TWAS hub - SIPA1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1930	0.0590	1.7e-05	0.003	NA	0.045	NA	0.025	1.9e-01	NA	2.5e-04	NA	5.6e-03
2	GTEx	Esophagus Mucosa	0.3410	0.0690	1.2e-07	0.166	NA	0.191	NA	0.201	2.9e-11	NA	7.8e-13	NA	1.6e-13
3	GTEx	Nerve Tibial	0.1721	0.0521	2.4e-05	0.012	NA	0.057	NA	0.057	4.7e-02	NA	6.8e-05	NA	7.3e-05
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0624	0.0297	1.2e-04	0.039	0.047	0.033	NA	0.043	3.2e-05	4.6e-06	1.2e-04	NA	1.3e-05
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0383	0.0245	9.0e-03	0.004	0.016	0.006	NA	0.004	9.6e-02	6.2e-03	6.2e-02	NA	1.0e-01
6	TCGA	Lung Squamous Cell Carcinoma	0.0919	0.0388	2.9e-06	0.034	0.063	0.050	NA	0.049	9.5e-05	1.2e-07	2.0e-06	NA	3.1e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Heel T-Score	16.2	129.2	207.4	11.9	8.9	8.5	13.4	14.4	9.8
Medication: Blood pressure	13.8	26.3	35.9	4.3	4.6	4.8	6.0	5.8	5.1
Systolic Blood Pressure	13.6	68.3	86.5	6.7	8.5	8.1	9.3	8.8	7.9
Heel bone mineral density (BMD) T-score, automated (right)	13.5	31.0	49.6	6.3	4.0	4.0	6.7	7.0	4.6
Heel bone mineral density (BMD) T-score, automated (left)	12.9	29.2	50.1	6.2	3.8	4.1	6.3	7.1	4.1
Diastolic blood pressure, automated reading	11.9	36.8	51.3	4.8	5.5	6.2	7.2	7.0	5.5
Cardiovascular Disease	11.3	37.3	68.7	5.6	4.8	8.3	6.1	6.1	5.1
Vascular/heart problems diagnosed by doctor	10.8	29.3	40.9	-5.3	-4.7	-6.4	-5.7	-5.7	-4.5
Waist Hip Ratio (WHR)	10.4	46.6	72.2	5.1	6.5	4.6	8.5	8.2	7.2
Hypertension (Self-reported)	10.0	27.7	36.0	5.8	4.1	5.7	5.6	6.0	4.0
Gout (self-reported)	9.9	13.6	22.6	4.8	2.4	1.6	4.4	4.6	3.2
HDL Cholesterol	9.8	16.4	23.6	-2.2	-4.0	-4.9	-4.4	-4.5	-3.8
High blood pressure	9.6	26.7	36.1	5.4	4.2	6.0	5.4	5.7	3.9
Medication: Amlodipine	8.9	12.5	19.3	3.9	2.6	2.9	4.3	4.4	2.7
Systolic blood pressure, automated reading	8.1	23.5	32.5	3.1	4.9	4.8	5.7	5.7	4.3
Medication: Allopurinol	7.8	10.4	16.4	3.9	2.3	1.4	3.9	4.1	2.9
Medication: Blood pressure	7.7	13.6	18.7	4.2	2.7	3.9	4.1	4.3	2.5
Medication for cholesterol, blood pressure or diabetes	6.8	11.2	19.1	-3.5	-2.9	-4.4	-3.2	-3.3	-2.4
Chest pain or discomfort	6.8	9.8	19.4	2.9	2.3	1.9	4.1	4.4	2.2
Medication: Cholesterol lowering	6.7	10.4	20.9	2.9	3.0	4.6	2.9	2.5	3.2
Alcohol intake versus 10 years previously	6.4	9.6	18.1	2.0	2.2	3.2	3.7	4.3	2.6
Type 2 Diabetes (T2D) (2018)	6.3	11.7	26.0	1.7	2.7	5.1	3.3	3.9	2.8
Relative age of first facial hair	6.2	12.7	18.5	-4.3	-2.3	-1.9	-4.2	-4.3	-3.6
Age started oral contraceptive pill	6.1	7.7	11.8	-3.4	-1.5	-3.2	-2.8	-3.4	-1.4
Had menopause	6.0	7.6	14.0	-1.4	-3.7	-3.6	-2.2	-1.8	-2.9
Triglycerides	5.9	9.7	12.6	1.9	3.5	2.8	3.5	3.5	3.2
Medication for cholesterol	5.9	8.9	11.9	-2.6	-2.5	-3.1	-3.3	-2.8	-3.5
Medication: Lisinopril	5.7	7.4	10.7	3.3	2.2	2.2	3.1	3.1	2.1
Heart attack	5.6	7.1	13.8	1.8	3.7	2.9	2.3	1.4	3.2
Comparative body size at age 10	5.2	14.4	22.9	-4.3	-3.2	1.3	-4.8	-3.6	-4.4
Heart attack/myocardial infarction (self-reported)	5.0	6.5	12.5	1.7	3.5	3.0	2.0	1.3	2.9
Townsend deprivation index at recruitment	4.8	6.8	15.4	3.9	1.5	1.9	2.7	3.0	1.8
Medication: Aspirin	4.8	6.3	8.9	2.2	2.3	2.1	3.0	2.3	2.9
Medication: Aspirin	4.7	6.2	8.4	1.8	2.5	2.2	2.9	2.4	2.9
Number of self-reported non-cancer illnesses	4.7	8.2	11.9	2.9	1.8	2.6	3.5	3.4	2.8
Medication: Simvastatin	4.4	6.5	21.7	1.5	1.4	4.7	2.1	1.5	2.6
Birth weight	4.4	9.5	24.3	-3.2	-3.5	-0.7	-3.0	-0.5	-4.9
Number of treatments/medications taken	4.2	7.6	11.8	2.8	1.2	3.3	3.2	3.4	1.9
Diabetes (mother)	4.1	5.3	10.4	2.6	1.6	3.2	2.0	2.4	1.6
Father’s age at death	4.1	5.5	8.8	-1.4	-1.4	-3.0	-2.7	-2.6	-2.4
Frequency of tiredness / lethargy in last 2 weeks	4.0	6.4	13.2	2.7	1.8	2.8	2.6	3.6	0.6
Fractured/broken bones in last 5 years	3.8	4.9	7.2	-1.2	-2.3	-2.6	-2.2	-1.9	-2.7
Wears glasses or contact lenses	3.7	4.2	5.8	-1.5	-2.4	-1.9	-2.2	-1.8	-2.4
Leg pain on walking	3.6	4.5	7.7	2.4	1.6	2.8	1.9	2.5	1.4
Medication: Bendroflumethiazide	3.6	5.4	9.5	2.8	2.1	2.2	2.3	3.1	0.7
Age when periods started (menarche)	3.5	8.5	25.9	-2.3	-1.9	-5.1	-2.3	-3.0	-1.4
Smoking status: Previous	3.4	5.0	15.4	1.9	0.8	3.9	1.9	1.9	1.9
Medication: Atorvastatin	3.4	4.2	6.8	1.6	2.2	1.0	2.5	2.0	2.6
Coronary Artery Disease (CAD)	3.2	3.8	7.5	0.7	1.4	0.5	2.7	2.4	2.5
Allergy or Eczema	3.1	8.1	15.8	3.0	-0.6	0.5	3.9	4.0	2.8
Average weekly fortified wine intake	3.1	3.6	4.6	-2.0	-1.7	-1.9	-2.1	-2.1	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	3.1	3.6	7.3	-1.2	-2.0	-0.5	-2.5	-2.7	-1.6
Overall health rating	3.1	6.7	31.4	0.2	0.1	5.6	1.5	2.6	0.2
Stomach or abdominal pain in last month	3.0	3.8	8.7	1.4	1.0	2.8	1.8	2.9	0.1
Illnesses of siblings: Diabetes	3.0	3.6	6.2	2.0	1.0	1.3	2.3	2.5	1.8
Medication: Ramipril	2.9	3.7	7.2	0.5	1.7	2.7	2.1	2.3	1.5
Handedness (chirality/laterality): Left-handed	2.9	3.4	6.3	-0.5	-2.0	-1.3	-2.5	-2.5	-1.6
Blood Eosinophil Count	2.8	21.9	38.6	6.2	-0.5	-3.6	5.6	4.1	5.6
Waist circumference	2.7	9.9	24.7	2.0	0.8	5.0	3.0	4.6	0.5
Eye problems/disorders: Glaucoma	2.7	3.2	6.9	1.5	1.1	-2.0	2.1	0.8	2.6
Blood Platelet Count	2.6	29.7	98.6	1.4	-4.8	-9.9	-3.5	-3.4	-5.5
Hayfever, allergic rhinitis or eczema	2.6	5.7	10.5	2.6	-0.0	0.7	3.2	3.1	2.7
High blood pressure (mother)	2.6	3.7	5.3	1.7	0.6	2.2	2.2	2.3	1.9
Mouth/teeth dental problems	2.6	4.0	21.4	-0.9	-0.3	-4.6	0.4	-0.8	0.9
High blood pressure (siblings)	2.6	3.8	6.3	1.5	1.4	2.3	2.3	2.5	1.2
Diabetes diagnosed by doctor	2.6	4.3	12.6	0.5	1.3	3.6	1.8	2.1	1.8
Fasting Glucose	2.5	3.0	5.7	1.6	1.5	2.4	1.5	1.2	1.9
Relative age voice broke	2.5	3.9	8.1	-2.9	-0.6	-0.6	-2.3	-2.4	-1.8
Glaucoma (self-reported)	2.5	2.9	12.3	0.5	0.4	-3.5	1.2	0.2	1.8
Angina (self-reported)	2.5	3.3	4.8	0.9	2.1	2.0	1.9	1.3	2.2
Mother’s age at death	2.5	3.1	4.7	-2.1	-0.7	-1.5	-2.1	-2.2	-1.6
Alzheimer’s Disease (in father)	2.4	2.6	4.5	1.1	2.1	-0.6	2.0	1.9	1.4
Breast Cancer	2.4	5.9	26.5	-1.2	-2.3	-5.2	-0.1	-1.3	0.6
Commuting to job workplace: Cycle	2.4	3.0	5.7	-1.4	-0.6	-1.2	-2.4	-2.2	-1.8
Prostate Cancer	2.3	3.2	6.8	-2.6	-0.3	0.8	-2.1	-2.1	-1.5
Angina	2.3	3.1	4.4	1.1	2.0	1.8	1.9	1.4	2.1
Medication: Metformin	2.3	3.3	11.4	-0.3	1.9	3.4	1.1	1.2	1.5
Past tobacco smoking	2.3	4.2	12.6	-1.7	-1.0	-3.6	-1.6	-2.2	-1.2
Worrier / anxious feelings	2.3	4.4	7.0	-1.8	-2.4	-0.3	-2.7	-2.4	-2.2
Illnesses of mother	2.3	2.9	4.4	-1.3	-1.6	-2.1	-1.8	-1.8	-1.5
Alcohol intake frequency.	2.3	5.3	10.9	1.5	1.1	2.9	2.8	3.3	1.1
Osteoporosis (self-reported)	2.3	2.9	5.0	-1.1	-1.8	-2.2	-1.6	-1.9	-1.3
Illnesses of father: None of the above (group 1)	2.3	2.8	5.4	-0.7	-1.3	-0.4	-2.3	-2.1	-2.1
Happiness	2.2	2.7	4.9	1.8	1.1	1.3	2.0	2.2	1.1
Peak expiratory flow (PEF)	2.2	5.0	8.7	1.2	3.0	0.8	2.6	2.9	2.0
Crohns Disease (2017)	2.1	4.7	12.2	0.1	-1.9	3.5	-1.8	-1.1	-2.8
Smoking Status	2.1	5.1	13.2	1.2	0.8	3.6	2.0	3.3	0.5
Hair Pigment	2.1	59.7	87.6	-6.5	-5.6	-6.0	-9.4	-8.6	-9.4
Allergy	2.1	4.9	9.2	-2.0	0.8	-0.5	-3.0	-2.7	-2.8
LDL Cholesterol	2.0	3.1	7.1	-1.6	-1.0	0.6	-2.6	-2.7	-0.9
Lupus	2.0	3.1	5.3	0.4	1.8	2.3	1.9	1.9	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.6	10.1	1.8	-0.7	3.2	-0.2	0.7	-1.2
Hair/balding pattern: Pattern 2	2.0	2.5	3.7	-1.5	-1.2	-1.6	-1.8	-1.5	-1.9
Forced vital capacity (FVC)	2.0	7.6	17.1	1.7	3.2	0.4	3.4	4.1	2.0
Eye problems/disorders: None of the above	2.0	2.3	3.5	-1.8	-1.6	0.2	-1.8	-1.2	-1.9
Eye problems/disorders: Cataract	2.0	2.3	3.6	1.0	1.9	-0.9	1.9	1.5	1.7
Average weekly champagne plus white wine intake	2.0	2.7	15.0	-0.9	-0.4	-3.9	-0.0	-0.4	-0.0
Number of operations (self-reported)	2.0	2.9	5.8	1.5	1.8	2.4	1.6	1.9	0.5
Exposure to tobacco smoke outside home	1.9	2.6	6.7	2.6	-1.1	1.8	1.2	1.6	0.2
Medication for pain relief, constipation, heartburn	1.9	3.3	6.0	-2.1	-0.7	-2.4	-1.7	-2.4	0.3
Had major operations	1.9	2.3	6.2	1.9	0.7	2.5	0.8	1.6	-0.5
Tinnitus: Yes, now most or all of the time	1.9	2.2	5.2	0.4	-1.2	-1.5	-1.7	-1.2	-2.3
Ever smoked	1.9	3.3	6.2	1.6	1.3	2.2	1.8	2.5	0.9
Had other major operations	1.8	2.2	4.0	1.3	1.6	0.6	2.0	1.7	1.3
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	3.6	1.9	1.3	-0.4	1.7	1.7	1.9
Illnesses of siblings	1.8	2.5	4.1	-2.0	-0.5	-1.6	-1.9	-1.9	-0.8
Heart disease (mother)	1.8	2.2	5.6	0.3	1.6	0.9	1.8	1.0	2.4
Supplements: Calcium	1.8	2.0	3.6	-1.4	-1.9	-1.5	-1.2	-1.4	-1.0
Type 2 Diabetes (T2D) (2012)	1.7	2.0	8.4	-0.0	0.9	2.9	0.7	1.3	0.8
Diabetes (self-reported)	1.7	2.6	7.8	0.2	1.2	2.8	1.5	1.7	1.2
Pulse wave reflection index	1.7	2.1	5.9	1.4	2.4	1.6	0.9	1.1	0.6
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	7.7	-1.5	-2.8	0.0	-1.0	-0.8	-1.1
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	5.1	-1.7	-1.6	-1.0	-1.2	-2.3	0.0
Irritable Bowel Disease (IBD)	1.6	3.8	12.4	-0.0	-1.9	3.5	-1.5	-0.8	-2.0
BMI	1.6	9.5	29.1	-0.0	-2.6	5.4	-1.7	0.9	-4.2
Medication: Co-codamol	1.6	1.9	7.7	-1.5	0.4	2.8	-0.7	-0.4	-0.5
Body mass index (BMI)	1.6	6.7	28.6	0.3	-1.7	5.3	-0.5	1.5	-2.5
Forced expiratory volume in 1-second (FEV1)	1.6	5.5	9.9	1.3	3.1	0.1	2.8	3.1	2.0
Medication: Ventolin 100micrograms inhaler	1.6	2.0	6.0	0.6	-2.5	-1.9	-0.2	0.7	-1.3
Migraine (self-reported)	1.6	2.0	3.3	-1.8	-0.9	-1.1	-1.6	-1.4	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.8	1.7	1.4	2.0	0.9	1.1	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	6.4	-2.5	0.1	-0.3	-1.3	-1.5	-0.8
Long-standing illness, disability or infirmity	1.6	2.4	6.8	0.0	0.6	2.6	1.6	2.0	1.0
Lung FVC	1.5	7.9	15.2	2.1	2.8	2.1	3.2	3.9	2.2
Qualifications: CSEs or equivalent	1.5	1.9	4.1	-0.5	1.4	2.0	1.3	1.8	0.8
Medication: Atenolol	1.5	1.9	3.2	1.8	1.1	0.5	1.8	1.4	1.3
Neck or shoulder pain in last month	1.5	2.2	10.6	-0.4	-0.7	3.2	0.4	1.1	-0.7
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.9	0.8	-0.1	1.4	1.4	2.0	0.6
Diabetes (father)	1.4	1.7	4.6	1.0	0.3	2.1	1.2	1.4	1.0
Shortness of breath walking on level ground	1.4	1.6	4.5	-1.7	0.2	0.0	-1.3	-0.8	-2.1
Body Mass Index (BMI) (2010)	1.3	1.7	6.1	0.1	1.0	2.5	1.0	1.3	0.7
Crohns Disease (2012)	1.3	2.1	8.2	0.4	-0.8	2.9	-0.9	-0.5	-1.6
Neuroticism (2016)	1.3	1.9	3.3	1.7	0.6	1.3	1.7	1.8	0.7
Serious illness, injury or assault to yourself	1.3	1.6	5.2	-0.0	0.9	0.9	1.6	2.3	0.5
Multivitamins +/- minerals	1.3	1.6	4.8	0.2	0.4	-0.4	1.9	2.2	1.0
Chronic bronchitis/emphysema (father)	1.3	1.6	3.0	-0.9	-1.7	0.1	-1.5	-1.2	-1.4
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	7.8	-0.3	-1.4	0.6	-1.2	0.2	-2.8
Pain all over the body in last month	1.3	1.4	5.0	0.6	1.4	2.2	0.4	0.0	1.0
Mouth/teeth dental problems: Dentures	1.3	2.2	8.8	1.4	-0.0	3.0	0.6	1.4	-0.2
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	5.1	1.3	-0.5	-1.1	2.3	2.1	1.6
Forced vital capacity (FVC), Best measure	1.3	4.6	12.1	1.3	2.5	-0.7	2.4	3.5	1.3
Age at first live birth	1.3	2.2	11.0	-0.5	0.3	-3.3	0.0	-1.1	1.0
Leg fat mass (left)	1.3	4.9	16.1	-0.4	-1.2	4.0	-0.1	2.1	-2.7
Rheumatoid Arthritis	1.2	1.7	4.0	1.3	0.5	0.8	1.7	2.0	0.7
Supplements: Zinc	1.2	1.3	1.9	-1.2	-1.3	-0.8	-1.3	-1.4	-0.9
Financial difficulties in last 2 years	1.2	1.7	4.9	1.3	1.3	0.5	1.2	2.2	-0.0
Medication: Lansoprazole	1.2	1.3	3.9	0.3	1.9	2.0	0.5	0.5	0.3
Lung cancer (father)	1.2	1.4	3.8	-0.9	0.2	1.1	-1.4	-0.8	-1.9
Arm fat mass (right)	1.2	4.9	20.0	0.1	-1.2	4.5	0.3	2.1	-1.9
Medication: Paracetamol	1.2	2.0	5.1	1.8	0.4	0.8	1.6	2.3	-0.6
Qualifications: College or University degree	1.2	3.9	12.9	-0.1	2.3	-3.6	0.3	-1.2	1.9
Knee pain experienced in last month	1.2	1.9	7.4	0.2	-0.2	2.7	-0.1	1.1	-1.6
Qualifications: nursing, teaching	1.2	1.9	8.2	0.5	1.5	-2.9	0.5	0.4	0.5
Miserableness	1.2	2.0	4.4	1.1	1.5	0.2	1.7	2.1	1.1
Alcohol drinker status: Never	1.2	1.4	2.1	-1.5	-0.7	-0.9	-1.3	-1.4	-1.1
Leg fat percentage (left)	1.2	4.3	18.4	-0.3	-0.8	4.3	0.1	1.7	-1.9
Depression (Nagel 2018)	1.1	1.6	3.7	1.2	-1.4	1.3	-0.7	0.5	-1.9
Blood Red Count	1.1	10.1	27.2	2.9	3.2	5.2	2.0	2.8	1.7
Respiratory disease	1.1	2.4	4.3	1.5	-1.2	0.5	2.0	2.1	1.5
Fluid intelligence score	1.1	2.3	6.0	0.6	2.4	-0.7	1.6	1.2	1.7
Arm fat percentage (right)	1.1	4.2	20.4	0.0	-1.4	4.5	-0.3	0.8	-1.5
Prospective memory result	1.1	1.4	3.2	-1.7	-1.8	-0.1	-0.8	-0.9	-0.8
Breastfed as a baby	1.1	1.4	4.3	-0.6	-0.8	-2.1	-1.0	-1.2	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	7.0	-0.6	-0.3	0.5	-0.5	1.4	-2.6
Hair/balding pattern: Pattern 4	1.1	2.7	9.6	1.1	1.5	-3.1	1.4	0.7	0.8
Pulse wave peak to peak time	1.1	1.3	2.7	-1.3	-1.2	-1.2	-0.8	-1.6	0.2
Whole body fat mass	1.1	4.8	15.6	0.0	-0.7	4.0	0.7	2.9	-1.9
Leg fat mass (right)	1.1	4.4	13.5	-0.7	-1.4	3.7	-0.2	1.9	-2.7
Illnesses of father: Heart disease	1.1	1.5	2.8	1.1	1.0	-0.7	1.6	1.2	1.7
Breast cancer (self-reported)	1.1	1.3	2.5	-1.3	-1.1	-0.5	-1.1	-1.0	-1.6
Arm fat mass (left)	1.1	4.6	16.6	0.1	-1.4	4.1	0.2	2.1	-2.1
Hearing aid user	1.1	1.3	2.0	-0.4	-1.4	-0.9	-1.2	-1.3	-1.2
Pain experienced in last month	1.1	1.8	5.5	0.0	0.5	-2.3	0.3	-1.2	1.8
Mean Putamen Volume	1.0	1.1	4.4	-0.5	-0.7	2.1	-0.9	-0.7	-0.5
Primary Biliary Cirrhosis	1.0	1.4	5.0	0.6	-0.8	2.2	0.3	1.3	-0.5
Impedance of leg (right)	1.0	4.8	11.3	-0.4	1.5	-3.2	2.2	0.2	3.4
Taking other prescription medications	1.0	1.6	4.7	0.6	0.3	1.2	1.6	2.2	0.6
Trunk fat mass	1.0	4.2	12.5	-0.0	-0.7	3.5	0.8	2.8	-1.8
Weight	1.0	4.9	12.3	0.2	-0.6	3.2	0.9	3.5	-2.4
Time employed in main current job	1.0	1.1	1.8	-0.4	-1.2	-1.4	-1.1	-1.0	-1.0
Pulse wave Arterial Stiffness index	1.0	1.1	2.9	1.2	1.1	0.7	0.8	1.7	-0.2
Body fat percentage	1.0	3.9	16.9	0.0	-0.9	4.1	0.5	2.0	-1.4
Leg fat percentage (right)	1.0	3.6	14.4	-0.8	-1.0	3.8	-0.1	1.4	-1.8
Arm fat percentage (left)	1.0	4.2	19.5	0.1	-1.3	4.4	-0.0	1.2	-1.5
Average weekly red wine intake	1.0	1.5	2.9	-1.3	1.6	-1.7	0.4	0.0	1.3
Back pain experienced in last month	1.0	1.5	4.0	1.5	0.4	1.3	0.8	2.0	-0.5
Medication: Paracetamol	1.0	1.6	3.9	1.5	0.2	0.9	1.5	2.0	-0.4
Age at First Birth	0.9	1.3	2.9	-0.8	1.7	-1.1	0.6	-0.0	1.6
Schizophrenia (2014)	0.9	2.1	6.4	-1.5	1.2	2.5	0.4	0.6	1.3
Hypothyroidism (self reported)	0.9	2.1	3.1	1.5	-1.0	-1.5	1.8	1.4	1.5
Average weekly spirits intake	0.9	1.1	2.0	-1.4	-0.9	0.3	-1.1	-0.6	-1.4
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.6	0.9	-0.7	1.4	-0.7	0.5	-1.9
Other serious medical condition/disability diagnosed by doctor	0.9	1.1	2.7	0.3	1.1	1.6	0.8	1.4	0.1
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.7	-0.2	-1.9	-1.3	-0.5	-0.6	-0.7
Severe depression (siblings)	0.9	1.0	2.4	-0.3	-1.6	-0.8	-0.7	-0.5	-1.4
Trunk fat percentage	0.9	3.5	13.5	0.1	-0.8	3.7	0.7	2.1	-1.2
Impedance of leg (left)	0.9	4.3	9.9	0.2	1.9	-2.7	2.2	0.5	3.1
Number of incorrect matches in round	0.9	1.5	2.9	0.3	-1.7	0.1	-1.3	-1.4	-1.6
Impedance of arm (left)	0.9	3.9	13.0	-0.2	0.7	-3.6	1.2	-0.8	2.8
Standing height	0.9	9.3	23.0	0.0	2.2	-4.2	3.2	4.8	0.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.5	0.6	-0.7	1.9	-0.8	-0.1	-1.2
Arm fat-free mass (right)	0.9	4.7	17.0	0.1	-0.2	1.4	1.1	4.1	-2.8
Health satisfaction	0.9	1.1	3.8	-1.0	-0.6	2.0	-0.1	0.8	-1.0
Arm predicted mass (right)	0.9	4.4	14.4	0.0	-0.4	1.2	0.7	3.8	-3.1
Age at last live birth	0.9	1.3	6.7	-0.1	0.4	-2.6	0.2	-0.7	0.7
Mineral and other dietary supplements	0.9	1.2	2.8	-0.5	-0.5	0.3	-1.7	-1.3	-1.5
Pain type(s) experienced in last month: Hip pain	0.9	1.1	3.0	0.4	1.0	0.2	1.5	1.7	0.5
Impedance of whole body	0.9	4.6	11.5	-0.5	1.3	-3.3	1.6	-0.6	3.4
Height	0.8	15.2	37.3	-0.2	1.7	-6.0	3.9	6.1	-1.0
Vitamin and mineral supplements	0.8	1.1	4.2	-0.7	0.1	-0.4	-1.3	-2.0	0.0
Maternal smoking around birth	0.8	1.2	3.7	1.9	-0.2	0.9	0.1	1.2	-1.1
Impedance of arm (right)	0.8	3.9	11.7	-0.3	0.5	-3.4	0.7	-1.6	2.9
Pulse rate	0.8	1.4	3.3	-0.6	-1.8	-1.1	-1.0	-0.6	-1.3
Noisy workplace	0.8	1.0	2.8	-0.1	-1.7	0.7	-0.9	-0.4	-1.4
Depression (self-reported)	0.8	1.0	3.8	0.2	-0.6	-0.5	1.1	1.9	-0.6
Loud music exposure frequency	0.8	0.9	3.1	1.8	-0.6	0.3	0.8	0.7	0.7
Medication: Gliclazide	0.8	0.9	3.0	-0.3	-0.2	1.7	0.7	1.3	-0.2
Arm fat-free mass (left)	0.8	4.1	12.5	0.2	-0.5	1.7	0.7	3.5	-2.9
Cholesterol lowering medication	0.8	1.1	4.5	0.2	0.3	2.1	0.8	0.4	1.2
Arm predicted mass (left)	0.8	3.9	11.5	0.2	-0.5	1.6	0.6	3.4	-2.9
Worry (Nagel 2018)	0.7	1.5	1.9	-1.1	-1.3	1.2	-1.4	-1.2	-1.2
Alzheimer’s Disease (including proxy)	0.7	1.0	2.2	1.0	1.5	-1.4	0.7	0.8	0.4
Reaction Time	0.7	1.3	3.3	-1.8	0.6	1.4	0.5	-0.1	1.4
Hand grip strength (left)	0.7	1.9	3.4	-0.9	-1.4	-1.8	-1.3	-0.3	-1.8
Current tobacco smoking	0.7	1.1	4.0	-0.2	0.4	1.3	0.7	2.0	-0.6
Fed-up feelings	0.7	1.2	3.2	0.8	0.6	1.2	1.2	1.8	0.4
Supplements: Glucosamine	0.7	0.9	1.6	0.9	0.3	0.8	1.3	1.1	0.9
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.8	-0.1	-1.3	1.3	-0.5	0.2	-1.1
Hip circumference	0.7	3.0	7.2	-0.5	-1.9	2.2	-0.4	1.5	-2.7
Falls in the last year	0.7	1.0	2.5	0.6	-1.6	-1.1	-0.7	-1.2	-0.3
Asthma	0.7	1.3	5.2	1.0	-2.3	0.2	0.7	1.1	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	4.8	0.5	2.2	-0.9	1.6	2.1	0.9
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	4.4	-0.9	-0.2	-2.1	-0.5	0.1	-1.3
Blood clot in the leg (DVT)	0.7	0.9	2.1	-1.3	-1.2	0.3	-0.5	-1.5	0.3
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.2	0.1	-1.1	0.8	-1.0	-0.9	-1.0
Number of children fathered	0.7	0.8	2.6	-0.1	-0.7	1.6	0.0	1.1	-0.7
Emphysema/chronic bronchitis	0.7	0.8	1.8	-1.1	0.9	-0.3	0.2	-0.8	1.3
Leg fat-free mass (right)	0.7	3.7	9.7	0.6	-0.5	2.0	0.5	3.1	-2.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.2	1.0	0.1	-1.5	0.1	0.6	-1.0
Asthma (self-reported)	0.7	1.4	6.1	0.8	-2.5	-0.4	0.7	1.0	0.4
Osteoarthritis (self-reported)	0.7	0.8	2.1	0.8	-0.8	1.4	0.7	1.1	0.1
Whole body water mass	0.7	3.8	13.3	0.2	-0.2	1.0	0.8	3.6	-2.8
Leg predicted mass (right)	0.7	3.6	9.3	0.5	-0.5	2.0	0.4	3.0	-2.8
High cholesterol (Self-reported)	0.7	1.3	6.4	0.5	-0.1	2.5	-0.0	-0.5	0.8
Basal metabolic rate	0.7	4.1	13.7	0.3	-0.2	1.8	1.0	3.7	-2.5
Average weekly beer plus cider intake	0.7	1.1	1.9	0.9	0.2	1.4	1.1	1.1	1.1
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.4	-1.2	-1.0	0.1	-0.4	-1.5	0.6
Ulcerative Colitis (UC)	0.6	1.2	5.8	-0.1	-1.0	2.4	-0.3	-0.0	-0.2
Major Depression (MDD)	0.6	0.7	1.7	-0.3	-0.1	0.5	1.1	1.3	0.9
Bipolar Disorder (2011)	0.6	0.6	1.3	0.6	-0.1	1.1	0.7	0.8	0.7
Leg fat-free mass (left)	0.6	3.4	9.0	0.2	-0.8	1.8	0.4	3.0	-2.7
Medication: Levothyroxine sodium	0.6	1.0	2.5	0.8	-0.8	-1.6	1.0	1.2	0.2
Sitting height	0.6	4.1	13.6	1.4	2.2	0.4	2.0	3.7	-0.1
Leg predicted mass (left)	0.6	3.3	8.8	0.2	-0.8	1.7	0.4	3.0	-2.7
Alcohol usually taken with meals	0.6	1.0	4.8	-0.6	0.8	-2.2	-0.3	-0.6	0.2
Qualifications: None of the above	0.6	1.4	5.6	0.8	0.0	2.4	0.8	0.7	0.9
Trunk fat-free mass	0.6	3.2	12.2	0.1	-0.0	0.2	0.9	3.5	-2.5
Trunk predicted mass	0.6	3.3	12.3	0.2	-0.1	0.2	0.8	3.5	-2.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.6	-0.7	0.1	1.9	-0.8	-0.3	-0.4
Headache pain in last month	0.6	1.1	2.3	1.1	-0.7	-1.5	0.4	1.1	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.5	-0.3	-1.2	-1.1	-0.1	0.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.5	0.8	1.4	-0.2	1.4	1.6	0.9
Whole body fat-free mass	0.6	3.6	12.5	0.2	-0.3	1.0	0.8	3.5	-2.7
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.0	1.4	0.4	1.1	-0.9	-0.8	-0.7
Smoking status: Current	0.6	1.0	2.9	-0.4	0.5	1.3	0.4	1.7	-0.8
Guilty feelings	0.6	1.0	2.5	1.6	0.1	0.5	1.0	1.3	0.4
Ever taken oral contraceptive pill	0.6	0.7	1.5	0.3	1.2	-0.9	0.6	0.6	0.9
Commuting to job workplace: Public transport	0.6	0.7	2.1	1.5	0.8	-0.1	0.3	-0.0	1.1
Ever had prostate specific antigen (PSA) test	0.6	0.6	1.3	-0.3	1.2	1.1	-0.8	-0.8	-0.1
Basal cell carcinoma (self-reported)	0.6	0.7	2.2	-0.2	1.5	-0.7	-0.2	-1.0	0.6
Bipolar Disorder or Schizophrenia	0.5	1.2	4.7	-2.2	-0.2	1.2	-0.6	-0.3	0.5
Depressed Affect (Nagel 2018)	0.5	1.1	4.5	0.6	-0.0	0.5	1.2	2.1	0.3
Ovarian Cancer	0.5	0.7	2.3	0.8	-0.4	-0.5	0.7	1.5	-0.7
HbA1C	0.5	0.6	1.3	0.6	0.6	1.1	0.5	0.2	1.1
Ulcerative Colitis	0.5	0.7	2.5	0.9	-0.8	1.6	-0.3	0.2	-0.3
Sensitivity / hurt feelings	0.5	0.9	2.6	0.6	-1.6	-0.3	-0.6	-0.3	-1.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.0	0.5	-0.4	1.4	-0.3	-0.2	-0.9
Qualifications: A levels/AS levels or equivalent	0.5	1.0	5.1	-0.6	0.5	-2.3	-0.3	-0.3	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.4	0.8	-0.5	0.6	-0.6	0.1	-1.5
Length of working week for main job	0.5	0.6	1.2	-0.4	-0.9	1.1	-0.7	-0.1	-1.0
Birth weight of first child	0.5	1.0	3.0	-1.2	-0.2	-0.2	-1.1	-0.0	-1.7
Worry too long after embarrassment	0.5	0.9	1.5	0.1	-0.9	-0.8	-1.2	-1.2	-0.8
Medication: Ibuprofen	0.5	0.6	1.9	0.8	-0.8	0.5	-0.5	-0.1	-1.4
Mean time to correctly identify matches	0.5	1.0	4.3	-2.1	0.3	0.4	-0.5	-1.0	0.5
Pulse rate, automated reading	0.5	1.5	3.0	0.3	-1.7	-1.3	-1.1	-1.2	-1.4
Comparative height size at age 10	0.5	2.8	6.7	-0.9	0.3	-2.4	1.1	2.6	-1.6
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.4	0.7	0.1	0.1	1.2	0.8	1.0
Illnesses of father: High blood pressure	0.5	0.6	1.2	0.5	0.5	-0.5	1.1	0.8	1.0
Myopia	0.5	0.7	1.9	0.7	-0.4	-1.1	-0.6	-1.4	-0.2
Bipolar Disorder (2018)	0.4	0.7	2.8	-1.7	-0.7	-0.0	-0.7	-0.4	-0.2
Schizophrenia (2018)	0.4	0.9	2.6	-1.4	0.3	1.6	-0.2	-0.0	0.8
Alzheimer’s Disease (in mother)	0.4	0.5	1.5	0.9	-0.2	-1.2	-0.2	0.1	-0.8
Chronotype (morning person)	0.4	1.0	4.5	0.6	-1.0	-2.1	-0.1	-0.3	0.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	2.7	-0.2	0.5	1.6	0.2	0.2	0.2
Tense / ‘highly strung’	0.4	0.7	2.6	0.4	-1.0	1.6	0.4	0.5	-0.0
Wheeze or whistling in the chest in last year	0.4	0.7	1.9	0.9	-1.4	0.7	0.4	0.7	-0.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.6	-0.3	1.3	0.4	0.4	0.5	0.7
Number of full sisters	0.4	0.5	0.9	0.5	-0.7	-0.4	1.0	0.5	0.9
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.0	-0.9	-0.4	0.3	-0.6	-0.3	-1.0
Mood swings	0.4	0.8	3.3	0.4	-0.5	0.5	0.9	1.8	-0.1
Friendships satisfaction	0.4	0.4	1.1	-1.0	-1.1	0.1	-0.1	-0.5	0.5
Financial situation satisfaction	0.4	0.5	1.3	1.0	0.2	0.6	0.7	1.1	-0.2
Unable to work because of sickness or disability	0.4	0.6	2.6	0.6	1.6	0.6	0.3	0.3	0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	1.9	-0.5	0.4	1.4	-0.3	-0.2	-0.1
Blood White Count	0.3	2.2	10.7	-0.5	-3.3	-1.0	-0.7	-0.9	-0.0
Hearing difficulty/problems: Yes	0.3	0.5	0.6	0.7	-0.7	-0.6	-0.8	-0.6	-0.7
Medication for hormone replacement therapy	0.3	0.4	1.3	-0.5	-0.1	-1.1	-0.4	-0.7	0.3
Pack years adult smoking proportion	0.3	0.4	1.1	0.5	0.9	0.2	-0.6	0.2	-1.1
Number of live births	0.3	0.4	0.7	0.8	0.5	-0.7	0.3	0.5	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.2	1.1	0.3	-0.2	-0.5	-0.2	-0.5
Number of full brothers	0.3	0.4	1.0	0.1	0.9	0.2	0.8	1.0	0.2
Medication: Omeprazole	0.3	0.4	1.5	-0.7	0.4	1.2	0.2	0.1	-0.1
Medication: Seretide 50 evohaler	0.3	0.3	0.8	0.3	-0.9	0.2	0.3	0.9	-0.2
Supplements: Vitamin C	0.3	0.4	1.3	0.3	-0.6	-0.4	-0.2	0.4	-1.2
Loneliness, isolation	0.3	0.4	1.4	1.2	0.1	0.5	0.4	0.7	-0.1
Ever had bowel cancer screening	0.3	0.4	1.2	-1.1	0.7	0.2	-0.2	-0.7	0.3
Ever depressed for a whole week	0.3	0.3	0.7	-0.6	-0.1	-0.4	-0.8	-0.6	-0.6
Pack years of smoking	0.3	0.5	1.7	0.6	1.3	0.2	-0.2	0.5	-0.7
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.3	0.4	0.9	-1.5	-0.3	-0.1	-0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.6	0.7	1.3	-0.0	0.2	0.0	0.3
Lung FEV1/FVC ratio	0.2	0.9	2.6	-0.6	1.6	-0.2	0.8	0.1	1.2
Neuroticism	0.2	0.6	1.5	0.7	-1.2	0.4	-0.4	0.4	-0.9
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	-0.4	0.4	0.2	-0.3	-0.2	-0.7
Hand grip strength (right)	0.2	0.5	2.0	0.4	-0.1	-0.4	0.6	1.4	-0.1
Nervous feelings	0.2	0.4	0.5	0.7	-0.5	0.5	-0.6	-0.7	-0.4
Hearing difficulty/problems with background noise	0.2	0.4	1.3	1.1	0.4	0.3	0.5	0.4	0.6
Neuroticism score	0.2	0.4	0.6	0.8	-0.7	0.5	-0.2	0.6	-0.7
Hair/balding pattern: Pattern 3	0.2	0.3	1.1	0.1	1.0	0.5	-0.4	-0.4	0.0
Exposure to tobacco smoke at home	0.2	0.2	0.8	0.1	0.4	0.9	0.1	-0.4	0.1
Suffer from ‘nerves’	0.2	0.3	0.9	0.1	0.7	1.0	-0.4	-0.5	-0.0
Family relationship satisfaction	0.2	0.2	0.8	-0.9	-0.4	0.4	0.1	0.1	-0.3
Commuting to job workplace: Walk	0.2	0.3	0.9	0.2	0.2	-0.9	-0.1	-0.7	0.3
Irritability	0.2	0.4	0.9	-0.2	-0.6	-0.7	0.3	1.0	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	-0.1	0.4	0.8	0.5	0.7	-0.4
Alcohol drinker status: Previous	0.2	0.2	0.5	-0.5	-0.7	0.5	-0.2	-0.2	-0.3
Neuroticism (Nagel 2018)	0.1	0.3	0.9	0.0	-0.9	0.8	0.3	0.7	-0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	-0.6	0.2	-0.0	-0.2	-0.3	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.4	0.6	-0.0	0.5	0.3	0.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.5	0.0	0.5	0.7	-0.3	-0.4	0.3
Heart disease (siblings)	0.1	0.1	0.3	-0.1	-0.6	0.4	0.1	-0.0	-0.3
Tanning	0.0	0.5	1.2	0.0	-1.1	-0.4	-0.9	-0.3	-1.0
Risk taking	0.0	0.1	0.2	0.4	-0.0	-0.3	0.2	0.2	0.2

Hub : Genes

SIPA1

Models

Trait associations