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chr3:48,381,826-51,009,435

Best TWAS P=5.08e-14 · Best GWAS P=6.62e-13 conditioned to 0.192

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	GPX1	0.12	0.19	blup	275	0.19	1.3e-22	4.4	5.6	2.2e-08	-0.54	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RNF123	0.14	0.10	blup	324	0.12	4.7e-14	5.1	5.5	4.1e-08	-0.69	0.98	0.02	FALSE
3	GTEx	Adipose Subcutaneous	TCTA	0.05	0.01	enet	10	0.01	5.8e-02	4.9	-6.0	1.9e-09	0.53	0.13	0.42	FALSE
4	GTEx	Adipose Subcutaneous	NICN1	0.20	0.12	lasso	17	0.13	6.7e-11	4.4	-6.4	2.1e-10	0.65	0.91	0.09	FALSE
5	GTEx	Adipose Subcutaneous	RNF123	0.19	0.18	enet	29	0.18	2.1e-14	5.5	5.9	3.2e-09	-0.61	1.00	0.00	FALSE
6	GTEx	Adipose Subcutaneous	NICN1-AS1	0.16	0.14	enet	20	0.14	2.4e-11	4.4	-5.6	1.7e-08	0.57	0.99	0.01	FALSE
7	GTEx	Adipose Visceral Omentum	RBM6	0.20	0.28	enet	30	0.30	6.4e-16	-4.6	-5.6	1.7e-08	0.55	1.00	0.00	FALSE
8	GTEx	Adipose Visceral Omentum	RNF123	0.08	0.11	lasso	4	0.07	2.2e-04	5.5	5.6	2.1e-08	-0.67	0.52	0.36	FALSE
9	GTEx	Adipose Visceral Omentum	GPX1	0.11	0.01	lasso	3	0.03	1.2e-02	-6.7	5.6	2.0e-08	-0.66	0.06	0.60	FALSE
10	GTEx	Artery Aorta	NICN1	0.15	0.21	enet	28	0.21	1.4e-11	5.0	-5.3	9.8e-08	0.50	1.00	0.00	FALSE
11	GTEx	Artery Coronary	RBM6	0.14	0.14	enet	23	0.15	1.0e-05	5.1	-5.5	3.1e-08	0.61	0.94	0.02	FALSE
12	GTEx	Artery Coronary	NICN1	0.10	0.01	lasso	13	0.01	1.3e-01	4.3	-6.0	2.4e-09	0.65	0.10	0.30	FALSE
13	GTEx	Artery Tibial	RBM6	0.24	0.31	enet	24	0.30	5.8e-24	-4.6	-5.1	2.8e-07	0.49	1.00	0.00	FALSE
14	GTEx	Artery Tibial	NICN1	0.20	0.17	enet	27	0.23	3.0e-18	4.4	-5.7	9.5e-09	0.73	0.72	0.28	FALSE
15	GTEx	Artery Tibial	RNF123	0.08	0.08	enet	12	0.09	2.5e-07	5.5	5.2	2.2e-07	-0.68	0.98	0.02	FALSE
16	GTEx	Artery Tibial	MST1R	0.06	0.02	lasso	5	0.02	1.5e-02	5.3	6.0	1.7e-09	-0.75	0.06	0.68	FALSE
17	GTEx	Artery Tibial	IP6K1	0.03	0.00	enet	22	0.01	2.5e-02	4.7	5.8	7.5e-09	-0.59	0.18	0.31	FALSE
18	GTEx	Artery Tibial	NICN1-AS1	0.13	0.08	lasso	5	0.12	2.5e-09	4.4	-5.1	2.7e-07	0.63	0.81	0.19	FALSE
19	GTEx	Brain Caudate basal ganglia	RNF123	0.13	0.04	enet	20	0.02	1.2e-01	5.5	5.9	4.1e-09	-0.68	0.20	0.29	FALSE
20	GTEx	Brain Cerebellar Hemisphere	RNF123	0.20	0.24	enet	29	0.20	7.7e-06	5.5	5.5	4.4e-08	-0.70	0.52	0.23	FALSE
21	GTEx	Brain Cerebellar Hemisphere	GPX1	0.18	0.11	enet	27	0.14	2.6e-04	-6.9	5.5	3.2e-08	-0.47	0.04	0.89	FALSE
22	GTEx	Brain Cerebellum	RNF123	0.36	0.31	enet	43	0.36	2.4e-11	5.5	5.9	3.1e-09	-0.49	0.98	0.01	FALSE
23	GTEx	Brain Cerebellum	MST1R	0.19	0.24	enet	22	0.20	1.8e-06	-4.7	6.0	2.5e-09	-0.62	0.72	0.25	FALSE
24	GTEx	Brain Cerebellum	FAM212A	0.27	0.35	lasso	5	0.34	9.7e-11	5.5	5.6	2.1e-08	-0.67	0.99	0.01	FALSE
25	GTEx	Brain Cerebellum	GPX1	0.31	0.09	enet	19	0.23	2.0e-07	-7.1	7.2	5.4e-13	-0.83	0.03	0.97	FALSE
26	GTEx	Brain Frontal Cortex BA9	RBM6	0.18	0.25	lasso	3	0.20	5.2e-06	5.0	5.2	2.3e-07	-0.50	0.87	0.02	FALSE
27	GTEx	Brain Frontal Cortex BA9	GPX1	0.16	0.06	lasso	6	0.15	7.9e-05	4.7	7.2	8.0e-13	-0.71	0.04	0.84	FALSE
28	GTEx	Brain Hypothalamus	MST1	0.32	0.13	lasso	3	0.12	9.4e-04	-6.8	-5.5	3.2e-08	0.91	0.03	0.82	FALSE
29	GTEx	Cells EBV-transformed lymphocytes	USP4	0.08	0.05	lasso	2	0.09	8.7e-04	5.0	6.8	7.5e-12	-0.72	0.10	0.65	FALSE
30	GTEx	Cells Transformed fibroblasts	TCTA	0.07	0.05	enet	14	0.07	9.4e-06	3.9	-5.3	8.9e-08	0.52	0.36	0.10	FALSE
31	GTEx	Cells Transformed fibroblasts	APEH	0.13	0.12	lasso	15	0.12	1.3e-09	-6.5	-6.6	5.1e-11	0.96	0.03	0.97	FALSE
32	GTEx	Cells Transformed fibroblasts	UBA7	0.07	0.06	enet	5	0.04	7.5e-04	5.5	-5.4	5.6e-08	0.66	0.95	0.02	FALSE
33	GTEx	Colon Sigmoid	AMT	0.16	0.17	lasso	15	0.13	3.3e-05	4.4	-5.2	1.7e-07	0.50	0.87	0.05	FALSE
34	GTEx	Colon Sigmoid	RNF123	0.22	0.10	enet	23	0.20	1.1e-07	3.9	5.7	1.3e-08	-0.62	0.70	0.26	FALSE
35	GTEx	Colon Sigmoid	IFRD2	0.19	0.07	lasso	4	0.03	3.1e-02	4.8	5.1	2.6e-07	-0.32	0.08	0.19	FALSE
36	GTEx	Colon Transverse	UBA7	0.28	0.30	lasso	2	0.30	1.1e-14	5.5	-5.6	2.6e-08	0.67	1.00	0.00	FALSE
37	GTEx	Esophagus Gastroesophageal Junction	RBM6	0.25	0.29	lasso	23	0.30	2.2e-11	-4.5	-5.4	6.9e-08	0.57	1.00	0.00	FALSE
38	GTEx	Esophagus Gastroesophageal Junction	RNF123	0.14	0.13	enet	30	0.10	2.3e-04	3.8	5.5	3.9e-08	-0.59	0.52	0.26	FALSE
39	GTEx	Esophagus Mucosa	RBM6	0.18	0.21	enet	18	0.23	3.0e-15	5.0	-5.3	9.7e-08	0.53	1.00	0.00	FALSE
40	GTEx	Esophagus Mucosa	UBA7	0.04	0.07	enet	8	0.05	4.5e-04	5.5	-5.6	2.8e-08	0.65	0.76	0.06	FALSE
41	GTEx	Esophagus Mucosa	FAM212A	0.19	0.26	enet	24	0.27	4.4e-18	5.6	5.5	3.7e-08	-0.66	1.00	0.00	FALSE
42	GTEx	Esophagus Muscularis	AMT	0.13	0.18	lasso	5	0.20	2.1e-12	4.3	-5.6	2.3e-08	0.58	1.00	0.00	FALSE
43	GTEx	Esophagus Muscularis	NICN1	0.11	0.03	enet	22	0.07	2.7e-05	-6.5	-6.8	8.5e-12	0.86	0.04	0.95	FALSE
44	GTEx	Esophagus Muscularis	RNF123	0.15	0.14	enet	17	0.14	1.2e-08	5.5	5.5	3.1e-08	-0.67	0.99	0.01	FALSE
45	GTEx	Esophagus Muscularis	MST1R	0.05	0.00	lasso	5	0.05	3.6e-04	-4.7	6.0	1.7e-09	-0.58	0.19	0.46	FALSE
46	GTEx	Esophagus Muscularis	GPX1	0.13	0.05	lasso	14	0.06	1.1e-04	-7.0	7.3	2.1e-13	-0.86	0.03	0.97	FALSE
47	GTEx	Esophagus Muscularis	NICN1-AS1	0.09	0.04	enet	14	0.06	2.3e-04	-7.2	-6.1	8.3e-10	0.85	0.04	0.94	FALSE
48	GTEx	Heart Atrial Appendage	RNF123	0.06	0.04	lasso	2	0.02	4.0e-02	5.5	6.6	3.7e-11	-0.86	0.06	0.82	FALSE
49	GTEx	Lung	NICN1	0.12	0.12	enet	13	0.15	2.6e-11	5.0	-6.1	1.2e-09	0.59	0.99	0.01	FALSE
50	GTEx	Lung	RNF123	0.13	0.05	enet	18	0.07	5.8e-06	5.5	6.1	9.9e-10	-0.78	0.25	0.72	FALSE
51	GTEx	Lung	GPX1	0.04	0.02	enet	13	0.04	5.7e-04	-6.8	7.5	5.1e-14	-0.87	0.06	0.75	TRUE
52	GTEx	Lung	NICN1-AS1	0.12	0.12	lasso	8	0.12	1.0e-09	4.4	-5.6	2.1e-08	0.55	0.97	0.03	FALSE
53	GTEx	Muscle Skeletal	FAM212A	0.05	0.08	lasso	3	0.07	4.9e-07	-6.7	6.8	8.3e-12	-0.95	0.15	0.84	FALSE
54	GTEx	Nerve Tibial	NICN1	0.13	0.15	enet	21	0.16	1.4e-11	4.4	-6.3	3.7e-10	0.68	0.93	0.07	FALSE
55	GTEx	Nerve Tibial	RNF123	0.24	0.16	lasso	5	0.15	1.0e-10	5.1	5.5	3.8e-08	-0.66	1.00	0.00	FALSE
56	GTEx	Nerve Tibial	NICN1-AS1	0.15	0.11	lasso	5	0.13	1.1e-09	4.4	-6.3	2.8e-10	0.74	0.26	0.74	FALSE
57	GTEx	Ovary	NICN1	0.14	0.07	lasso	9	0.06	1.5e-02	3.5	-5.4	6.5e-08	0.58	0.08	0.44	FALSE
58	GTEx	Pituitary	QRICH1	0.28	0.05	lasso	11	0.10	1.5e-03	4.4	5.9	4.1e-09	-0.59	0.10	0.75	FALSE
59	GTEx	Prostate	RBM6	0.14	0.12	enet	15	0.05	1.8e-02	-4.7	-5.4	8.1e-08	0.54	0.30	0.20	FALSE
60	GTEx	Skin Not Sun Exposed Suprapubic	RBM6	0.16	0.17	enet	24	0.23	1.2e-12	-4.5	-5.2	2.0e-07	0.48	1.00	0.00	FALSE
61	GTEx	Skin Not Sun Exposed Suprapubic	MST1	0.12	0.09	enet	34	0.11	1.5e-06	-6.7	-6.4	1.8e-10	0.71	0.06	0.92	FALSE
62	GTEx	Skin Sun Exposed Lower leg	MST1R	0.06	0.07	lasso	2	0.06	1.1e-05	5.3	5.3	1.3e-07	-0.49	0.83	0.01	FALSE
63	GTEx	Skin Sun Exposed Lower leg	MST1	0.07	0.00	enet	10	0.01	4.1e-02	-6.8	-5.8	6.8e-09	0.84	0.05	0.82	FALSE
64	GTEx	Skin Sun Exposed Lower leg	UBA7	0.04	0.01	lasso	8	0.00	2.9e-01	5.5	-5.5	4.4e-08	0.59	0.17	0.19	FALSE
65	GTEx	Skin Sun Exposed Lower leg	FAM212A	0.05	0.07	enet	16	0.06	1.1e-05	5.6	5.6	2.6e-08	-0.67	0.97	0.02	FALSE
66	GTEx	Small Intestine Terminal Ileum	MST1R	0.20	0.05	lasso	5	0.10	3.6e-03	4.4	5.1	2.8e-07	-0.41	0.22	0.08	FALSE
67	GTEx	Spleen	RNF123	0.13	0.13	lasso	5	0.10	1.3e-03	5.5	5.5	3.0e-08	-0.67	0.13	0.41	FALSE
68	GTEx	Spleen	UBA7	0.19	0.14	lasso	22	0.11	8.8e-04	5.4	-5.6	2.5e-08	0.66	0.22	0.56	FALSE
69	GTEx	Spleen	QRICH1	0.24	0.21	enet	26	0.19	1.3e-05	3.4	5.3	9.3e-08	-0.59	0.27	0.52	FALSE
70	GTEx	Stomach	AMT	0.13	0.14	enet	19	0.14	3.7e-07	5.0	-5.3	1.1e-07	0.43	0.97	0.01	FALSE
71	GTEx	Stomach	RNF123	0.23	0.12	lasso	15	0.16	4.6e-08	3.9	5.4	6.7e-08	-0.57	0.97	0.02	FALSE
72	GTEx	Testis	MON1A	0.08	0.06	enet	13	0.05	2.4e-03	4.4	-5.3	1.1e-07	0.50	0.40	0.08	FALSE
73	GTEx	Testis	GPX1	0.08	0.00	lasso	6	0.04	1.0e-02	-7.0	5.2	1.6e-07	-0.80	0.03	0.85	FALSE
74	GTEx	Thyroid	RNF123	0.09	0.13	lasso	9	0.12	2.7e-09	5.1	5.2	1.7e-07	-0.66	0.99	0.01	FALSE
75	GTEx	Thyroid	GPX1	0.10	0.12	enet	23	0.11	9.1e-09	4.4	5.9	4.2e-09	-0.62	0.98	0.02	FALSE
76	GTEx	Whole Blood	UBA7	0.03	0.04	lasso	2	0.01	1.5e-02	5.5	-5.3	9.7e-08	0.64	0.44	0.10	FALSE
77	NTR	Blood	UBA7	0.02	0.03	lasso	4	0.03	1.6e-09	5.5	-5.5	3.0e-08	0.64	1.00	0.00	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	RNF123	0.04	0.05	lasso	3	0.05	1.4e-06	5.1	5.5	3.1e-08	-0.63	0.97	0.02	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	MST1R	0.02	0.00	blup	278	0.01	4.5e-02	4.9	5.8	5.6e-09	-0.60	0.66	0.06	FALSE
80	ROSMAP	Brain Pre-frontal Cortex	GPX1	0.23	0.25	lasso	10	0.30	1.5e-39	4.4	6.4	1.8e-10	-0.71	1.00	0.00	FALSE
81	YFS	Blood	APEH	0.11	0.05	enet	46	0.06	1.3e-19	-6.7	-5.5	2.9e-08	0.75	0.15	0.85	FALSE
82	YFS	Blood	UBA7	0.16	0.24	lasso	6	0.23	4.0e-75	5.4	-5.4	6.0e-08	0.67	1.00	0.00	FALSE
83	The Cancer Genome Atlas	Breast Invasive Carcinoma	AMIGO3	0.01	0.00	enet	13	0.01	5.7e-03	3.9	6.5	9.6e-11	-0.77	0.01	0.48	FALSE
84	The Cancer Genome Atlas	Breast Invasive Carcinoma	GMPPB	0.03	0.03	enet	12	0.03	3.0e-07	3.9	5.4	7.5e-08	-0.58	0.98	0.02	FALSE
85	The Cancer Genome Atlas	Glioblastoma Multiforme	AMIGO3	0.18	0.02	enet	24	0.07	2.9e-03	3.9	5.7	1.5e-08	-0.69	0.02	0.25	FALSE
86	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AMT	0.03	0.02	lasso	4	0.01	1.1e-02	4.4	-5.8	7.2e-09	0.59	0.02	0.32	FALSE
87	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	APEH	0.02	0.02	blup	49	0.02	2.5e-03	-6.8	-6.7	2.9e-11	0.93	0.01	0.92	FALSE
88	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UBA7	0.02	0.02	blup	30	0.02	3.8e-03	5.5	-5.8	6.6e-09	0.67	0.01	0.84	FALSE
89	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MST1R	0.03	0.04	blup	32	0.05	4.0e-06	5.3	5.2	2.4e-07	-0.51	0.04	0.95	FALSE
90	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBA7	0.08	0.09	lasso	5	0.09	3.4e-10	5.5	-5.5	2.9e-08	0.66	0.01	0.99	FALSE
91	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UBA7	0.13	0.16	lasso	6	0.15	1.1e-08	5.5	-5.5	2.9e-08	0.70	0.01	0.99	FALSE
92	The Cancer Genome Atlas	Brain Lower Grade Glioma	C3orf62	0.02	0.00	blup	31	0.02	6.4e-03	5.0	5.7	1.3e-08	-0.69	0.01	0.40	FALSE
93	The Cancer Genome Atlas	Lung Adenocarcinoma	AMIGO3	0.02	0.00	blup	40	0.00	3.0e-01	5.5	5.9	2.9e-09	-0.67	0.06	0.19	FALSE
94	The Cancer Genome Atlas	Lung Adenocarcinoma	UBA7	0.03	0.04	enet	9	0.02	1.8e-03	5.5	-5.5	4.2e-08	0.67	0.01	0.99	FALSE
95	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBA7	0.02	0.01	blup	30	0.02	5.3e-03	5.4	-5.2	1.7e-07	0.62	0.01	0.88	FALSE
96	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GMPPB	0.04	0.02	blup	40	0.02	1.4e-02	5.5	5.7	1.5e-08	-0.62	0.05	0.10	FALSE
97	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UBA7	0.11	0.14	enet	7	0.11	2.7e-05	5.4	-5.4	5.7e-08	0.66	0.01	0.98	FALSE
98	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GMPPB	0.13	0.08	blup	40	0.09	2.7e-04	3.9	5.6	2.1e-08	-0.63	0.06	0.40	FALSE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	RHOA	0.06	0.00	enet	11	0.01	1.2e-02	4.5	5.7	1.1e-08	-0.49	0.01	0.36	FALSE
100	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBA7	0.05	0.04	enet	7	0.05	1.6e-05	5.5	-5.5	3.6e-08	0.65	0.01	0.99	FALSE
101	The Cancer Genome Atlas	Stomach Adenocarcinoma	UBA7	0.04	0.05	lasso	1	0.04	1.0e-03	5.5	-5.5	3.8e-08	0.66	0.01	0.95	FALSE
102	The Cancer Genome Atlas	Thyroid Carcinoma	MST1R	0.03	0.01	blup	32	0.03	3.1e-04	5.0	5.2	1.6e-07	-0.50	0.04	0.84	FALSE
103	The Cancer Genome Atlas	Thyroid Carcinoma	UBA7	0.03	0.01	blup	30	0.02	2.0e-03	5.5	-5.7	1.5e-08	0.62	0.01	0.87	FALSE