Best TWAS P=2.44e-08 · Best GWAS P=1.58e-07 conditioned to 0.445
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | PDXDC2P | 0.26 | 0.17 | lasso | 4 | 0.13 | 2.2e-05 | 4.8 | -5.3 | 1.2e-07 | -0.88 | 0.02 | 0.92 | FALSE |
2 | GTEx | Artery Aorta | SF3B3 | 0.05 | 0.01 | enet | 9 | 0.01 | 6.4e-02 | 5.2 | 5.1 | 2.7e-07 | 0.95 | 0.02 | 0.88 | FALSE |
3 | GTEx | Brain Cerebellum | PDPR | 0.23 | 0.06 | enet | 20 | 0.11 | 3.7e-04 | -4.3 | -5.5 | 4.2e-08 | -0.58 | 0.04 | 0.37 | FALSE |
4 | GTEx | Brain Cerebellum | RP11-296I10.3 | 0.20 | 0.03 | enet | 12 | 0.14 | 8.8e-05 | -4.4 | -5.3 | 1.3e-07 | -0.48 | 0.03 | 0.25 | FALSE |
5 | GTEx | Breast Mammary Tissue | RP11-296I10.6 | 0.31 | 0.30 | enet | 17 | 0.30 | 7.1e-16 | -4.3 | -5.1 | 2.8e-07 | -0.74 | 0.11 | 0.84 | FALSE |
6 | GTEx | Breast Mammary Tissue (Female) | PDXDC2P | 0.44 | 0.14 | enet | 16 | 0.16 | 1.9e-05 | -5.0 | -5.2 | 1.7e-07 | -0.78 | 0.02 | 0.94 | FALSE |
7 | GTEx | Colon Sigmoid | PDXDC2P | 0.30 | 0.16 | enet | 13 | 0.14 | 8.8e-06 | 4.5 | -5.5 | 3.1e-08 | -0.82 | 0.04 | 0.93 | FALSE |
8 | GTEx | Colon Sigmoid | RP11-296I10.6 | 0.32 | 0.33 | enet | 20 | 0.33 | 2.2e-12 | -4.4 | -5.2 | 1.5e-07 | -0.79 | 0.08 | 0.88 | FALSE |
9 | GTEx | Esophagus Gastroesophageal Junction | RP11-296I10.6 | 0.26 | 0.22 | enet | 15 | 0.20 | 7.9e-08 | -4.4 | -5.6 | 2.4e-08 | -0.87 | 0.04 | 0.93 | TRUE |
10 | GTEx | Esophagus Muscularis | SF3B3 | 0.05 | 0.02 | enet | 19 | 0.02 | 2.7e-02 | -3.9 | 5.1 | 3.1e-07 | 0.67 | 0.09 | 0.40 | FALSE |
11 | GTEx | Stomach | RP11-296I10.6 | 0.24 | 0.15 | enet | 14 | 0.16 | 4.5e-08 | -4.4 | -5.4 | 6.3e-08 | -0.70 | 0.12 | 0.83 | FALSE |
12 | GTEx | Thyroid | PDXDC2P | 0.41 | 0.27 | lasso | 10 | 0.30 | 5.0e-23 | 4.8 | -5.4 | 7.2e-08 | -0.87 | 0.02 | 0.97 | FALSE |
13 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | AARS | 0.10 | 0.09 | lasso | 2 | 0.06 | 7.6e-03 | 4.8 | 5.4 | 6.4e-08 | 0.88 | 0.00 | 0.35 | FALSE |