TWAS hub - PDPR

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2290	0.0960	0.00065	0.059	NA	0.111	NA	0.019	0.0082	NA	3.7e-04	NA	0.090
2	YFS	Blood	0.0188	0.0091	0.00032	-0.001	0.009	0.014	0.01	0.002	0.9100	0.00048	1.8e-05	3e-04	0.086

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Arm fat percentage (left)	19.2	76.7	89.5	-9.5	8.0
Arm fat percentage (right)	18.2	71.6	82.3	-9.1	7.8
BMI	17.3	100.4	130.0	-11.4	8.4
Body mass index (BMI)	15.0	64.1	77.9	-8.8	7.1
Body fat percentage	13.9	55.0	70.4	-8.4	6.3
Leg fat percentage (right)	12.4	44.8	62.7	-7.9	5.2
Arm fat mass (left)	12.4	51.1	61.3	-7.8	6.4
Trunk fat percentage	12.3	49.2	60.5	-7.8	6.2
Arm fat mass (right)	12.2	50.2	61.6	-7.8	6.2
Leg fat percentage (left)	12.1	43.7	57.8	-7.6	5.4
Whole body fat mass	10.8	45.3	59.0	-7.7	5.6
Leg fat mass (right)	10.7	41.4	55.4	-7.4	5.2
Waist circumference	10.5	38.3	52.7	-7.3	4.9
Serious illness, injury or assault to yourself	10.2	12.4	15.1	-3.9	3.1
Leg fat mass (left)	10.0	39.1	50.8	-7.1	5.2
Hip circumference	9.7	41.6	57.5	-7.6	5.1
Trunk fat mass	9.4	40.2	51.1	-7.2	5.4
Medication for cholesterol, blood pressure or diabetes	7.6	12.5	17.7	4.2	-2.7
Falls in the last year	7.3	9.9	12.4	-2.7	3.5
Hypertension (Self-reported)	6.9	19.0	30.0	-5.5	2.8
Cardiovascular Disease	6.5	21.5	27.6	-5.2	3.9
Medication: Simvastatin	6.2	9.2	11.2	-3.3	2.7
High blood pressure	6.1	16.9	27.1	-5.2	2.6
High blood pressure (siblings)	6.0	8.7	11.7	-3.4	2.4
Worrier / anxious feelings	5.9	11.2	16.5	2.4	-4.1
Pack years adult smoking proportion	5.7	8.7	11.1	-3.3	2.5
Forced vital capacity (FVC), Best measure	5.6	20.4	29.4	3.4	-5.4
Medication: Cholesterol lowering	5.5	8.5	9.7	-3.1	2.7
Number of self-reported non-cancer illnesses	5.5	9.5	14.9	-3.9	2.0
Supplements: Vitamin C	5.4	6.4	7.8	2.8	-2.2
Pack years of smoking	5.4	8.0	9.8	-3.1	2.5
Medication: Atenolol	5.3	6.6	8.7	-2.1	2.9
Alzheimer’s Disease (in father)	5.2	5.6	7.1	2.7	-2.0
Alcohol intake versus 10 years previously	5.2	7.7	15.4	-3.9	0.1
Systolic blood pressure, automated reading	5.1	14.8	28.0	-5.3	1.2
High cholesterol (Self-reported)	5.1	9.1	12.5	-3.5	2.4
Illnesses of siblings	5.0	7.0	10.6	3.2	-1.8
Diabetes diagnosed by doctor	5.0	8.1	8.2	-2.9	2.8
Impedance of leg (left)	4.8	23.4	28.6	4.3	-5.3
Standing height	4.8	47.9	48.6	6.9	-7.0
Type 2 Diabetes (T2D) (2018)	4.7	8.8	11.6	-3.4	2.5
Impedance of leg (right)	4.5	22.0	29.5	3.8	-5.4
Pulse rate, automated reading	4.4	14.3	17.0	-3.4	4.1
Weight	4.3	21.0	29.1	-5.4	3.6
Medication: Blood pressure	4.3	7.5	11.8	-3.4	1.8
Vascular/heart problems diagnosed by doctor	4.3	11.7	16.9	4.1	-2.6
Height	4.2	81.7	92.2	8.4	-9.6
Nervous feelings	4.2	7.8	9.1	3.0	-2.5
Alcohol intake frequency.	4.2	9.7	15.6	-3.9	2.0
Breast Cancer	4.1	9.9	15.1	2.2	-3.9
Forced vital capacity (FVC)	4.1	15.9	20.3	3.4	-4.5
Alcohol drinker status: Never	4.1	4.9	9.6	-3.1	0.5
Number of full brothers	4.0	5.0	9.7	-3.1	-0.5
Diabetes (mother)	3.9	4.9	5.5	-2.3	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	3.7	11.9	16.2	2.7	-4.0
Illnesses of father: None of the above (group 1)	3.6	4.4	7.3	1.3	-2.7
Worry (Nagel 2018)	3.5	7.3	9.7	2.2	-3.1
Maternal smoking around birth	3.5	5.1	8.5	-1.3	2.9
Comparative body size at age 10	3.5	9.8	15.0	-2.1	3.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.5	4.1	6.7	2.6	-1.2
Medication: Bendroflumethiazide	3.5	5.3	10.3	-3.2	0.5
Diabetes (self-reported)	3.4	5.3	6.2	-2.5	2.1
Happiness	3.4	4.1	7.2	1.0	-2.7
Long-standing illness, disability or infirmity	3.4	5.1	6.3	-2.0	2.5
Illnesses of father: High blood pressure	3.3	4.1	5.9	-2.4	1.5
Bipolar Disorder (2018)	3.2	5.1	5.1	-2.2	2.3
Neuroticism	3.2	7.7	12.0	1.8	-3.5
Number of treatments/medications taken	3.2	5.7	6.2	-2.5	2.3
Stomach or abdominal pain in last month	3.2	4.0	4.7	2.2	-1.8
Sitting height	3.2	23.0	24.9	4.6	-5.0
Crohns Disease (2012)	3.1	5.0	10.1	0.2	3.2
Medication: Metformin	3.1	4.4	7.3	-2.7	1.3
Relative age voice broke	3.1	4.8	5.1	2.2	-2.1
Birth weight of first child	3.1	5.6	11.3	3.4	0.1
Age when periods started (menarche)	3.0	7.2	9.0	2.3	-3.0
Knee pain experienced in last month	3.0	4.7	8.1	-2.8	1.2
Illnesses of siblings: Diabetes	3.0	3.7	5.2	-2.3	1.5
Eye problems/disorders: Cataract	3.0	3.4	6.1	-2.5	0.9
Mean Putamen Volume	2.9	3.4	3.6	-1.9	1.8
Neuroticism score	2.9	6.0	8.9	1.8	-3.0
Pulse rate	2.9	4.9	5.0	-2.2	2.2
Friendships satisfaction	2.9	3.6	6.9	0.5	-2.6
Supplements: Calcium	2.9	3.1	5.6	2.4	0.8
Triglycerides	2.8	4.6	8.7	-0.7	2.9
Hand grip strength (left)	2.8	7.4	7.7	2.7	-2.8
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	5.7	0.6	-2.4
Birth weight	2.8	6.1	6.9	2.6	-2.3
Shortness of breath walking on level ground	2.8	3.4	3.9	-2.0	1.7
Crohns Disease (2017)	2.7	6.0	10.2	-1.3	3.2
Chronic bronchitis/emphysema (father)	2.7	3.1	4.5	-2.1	1.3
Alzheimer’s Disease (including proxy)	2.6	3.7	6.1	1.1	-2.5
Eye problems/disorders: Diabetes related eye disease	2.6	2.9	5.2	-0.7	2.3
Hand grip strength (right)	2.6	7.1	7.5	2.6	-2.7
Forced expiratory volume in 1-second (FEV1)	2.6	8.7	11.3	2.5	-3.4
Illnesses of mother	2.6	3.2	4.6	1.4	-2.1
Medication: Amlodipine	2.5	3.5	3.6	-1.8	1.9
Medication for hormone replacement therapy	2.4	2.7	2.9	1.7	-1.6
Diastolic blood pressure, automated reading	2.4	7.4	10.7	-3.3	2.0
Unable to work because of sickness or disability	2.4	3.1	3.3	-1.8	1.7
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	4.1	2.0	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.8	5.2	2.1	-2.3
Back pain experienced in last month	2.3	3.4	5.7	1.1	-2.4
Length of working week for main job	2.2	2.5	3.5	-1.9	1.2
Financial situation satisfaction	2.2	2.7	4.7	0.8	-2.2
Pain type(s) experienced in last month: Hip pain	2.2	2.8	5.1	-2.3	0.7
Irritable Bowel Disease (IBD)	2.1	5.1	9.5	-0.8	3.1
Systolic Blood Pressure	2.1	10.6	20.0	-4.5	1.1
Fluid intelligence score	2.1	4.4	5.2	-1.9	2.3
Loud music exposure frequency	2.1	2.3	4.2	0.6	-2.0
Wheeze or whistling in the chest in last year	2.1	3.8	5.6	-1.4	2.4
Medication: Blood pressure	2.1	3.9	6.8	-1.0	2.6
Ever had bowel cancer screening	2.0	2.4	4.2	2.1	-0.7
Impedance of whole body	2.0	10.0	11.2	3.3	-3.0
Father’s age at death	1.9	2.6	3.3	1.8	-1.3
Prospective memory result	1.9	2.3	2.9	1.3	-1.7
Illnesses of father: Heart disease	1.9	2.7	3.2	1.5	1.8
Osteoarthritis (self-reported)	1.9	2.5	4.3	-2.1	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.0	6.0	1.4	-2.4
Hearing difficulty/problems: Yes	1.8	2.8	3.4	-1.9	1.4
Severe depression (siblings)	1.8	2.0	3.4	-1.8	-0.8
Neuroticism (Nagel 2018)	1.7	4.0	6.6	1.2	-2.6
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	5.3	0.3	-2.3
Breastfed as a baby	1.7	2.2	4.2	2.0	-0.4
Body Mass Index (BMI) (2010)	1.6	2.2	4.0	-2.0	0.6
Sensitivity / hurt feelings	1.6	2.7	4.7	0.8	-2.2
Vitamin and mineral supplements	1.6	2.2	2.5	-1.6	1.3
Diabetes (father)	1.6	2.0	3.3	-1.8	0.8
Hayfever/allergic rhinitis (self-reported)	1.6	2.2	4.3	-0.1	-2.1
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	2.2	-1.2	1.5
Age at first live birth	1.6	2.9	5.5	2.3	-0.4
Handedness (chirality/laterality): Left-handed	1.6	2.0	2.6	1.2	-1.6
Guilty feelings	1.6	2.5	2.9	1.4	-1.7
Reaction Time	1.5	2.9	3.4	-1.6	1.9
Prostate Cancer	1.5	2.1	2.5	-1.3	1.6
Fasting Glucose	1.5	1.8	3.5	0.2	1.9
Relative age of first facial hair	1.5	3.1	3.9	2.0	-1.5
Qualifications: CSEs or equivalent	1.5	2.0	3.0	1.7	1.0
Hayfever, allergic rhinitis or eczema	1.5	3.3	6.2	0.6	-2.5
Supplements: Glucosamine	1.5	2.0	3.6	-1.9	0.6
Qualifications: None of the above	1.5	3.2	3.5	-1.7	-1.9
Osteoporosis (self-reported)	1.5	1.9	3.2	1.8	0.8
Blood White Count	1.4	10.5	15.6	-2.3	4.0
Average weekly fortified wine intake	1.4	1.6	2.3	1.5	-1.0
Hearing difficulty/problems with background noise	1.4	2.3	2.9	-1.3	1.7
Suffer from ‘nerves’	1.4	2.1	4.1	0.4	-2.0
Chest pain or discomfort	1.4	2.0	2.4	-1.2	1.6
Pain experienced in last month	1.4	2.3	3.4	1.1	1.8
Leg predicted mass (left)	1.3	6.6	7.6	-2.8	2.4
Hair/balding pattern: Pattern 3	1.3	1.9	2.8	-1.0	1.7
Tense / ‘highly strung’	1.3	2.1	3.5	0.9	-1.9
Gout (self-reported)	1.3	1.8	3.5	-1.9	0.3
Number of full sisters	1.3	1.6	2.9	-1.7	0.6
Mood swings	1.3	2.3	3.4	1.1	-1.8
Depressed Affect (Nagel 2018)	1.2	2.6	5.0	0.3	-2.2
Schizophrenia vs Biploar Disorder	1.2	1.5	1.6	1.2	-1.3
HDL Cholesterol	1.2	2.1	4.1	-0.0	-2.0
Allergy or Eczema	1.2	3.1	6.2	-0.1	-2.5
Hypothyroidism (self reported)	1.2	2.8	5.0	-0.8	2.2
Leg fat-free mass (left)	1.2	6.4	7.0	-2.6	2.4
Health satisfaction	1.2	1.6	3.1	0.3	-1.8
Loneliness, isolation	1.2	1.6	1.6	1.3	-1.3
Breast cancer (self-reported)	1.2	1.4	2.8	-1.7	0.1
Mother’s age at death	1.2	1.5	2.9	1.7	0.4
Lupus	1.1	1.6	1.6	1.3	-1.3
Ulcerative Colitis	1.1	1.7	3.3	0.3	1.8
Angina	1.1	1.4	2.7	0.3	1.7
High blood pressure (mother)	1.1	1.5	2.1	-1.4	1.0
Pulse wave reflection index	1.1	1.3	1.4	1.1	-1.2
Neck or shoulder pain in last month	1.1	1.5	2.1	-1.4	-1.0
Medication: Aspirin	1.1	1.4	1.9	-0.9	1.4
Age started oral contraceptive pill	1.1	1.4	2.3	0.7	-1.5
Neuroticism (2016)	1.0	1.4	2.0	0.9	-1.4
Fed-up feelings	1.0	1.8	3.7	-0.1	-1.9
Taking other prescription medications	1.0	1.5	2.3	-1.5	0.9
Chronic bronchitis/emphysema (mother)	1.0	1.2	1.6	-0.9	1.3
Qualifications: nursing, teaching	1.0	1.6	1.9	1.4	1.1
Average weekly champagne plus white wine intake	1.0	1.4	2.4	1.6	-0.6
Cholesterol lowering medication	1.0	1.5	1.9	-1.0	1.4
Alcohol drinker status: Previous	1.0	1.1	2.2	0.0	1.5
Blood Eosinophil Count	0.9	7.0	11.4	-3.4	1.6
Heel T-Score	0.9	7.3	13.9	-0.8	-3.7
Average weekly spirits intake	0.9	1.1	2.1	-1.5	0.4
Townsend deprivation index at recruitment	0.9	1.2	1.9	-0.7	1.4
Past tobacco smoking	0.9	1.6	2.6	-0.8	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.9	-1.7	0.2
Noisy workplace	0.9	1.1	1.1	1.0	-1.1
Medication: Ventolin 100micrograms inhaler	0.9	1.1	1.8	1.3	-0.7
Angina (self-reported)	0.9	1.2	2.2	0.4	1.5
Leg fat-free mass (right)	0.9	4.8	5.2	-2.1	2.3
Leg predicted mass (right)	0.9	5.0	5.2	-2.2	2.3
Risk taking	0.9	1.3	2.6	0.2	1.6
Verbal and Numeric Reasoning (VNR)	0.8	1.8	3.6	-1.9	0.1
Age at First Birth	0.8	1.2	1.4	1.1	-1.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.1	0.8	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	3.3	-1.8	-0.4
Lung cancer (father)	0.8	0.9	1.7	-1.3	0.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	1.9	-1.0	1.4
Mean time to correctly identify matches	0.8	1.5	1.8	-1.4	1.1
Overall health rating	0.8	1.7	3.1	-1.8	0.5
Medication: Aspirin	0.8	1.0	1.3	-0.9	1.1
Medication: Gliclazide	0.8	0.9	0.9	-0.9	1.0
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.4	1.2	-0.8
Alzheimer’s Disease (in mother)	0.7	0.8	1.0	-0.8	-1.0
Ulcerative Colitis (UC)	0.7	1.3	2.5	-0.1	1.6
Rheumatoid Arthritis	0.7	0.9	1.7	0.4	1.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.7	-0.1	-1.3
Medication: Levothyroxine sodium	0.7	1.2	1.9	-1.4	0.7
Allergy	0.7	1.6	3.3	-0.1	1.8
Exposure to tobacco smoke outside home	0.7	0.9	1.0	0.9	-1.0
Pulse wave peak to peak time	0.7	0.8	1.4	1.2	-0.5
Eye problems/disorders: None of the above	0.7	0.9	1.0	0.9	-1.0
Medication: Allopurinol	0.7	0.9	1.7	-1.3	0.4
Heart disease (mother)	0.7	0.8	0.8	0.9	0.9
Smoking status: Previous	0.7	1.0	1.7	0.5	1.3
Commuting to job workplace: Walk	0.7	0.7	1.4	0.2	1.2
Fractured/broken bones in last 5 years	0.7	0.9	1.5	1.2	-0.5
Schizophrenia (2018)	0.6	1.2	2.3	1.5	-0.4
Major Depression (MDD)	0.6	0.8	1.0	-1.0	0.7
Bipolar Disorder (2011)	0.6	0.6	0.9	-0.6	0.9
LDL Cholesterol	0.6	1.0	1.1	-1.0	0.9
Chronotype (morning person)	0.6	1.5	2.9	0.2	-1.7
Ever had hysterectomy (womb removed)	0.6	0.7	0.9	-1.0	0.6
Alcohol usually taken with meals	0.6	1.0	1.1	1.0	-1.0
Pain all over the body in last month	0.6	0.7	1.2	-1.1	0.3
Time employed in main current job	0.6	0.7	0.9	1.0	-0.8
Peak expiratory flow (PEF)	0.6	1.5	2.7	1.6	-0.5
Number of children fathered	0.6	0.7	1.4	-0.0	-1.2
Medication: Ibuprofen	0.6	0.8	0.8	-0.9	0.9
Medication: Seretide 50 evohaler	0.6	0.7	1.3	-0.2	1.1
Had major operations	0.6	0.7	1.3	-1.2	0.1
Age at last live birth	0.6	0.9	1.7	1.3	-0.4
Leg pain on walking	0.6	0.7	1.4	-1.2	0.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.2	-0.5	1.1
Average weekly red wine intake	0.6	0.9	1.5	1.2	-0.6
Miserableness	0.6	1.1	1.8	0.7	-1.3
Medication: Lisinopril	0.6	0.7	0.8	-0.8	0.9
Irritability	0.6	0.9	1.9	0.1	-1.4
Blood Platelet Count	0.5	6.2	10.3	3.2	1.5
Blood Red Count	0.5	4.9	8.3	-2.9	1.2
Lung FEV1/FVC ratio	0.5	2.6	4.8	-2.2	0.6
Lung FVC	0.5	2.5	5.0	-0.0	-2.2
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.0	1.0	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	1.9	-1.4	-0.6
Had menopause	0.5	0.7	1.1	0.5	-1.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	0.4	1.0
Financial difficulties in last 2 years	0.5	0.7	1.1	-1.1	0.6
Heart attack	0.5	0.7	1.1	0.5	1.1
Number of live births	0.5	0.7	1.4	0.3	-1.2
Glaucoma (self-reported)	0.5	0.5	1.0	-0.2	-1.0
Worry too long after embarrassment	0.5	0.8	1.3	-0.5	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.9	-0.5	-1.0
Medication: Omeprazole	0.5	0.6	1.2	-1.1	-0.1
Comparative height size at age 10	0.5	2.7	4.9	0.6	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	0.9	0.4	-0.9
Commuting to job workplace: Public transport	0.5	0.6	1.1	1.0	-0.3
Basal metabolic rate	0.5	2.6	4.3	-2.1	0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.6	0.8	0.7	0.9
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.3	0.3	1.1
Heart disease (siblings)	0.5	0.7	1.3	0.1	1.1
Depression (Nagel 2018)	0.4	0.6	1.1	0.4	-1.1
Mouth/teeth dental problems	0.4	0.6	0.7	-0.8	0.8
Depression (self-reported)	0.4	0.4	0.5	-0.7	-0.6
Exposure to tobacco smoke at home	0.4	0.5	1.0	-1.0	0.1
Blood clot in the leg (DVT)	0.4	0.5	0.9	-0.0	1.0
Medication for pain relief, constipation, heartburn	0.4	0.7	1.2	1.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.7	0.9	0.6
Family relationship satisfaction	0.4	0.5	0.8	-0.9	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.8	-0.4	-0.9
Commuting to job workplace: Cycle	0.4	0.5	0.9	0.2	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	-0.9	-0.4
Bipolar Disorder or Schizophrenia	0.3	0.6	1.2	-0.3	1.1
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.4	-1.2	0.4
Ovarian Cancer	0.3	0.5	0.9	1.0	0.1
Supplements: Zinc	0.3	0.3	0.5	0.7	0.4
Impedance of arm (right)	0.3	1.2	2.0	1.4	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.5	-0.7	0.5
Pulse wave Arterial Stiffness index	0.3	0.4	0.7	-0.9	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.5	-0.7	0.6
Hair/balding pattern: Pattern 4	0.3	0.6	0.8	-0.9	0.7
Qualifications: College or University degree	0.3	0.8	1.5	0.4	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.8	0.9	-0.0
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.8	-0.9	-0.1
Medication: Paracetamol	0.3	0.5	0.9	-1.0	0.3
Ever smoked	0.3	0.5	0.7	0.8	0.6
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.5	-0.7	-0.4
Primary Biliary Cirrhosis	0.2	0.3	0.3	0.5	-0.5
Waist Hip Ratio (WHR)	0.2	0.9	1.0	0.8	-1.0
Smoking Status	0.2	0.5	0.9	0.9	-0.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	0.8	-0.1
Hair/balding pattern: Pattern 2	0.2	0.3	0.4	0.7	-0.4
Medication: Ramipril	0.2	0.2	0.4	-0.7	-0.2
Trunk fat-free mass	0.2	1.4	2.7	0.3	-1.6
Medication: Lansoprazole	0.2	0.2	0.2	0.4	0.5
Impedance of arm (left)	0.2	0.7	1.1	1.0	-0.6
Trunk predicted mass	0.2	1.4	2.6	0.3	-1.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.7	0.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	0.3	-0.5	0.4
Headache pain in last month	0.2	0.3	0.5	-0.7	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.6	-0.2
Migraine (self-reported)	0.2	0.3	0.5	-0.7	0.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.4	0.5	-0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.2	-0.6
Myopia	0.2	0.3	0.3	0.5	-0.5
Coronary Artery Disease (CAD)	0.1	0.1	0.1	0.1	0.4
HbA1C	0.1	0.1	0.2	-0.5	0.1
Schizophrenia (2014)	0.1	0.3	0.6	0.8	-0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.4	-0.3
Respiratory disease	0.1	0.3	0.5	0.7	0.0
Hair Pigment	0.1	4.2	6.9	2.6	-1.3
Current tobacco smoking	0.1	0.2	0.3	-0.5	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	0.5	-0.3
Multivitamins +/- minerals	0.1	0.1	0.2	0.5	0.0
Number of incorrect matches in round	0.1	0.1	0.3	-0.0	-0.5
Had other major operations	0.1	0.1	0.2	0.5	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.2	0.3	0.5
Mouth/teeth dental problems: Dentures	0.1	0.3	0.4	0.3	0.7
Asthma	0.1	0.3	0.6	0.8	-0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.4	0.1
Medication: Paracetamol	0.1	0.2	0.3	-0.6	0.2
Arm fat-free mass (right)	0.1	0.4	0.8	-0.3	-0.9
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.2	-0.5	0.4
Emphysema/chronic bronchitis	0.1	0.1	0.1	0.3	-0.2
Arm predicted mass (right)	0.1	0.5	0.8	-0.5	-0.9
Whole body fat-free mass	0.1	0.3	0.6	-0.8	-0.1
Medication for cholesterol	0.1	0.2	0.2	-0.4	-0.4
Mineral and other dietary supplements	0.1	0.1	0.2	-0.4	-0.1
Asthma (self-reported)	0.1	0.3	0.6	0.8	0.0
Smoking status: Current	0.1	0.2	0.3	-0.1	-0.6
Wears glasses or contact lenses	0.1	0.1	0.3	-0.5	0.1
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.0	0.5
Hearing aid user	0.1	0.1	0.2	-0.0	-0.5
Medication: Atorvastatin	0.1	0.1	0.1	0.3	0.3
Arm fat-free mass (left)	0.1	0.3	0.4	-0.5	-0.6
Number of operations (self-reported)	0.1	0.2	0.3	-0.6	-0.0
Average weekly beer plus cider intake	0.1	0.2	0.4	0.1	-0.6
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.3	-0.4
Tanning	0.0	0.3	0.4	0.4	0.6
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	-0.3	-0.1
Medication: Co-codamol	0.0	0.0	0.0	0.2	0.0
Whole body water mass	0.0	0.3	0.5	-0.7	-0.1
Ever depressed for a whole week	0.0	0.0	0.1	0.0	0.3
Arm predicted mass (left)	0.0	0.3	0.3	-0.5	-0.5

Hub : Genes

PDPR

Models

Trait associations