Best TWAS P=7.49e-09 · Best GWAS P=3.69e-11 conditioned to 2.73e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cortex | NCOA6 | 0.14 | 0.03 | enet | 13 | 0.05 | 1.6e-02 | -3.6 | 5.2 | 1.6e-07 | 0.57 | 0.10 | 0.34 | FALSE |
2 | GTEx | Brain Frontal Cortex BA9 | NCOA6 | 0.13 | 0.00 | enet | 30 | 0.06 | 1.3e-02 | -3.5 | 5.7 | 1.0e-08 | 0.68 | 0.12 | 0.40 | FALSE |
3 | GTEx | Brain Nucleus accumbens basal ganglia | NCOA6 | 0.24 | 0.01 | lasso | 12 | 0.08 | 3.2e-03 | -3.6 | 5.4 | 5.1e-08 | 0.56 | 0.25 | 0.11 | FALSE |
4 | GTEx | Breast Mammary Tissue | NCOA6 | 0.12 | 0.02 | enet | 35 | 0.04 | 4.5e-03 | -3.6 | 5.4 | 6.6e-08 | 0.57 | 0.12 | 0.68 | FALSE |
5 | GTEx | Breast Mammary Tissue (Female) | NCOA6 | 0.08 | -0.01 | lasso | 4 | 0.00 | 4.6e-01 | 4.2 | 5.2 | 2.4e-07 | 0.64 | 0.04 | 0.46 | FALSE |
6 | GTEx | Esophagus Gastroesophageal Junction | NCOA6 | 0.24 | 0.07 | lasso | 4 | 0.08 | 5.9e-04 | 4.6 | 5.2 | 1.6e-07 | 0.56 | 0.25 | 0.40 | FALSE |
7 | GTEx | Esophagus Mucosa | NCOA6 | 0.10 | 0.06 | lasso | 16 | 0.09 | 8.0e-07 | -3.7 | 5.8 | 7.5e-09 | 0.53 | 0.66 | 0.31 | TRUE |
8 | GTEx | Esophagus Muscularis | NCOA6 | 0.14 | 0.10 | enet | 22 | 0.20 | 2.6e-12 | -3.5 | 5.2 | 2.0e-07 | 0.53 | 1.00 | 0.00 | FALSE |
9 | GTEx | Heart Left Ventricle | GSS | 0.12 | 0.06 | enet | 10 | 0.04 | 2.2e-03 | 3.7 | 5.1 | 3.1e-07 | 0.48 | 0.76 | 0.01 | FALSE |
10 | GTEx | Heart Left Ventricle | NCOA6 | 0.09 | 0.01 | enet | 19 | 0.05 | 1.1e-03 | -3.5 | 5.8 | 8.7e-09 | 0.43 | 0.45 | 0.18 | FALSE |
11 | GTEx | Thyroid | NCOA6 | 0.16 | 0.12 | enet | 29 | 0.16 | 2.1e-12 | 4.6 | 5.6 | 2.8e-08 | 0.56 | 0.99 | 0.01 | FALSE |
12 | METSIM | Adipose | NCOA6 | 0.05 | 0.02 | bslmm | 373 | 0.02 | 1.3e-04 | 3.0 | 5.2 | 1.7e-07 | 0.60 | 0.95 | 0.01 | FALSE |
13 | ROSMAP | Brain Pre-frontal Cortex | NCOA6 | 0.07 | 0.08 | blup | 365 | 0.09 | 1.9e-11 | -3.5 | 5.4 | 8.0e-08 | 0.50 | 1.00 | 0.00 | FALSE |
14 | YFS | Blood | NCOA6 | 0.03 | 0.03 | blup | 368 | 0.03 | 6.9e-10 | -3.6 | 5.2 | 2.0e-07 | 0.52 | 1.00 | 0.00 | FALSE |
15 | The Cancer Genome Atlas | Thyroid Carcinoma | NCOA6 | 0.03 | 0.01 | blup | 65 | 0.02 | 5.2e-03 | 4.6 | 5.2 | 1.5e-07 | 0.54 | 0.02 | 0.28 | FALSE |