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chr3:48,350,366-50,144,951

Best TWAS P=2.65e-09 · Best GWAS P=6.06e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	KLHDC8B	0.04	0.01	lasso	5	0.00	1.3e-01	4.4	5.3	9.9e-08	0.88	0.06	0.86	FALSE
2	GTEx	Artery Coronary	WDR6	0.12	0.06	enet	14	0.06	3.5e-03	4.8	5.5	4.0e-08	0.79	0.09	0.58	FALSE
3	GTEx	Brain Cerebellum	WDR6	0.08	0.06	enet	31	0.04	2.6e-02	4.9	5.2	2.5e-07	0.92	0.08	0.69	FALSE
4	GTEx	Brain Frontal Cortex BA9	WDR6	0.08	0.04	lasso	5	0.04	3.0e-02	5.8	5.4	6.1e-08	0.96	0.05	0.60	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	CCDC71	0.19	0.10	lasso	9	0.07	3.3e-03	5.8	5.5	3.7e-08	0.98	0.04	0.88	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	WDR6	0.19	0.27	enet	15	0.29	3.5e-10	5.8	5.3	1.2e-07	0.95	0.02	0.98	FALSE
7	GTEx	Esophagus Mucosa	GPX1	0.04	0.02	enet	18	0.02	2.0e-02	5.6	5.2	2.3e-07	0.93	0.05	0.91	FALSE
8	GTEx	Pancreas	WDR6	0.05	0.01	enet	17	0.01	1.1e-01	5.8	5.1	2.7e-07	0.94	0.06	0.74	FALSE
9	GTEx	Prostate	AMT	0.16	0.12	lasso	9	0.08	3.9e-03	5.8	-5.7	1.2e-08	-0.99	0.02	0.94	FALSE
10	GTEx	Thyroid	WDR6	0.03	0.02	lasso	4	0.02	1.6e-02	5.6	5.6	2.5e-08	0.97	0.05	0.71	FALSE
11	GTEx	Whole Blood	CCDC71	0.03	0.02	lasso	7	0.02	1.1e-02	4.9	5.2	2.2e-07	0.95	0.07	0.83	FALSE
12	NTR	Blood	USP4	0.02	0.02	lasso	5	0.02	2.5e-07	4.4	5.3	1.1e-07	0.91	0.06	0.94	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	CCDC71	0.07	0.07	lasso	5	0.06	8.5e-08	5.8	5.8	7.2e-09	1.00	0.01	0.99	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	RP11-3B7.1	0.06	0.01	bslmm	263	0.01	5.2e-03	5.7	-5.4	6.4e-08	-0.85	0.02	0.96	FALSE
15	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CCDC36	0.04	0.02	blup	49	0.03	7.8e-04	5.7	-5.5	2.8e-08	-0.97	0.01	0.94	FALSE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	USP4	0.06	0.04	lasso	5	0.05	5.3e-04	5.6	5.3	9.0e-08	0.92	0.01	0.96	FALSE
17	The Cancer Genome Atlas	Esophageal Carcinoma	CCDC36	0.09	0.09	lasso	3	0.07	2.9e-03	5.7	-5.7	1.2e-08	-0.95	0.01	0.86	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC36	0.11	0.12	enet	8	0.11	8.2e-13	5.8	-6.0	2.7e-09	-0.98	0.01	0.99	TRUE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC71	0.03	0.05	lasso	3	0.05	4.9e-06	5.7	5.8	7.8e-09	0.96	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC71	0.02	0.01	blup	31	0.02	1.9e-03	5.8	5.5	3.7e-08	0.98	0.01	0.85	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC36	0.10	0.09	enet	19	0.10	1.1e-10	5.7	-5.4	6.0e-08	-0.89	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	CCDC36	0.08	0.06	lasso	3	0.06	3.8e-05	5.8	-5.8	6.1e-09	-1.00	0.01	0.99	FALSE