Best TWAS P=1.47e-08 · Best GWAS P=7.92e-08 conditioned to 0.00246
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CCDC88B | 0.22 | 0.24 | bslmm | 358 | 0.25 | 5.8e-30 | -5.2 | 5.2 | 2.2e-07 | -0.54 | 0.01 | 0.99 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | PPP1R14B | 0.10 | 0.09 | lasso | 5 | 0.09 | 1.1e-10 | -5.1 | 5.2 | 2.2e-07 | -0.54 | 0.01 | 0.99 | FALSE |
3 | GTEx | Artery Aorta | PPP1R14B | 0.12 | 0.03 | lasso | 4 | 0.08 | 3.0e-05 | -5.2 | 5.7 | 1.5e-08 | -0.48 | 0.02 | 0.95 | TRUE |
4 | GTEx | Brain Cerebellar Hemisphere | CCDC88B | 0.45 | 0.39 | lasso | 3 | 0.41 | 1.2e-11 | -5.2 | 5.4 | 8.2e-08 | -0.57 | 0.02 | 0.98 | FALSE |
5 | GTEx | Brain Cerebellum | CCDC88B | 0.48 | 0.55 | lasso | 4 | 0.54 | 1.6e-18 | -5.2 | 5.1 | 2.9e-07 | -0.51 | 0.01 | 0.99 | FALSE |
6 | GTEx | Esophagus Muscularis | CCDC88B | 0.09 | 0.00 | lasso | 3 | 0.06 | 1.1e-04 | 3.4 | 5.3 | 1.2e-07 | -0.42 | 0.04 | 0.69 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCDC88B | 0.02 | 0.02 | enet | 9 | 0.02 | 2.4e-05 | -5.2 | 5.6 | 2.5e-08 | -0.60 | 0.01 | 0.99 | FALSE |