hormone-replacement therapy (HRT) 0.6 0.8 0.9 -0.9 0.9
Ever had hysterectomy (womb removed) 0.4 0.4 0.9 -0.0 0.9
Systolic blood pressure, automated reading 0.5 1.5 2.9 1.7 0.3
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 1.6 0.7 -1.3
Angina 0.1 0.1 0.1 0.4 0.3
Medication for hormone replacement therapy 0.4 0.4 0.6 -0.5 0.8
Vitamin and mineral supplements 0.4 0.6 1.1 -0.2 1.1
Supplements: Zinc 2.7 2.9 5.7 -0.4 -2.4
Medication: Co-codamol 2.5 2.9 4.6 -2.1 1.1
Medication: Metformin 0.5 0.8 1.4 0.4 1.2
Diabetes (father) 1.0 1.2 2.4 -0.0 1.5
Diabetes (mother) 0.3 0.4 0.8 0.1 0.9
Severe depression (siblings) 2.1 2.3 2.7 -1.6 1.4
Pack years adult smoking proportion 0.0 0.0 0.1 0.3 -0.2
Impedance of leg (right) 0.5 2.4 4.8 0.3 2.2
Leg fat-free mass (left) 0.7 3.5 3.7 -1.9 -1.8
Trunk fat percentage 0.5 1.9 3.7 0.1 -1.9
Hand grip strength (right) 0.2 0.6 0.6 -0.7 -0.8
Townsend deprivation index at recruitment 0.1 0.1 0.2 0.0 0.5
Current tobacco smoking 0.8 1.4 2.1 1.4 -0.8
Average weekly fortified wine intake 0.2 0.2 0.4 -0.2 0.7
Maternal smoking around birth 2.2 3.1 3.8 1.6 -1.9
Fed-up feelings 0.2 0.3 0.4 0.4 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 2.2 -1.5 0.4
Relative age voice broke 0.1 0.2 0.3 -0.6 0.2
Taking other prescription medications 0.1 0.1 0.2 0.1 -0.5
Age when periods started (menarche) 0.3 0.7 1.2 0.6 1.1
Bilateral oophorectomy (both ovaries removed) 0.0 0.0 0.0 -0.1 0.2
Heel bone mineral density (BMD) T-score, automated (left) 1.8 4.0 5.8 2.4 -1.5
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.4 -0.5 1.2
Qualifications: CSEs or equivalent 1.0 1.3 2.3 -0.5 -1.5
Serious illness, injury or assault to yourself 1.6 2.0 2.7 -1.1 1.6
High blood pressure 0.8 2.3 4.2 2.1 -0.5
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.5 -0.7 -0.4
Multivitamins +/- minerals 1.5 1.9 2.7 1.1 -1.6
Stomach or abdominal pain in last month 0.3 0.4 0.6 0.7 0.4
Supplements: Glucosamine 0.4 0.5 0.7 0.5 -0.9
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.6 -0.1 -1.3
Medication: Atenolol 0.1 0.1 0.2 0.5 -0.2
Medication: Levothyroxine sodium 1.2 2.0 3.9 0.4 -2.0
Sitting height 1.0 7.5 13.1 -3.6 1.3
Chronic bronchitis/emphysema (father) 0.0 0.0 0.1 -0.2 0.0
High blood pressure (mother) 0.2 0.3 0.7 -0.0 -0.8
Body mass index (BMI) 1.2 5.1 9.9 0.6 -3.1
Impedance of leg (left) 0.7 3.4 6.7 -0.0 2.6
Leg predicted mass (left) 0.7 3.5 3.5 -1.9 -1.8
Trunk fat mass 0.5 2.0 3.6 -0.6 -1.9
Waist circumference 0.6 2.2 4.3 0.3 -2.1
Number of incorrect matches in round 0.1 0.1 0.2 -0.1 0.5
Past tobacco smoking 0.4 0.8 1.4 -0.4 1.2
Alcohol usually taken with meals 0.2 0.3 0.4 -0.4 0.6
Nervous feelings 0.6 1.1 2.1 1.4 -0.3
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.2 3.1 -1.2 -1.8
Hearing difficulty/problems with background noise 0.3 0.4 0.6 -0.7 0.6
Hair/balding pattern: Pattern 2 0.8 1.0 2.0 -1.4 -0.1
Had menopause 0.1 0.2 0.3 0.1 0.5
Had other major operations 0.8 1.0 2.0 -1.4 -0.1
Forced vital capacity (FVC) 1.2 4.7 6.4 -2.5 -1.7
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 1.7 1.3 -0.7
Ever unenthusiastic/disinterested for a whole week 2.3 2.8 5.4 -2.3 -0.6
Qualifications: None of the above 0.2 0.4 0.5 0.6 0.7
Financial difficulties in last 2 years 0.2 0.2 0.4 -0.0 -0.6
Mouth/teeth dental problems 1.0 1.5 2.9 -1.7 0.3
Heart attack 0.1 0.1 0.2 -0.4 0.4
Allergy 0.2 0.5 0.7 0.4 0.8
Pain all over the body in last month 0.7 0.8 1.4 -1.2 0.5
Diabetes (self-reported) 1.0 1.5 2.7 1.6 0.6
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.6 -1.3 -0.0
Medication: Ramipril 0.2 0.3 0.3 -0.6 0.5
Medication: Simvastatin 2.8 4.2 5.1 2.2 -1.8
Fluid intelligence score 0.3 0.7 1.3 0.1 -1.2
Illnesses of siblings 1.2 1.7 2.4 -1.1 1.5
Neuroticism score 0.3 0.6 0.9 -0.5 -1.0
Weight 0.7 3.2 4.2 -1.5 -2.0
Impedance of arm (right) 0.1 0.6 1.1 -0.4 1.1
Arm fat percentage (right) 1.8 7.0 13.1 1.0 -3.6
Trunk fat-free mass 0.7 3.8 7.2 -2.7 -0.7
Hip circumference 0.3 1.4 1.8 -1.4 -0.9
Time employed in main current job 0.0 0.0 0.0 0.1 -0.0
Alcohol intake versus 10 years previously 0.5 0.7 1.1 -0.5 -1.1
Father’s age at death 2.6 3.5 6.7 -0.6 2.6
Worrier / anxious feelings 0.0 0.1 0.1 -0.4 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.7 1.5 -1.2 0.1
Falls in the last year 0.3 0.4 0.4 0.6 -0.6
Hair/balding pattern: Pattern 3 0.1 0.1 0.2 -0.3 0.4
Number of live births 0.1 0.2 0.2 0.4 0.5
Forced expiratory volume in 1-second (FEV1) 1.4 4.8 6.5 -1.8 -2.5
Pulse rate 3.0 5.1 7.5 1.7 -2.7
Happiness 0.3 0.4 0.6 -0.5 -0.7
Noisy workplace 0.2 0.2 0.3 -0.2 0.6
Qualifications: A levels/AS levels or equivalent 0.6 1.4 2.5 -0.4 -1.6
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.0 0.3 -1.0
Mouth/teeth dental problems: Dentures 0.5 0.8 1.6 1.2 -0.3
Asthma 0.0 0.1 0.1 0.1 -0.3
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 3.0 1.7 0.8
Medication: Cholesterol lowering 0.5 0.7 1.1 1.1 -0.6
Depression (self-reported) 0.0 0.1 0.1 -0.3 0.1
Medication: Lansoprazole 1.2 1.4 2.1 0.8 -1.4
Prospective memory result 0.2 0.2 0.4 0.6 -0.1
Lung cancer (father) 3.7 4.3 6.0 -1.6 2.5
Illnesses of mother 0.5 0.6 1.2 0.2 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.1 5.6 -0.8 -2.4
Pulse wave Arterial Stiffness index 1.2 1.4 1.9 1.0 -1.4
Impedance of arm (left) 0.3 1.4 2.6 -0.5 1.6
Arm fat mass (right) 1.5 6.1 12.1 -0.0 -3.5
Trunk predicted mass 0.7 4.0 7.5 -2.7 -0.7
Standing height 1.4 13.6 23.3 -4.8 1.9
Length of working week for main job 0.6 0.7 0.9 0.7 -1.0
Exposure to tobacco smoke at home 0.1 0.1 0.3 -0.0 0.5
Breastfed as a baby 0.5 0.7 0.8 0.7 0.9
Tense / ‘highly strung’ 0.5 0.9 1.1 -1.1 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.8 0.0 -1.4
Hair/balding pattern: Pattern 4 2.7 6.5 12.6 0.7 3.5
Birth weight of first child 0.9 1.6 1.9 -1.4 1.2
Peak expiratory flow (PEF) 3.4 8.0 15.5 0.6 -3.9
Pulse wave reflection index 0.4 0.5 0.5 0.7 -0.7
Ever highly irritable/argumentative for 2 days 0.0 0.1 0.1 -0.2 -0.3
Loud music exposure frequency 1.6 1.7 3.3 0.5 -1.8
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 1.8 1.2 -1.3
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.3 -0.6 0.5
Blood clot in the leg (DVT) 0.2 0.2 0.4 -0.6 -0.2
Medication: Paracetamol 0.8 1.4 1.7 -1.0 1.3
Headache pain in last month 0.4 0.7 1.3 -1.1 0.2
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.6 -0.8 0.4
Glaucoma (self-reported) 1.2 1.4 2.6 -1.6 -0.4
Gout (self-reported) 1.6 2.2 3.8 -2.0 0.8
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 0.8 0.4 -0.9
Medication: Amlodipine 2.3 3.2 6.4 2.5 -0.1
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.7 0.2 -0.9
Birth weight 0.7 1.6 1.6 -1.2 1.3
Chronic bronchitis/emphysema (mother) 0.4 0.5 0.9 0.2 -0.9
High blood pressure (siblings) 2.0 2.9 4.2 2.0 -1.3
Forced vital capacity (FVC), Best measure 0.7 2.4 3.0 -1.7 -1.4
Body fat percentage 0.4 1.7 3.2 0.5 -1.8
Leg fat percentage (right) 0.4 1.3 2.1 0.8 -1.4
Arm fat-free mass (right) 0.6 3.1 5.7 -2.4 -0.7
Exposure to tobacco smoke outside home 0.5 0.6 1.1 0.4 -1.0
Comparative body size at age 10 0.1 0.3 0.6 -0.1 -0.8
Number of full brothers 0.3 0.4 0.6 -0.3 -0.8
Worry too long after embarrassment 1.6 2.7 5.1 0.5 -2.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.0 -1.0 -0.3
Wheeze or whistling in the chest in last year 0.1 0.1 0.2 0.4 0.0
Number of children fathered 0.1 0.1 0.2 -0.5 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.4 -0.6 -0.1
Age at first live birth 0.3 0.5 0.8 -0.9 0.4
Pulse wave peak to peak time 1.8 2.1 2.5 -1.3 1.6
Health satisfaction 0.1 0.1 0.1 0.4 -0.0
Shortness of breath walking on level ground 3.0 3.6 6.7 0.7 2.6
Qualifications: College or University degree 0.1 0.2 0.4 -0.6 0.3
Eye problems/disorders: None of the above 1.3 1.5 2.9 1.7 0.4
Mouth/teeth dental problems: Loose teeth 3.0 3.6 5.7 1.2 2.4
Emphysema/chronic bronchitis 1.9 2.2 3.1 -1.1 1.8
Medication for pain relief, constipation, heartburn 0.3 0.5 0.8 0.5 -0.9
Neck or shoulder pain in last month 0.3 0.5 0.9 -0.2 1.0
Medication: Blood pressure 0.4 0.7 1.3 1.1 -0.0
Angina (self-reported) 0.2 0.2 0.4 0.2 0.7
Migraine (self-reported) 0.1 0.1 0.2 -0.4 -0.2
Medication: Ibuprofen 0.9 1.1 1.1 1.1 1.0
Medication: Allopurinol 0.9 1.3 2.5 -1.6 -0.2
Medication: Omeprazole 0.0 0.0 0.0 -0.1 0.1
Medication: Seretide 50 evohaler 0.9 1.1 1.8 0.6 1.3
Mean time to correctly identify matches 0.8 1.5 2.9 -1.7 -0.0
Heart disease (mother) 0.3 0.4 0.8 0.3 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.7 3.2 6.2 -2.5 -0.5
Whole body fat mass 0.5 2.2 4.2 -0.5 -2.0
Leg fat mass (right) 0.5 2.0 4.0 -0.2 -2.0
Arm predicted mass (right) 0.6 3.0 5.5 -2.4 -0.6
Pulse rate, automated reading 1.9 6.2 7.2 2.3 -2.7
Alcohol intake frequency. 2.0 4.6 7.8 -2.8 -1.2
Comparative height size at age 10 3.2 17.4 28.4 -5.3 2.5
Number of full sisters 0.6 0.7 0.7 0.8 -0.8
Suffer from ‘nerves’ 0.1 0.2 0.2 0.5 -0.3
Overall health rating 0.1 0.2 0.3 0.4 -0.5
Chest pain or discomfort 1.1 1.6 2.6 -0.8 1.6
Had major operations 3.8 4.5 8.5 -0.7 2.9
Age at last live birth 0.4 0.6 0.9 -1.0 0.5
Family relationship satisfaction 0.9 1.0 2.1 -1.4 0.1
Leg pain on walking 0.2 0.3 0.6 -0.0 0.8
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 0.7 0.7 -0.8
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.4 0.6 0.3
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 3.0 -1.7 0.1
Medication: Aspirin 0.2 0.2 0.3 0.3 -0.5
Supplements: Vitamin C 1.7 2.0 3.5 -0.7 -1.9
Knee pain experienced in last month 2.1 3.2 5.9 -0.7 2.4
Hypertension (Self-reported) 0.9 2.5 4.7 2.2 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 0.5 -0.7 -0.7
Illnesses of father: Heart disease 0.0 0.0 0.0 -0.1 0.1
Illnesses of siblings: Diabetes 1.3 1.6 1.7 -1.3 1.2
Smoking status: Previous 0.2 0.3 0.4 0.4 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.8 -1.7 0.0
Whole body fat-free mass 0.6 3.6 5.9 -2.4 -1.2
Leg fat-free mass (right) 0.6 3.3 3.9 -2.0 -1.6
Arm fat percentage (left) 1.3 5.2 9.7 0.9 -3.1
Average weekly red wine intake 0.8 1.2 1.6 -1.3 0.9
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.2 -0.4 -0.5
Mood swings 0.8 1.4 2.1 -0.9 1.5
Loneliness, isolation 0.4 0.6 1.2 -1.1 -0.1
Long-standing illness, disability or infirmity 0.2 0.3 0.6 0.1 0.8
Ever had bowel cancer screening 1.4 1.6 2.2 -1.0 1.5
Diabetes diagnosed by doctor 0.4 0.7 1.2 1.1 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.6 -0.5 0.8
Friendships satisfaction 1.1 1.3 2.2 -1.5 -0.7
Qualifications: nursing, teaching 0.1 0.1 0.1 0.4 0.1
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.4 0.1
Eye problems/disorders: Cataract 0.7 0.8 0.9 -0.9 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.3 0.5 0.1
Medication for cholesterol 0.7 1.1 1.2 -1.1 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.4 2.8 4.8 -0.9 2.2
Back pain experienced in last month 2.0 2.9 3.8 -1.4 -1.9
Mineral and other dietary supplements 0.1 0.1 0.1 -0.3 0.3
Breast cancer (self-reported) 1.2 1.5 2.0 0.9 -1.4
Asthma (self-reported) 0.0 0.0 0.0 0.1 -0.0
Osteoporosis (self-reported) 0.2 0.3 0.4 -0.3 0.7
Osteoarthritis (self-reported) 0.2 0.2 0.4 -0.7 0.0
Medication: Aspirin 0.3 0.4 0.7 -0.1 -0.8
Medication: Gliclazide 2.8 3.2 6.0 2.4 0.7
Illnesses of father: None of the above (group 1) 0.3 0.4 0.8 -0.1 0.9
Smoking status: Current 0.6 0.9 1.5 1.2 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.3 6.3 0.6 -2.5
Whole body water mass 0.6 3.4 5.8 -2.4 -1.0
Leg predicted mass (right) 0.6 3.1 3.7 -1.9 -1.6
Arm fat mass (left) 1.0 3.9 7.8 -0.1 -2.8
Number of self-reported non-cancer illnesses 0.4 0.8 1.0 -1.0 0.7
Average weekly champagne plus white wine intake 0.0 0.0 0.0 0.1 0.2
Miserableness 0.5 0.9 1.7 0.1 1.3
Guilty feelings 0.4 0.7 1.3 0.2 -1.1
Wears glasses or contact lenses 0.5 0.5 0.7 0.6 0.8
Ever taken oral contraceptive pill 0.6 0.6 1.2 0.2 1.1
Hearing aid user 1.7 1.9 3.7 -1.9 -0.1
Mother’s age at death 0.4 0.5 1.0 -1.0 0.1
Financial situation satisfaction 0.6 0.7 1.2 1.1 0.5
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 0.2 -0.5
Commuting to job workplace: Public transport 0.8 0.9 1.1 -0.8 -1.1
Eye problems/disorders: Glaucoma 1.0 1.2 2.2 -1.5 0.5
Medication: Blood pressure 0.8 1.4 2.0 1.4 -1.0
Pain type(s) experienced in last month: Hip pain 1.7 2.1 2.4 -1.6 1.4
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.4 0.7 -0.5
High cholesterol (Self-reported) 0.4 0.7 0.9 0.7 -1.0
Medication: Bendroflumethiazide 1.1 1.6 2.9 1.7 -0.5
Medication: Paracetamol 1.0 1.6 2.2 -1.5 0.9
Medication: Lisinopril 1.7 2.1 3.2 1.8 -1.0
Medication: Atorvastatin 1.6 2.0 3.5 -0.7 1.9
Illnesses of father: High blood pressure 4.7 5.9 6.7 2.3 -2.6
Alcohol drinker status: Never 1.9 2.3 3.5 1.0 -1.9
Ever smoked 0.4 0.7 1.3 -0.1 -1.1
Basal metabolic rate 0.6 3.6 4.7 -2.2 -1.6
Leg fat percentage (left) 0.3 1.0 1.6 0.6 -1.3
Arm fat-free mass (left) 0.5 2.8 4.6 -2.1 -1.0
Number of operations (self-reported) 0.6 0.9 1.7 -0.3 1.3
Average weekly beer plus cider intake 0.6 0.9 1.3 1.2 -0.7
Irritability 1.1 1.8 3.7 -1.9 0.1
Risk taking 0.0 0.1 0.1 0.4 0.0
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.7 -0.0 0.9
Fractured/broken bones in last 5 years 0.7 0.9 1.8 1.3 -0.0
Age started oral contraceptive pill 2.6 3.2 3.8 -1.9 1.6
Diastolic blood pressure, automated reading 0.8 2.5 3.4 1.2 -1.9
Ever depressed for a whole week 3.6 4.4 8.8 -3.0 -0.0
Unable to work because of sickness or disability 0.0 0.0 0.0 0.2 -0.0
Commuting to job workplace: Cycle 0.3 0.3 0.4 0.6 0.6
Myopia 1.0 1.4 2.7 1.6 0.5
Vascular/heart problems diagnosed by doctor 0.4 1.0 1.7 -1.3 0.6
Cholesterol lowering medication 0.9 1.4 1.4 1.2 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 -0.4 -0.3
Pain experienced in last month 1.2 2.0 3.6 1.9 -0.6
Supplements: Calcium 0.9 1.0 1.3 1.1 0.8
Basal cell carcinoma (self-reported) 1.1 1.3 2.2 0.6 1.5
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.0 -0.1 0.1
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.2 -0.4 -0.5
Heart disease (siblings) 0.1 0.2 0.2 -0.3 -0.5
Alcohol drinker status: Previous 2.8 3.2 5.8 -2.4 0.8
Pack years of smoking 0.0 0.0 0.0 0.2 0.1
Impedance of whole body 0.3 1.8 3.5 -0.3 1.9
Leg fat mass (left) 0.5 2.1 4.2 -0.3 -2.0
Arm predicted mass (left) 0.6 3.2 5.0 -2.2 -1.2