Hub : Traits :

Basal cell carcinoma (self-reported)

157 significantly associated models · 23 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 201308117 203035423 4 1 2.4e-14 6.3e-14 1.0e+00 100 CASP8
2 5 619022 2041665 1 1 2.3e-08 2.2e-10 1.2e-03 74 CLPTM1L
3 9 21303958 22705094 1 1 2.8e-07 1.5e-07 6.7e-03 73 CDKN2B
4 12 52182052 53586255 1 1 1.1e-07 4.2e-09 1.5e-03 71 KRT6A
5 16 88934149 90172696 14 1 1.1e-22 6.7e-17 8.4e-01 100 DBNDD1
6 20 32594714 34225302 2 1 7.5e-09 3.7e-11 2.7e-05 60 NCOA6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Neuroticism (Nagel 2018) 2.02 1 0 0.0 0.00 1.00 NCOA6
Worry (Nagel 2018) 3.03 1 1 2.2 0.00 1.00 NCOA6
Crohns Disease (2017) 1.29 1 0 0.0 0.00 1.00 CDKN2B
Breast Cancer 11.05 2 2 4.4 0.00 1.00 CASP8 CDKN2B
Age at First Birth 3.06 1 0 0.0 0.00 1.00 DBNDD1
Coronary Artery Disease (CAD) 6.17 1 1 2.2 0.00 1.00 CDKN2B
Blood Platelet Count 2.68 3 2 4.4 0.00 1.00 CASP8 CDKN2B NCOA6
Blood Red Count 0.81 1 1 2.2 0.00 1.00 NCOA6
Blood White Count 1.62 2 2 4.4 0.00 1.00 CASP8 CDKN2B
Heel T-Score 1.31 1 1 2.2 0.00 1.00 NCOA6
Height 1.11 2 1 2.2 0.00 1.00 DBNDD1 NCOA6
Smoking Status 1.50 1 0 0.0 0.00 1.00 DBNDD1
Neuroticism 2.16 1 0 0.0 0.00 1.00 NCOA6
Hair Pigment 314.20 4 2 4.4 0.68 0.32 CDKN2B CLPTM1L DBNDD1 NCOA6
Tanning 311.75 2 2 4.4 0.00 1.00 DBNDD1 NCOA6
Relative age of first facial hair 6.38 1 1 2.2 0.00 1.00 DBNDD1
Angina 3.46 1 0 0.0 0.00 1.00 CDKN2B
Trunk fat percentage 1.81 1 1 2.2 0.00 1.00 DBNDD1
Relative age voice broke 2.44 1 0 0.0 0.00 1.00 DBNDD1
High blood pressure 2.05 1 0 0.0 0.00 1.00 DBNDD1
Impedance of leg (left) 1.11 1 0 0.0 0.00 1.00 CLPTM1L
Trunk fat mass 1.59 1 1 2.2 0.00 1.00 DBNDD1
Waist circumference 1.36 1 0 0.0 0.00 1.00 DBNDD1
Nervous feelings 2.56 1 0 0.0 0.00 1.00 NCOA6
Heart attack 2.43 1 0 0.0 0.00 1.00 CDKN2B
Weight 0.90 1 0 0.0 0.00 1.00 DBNDD1
Impedance of arm (right) 1.59 1 0 0.0 0.00 1.00 DBNDD1
Arm fat percentage (right) 0.96 1 0 0.0 0.00 1.00 DBNDD1
Hip circumference 0.88 1 0 0.0 0.00 1.00 DBNDD1
Number of live births 4.22 1 0 0.0 0.00 1.00 DBNDD1
Lung cancer (father) 6.97 1 1 2.2 0.00 1.00 CLPTM1L
Impedance of arm (left) 1.41 1 0 0.0 0.00 1.00 DBNDD1
Standing height 0.87 1 1 2.2 0.00 1.00 DBNDD1
Hair/balding pattern: Pattern 4 3.87 2 0 0.0 0.00 1.00 DBNDD1 KRT6A
Forced vital capacity (FVC), Best measure 1.12 1 0 0.0 0.00 1.00 CLPTM1L
Body fat percentage 1.31 1 0 0.0 0.00 1.00 DBNDD1
Worry too long after embarrassment 4.81 2 1 2.2 0.00 1.00 DBNDD1 NCOA6
Angina (self-reported) 3.42 1 0 0.0 0.00 1.00 CDKN2B
Whole body fat mass 1.16 1 0 0.0 0.00 1.00 DBNDD1
Hypertension (Self-reported) 1.95 1 0 0.0 0.00 1.00 DBNDD1
Illnesses of father: Heart disease 2.99 1 0 0.0 0.00 1.00 CDKN2B
Arm fat percentage (left) 0.92 1 0 0.0 0.00 1.00 DBNDD1
Medication: Aspirin 3.49 1 0 0.0 0.00 1.00 DBNDD1
Illnesses of father: None of the above (group 1) 2.92 1 0 0.0 0.00 1.00 CDKN2B
Irritability 2.30 1 0 0.0 0.00 1.00 NCOA6
Ever had prostate specific antigen (PSA) test 5.15 1 0 0.0 0.00 1.00 CLPTM1L
Vascular/heart problems diagnosed by doctor 1.84 1 0 0.0 0.00 1.00 DBNDD1
Heart attack/myocardial infarction (self-reported) 2.50 1 0 0.0 0.00 1.00 CDKN2B
Impedance of whole body 1.39 1 0 0.0 0.00 1.00 DBNDD1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 4 0.115 1.2
GTEx Adipose Visceral Omentum 3 0.147 1.2
GTEx Adrenal Gland 4 0.275 1.3
GTEx Artery Aorta 4 0.134 1.2
GTEx Artery Coronary 1 0.085 1.2
GTEx Artery Tibial 4 0.106 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.1
GTEx Brain Cerebellar Hemisphere 4 0.269 1.4
GTEx Brain Cerebellum 5 0.252 1.3
GTEx Brain Cortex 5 0.483 1.4
GTEx Brain Frontal Cortex BA9 3 0.325 1.3
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.1
GTEx Brain Nucleus accumbens basal ganglia 2 0.231 1.2
GTEx Brain Putamen basal ganglia 1 0.160 1.3
GTEx Breast Mammary Tissue 3 0.152 1.2
GTEx Breast Mammary Tissue (Male) 3 0.251 1.3
GTEx Breast Mammary Tissue (Female) 3 0.182 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 4 0.095 1.2
GTEx Colon Sigmoid 3 0.205 1.3
GTEx Colon Transverse 4 0.194 1.2
GTEx Esophagus Gastroesophageal Junction 2 0.138 1.3
GTEx Esophagus Mucosa 4 0.120 1.2
GTEx Esophagus Muscularis 4 0.124 1.2
GTEx Heart Atrial Appendage 3 0.190 1.3
GTEx Heart Left Ventricle 3 0.196 1.2
GTEx Liver 0 0.000 1.1
GTEx Lung 3 0.104 1.2
GTEx Muscle Skeletal 4 0.138 1.2
GTEx Nerve Tibial 3 0.069 1.2
GTEx Ovary 1 0.110 1.1
GTEx Pancreas 3 0.184 1.2
GTEx Pituitary 2 0.179 1.2
GTEx Prostate 1 0.120 1.2
GTEx Skin Not Sun Exposed Suprapubic 4 0.163 1.2
GTEx Skin Sun Exposed Lower leg 5 0.137 1.2
GTEx Small Intestine Terminal Ileum 2 0.434 1.3
GTEx Spleen 2 0.142 1.2
GTEx Stomach 5 0.344 1.3
GTEx Testis 2 0.063 1.2
GTEx Thyroid 4 0.100 1.2
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 1 0.050 1.2
METSIM Adipose 6 0.130 1.2
NTR Blood 2 0.083 1.2
ROSMAP Brain Pre-frontal Cortex 2 0.046 1.2
YFS Blood 1 0.022 1.2
CommonMind Brain Pre-frontal Cortex 2 0.037 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Breast Invasive Carcinoma 2 0.045 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 2 0.182 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 4 0.098 1.1
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 3 0.070 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Adenocarcinoma 2 0.068 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 2 0.080 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 2 0.120 1.1
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.1
The Cancer Genome Atlas Prostate Adenocarcinoma 2 0.043 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 2 0.187 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.3
The Cancer Genome Atlas Thyroid Carcinoma 2 0.039 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2