Best TWAS P=1.16e-08 · Best GWAS P=8.51e-09 conditioned to 0.257
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | FBF1 | 0.36 | 0.29 | lasso | 2 | 0.29 | 5.4e-24 | -5.6 | -5.7 | 1.5e-08 | 0.89 | 0.00 | 1.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | MRPL38 | 0.08 | 0.07 | lasso | 4 | 0.06 | 9.3e-06 | -4.7 | 5.2 | 2.0e-07 | -0.88 | 0.04 | 0.95 | FALSE |
3 | GTEx | Adipose Visceral Omentum | FBF1 | 0.29 | 0.23 | lasso | 1 | 0.22 | 1.4e-11 | -5.6 | -5.6 | 2.1e-08 | 0.88 | 0.00 | 1.00 | FALSE |
4 | GTEx | Artery Aorta | FBF1 | 0.32 | 0.27 | lasso | 2 | 0.26 | 2.2e-14 | -5.6 | -5.5 | 2.9e-08 | 0.89 | 0.00 | 1.00 | FALSE |
5 | GTEx | Artery Coronary | FBF1 | 0.41 | 0.18 | lasso | 8 | 0.14 | 2.2e-05 | -5.6 | -5.1 | 2.8e-07 | 0.86 | 0.00 | 0.99 | FALSE |
6 | GTEx | Artery Tibial | FBF1 | 0.36 | 0.33 | enet | 12 | 0.33 | 3.7e-26 | -5.6 | -5.5 | 4.1e-08 | 0.92 | 0.00 | 1.00 | FALSE |
7 | GTEx | Breast Mammary Tissue | FBF1 | 0.15 | 0.20 | lasso | 3 | 0.19 | 6.9e-10 | -5.6 | -5.6 | 2.0e-08 | 0.89 | 0.00 | 1.00 | FALSE |
8 | GTEx | Colon Transverse | FBF1 | 0.28 | 0.21 | lasso | 3 | 0.19 | 2.8e-09 | -5.6 | -5.6 | 2.1e-08 | 0.86 | 0.00 | 1.00 | FALSE |
9 | GTEx | Esophagus Gastroesophageal Junction | FBF1 | 0.33 | 0.16 | lasso | 6 | 0.13 | 2.3e-05 | -4.7 | -5.2 | 2.5e-07 | 0.84 | 0.01 | 0.99 | FALSE |
10 | GTEx | Esophagus Muscularis | FBF1 | 0.34 | 0.33 | lasso | 3 | 0.32 | 5.5e-20 | -5.6 | -5.7 | 1.4e-08 | 0.88 | 0.00 | 1.00 | FALSE |
11 | GTEx | Lung | FBF1 | 0.20 | 0.18 | lasso | 1 | 0.17 | 2.6e-13 | -5.6 | -5.6 | 2.1e-08 | 0.88 | 0.00 | 1.00 | FALSE |
12 | GTEx | Pituitary | FBF1 | 0.34 | 0.37 | lasso | 4 | 0.39 | 7.6e-11 | -5.6 | -5.4 | 7.6e-08 | 0.89 | 0.00 | 1.00 | FALSE |
13 | GTEx | Prostate | FBF1 | 0.26 | 0.24 | lasso | 1 | 0.20 | 1.2e-05 | -5.6 | -5.6 | 2.1e-08 | 0.88 | 0.00 | 0.99 | FALSE |
14 | GTEx | Skin Sun Exposed Lower leg | TRIM47 | 0.09 | 0.03 | lasso | 3 | 0.03 | 1.5e-03 | -5.5 | 5.5 | 4.6e-08 | -0.89 | 0.01 | 0.99 | FALSE |
15 | GTEx | Skin Sun Exposed Lower leg | FBF1 | 0.22 | 0.23 | lasso | 1 | 0.21 | 3.0e-17 | -5.6 | -5.6 | 2.1e-08 | 0.88 | 0.00 | 1.00 | FALSE |
16 | GTEx | Stomach | FBF1 | 0.28 | 0.17 | enet | 12 | 0.17 | 1.5e-08 | -5.6 | -5.7 | 1.2e-08 | 0.94 | 0.00 | 1.00 | TRUE |
17 | GTEx | Testis | FBF1 | 0.37 | 0.38 | lasso | 2 | 0.38 | 8.4e-18 | -5.6 | -5.6 | 1.9e-08 | 0.88 | 0.00 | 1.00 | FALSE |
18 | GTEx | Thyroid | TRIM65 | 0.19 | 0.11 | lasso | 2 | 0.09 | 3.5e-07 | -5.6 | -5.3 | 8.8e-08 | 0.85 | 0.01 | 0.99 | FALSE |
19 | GTEx | Thyroid | FBF1 | 0.24 | 0.23 | lasso | 2 | 0.23 | 8.0e-18 | -5.6 | -5.4 | 8.6e-08 | 0.87 | 0.00 | 1.00 | FALSE |