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chr3:135,273,949-137,261,517

Best TWAS P=7.53e-11 · Best GWAS P=4.66e-10 conditioned to 0.624

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PCCB	0.09	0.19	lasso	7	0.18	1.2e-21	-5.7	-5.4	5.9e-08	-0.61	0.10	0.90	FALSE
2	GTEx	Artery Coronary	RP11-85F14.5	0.15	0.01	lasso	4	0.00	2.3e-01	-6.0	-5.5	3.4e-08	-0.53	0.04	0.77	FALSE
3	GTEx	Brain Caudate basal ganglia	PCCB	0.11	0.01	enet	12	0.01	2.1e-01	-6.0	-5.3	1.4e-07	-0.55	0.05	0.41	FALSE
4	GTEx	Cells Transformed fibroblasts	PCCB	0.10	0.09	lasso	3	0.07	5.0e-06	-5.6	-5.2	1.7e-07	-0.51	0.11	0.89	FALSE
5	GTEx	Colon Transverse	PCCB	0.07	0.06	lasso	3	0.04	7.7e-03	-5.6	-5.5	4.6e-08	-0.57	0.09	0.77	FALSE
6	GTEx	Esophagus Mucosa	PCCB	0.10	0.12	lasso	3	0.11	4.8e-08	-5.6	-5.4	5.9e-08	-0.66	0.06	0.94	FALSE
7	GTEx	Lung	PCCB	0.07	0.04	lasso	3	0.03	4.2e-03	-5.6	-5.6	1.7e-08	-0.57	0.11	0.72	FALSE
8	GTEx	Testis	PCCB	0.26	0.22	lasso	10	0.22	4.7e-10	-5.6	-5.2	1.7e-07	-0.48	0.08	0.92	FALSE
9	YFS	Blood	PCCB	0.13	0.20	lasso	9	0.20	1.3e-64	-5.7	-5.4	6.2e-08	-0.57	0.09	0.91	FALSE
10	The Cancer Genome Atlas	Colon Adenocarcinoma	PCCB	0.11	0.03	blup	54	0.04	2.3e-03	-5.7	-5.7	1.0e-08	-0.65	0.01	0.69	FALSE
11	The Cancer Genome Atlas	Esophageal Carcinoma	PCCB	0.15	0.03	blup	54	0.05	9.6e-03	-5.0	-6.0	2.2e-09	-0.70	0.01	0.57	FALSE
12	The Cancer Genome Atlas	Glioblastoma Multiforme	PCCB	0.10	0.03	blup	53	0.02	5.8e-02	-5.0	-5.6	2.4e-08	-0.59	0.02	0.57	FALSE
13	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MSL2	0.07	0.02	enet	6	0.03	1.7e-04	-5.4	-5.7	9.9e-09	-0.65	0.00	0.97	FALSE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PCCB	0.12	0.05	enet	7	0.09	9.7e-11	-5.4	-5.6	1.9e-08	-0.59	0.04	0.96	FALSE
15	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STAG1	0.04	0.02	lasso	3	0.02	4.1e-03	6.1	-6.5	7.5e-11	-0.93	0.02	0.94	TRUE
16	The Cancer Genome Atlas	Lung Adenocarcinoma	PCCB	0.11	0.10	lasso	3	0.10	1.3e-11	-5.7	-5.5	3.8e-08	-0.61	0.03	0.97	FALSE
17	The Cancer Genome Atlas	Lung Adenocarcinoma	STAG1	0.02	0.02	enet	6	0.02	3.5e-03	-6.0	-5.9	3.2e-09	-0.63	0.03	0.84	FALSE
18	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MSL2	0.04	0.02	blup	35	0.01	1.9e-02	-5.4	-5.1	2.7e-07	-0.48	0.00	0.93	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	STAG1	0.05	0.00	blup	151	0.01	2.9e-02	-5.7	-6.1	1.1e-09	-0.69	0.10	0.88	FALSE
20	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PCCB	0.12	0.07	enet	3	0.06	1.0e-04	-5.4	-5.1	2.9e-07	-0.45	0.04	0.89	FALSE
21	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PCCB	0.12	0.02	lasso	5	0.02	6.7e-02	-6.0	-5.9	4.8e-09	-0.69	0.01	0.82	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	PCCB	0.06	0.02	lasso	2	0.03	2.3e-04	5.3	-5.8	8.0e-09	-0.83	0.04	0.91	FALSE
23	The Cancer Genome Atlas	Soft Tissue Sarcoma	PCCB	0.14	0.10	enet	6	0.10	1.0e-06	-5.7	-5.5	3.2e-08	-0.61	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Soft Tissue Sarcoma	STAG1	0.06	0.06	lasso	1	0.04	2.0e-03	-5.7	-5.7	1.4e-08	-0.61	0.04	0.65	FALSE
25	The Cancer Genome Atlas	Stomach Adenocarcinoma	PCCB	0.07	0.04	lasso	1	0.02	1.1e-02	-5.6	-5.6	2.7e-08	-0.60	0.01	0.95	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	PCCB	0.06	0.03	enet	8	0.03	2.3e-04	-6.0	-5.4	5.4e-08	-0.55	0.01	0.99	FALSE