Best TWAS P=6.83e-14 · Best GWAS P=1.33e-17 conditioned to 0.0338
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ZNF354C | 0.09 | 0.03 | lasso | 3 | 0.01 | 1.1e-01 | 7.4 | 7.5 | 9.5e-14 | -0.02 | 0.02 | 0.97 | TRUE |
| 2 | GTEx | Adrenal Gland | CTB-129O4.1 | 0.24 | 0.02 | enet | 11 | 0.09 | 3.4e-04 | -8.5 | -5.5 | 3.2e-08 | 0.77 | 0.01 | 0.92 | FALSE |
| 3 | GTEx | Artery Tibial | ZNF354C | 0.14 | 0.06 | lasso | 2 | 0.03 | 2.2e-03 | 7.4 | 7.4 | 1.1e-13 | -0.01 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Brain Caudate basal ganglia | CTB-129O4.1 | 0.25 | -0.01 | lasso | 10 | 0.00 | 2.7e-01 | 4.6 | -5.7 | 9.4e-09 | 0.61 | 0.04 | 0.62 | FALSE |
| 5 | GTEx | Brain Cerebellar Hemisphere | CTB-129O4.1 | 0.24 | 0.04 | enet | 23 | 0.12 | 5.0e-04 | 4.6 | -5.4 | 6.3e-08 | 0.57 | 0.04 | 0.74 | FALSE |
| 6 | GTEx | Lung | MAPK9 | 0.10 | 0.05 | lasso | 4 | 0.05 | 2.2e-04 | 5.3 | 5.3 | 9.8e-08 | -0.59 | 0.42 | 0.15 | FALSE |
| 7 | GTEx | Nerve Tibial | MAPK9 | 0.13 | 0.06 | lasso | 5 | 0.05 | 1.7e-04 | 5.3 | 7.5 | 6.8e-14 | -0.87 | 0.01 | 0.99 | TRUE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | MAPK9 | 0.21 | 0.07 | lasso | 5 | 0.05 | 8.5e-04 | 4.7 | 5.2 | 2.3e-07 | -0.52 | 0.54 | 0.33 | FALSE |
| 9 | GTEx | Testis | CTB-129O4.1 | 0.19 | 0.07 | lasso | 4 | 0.10 | 2.6e-05 | 4.7 | -5.3 | 1.1e-07 | 0.40 | 0.23 | 0.48 | FALSE |
| 10 | GTEx | Thyroid | ZNF354C | 0.09 | 0.00 | lasso | 4 | 0.00 | 8.4e-01 | 7.4 | 7.0 | 2.7e-12 | 0.01 | 0.02 | 0.87 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | ZNF354C | 0.23 | 0.14 | lasso | 5 | 0.22 | 1.2e-27 | -2.6 | 6.2 | 6.8e-10 | -0.04 | 0.01 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZNF354C | 0.02 | 0.00 | blup | 54 | 0.01 | 5.0e-03 | 5.8 | 5.4 | 6.3e-08 | -0.05 | 0.06 | 0.66 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MAPK9 | 0.07 | 0.00 | blup | 96 | 0.02 | 8.4e-04 | 4.8 | 6.7 | 1.7e-11 | -0.67 | 0.03 | 0.48 | FALSE |
| 14 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | GFPT2 | 0.13 | 0.16 | lasso | 3 | 0.14 | 2.5e-06 | 5.3 | 5.3 | 9.8e-08 | -0.60 | 0.32 | 0.30 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | MAPK9 | 0.06 | 0.04 | lasso | 3 | 0.05 | 2.9e-05 | 7.0 | 7.1 | 1.1e-12 | -0.69 | 0.04 | 0.92 | TRUE |