Best TWAS P=7.05e-09 · Best GWAS P=4.28e-08 conditioned to 0.862
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TTC19 | 0.08 | 0.12 | enet | 12 | 0.10 | 3.1e-08 | 5.4 | 5.5 | 3.4e-08 | 0.97 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Heart Left Ventricle | TTC19 | 0.06 | 0.01 | enet | 5 | 0.01 | 1.6e-01 | -4.6 | 5.1 | 3.1e-07 | 0.67 | 0.09 | 0.41 | FALSE |
| 3 | GTEx | Nerve Tibial | TTC19 | 0.09 | 0.11 | lasso | 3 | 0.11 | 2.3e-08 | -4.7 | 5.3 | 1.4e-07 | 0.92 | 0.11 | 0.88 | FALSE |
| 4 | GTEx | Testis | TTC19 | 0.14 | 0.13 | enet | 24 | 0.08 | 2.5e-04 | 5.4 | 5.6 | 2.5e-08 | 0.90 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Testis | PIGL | 0.20 | 0.06 | enet | 10 | 0.10 | 2.6e-05 | 5.3 | 5.6 | 2.1e-08 | 0.85 | 0.02 | 0.96 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PIGL | 0.03 | 0.03 | blup | 72 | 0.01 | 1.9e-02 | 5.5 | -5.8 | 7.1e-09 | -0.94 | 0.02 | 0.92 | TRUE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CENPV | 0.03 | 0.00 | blup | 40 | 0.01 | 1.9e-02 | 5.4 | -5.3 | 1.1e-07 | -0.89 | 0.01 | 0.57 | FALSE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PIGL | 0.26 | 0.13 | enet | 5 | 0.06 | 2.5e-03 | 5.5 | -5.5 | 4.7e-08 | -1.00 | 0.02 | 0.97 | FALSE |