Hub : Traits :

Basal cell carcinoma (self-reported)

157 significantly associated models · 23 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	201308117	203035423	4	1	2.4e-14	6.3e-14	1.0e+00	100	CASP8
2	5	619022	2041665	1	1	2.3e-08	2.2e-10	1.2e-03	74	CLPTM1L
3	9	21303958	22705094	1	1	2.8e-07	1.5e-07	6.7e-03	73	CDKN2B
4	12	52182052	53586255	1	1	1.1e-07	4.2e-09	1.5e-03	71	KRT6A
5	16	88934149	90172696	14	1	1.1e-22	6.7e-17	8.4e-01	100	DBNDD1
6	20	32594714	34225302	2	1	7.5e-09	3.7e-11	2.7e-05	60	NCOA6

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Neuroticism (Nagel 2018)	2.02	1	0	0.0	0.00	1.00	NCOA6
Worry (Nagel 2018)	3.03	1	1	2.2	0.00	1.00	NCOA6
Crohns Disease (2017)	1.29	1	0	0.0	0.00	1.00	CDKN2B
Breast Cancer	11.05	2	2	4.4	0.00	1.00	CASP8 CDKN2B
Age at First Birth	3.06	1	0	0.0	0.00	1.00	DBNDD1
Coronary Artery Disease (CAD)	6.17	1	1	2.2	0.00	1.00	CDKN2B
Blood Platelet Count	2.68	3	2	4.4	0.00	1.00	CASP8 CDKN2B NCOA6
Blood Red Count	0.81	1	1	2.2	0.00	1.00	NCOA6
Blood White Count	1.62	2	2	4.4	0.00	1.00	CASP8 CDKN2B
Heel T-Score	1.31	1	1	2.2	0.00	1.00	NCOA6
Height	1.11	2	1	2.2	0.00	1.00	DBNDD1 NCOA6
Smoking Status	1.50	1	0	0.0	0.00	1.00	DBNDD1
Neuroticism	2.16	1	0	0.0	0.00	1.00	NCOA6
Hair Pigment	314.20	4	2	4.4	0.68	0.32	CDKN2B CLPTM1L DBNDD1 NCOA6
Tanning	311.75	2	2	4.4	0.00	1.00	DBNDD1 NCOA6
Relative age of first facial hair	6.38	1	1	2.2	0.00	1.00	DBNDD1
Angina	3.46	1	0	0.0	0.00	1.00	CDKN2B
Trunk fat percentage	1.81	1	1	2.2	0.00	1.00	DBNDD1
Relative age voice broke	2.44	1	0	0.0	0.00	1.00	DBNDD1
High blood pressure	2.05	1	0	0.0	0.00	1.00	DBNDD1
Impedance of leg (left)	1.11	1	0	0.0	0.00	1.00	CLPTM1L
Trunk fat mass	1.59	1	1	2.2	0.00	1.00	DBNDD1
Waist circumference	1.36	1	0	0.0	0.00	1.00	DBNDD1
Nervous feelings	2.56	1	0	0.0	0.00	1.00	NCOA6
Heart attack	2.43	1	0	0.0	0.00	1.00	CDKN2B
Weight	0.90	1	0	0.0	0.00	1.00	DBNDD1
Impedance of arm (right)	1.59	1	0	0.0	0.00	1.00	DBNDD1
Arm fat percentage (right)	0.96	1	0	0.0	0.00	1.00	DBNDD1
Hip circumference	0.88	1	0	0.0	0.00	1.00	DBNDD1
Number of live births	4.22	1	0	0.0	0.00	1.00	DBNDD1
Lung cancer (father)	6.97	1	1	2.2	0.00	1.00	CLPTM1L
Impedance of arm (left)	1.41	1	0	0.0	0.00	1.00	DBNDD1
Standing height	0.87	1	1	2.2	0.00	1.00	DBNDD1
Hair/balding pattern: Pattern 4	3.87	2	0	0.0	0.00	1.00	DBNDD1 KRT6A
Forced vital capacity (FVC), Best measure	1.12	1	0	0.0	0.00	1.00	CLPTM1L
Body fat percentage	1.31	1	0	0.0	0.00	1.00	DBNDD1
Worry too long after embarrassment	4.81	2	1	2.2	0.00	1.00	DBNDD1 NCOA6
Angina (self-reported)	3.42	1	0	0.0	0.00	1.00	CDKN2B
Whole body fat mass	1.16	1	0	0.0	0.00	1.00	DBNDD1
Hypertension (Self-reported)	1.95	1	0	0.0	0.00	1.00	DBNDD1
Illnesses of father: Heart disease	2.99	1	0	0.0	0.00	1.00	CDKN2B
Arm fat percentage (left)	0.92	1	0	0.0	0.00	1.00	DBNDD1
Medication: Aspirin	3.49	1	0	0.0	0.00	1.00	DBNDD1
Illnesses of father: None of the above (group 1)	2.92	1	0	0.0	0.00	1.00	CDKN2B
Irritability	2.30	1	0	0.0	0.00	1.00	NCOA6
Ever had prostate specific antigen (PSA) test	5.15	1	0	0.0	0.00	1.00	CLPTM1L
Vascular/heart problems diagnosed by doctor	1.84	1	0	0.0	0.00	1.00	DBNDD1
Heart attack/myocardial infarction (self-reported)	2.50	1	0	0.0	0.00	1.00	CDKN2B
Impedance of whole body	1.39	1	0	0.0	0.00	1.00	DBNDD1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	4	0.115	1.2
GTEx	Adipose Visceral Omentum	3	0.147	1.2
GTEx	Adrenal Gland	4	0.275	1.3
GTEx	Artery Aorta	4	0.134	1.2
GTEx	Artery Coronary	1	0.085	1.2
GTEx	Artery Tibial	4	0.106	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.1
GTEx	Brain Cerebellar Hemisphere	4	0.269	1.4
GTEx	Brain Cerebellum	5	0.252	1.3
GTEx	Brain Cortex	5	0.483	1.4
GTEx	Brain Frontal Cortex BA9	3	0.325	1.3
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.1
GTEx	Brain Nucleus accumbens basal ganglia	2	0.231	1.2
GTEx	Brain Putamen basal ganglia	1	0.160	1.3
GTEx	Breast Mammary Tissue	3	0.152	1.2
GTEx	Breast Mammary Tissue (Male)	3	0.251	1.3
GTEx	Breast Mammary Tissue (Female)	3	0.182	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	4	0.095	1.2
GTEx	Colon Sigmoid	3	0.205	1.3
GTEx	Colon Transverse	4	0.194	1.2
GTEx	Esophagus Gastroesophageal Junction	2	0.138	1.3
GTEx	Esophagus Mucosa	4	0.120	1.2
GTEx	Esophagus Muscularis	4	0.124	1.2
GTEx	Heart Atrial Appendage	3	0.190	1.3
GTEx	Heart Left Ventricle	3	0.196	1.2
GTEx	Liver	0	0.000	1.1
GTEx	Lung	3	0.104	1.2
GTEx	Muscle Skeletal	4	0.138	1.2
GTEx	Nerve Tibial	3	0.069	1.2
GTEx	Ovary	1	0.110	1.1
GTEx	Pancreas	3	0.184	1.2
GTEx	Pituitary	2	0.179	1.2
GTEx	Prostate	1	0.120	1.2
GTEx	Skin Not Sun Exposed Suprapubic	4	0.163	1.2
GTEx	Skin Sun Exposed Lower leg	5	0.137	1.2
GTEx	Small Intestine Terminal Ileum	2	0.434	1.3
GTEx	Spleen	2	0.142	1.2
GTEx	Stomach	5	0.344	1.3
GTEx	Testis	2	0.063	1.2
GTEx	Thyroid	4	0.100	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
GTEx	Whole Blood	1	0.050	1.2
METSIM	Adipose	6	0.130	1.2
NTR	Blood	2	0.083	1.2
ROSMAP	Brain Pre-frontal Cortex	2	0.046	1.2
YFS	Blood	1	0.022	1.2
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	2	0.182	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	4	0.098	1.1
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	3	0.070	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Lung Adenocarcinoma	2	0.068	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	2	0.080	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	2	0.120	1.1
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Soft Tissue Sarcoma	2	0.187	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.1
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	2	0.039	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2