Hub : Traits :

Fed-up feelings

640 significantly associated models · 86 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	23453834	25141538	4	2	3.2e-10	2.2e-10	3.0e-02	88	C2orf84 UBXN2A
2	3	48381826	51009435	21	1	5.1e-14	6.6e-13	1.9e-01	97	GPX1
3	3	135273949	137261517	4	1	7.5e-11	4.7e-10	6.2e-01	99	STAG1
4	3	149722394	151134540	1	1	4.1e-12	1.1e-05	3.7e-01	96	RP11-103G8.2
5	7	116660803	118207833	1	1	7.6e-08	5.5e-10	4.0e-04	68	CTTNBP2
6	8	8092025	11891593	12	1	6.0e-13	4.3e-11	2.3e-01	97	FAM86B3P
7	9	119768572	121177842	1	1	2.3e-07	3.3e-07	1.0e+00	100	TLR4
8	11	46010847	48285906	8	1	1.4e-11	5.7e-10	2.5e-02	87	ZNF408
9	11	63316786	64820283	2	1	1.5e-08	7.9e-08	2.5e-03	68	PPP1R14B
10	12	111154626	112582540	1	1	1.5e-07	9.7e-07	2.4e-01	94	SH2B3
11	14	74424938	76226003	5	2	2.5e-10	3.1e-11	8.3e-02	93	AREL1 DLST
12	17	42774693	45796313	19	1	5.2e-12	2.4e-11	1.0e+00	100	KANSL1-AS1
13	18	34614002	35378540	1	1	4.5e-09	2.3e-12	4.3e-05	66	CELF4
14	18	49172179	51753106	1	1	1.5e-07	6.1e-12	2.3e-06	53	DCC
15	19	32209988	33668090	2	1	3.9e-10	1.0e-09	1.0e+00	100	DPY19L3
16	20	2429222	3827309	1	1	1.7e-07	5.2e-05	2.2e-01	91	FASTKD5
17	20	44501458	44999958	1	1	1.1e-07	5.1e-07	1.0e-01	89	CD40

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Depressed Affect (Nagel 2018)	16.33	16	12	26.7	0.98	9.8e-12	AREL1 C2orf84 CD40 CELF4 DCC DLST DPY19L3 FASTKD5 GPX1 KANSL1-AS1 RP11-103G8.2 SH2B3 STAG1 TLR4 UBXN2A ZNF408
Neuroticism score	14.47	14	9	20.0	0.98	3.3e-09	AREL1 C2orf84 CD40 CELF4 CTTNBP2 DLST DPY19L3 FAM86B3P GPX1 KANSL1-AS1 STAG1 TLR4 UBXN2A ZNF408
Neuroticism (Nagel 2018)	13.90	15	10	22.2	0.97	4.7e-09	AREL1 CD40 CELF4 CTTNBP2 DCC DLST DPY19L3 FASTKD5 GPX1 KANSL1-AS1 RP11-103G8.2 STAG1 TLR4 UBXN2A ZNF408
Mood swings	13.18	13	5	11.1	0.98	1.9e-09	AREL1 CD40 CELF4 CTTNBP2 DCC DLST DPY19L3 FAM86B3P GPX1 KANSL1-AS1 STAG1 TLR4 ZNF408
Neuroticism	13.02	14	10	22.2	0.97	1.1e-08	AREL1 C2orf84 CD40 CELF4 CTTNBP2 DLST DPY19L3 FASTKD5 GPX1 KANSL1-AS1 STAG1 TLR4 UBXN2A ZNF408
Miserableness	12.19	12	6	13.3	0.99	3.0e-10	C2orf84 CD40 CELF4 CTTNBP2 DPY19L3 FAM86B3P GPX1 KANSL1-AS1 RP11-103G8.2 STAG1 UBXN2A ZNF408
Blood Eosinophil Count	10.62	2	2	4.4	0.00	1.0e+00	KANSL1-AS1 SH2B3
Guilty feelings	9.89	7	4	8.9	0.95	9.4e-04	AREL1 C2orf84 DLST FAM86B3P GPX1 KANSL1-AS1 UBXN2A
Frequency of depressed mood in last 2 weeks	9.16	5	1	2.2	0.99	1.3e-03	FAM86B3P KANSL1-AS1 STAG1 UBXN2A ZNF408
Neuroticism (2016)	8.46	6	2	4.4	0.98	4.0e-04	AREL1 CELF4 FAM86B3P KANSL1-AS1 TLR4 ZNF408
Hypothyroidism (self reported)	8.14	2	2	4.4	0.00	1.0e+00	PPP1R14B SH2B3
Worrier / anxious feelings	8.08	6	5	11.1	0.99	1.3e-04	AREL1 DLST FAM86B3P KANSL1-AS1 STAG1 TLR4
Frequency of tenseness / restlessness in last 2 weeks	7.92	5	3	6.7	0.98	4.2e-03	GPX1 KANSL1-AS1 STAG1 UBXN2A ZNF408
Hypothyroidism/myxoedema (self-reported)	7.79	3	2	4.4	0.00	1.0e+00	FAM86B3P PPP1R14B SH2B3
Frequency of unenthusiasm / disinterest in last 2 weeks	7.60	4	0	0.0	0.98	1.5e-02	DCC GPX1 STAG1 UBXN2A
Loneliness, isolation	7.55	5	0	0.0	1.00	1.1e-04	GPX1 KANSL1-AS1 SH2B3 STAG1 ZNF408
Depression (Nagel 2018)	7.47	7	1	2.2	0.99	1.1e-05	CD40 DCC DPY19L3 KANSL1-AS1 STAG1 UBXN2A ZNF408
Medication: Levothyroxine sodium	7.31	3	2	4.4	0.00	1.0e+00	FAM86B3P PPP1R14B SH2B3
Frequency of tiredness / lethargy in last 2 weeks	7.31	5	1	2.2	0.98	3.4e-03	DCC GPX1 STAG1 UBXN2A ZNF408
Worry (Nagel 2018)	6.79	5	4	8.9	0.98	2.6e-03	AREL1 DLST KANSL1-AS1 STAG1 ZNF408
Blood White Count	6.70	7	6	13.3	-0.96	7.6e-04	C2orf84 FASTKD5 GPX1 KANSL1-AS1 RP11-103G8.2 SH2B3 UBXN2A
Irritability	6.69	5	2	4.4	0.99	1.6e-03	AREL1 CELF4 FAM86B3P KANSL1-AS1 TLR4
Sensitivity / hurt feelings	6.44	4	1	2.2	0.92	8.1e-02	CELF4 FAM86B3P KANSL1-AS1 STAG1
Nervous feelings	6.17	6	3	6.7	0.99	3.3e-04	AREL1 DLST FAM86B3P KANSL1-AS1 STAG1 ZNF408
Hair/balding pattern: Pattern 4	5.97	1	1	2.2	0.00	1.0e+00	KANSL1-AS1
Diastolic blood pressure, automated reading	5.80	4	3	6.7	-0.70	3.0e-01	FAM86B3P GPX1 SH2B3 ZNF408
Taking other prescription medications	5.62	5	3	6.7	0.58	3.1e-01	AREL1 DLST GPX1 PPP1R14B SH2B3
Qualifications: College or University degree	5.54	5	3	6.7	-0.92	2.7e-02	CELF4 CTTNBP2 GPX1 KANSL1-AS1 PPP1R14B
Suffer from 'nerves'	5.46	4	2	4.4	1.00	7.8e-04	AREL1 DLST FAM86B3P ZNF408
Number of treatments/medications taken	5.33	4	4	8.9	0.60	4.0e-01	AREL1 DLST GPX1 SH2B3
Systolic Blood Pressure	5.17	6	5	11.1	-0.68	1.4e-01	AREL1 GPX1 KANSL1-AS1 PPP1R14B SH2B3 ZNF408
Systolic blood pressure, automated reading	4.98	6	4	8.9	-0.57	2.4e-01	AREL1 FAM86B3P GPX1 KANSL1-AS1 SH2B3 ZNF408
Qualifications: A levels/AS levels or equivalent	4.87	2	1	2.2	0.00	1.0e+00	GPX1 KANSL1-AS1
Worry too long after embarrassment	4.73	3	2	4.4	0.00	1.0e+00	FAM86B3P KANSL1-AS1 STAG1
Seen doctor (GP) for nerves, anxiety, tension or depression	4.66	4	0	0.0	1.00	4.4e-03	AREL1 CELF4 CTTNBP2 ZNF408
Medication for pain relief, constipation, heartburn	4.60	3	1	2.2	0.00	1.0e+00	AREL1 GPX1 KANSL1-AS1
Blood Red Count	4.57	4	4	8.9	-0.24	7.6e-01	C2orf84 KANSL1-AS1 SH2B3 UBXN2A
Father's age at death	4.57	2	1	2.2	0.00	1.0e+00	GPX1 SH2B3
Headache pain in last month	4.41	2	1	2.2	0.00	1.0e+00	KANSL1-AS1 TLR4
Age at first live birth	4.39	2	1	2.2	0.00	1.0e+00	CELF4 GPX1
Forced expiratory volume in 1-second (FEV1)	4.37	5	2	4.4	0.09	8.8e-01	C2orf84 FAM86B3P GPX1 KANSL1-AS1 UBXN2A
Medication: Paracetamol	4.30	2	1	2.2	0.00	1.0e+00	GPX1 KANSL1-AS1
Medication: Paracetamol	4.28	2	1	2.2	0.00	1.0e+00	GPX1 KANSL1-AS1
Tense / 'highly strung'	4.24	2	1	2.2	0.00	1.0e+00	AREL1 FAM86B3P
Heel bone mineral density (BMD) T-score, automated (right)	4.23	2	2	4.4	0.00	1.0e+00	FAM86B3P ZNF408
Exposure to tobacco smoke outside home	4.22	1	1	2.2	0.00	1.0e+00	CTTNBP2
Number of self-reported non-cancer illnesses	4.19	4	1	2.2	-0.99	8.5e-03	AREL1 PPP1R14B SH2B3 ZNF408
Major Depression (MDD)	4.18	1	0	0.0	0.00	1.0e+00	GPX1
Overall health rating	4.18	2	1	2.2	0.00	1.0e+00	GPX1 ZNF408
Qualifications: None of the above	4.14	2	1	2.2	0.00	1.0e+00	CELF4 GPX1
High blood pressure	4.11	3	3	6.7	0.00	1.0e+00	FAM86B3P SH2B3 ZNF408
Ever unenthusiastic/disinterested for a whole week	4.05	1	0	0.0	0.00	1.0e+00	KANSL1-AS1
Vascular/heart problems diagnosed by doctor	3.99	3	2	4.4	0.00	1.0e+00	FAM86B3P SH2B3 ZNF408
Medication: Blood pressure	3.97	3	1	2.2	0.00	1.0e+00	KANSL1-AS1 SH2B3 ZNF408
Lung FVC	3.96	5	3	6.7	-0.59	3.0e-01	DCC GPX1 KANSL1-AS1 SH2B3 UBXN2A
Hypertension (Self-reported)	3.95	3	3	6.7	0.00	1.0e+00	FAM86B3P SH2B3 ZNF408
Age at First Birth	3.94	1	1	2.2	0.00	1.0e+00	GPX1
Forced expiratory volume in 1-second (FEV1), Best measure	3.94	3	2	4.4	0.00	1.0e+00	GPX1 KANSL1-AS1 ZNF408
Intelligence (Savage-Jansen 2018)	3.91	3	2	4.4	0.00	1.0e+00	GPX1 KANSL1-AS1 STAG1
Pain experienced in last month	3.84	2	1	2.2	0.00	1.0e+00	GPX1 KANSL1-AS1
Leg fat percentage (right)	3.81	6	3	6.7	0.61	2.0e-01	AREL1 C2orf84 DPY19L3 FAM86B3P GPX1 UBXN2A
Heel bone mineral density (BMD) T-score, automated (left)	3.79	2	2	4.4	0.00	1.0e+00	FAM86B3P ZNF408
Leg fat percentage (left)	3.76	6	3	6.7	0.60	2.1e-01	AREL1 C2orf84 DPY19L3 FAM86B3P GPX1 UBXN2A
Smoking Status	3.75	3	2	4.4	0.00	1.0e+00	CTTNBP2 GPX1 PPP1R14B
Impedance of arm (left)	3.74	5	4	8.9	-0.61	2.8e-01	FAM86B3P GPX1 KANSL1-AS1 SH2B3 STAG1
Hair/balding pattern: Pattern 3	3.58	1	1	2.2	0.00	1.0e+00	KANSL1-AS1
Cardiovascular Disease	3.57	3	2	4.4	0.00	1.0e+00	PPP1R14B SH2B3 ZNF408
Alcohol usually taken with meals	3.52	2	2	4.4	0.00	1.0e+00	CELF4 CTTNBP2
Ever highly irritable/argumentative for 2 days	3.52	1	0	0.0	0.00	1.0e+00	GPX1
Mean time to correctly identify matches	3.51	2	1	2.2	0.00	1.0e+00	SH2B3 ZNF408
Average weekly beer plus cider intake	3.50	2	0	0.0	0.00	1.0e+00	CELF4 FAM86B3P
Impedance of arm (right)	3.47	4	4	8.9	-0.53	4.7e-01	FAM86B3P GPX1 KANSL1-AS1 STAG1
Relative age of first facial hair	3.46	1	1	2.2	0.00	1.0e+00	KANSL1-AS1
Qualifications: nursing, teaching	3.46	1	0	0.0	0.00	1.0e+00	GPX1
Ever smoked	3.46	2	1	2.2	0.00	1.0e+00	CTTNBP2 SH2B3
Reaction Time	3.43	1	1	2.2	0.00	1.0e+00	SH2B3
Forced vital capacity (FVC)	3.43	2	2	4.4	0.00	1.0e+00	GPX1 KANSL1-AS1
Forced vital capacity (FVC), Best measure	3.40	3	2	4.4	0.00	1.0e+00	GPX1 KANSL1-AS1 ZNF408
Impedance of whole body	3.40	6	4	8.9	-0.36	4.9e-01	AREL1 FAM86B3P GPX1 KANSL1-AS1 STAG1 UBXN2A
Irritable Bowel Disease (IBD)	3.36	1	1	2.2	0.00	1.0e+00	GPX1
Verbal and Numeric Reasoning (VNR)	3.26	3	1	2.2	0.00	1.0e+00	GPX1 KANSL1-AS1 STAG1
Past tobacco smoking	3.26	2	0	0.0	0.00	1.0e+00	CTTNBP2 SH2B3
Medication for cholesterol	3.24	1	1	2.2	0.00	1.0e+00	SH2B3
Current tobacco smoking	3.23	2	0	0.0	0.00	1.0e+00	CELF4 CTTNBP2
Medication: Blood pressure	3.19	1	1	2.2	0.00	1.0e+00	SH2B3
Financial situation satisfaction	3.19	1	1	2.2	0.00	1.0e+00	GPX1
Age at last live birth	3.18	1	1	2.2	0.00	1.0e+00	GPX1
Rheumatoid Arthritis	3.16	2	1	2.2	0.00	1.0e+00	CD40 SH2B3
Primary Biliary Cirrhosis	3.11	3	1	2.2	0.00	1.0e+00	KANSL1-AS1 PPP1R14B SH2B3
Waist Hip Ratio (WHR)	3.10	6	3	6.7	-0.10	8.6e-01	C2orf84 GPX1 KANSL1-AS1 PPP1R14B STAG1 UBXN2A
Ovarian Cancer	3.05	1	1	2.2	0.00	1.0e+00	KANSL1-AS1
Medication: Bendroflumethiazide	3.04	2	0	0.0	0.00	1.0e+00	FAM86B3P SH2B3
Heel T-Score	3.03	5	2	4.4	-0.21	7.3e-01	AREL1 DLST KANSL1-AS1 PPP1R14B ZNF408
Body mass index (BMI)	3.02	4	3	6.7	0.46	5.4e-01	DPY19L3 FAM86B3P GPX1 STAG1
Crohns Disease (2017)	2.98	2	1	2.2	0.00	1.0e+00	GPX1 PPP1R14B
Smoking status: Current	2.98	1	0	0.0	0.00	1.0e+00	CTTNBP2
Mouth/teeth dental problems: Mouth ulcers	2.95	2	1	2.2	0.00	1.0e+00	KANSL1-AS1 SH2B3
Medication: Ibuprofen (e.g. Nurofen)	2.92	2	0	0.0	0.00	1.0e+00	KANSL1-AS1 UBXN2A
Leg fat mass (right)	2.86	3	3	6.7	0.00	1.0e+00	DPY19L3 FAM86B3P GPX1
Medication: Atenolol	2.84	1	1	2.2	0.00	1.0e+00	SH2B3
Leg pain on walking	2.84	1	0	0.0	0.00	1.0e+00	GPX1
Leg fat mass (left)	2.84	3	3	6.7	0.00	1.0e+00	DPY19L3 FAM86B3P GPX1
Pack years adult smoking proportion	2.82	2	0	0.0	0.00	1.0e+00	CELF4 GPX1
Fluid intelligence score	2.82	2	2	4.4	0.00	1.0e+00	GPX1 STAG1
Wheeze or whistling in the chest in last year	2.79	1	0	0.0	0.00	1.0e+00	GPX1
Alcohol intake versus 10 years previously	2.77	1	0	0.0	0.00	1.0e+00	GPX1
Smoking status: Previous	2.77	1	0	0.0	0.00	1.0e+00	SH2B3
Body fat percentage	2.76	5	3	6.7	0.99	6.1e-04	AREL1 C2orf84 DPY19L3 GPX1 UBXN2A
Qualifications: O levels/GCSEs or equivalent	2.74	1	0	0.0	0.00	1.0e+00	GPX1
Relative age voice broke	2.69	1	1	2.2	0.00	1.0e+00	KANSL1-AS1
Alcohol intake frequency.	2.67	2	1	2.2	0.00	1.0e+00	DCC KANSL1-AS1
Sitting height	2.66	5	4	8.9	-0.81	9.5e-02	C2orf84 DCC KANSL1-AS1 UBXN2A ZNF408
Coronary Artery Disease (CAD)	2.59	1	0	0.0	0.00	1.0e+00	SH2B3
Impedance of leg (left)	2.58	6	4	8.9	-0.23	6.5e-01	AREL1 FAM86B3P GPX1 KANSL1-AS1 STAG1 UBXN2A
Average weekly champagne plus white wine intake	2.57	1	0	0.0	0.00	1.0e+00	KANSL1-AS1
Stomach or abdominal pain in last month	2.56	1	0	0.0	0.00	1.0e+00	STAG1
Peak expiratory flow (PEF)	2.55	2	1	2.2	0.00	1.0e+00	FAM86B3P KANSL1-AS1
Health satisfaction	2.55	1	0	0.0	0.00	1.0e+00	GPX1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.55	1	1	2.2	0.00	1.0e+00	KANSL1-AS1
Medication: Co-codamol	2.54	1	0	0.0	0.00	1.0e+00	GPX1
Number of full brothers	2.53	1	0	0.0	0.00	1.0e+00	GPX1
Medication: Aspirin	2.53	1	0	0.0	0.00	1.0e+00	SH2B3
Trunk fat percentage	2.52	6	3	6.7	0.61	2.0e-01	AREL1 C2orf84 DPY19L3 GPX1 KANSL1-AS1 UBXN2A
Birth weight of first child	2.49	1	1	2.2	0.00	1.0e+00	SH2B3
Crohns Disease (2012)	2.48	1	1	2.2	0.00	1.0e+00	GPX1
Hand grip strength (left)	2.48	2	2	4.4	0.00	1.0e+00	AREL1 KANSL1-AS1
Impedance of leg (right)	2.48	6	2	4.4	-0.25	6.3e-01	AREL1 FAM86B3P GPX1 KANSL1-AS1 STAG1 UBXN2A
Mouth/teeth dental problems: Dentures	2.48	2	0	0.0	0.00	1.0e+00	GPX1 STAG1
Pack years of smoking	2.48	2	0	0.0	0.00	1.0e+00	CELF4 GPX1
Townsend deprivation index at recruitment	2.40	1	0	0.0	0.00	1.0e+00	CTTNBP2
Medication for cholesterol, blood pressure or diabetes	2.39	1	1	2.2	0.00	1.0e+00	SH2B3
Schizophrenia (2014)	2.37	2	0	0.0	0.00	1.0e+00	FAM86B3P STAG1
Blood Platelet Count	2.37	5	4	8.9	-0.76	1.3e-01	AREL1 DLST KANSL1-AS1 PPP1R14B SH2B3
Ulcerative Colitis (UC)	2.36	1	1	2.2	0.00	1.0e+00	GPX1
Hearing difficulty/problems with background noise	2.35	2	0	0.0	0.00	1.0e+00	KANSL1-AS1 ZNF408
Arm fat percentage (left)	2.33	3	2	4.4	0.00	1.0e+00	DPY19L3 FAM86B3P GPX1
Illness, injury, bereavement, stress in last 2 years	2.32	1	0	0.0	0.00	1.0e+00	CTTNBP2
Arm fat mass (right)	2.31	3	3	6.7	0.00	1.0e+00	DPY19L3 FAM86B3P GPX1
Exposure to tobacco smoke at home	2.30	1	0	0.0	0.00	1.0e+00	GPX1
Whole body fat mass	2.29	3	2	4.4	0.00	1.0e+00	DPY19L3 FAM86B3P GPX1
Arm fat percentage (right)	2.25	3	2	4.4	0.00	1.0e+00	DPY19L3 FAM86B3P GPX1
Medication: Lisinopril	2.25	1	0	0.0	0.00	1.0e+00	ZNF408
Arm fat mass (left)	2.23	3	3	6.7	0.00	1.0e+00	DPY19L3 FAM86B3P GPX1
Illnesses of siblings	2.22	1	0	0.0	0.00	1.0e+00	SH2B3
Gout (self-reported)	2.22	2	0	0.0	0.00	1.0e+00	PPP1R14B SH2B3
Schizophrenia (2018)	2.13	2	0	0.0	0.00	1.0e+00	DCC STAG1
Neck or shoulder pain in last month	2.13	1	0	0.0	0.00	1.0e+00	GPX1
Ulcerative Colitis	2.11	1	1	2.2	0.00	1.0e+00	GPX1
Age started oral contraceptive pill	2.11	1	0	0.0	0.00	1.0e+00	GPX1
Medication: Allopurinol	2.09	2	0	0.0	0.00	1.0e+00	PPP1R14B SH2B3
Arm fat-free mass (left)	2.08	4	2	4.4	0.61	3.9e-01	DPY19L3 FAM86B3P GPX1 SH2B3
Lupus	2.07	1	0	0.0	0.00	1.0e+00	FAM86B3P
Trunk fat mass	2.05	3	2	4.4	0.00	1.0e+00	DPY19L3 GPX1 KANSL1-AS1
Arm predicted mass (left)	2.05	4	2	4.4	0.61	3.9e-01	CD40 FAM86B3P GPX1 SH2B3
Prostate Cancer	2.04	1	0	0.0	0.00	1.0e+00	GPX1
LDL Cholesterol	2.00	1	0	0.0	0.00	1.0e+00	SH2B3
Comparative height size at age 10	2.00	4	3	6.7	-0.58	4.2e-01	DLST KANSL1-AS1 SH2B3 STAG1
Arm predicted mass (right)	1.99	3	3	6.7	0.00	1.0e+00	FAM86B3P GPX1 SH2B3
Lung FEV1/FVC ratio	1.97	5	2	4.4	-0.69	1.9e-01	AREL1 CTTNBP2 DLST GPX1 KANSL1-AS1
Pain all over the body in last month	1.97	1	0	0.0	0.00	1.0e+00	GPX1
Hip circumference	1.96	5	2	4.4	0.41	4.9e-01	DPY19L3 FAM86B3P GPX1 PPP1R14B SH2B3
Trunk fat-free mass	1.91	5	1	2.2	0.49	4.0e-01	CD40 GPX1 SH2B3 UBXN2A ZNF408
Trunk predicted mass	1.90	5	1	2.2	0.51	3.9e-01	CD40 GPX1 SH2B3 UBXN2A ZNF408
Arm fat-free mass (right)	1.88	3	2	4.4	0.00	1.0e+00	FAM86B3P GPX1 SH2B3
Age when periods started (menarche)	1.87	1	1	2.2	0.00	1.0e+00	GPX1
HDL Cholesterol	1.85	1	0	0.0	0.00	1.0e+00	DPY19L3
Whole body water mass	1.84	5	2	4.4	0.44	4.6e-01	FAM86B3P GPX1 SH2B3 UBXN2A ZNF408
Schizophrenia vs Biploar Disorder	1.83	1	0	0.0	0.00	1.0e+00	KANSL1-AS1
Whole body fat-free mass	1.81	5	2	4.4	0.43	4.7e-01	FAM86B3P GPX1 SH2B3 UBXN2A ZNF408
Breast Cancer	1.80	2	1	2.2	0.00	1.0e+00	GPX1 KANSL1-AS1
Waist circumference	1.80	2	2	4.4	0.00	1.0e+00	DPY19L3 GPX1
Heart attack/myocardial infarction (self-reported)	1.80	1	0	0.0	0.00	1.0e+00	SH2B3
Hair/balding pattern: Pattern 2	1.79	1	0	0.0	0.00	1.0e+00	KANSL1-AS1
BMI	1.78	4	1	2.2	0.66	3.4e-01	DPY19L3 GPX1 PPP1R14B TLR4
High blood pressure (siblings)	1.78	1	0	0.0	0.00	1.0e+00	SH2B3
Heart attack	1.77	1	0	0.0	0.00	1.0e+00	SH2B3
Hand grip strength (right)	1.76	1	1	2.2	0.00	1.0e+00	KANSL1-AS1
Handedness (chirality/laterality): Left-handed	1.76	1	0	0.0	0.00	1.0e+00	KANSL1-AS1
Weight	1.74	4	1	2.2	0.57	4.3e-01	DPY19L3 FAM86B3P GPX1 SH2B3
Illnesses of father: None of the above (group 1)	1.74	1	0	0.0	0.00	1.0e+00	SH2B3
Basal metabolic rate	1.74	4	2	4.4	0.57	4.3e-01	DPY19L3 FAM86B3P GPX1 SH2B3
Illnesses of father: High blood pressure	1.71	1	0	0.0	0.00	1.0e+00	SH2B3
Number of live births	1.70	1	0	0.0	0.00	1.0e+00	KANSL1-AS1
Bipolar Disorder or Schizophrenia	1.65	2	0	0.0	0.00	1.0e+00	DCC FAM86B3P
Type 2 Diabetes (T2D) (2018)	1.64	1	0	0.0	0.00	1.0e+00	SH2B3
Leg predicted mass (right)	1.63	4	1	2.2	0.30	7.0e-01	FAM86B3P GPX1 SH2B3 ZNF408
Leg fat-free mass (right)	1.62	3	1	2.2	0.00	1.0e+00	FAM86B3P GPX1 SH2B3
Leg predicted mass (left)	1.61	3	1	2.2	0.00	1.0e+00	FAM86B3P GPX1 SH2B3
Birth weight	1.61	1	1	2.2	0.00	1.0e+00	SH2B3
Leg fat-free mass (left)	1.58	3	1	2.2	0.00	1.0e+00	FAM86B3P GPX1 SH2B3
Qualifications: CSEs or equivalent	1.57	1	0	0.0	0.00	1.0e+00	GPX1
Standing height	1.49	8	3	6.7	-0.41	3.1e-01	C2orf84 FAM86B3P GPX1 KANSL1-AS1 SH2B3 STAG1 UBXN2A ZNF408
Height	1.48	10	8	17.8	-0.54	1.1e-01	AREL1 C2orf84 CD40 CTTNBP2 DCC GPX1 KANSL1-AS1 SH2B3 STAG1 UBXN2A
Comparative body size at age 10	1.42	1	1	2.2	0.00	1.0e+00	FAM86B3P
Allergy or Eczema	1.16	1	0	0.0	0.00	1.0e+00	CD40
Tanning	0.39	2	0	0.0	0.00	1.0e+00	AREL1 SH2B3
Hair Pigment	0.20	2	1	2.2	0.00	1.0e+00	KANSL1-AS1 SH2B3

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Uterus	8	1.411	2.3
GTEx	Prostate	8	0.958	2.2
GTEx	Artery Coronary	11	0.930	2.1
GTEx	Brain Frontal Cortex BA9	8	0.866	2.1
GTEx	Ovary	7	0.771	2.1
GTEx	Skin Not Sun Exposed Suprapubic	14	0.569	2.1
GTEx	Small Intestine Terminal Ileum	5	1.085	2.1
GTEx	Vagina	7	1.102	2.1
GTEx	Adipose Visceral Omentum	11	0.540	2.0
GTEx	Brain Caudate basal ganglia	7	0.761	2.0
GTEx	Brain Cortex	8	0.773	2.0
GTEx	Brain Hippocampus	4	0.763	2.0
GTEx	Brain Hypothalamus	6	1.017	2.0
GTEx	Brain Putamen basal ganglia	6	0.962	2.0
GTEx	Breast Mammary Tissue	9	0.456	2.0
GTEx	Cells EBV-transformed lymphocytes	9	0.632	2.0
GTEx	Colon Sigmoid	12	0.821	2.0
GTEx	Esophagus Gastroesophageal Junction	9	0.623	2.0
GTEx	Esophagus Muscularis	21	0.650	2.0
GTEx	Heart Left Ventricle	9	0.588	2.0
GTEx	Skin Sun Exposed Lower leg	16	0.440	2.0
GTEx	Spleen	10	0.709	2.0
GTEx	Stomach	11	0.757	2.0
The Cancer Genome Atlas	Esophageal Carcinoma	6	0.876	2.0
GTEx	Adipose Subcutaneous	12	0.344	1.9
GTEx	Adrenal Gland	8	0.549	1.9
GTEx	Artery Aorta	13	0.437	1.9
GTEx	Artery Tibial	14	0.372	1.9
GTEx	Brain Cerebellar Hemisphere	11	0.739	1.9
GTEx	Brain Cerebellum	12	0.605	1.9
GTEx	Brain Nucleus accumbens basal ganglia	7	0.809	1.9
GTEx	Breast Mammary Tissue (Female)	9	0.547	1.9
GTEx	Cells Transformed fibroblasts	17	0.405	1.9
GTEx	Colon Transverse	14	0.678	1.9
GTEx	Esophagus Mucosa	18	0.542	1.9
GTEx	Heart Atrial Appendage	11	0.697	1.9
GTEx	Lung	17	0.592	1.9
GTEx	Muscle Skeletal	10	0.346	1.9
GTEx	Nerve Tibial	12	0.278	1.9
GTEx	Pancreas	9	0.551	1.9
GTEx	Pituitary	7	0.628	1.9
GTEx	Testis	16	0.507	1.9
GTEx	Thyroid	15	0.375	1.9
ROSMAP	Brain Pre-frontal Cortex	15	0.342	1.9
GTEx	Breast Mammary Tissue (Male)	7	0.587	1.8
GTEx	Liver	4	0.558	1.8
GTEx	Whole Blood	6	0.301	1.8
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	4	0.365	1.8
The Cancer Genome Atlas	Colon Adenocarcinoma	3	0.145	1.8
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	9	0.331	1.8
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	6	0.293	1.8
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	8	0.319	1.8
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	5	0.377	1.8
The Cancer Genome Atlas	Rectum Adenocarcinoma	3	0.434	1.8
The Cancer Genome Atlas	Soft Tissue Sarcoma	3	0.281	1.8
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.187	1.8
The Cancer Genome Atlas	Stomach Adenocarcinoma	5	0.297	1.8
NTR	Blood	7	0.291	1.7
CommonMind	Brain Pre-frontal Cortex	12	0.223	1.7
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	3	0.181	1.7
The Cancer Genome Atlas	Breast Invasive Carcinoma	6	0.136	1.7
The Cancer Genome Atlas	Glioblastoma Multiforme	4	0.391	1.7
The Cancer Genome Atlas	Brain Lower Grade Glioma	9	0.209	1.7
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	3	0.271	1.7
The Cancer Genome Atlas	Lung Adenocarcinoma	13	0.442	1.7
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	6	0.377	1.7
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	6	0.361	1.7
The Cancer Genome Atlas	Prostate Adenocarcinoma	10	0.216	1.7
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.7
The Cancer Genome Atlas	Thyroid Carcinoma	10	0.194	1.7
METSIM	Adipose	4	0.087	1.6
YFS	Blood	4	0.087	1.6
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	7	0.171	1.6
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	2	0.394	1.6