Best TWAS P=2.27e-14 · Best GWAS P=5.56e-14 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Female) | KDM2B | 0.13 | 0.00 | lasso | 3 | 0.01 | 1.2e-01 | -7.4 | 7.6 | 2.3e-14 | -0.91 | 0.03 | 0.38 | TRUE |
| 2 | GTEx | Lung | KDM2B | 0.10 | 0.06 | lasso | 3 | 0.05 | 1.4e-04 | -7.3 | 7.3 | 2.2e-13 | -0.97 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Nerve Tibial | KDM2B | 0.08 | 0.04 | enet | 16 | 0.05 | 1.6e-04 | -7.4 | 5.3 | 1.3e-07 | -0.81 | 0.02 | 0.96 | FALSE |
| 4 | GTEx | Testis | RNF34 | 0.18 | 0.20 | lasso | 3 | 0.17 | 5.2e-08 | -7.4 | 7.3 | 2.3e-13 | -0.97 | 0.01 | 0.99 | TRUE |
| 5 | GTEx | Thyroid | KDM2B | 0.13 | 0.05 | enet | 20 | 0.05 | 8.1e-05 | -4.9 | 6.8 | 1.0e-11 | -0.91 | 0.02 | 0.98 | FALSE |
| 6 | METSIM | Adipose | WDR66 | 0.04 | 0.00 | blup | 341 | 0.01 | 1.4e-02 | -1.0 | -5.8 | 5.9e-09 | 0.18 | 0.05 | 0.04 | TRUE |