Best TWAS P=7.59e-10 · Best GWAS P=2.96e-13 conditioned to 0.0218
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | SIPA1 | 0.19 | 0.00 | enet | 30 | 0.05 | 2.5e-04 | 5.05 | 5.8 | 8.3e-09 | -0.48 | 0.05 | 0.81 | TRUE |
| 2 | GTEx | Nerve Tibial | SIPA1 | 0.17 | 0.01 | enet | 19 | 0.06 | 6.8e-05 | -4.71 | 5.7 | 1.5e-08 | -0.42 | 0.08 | 0.78 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | CTSW | 0.06 | 0.03 | bslmm | 328 | 0.03 | 3.6e-05 | 2.74 | -6.2 | 7.6e-10 | 0.46 | 0.46 | 0.25 | TRUE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RNASEH2C | 0.05 | 0.00 | blup | 32 | 0.02 | 1.1e-04 | 0.53 | -6.1 | 1.3e-09 | 0.42 | 0.02 | 0.20 | FALSE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SIPA1 | 0.06 | 0.04 | blup | 43 | 0.05 | 4.6e-06 | -3.69 | 5.6 | 1.8e-08 | -0.52 | 0.04 | 0.89 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SIPA1 | 0.04 | 0.00 | blup | 43 | 0.02 | 6.2e-03 | -5.27 | 6.0 | 2.0e-09 | -0.59 | 0.01 | 0.41 | FALSE |