Best TWAS P=1.41e-11 · Best GWAS P=5.75e-10 conditioned to 0.0247
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LRP4 | 0.04 | 0.05 | lasso | 4 | 0.04 | 6.6e-06 | -6.1 | -6.4 | 1.2e-10 | 0.96 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | ARHGAP1 | 0.08 | 0.03 | lasso | 6 | 0.05 | 3.4e-05 | -5.9 | 5.6 | 2.6e-08 | -0.87 | 0.04 | 0.95 | FALSE |
| 3 | GTEx | Artery Aorta | CKAP5 | 0.09 | 0.12 | lasso | 1 | 0.07 | 1.2e-04 | -5.4 | -5.4 | 5.4e-08 | 0.86 | 0.37 | 0.60 | FALSE |
| 4 | GTEx | Artery Tibial | LRP4 | 0.06 | 0.00 | lasso | 5 | 0.00 | 6.4e-01 | 4.7 | 5.7 | 1.2e-08 | -0.59 | 0.04 | 0.42 | FALSE |
| 5 | GTEx | Artery Tibial | ZNF408 | 0.10 | 0.00 | lasso | 6 | 0.04 | 2.0e-04 | -4.6 | 6.8 | 1.4e-11 | -0.67 | 0.10 | 0.72 | TRUE |
| 6 | GTEx | Cells Transformed fibroblasts | PACSIN3 | 0.07 | 0.00 | enet | 7 | 0.01 | 1.2e-01 | -6.0 | 5.5 | 4.8e-08 | -0.77 | 0.04 | 0.64 | FALSE |
| 7 | GTEx | Esophagus Muscularis | CKAP5 | 0.05 | 0.03 | lasso | 4 | 0.04 | 3.3e-03 | -5.4 | -5.8 | 6.9e-09 | 0.89 | 0.05 | 0.88 | FALSE |
| 8 | GTEx | Esophagus Muscularis | ARHGAP1 | 0.07 | 0.08 | lasso | 3 | 0.07 | 6.1e-05 | -5.4 | 5.5 | 4.9e-08 | -0.85 | 0.15 | 0.82 | FALSE |
| 9 | GTEx | Prostate | CELF1 | 0.17 | 0.16 | lasso | 2 | 0.12 | 6.2e-04 | -6.2 | -6.2 | 5.8e-10 | 1.00 | 0.02 | 0.88 | FALSE |
| 10 | GTEx | Prostate | ZNF408 | 0.19 | 0.10 | lasso | 2 | 0.10 | 1.6e-03 | -6.1 | 5.8 | 8.8e-09 | -0.95 | 0.03 | 0.81 | FALSE |
| 11 | GTEx | Skin Not Sun Exposed Suprapubic | ARHGAP1 | 0.06 | 0.01 | lasso | 9 | 0.00 | 2.8e-01 | -6.1 | 5.8 | 5.9e-09 | -0.90 | 0.04 | 0.79 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | DDB2 | 0.08 | 0.10 | lasso | 4 | 0.10 | 5.8e-09 | -4.7 | -5.6 | 1.8e-08 | 0.88 | 0.15 | 0.85 | FALSE |
| 13 | METSIM | Adipose | DDB2 | 0.03 | 0.03 | lasso | 2 | 0.02 | 1.9e-04 | -5.4 | 5.6 | 2.3e-08 | -0.87 | 0.04 | 0.95 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | LRP4 | 0.04 | 0.06 | blup | 286 | 0.05 | 3.5e-07 | -3.3 | -5.2 | 1.8e-07 | 0.86 | 0.12 | 0.88 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | DDB2 | 0.04 | 0.03 | enet | 15 | 0.03 | 7.1e-05 | -6.1 | 5.6 | 1.8e-08 | -0.87 | 0.03 | 0.97 | FALSE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | C11orf49 | 0.02 | 0.02 | blup | 322 | 0.02 | 3.3e-04 | -4.8 | -5.4 | 7.5e-08 | 0.88 | 0.10 | 0.89 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | ZNF408 | 0.04 | 0.02 | blup | 243 | 0.03 | 5.0e-05 | -5.5 | 5.3 | 1.2e-07 | -0.86 | 0.09 | 0.90 | FALSE |