Best TWAS P=3.01e-08 · Best GWAS P=1.46e-07 conditioned to 0.459
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ABO | 0.07 | 0.08 | lasso | 3 | 0.08 | 5.0e-16 | -5.1 | -5.1 | 2.9e-07 | 0.93 | 0 | 1.00 | FALSE |
2 | The Cancer Genome Atlas | Colon Adenocarcinoma | ABO | 0.27 | 0.31 | blup | 43 | 0.33 | 2.1e-19 | -5.1 | -5.5 | 5.1e-08 | 0.87 | 0 | 1.00 | FALSE |
3 | The Cancer Genome Atlas | Esophageal Carcinoma | ABO | 0.27 | 0.13 | lasso | 2 | 0.11 | 1.8e-04 | -5.1 | -5.1 | 2.7e-07 | 0.93 | 0 | 0.98 | FALSE |
4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ABO | 0.11 | 0.08 | blup | 43 | 0.12 | 2.5e-13 | -5.1 | -5.1 | 3.0e-07 | 0.78 | 0 | 1.00 | FALSE |
5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ABO | 0.26 | 0.23 | enet | 10 | 0.26 | 6.0e-29 | -5.1 | -5.5 | 3.4e-08 | 0.87 | 0 | 0.99 | FALSE |
6 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABO | 0.23 | 0.23 | lasso | 2 | 0.24 | 2.2e-11 | -5.3 | -5.3 | 1.3e-07 | 1.00 | 0 | 1.00 | FALSE |
7 | The Cancer Genome Atlas | Lung Adenocarcinoma | ABO | 0.21 | 0.25 | lasso | 5 | 0.25 | 2.1e-29 | -5.1 | -5.3 | 1.4e-07 | 0.97 | 0 | 1.00 | FALSE |
8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ABO | 0.28 | 0.22 | lasso | 8 | 0.22 | 1.2e-14 | -5.1 | -5.2 | 1.5e-07 | 0.94 | 0 | 1.00 | FALSE |
9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ABO | 0.23 | 0.21 | lasso | 5 | 0.20 | 6.7e-09 | -5.3 | -5.3 | 1.1e-07 | 0.96 | 0 | 1.00 | FALSE |
10 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ABO | 0.48 | 0.23 | enet | 10 | 0.27 | 4.7e-07 | -5.1 | -5.5 | 3.0e-08 | 0.89 | 0 | 0.97 | TRUE |
11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ABO | 0.20 | 0.10 | blup | 42 | 0.18 | 5.8e-13 | -5.1 | -5.4 | 6.8e-08 | 0.83 | 0 | 1.00 | FALSE |