Best TWAS P=3.1e-25 · Best GWAS P=1.64e-23 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RAB24 | 0.14 | 0.06 | enet | 14 | 0.09 | 4.2e-11 | 7.4 | 9.7 | 2.9e-22 | -0.27 | 0.65 | 0.35 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | RAB24 | 0.17 | 0.08 | enet | 26 | 0.14 | 1.7e-11 | 7.5 | 8.1 | 4.8e-16 | -0.16 | 0.80 | 0.20 | FALSE |
| 3 | GTEx | Artery Tibial | FGFR4 | 0.07 | 0.00 | enet | 11 | 0.00 | 2.6e-01 | -7.4 | -6.5 | 9.3e-11 | 0.71 | 0.03 | 0.80 | FALSE |
| 4 | GTEx | Artery Tibial | RAB24 | 0.18 | 0.09 | lasso | 3 | 0.07 | 2.3e-06 | 7.5 | 8.6 | 5.9e-18 | -0.24 | 0.34 | 0.65 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | MXD3 | 0.23 | 0.08 | lasso | 3 | 0.09 | 1.1e-03 | 6.1 | 5.6 | 2.4e-08 | 0.04 | 0.07 | 0.07 | FALSE |
| 6 | GTEx | Esophagus Gastroesophageal Junction | RP11-1277A3.3 | 0.26 | 0.04 | enet | 13 | 0.10 | 1.3e-04 | 2.9 | -5.9 | 4.6e-09 | 0.23 | 0.13 | 0.20 | FALSE |
| 7 | GTEx | Esophagus Mucosa | UIMC1 | 0.08 | 0.00 | lasso | 5 | 0.00 | 3.5e-01 | -9.9 | -10.4 | 3.1e-25 | 0.99 | 0.01 | 0.90 | TRUE |
| 8 | GTEx | Esophagus Mucosa | FGFR4 | 0.18 | 0.16 | enet | 8 | 0.16 | 9.2e-11 | -9.9 | -9.2 | 4.0e-20 | 0.99 | 0.00 | 1.00 | FALSE |
| 9 | GTEx | Nerve Tibial | FGFR4 | 0.44 | 0.48 | lasso | 7 | 0.47 | 2.1e-37 | -9.9 | -9.8 | 7.6e-23 | 1.00 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Nerve Tibial | RAB24 | 0.27 | 0.08 | enet | 32 | 0.17 | 6.3e-12 | 6.4 | 9.1 | 6.4e-20 | -0.16 | 0.54 | 0.38 | TRUE |
| 11 | GTEx | Pituitary | FGFR4 | 0.30 | 0.21 | lasso | 3 | 0.11 | 1.0e-03 | -7.4 | -7.9 | 2.8e-15 | 0.92 | 0.02 | 0.87 | FALSE |
| 12 | GTEx | Skin Not Sun Exposed Suprapubic | FGFR4 | 0.19 | 0.11 | lasso | 5 | 0.11 | 8.3e-07 | -9.9 | -8.6 | 9.3e-18 | 0.96 | 0.01 | 0.99 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | FAM193B | 0.07 | 0.00 | enet | 8 | 0.03 | 8.2e-04 | 2.9 | -5.6 | 1.9e-08 | -0.10 | 0.16 | 0.04 | TRUE |
| 14 | GTEx | Skin Sun Exposed Lower leg | FGFR4 | 0.09 | 0.11 | enet | 10 | 0.12 | 7.1e-10 | -10.0 | -6.3 | 3.1e-10 | 0.90 | 0.00 | 1.00 | TRUE |
| 15 | GTEx | Skin Sun Exposed Lower leg | MXD3 | 0.19 | 0.14 | lasso | 6 | 0.12 | 4.2e-10 | 6.1 | 5.3 | 1.3e-07 | -0.03 | 1.00 | 0.00 | FALSE |
| 16 | METSIM | Adipose | RAB24 | 0.05 | 0.02 | lasso | 4 | 0.02 | 1.2e-03 | 7.4 | 7.4 | 1.2e-13 | -0.22 | 0.19 | 0.66 | TRUE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | FGFR4 | 0.26 | 0.14 | lasso | 20 | 0.21 | 4.5e-26 | -7.4 | -7.5 | 4.9e-14 | 0.77 | 0.36 | 0.64 | FALSE |
| 18 | YFS | Blood | MXD3 | 0.04 | 0.03 | lasso | 4 | 0.04 | 5.8e-13 | -4.1 | 7.9 | 2.7e-15 | 0.06 | 1.00 | 0.00 | FALSE |
| 19 | The Cancer Genome Atlas | Colon Adenocarcinoma | RAB24 | 0.08 | 0.04 | enet | 7 | 0.06 | 3.4e-04 | -3.9 | 8.2 | 1.9e-16 | 0.00 | 0.02 | 0.64 | FALSE |
| 20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FGFR4 | 0.08 | 0.06 | blup | 46 | 0.07 | 2.5e-08 | -1.1 | -5.2 | 2.0e-07 | 0.76 | 0.17 | 0.83 | FALSE |
| 21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LMAN2 | 0.04 | 0.00 | blup | 46 | 0.00 | 1.6e-01 | 6.1 | -6.1 | 9.5e-10 | 0.00 | 0.02 | 0.03 | FALSE |
| 22 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MXD3 | 0.05 | 0.00 | lasso | 6 | 0.00 | 6.9e-01 | -7.0 | -5.9 | 4.3e-09 | -0.14 | 0.01 | 0.35 | TRUE |
| 23 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FGFR4 | 0.06 | 0.02 | enet | 7 | 0.05 | 1.2e-06 | -3.3 | -5.7 | 1.2e-08 | 0.58 | 0.04 | 0.90 | TRUE |
| 24 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | F12 | 0.16 | 0.06 | enet | 4 | 0.11 | 5.2e-06 | 6.2 | -6.1 | 1.0e-09 | 0.19 | 0.08 | 0.19 | FALSE |
| 25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RAB24 | 0.23 | 0.04 | enet | 19 | 0.06 | 6.5e-07 | 7.4 | 5.7 | 1.4e-08 | -0.15 | 0.00 | 0.98 | FALSE |