Hub : Genes

TRIM47

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1540 0.0370 9.1e-10 0.116 0.089 0.145 0.126 0.134 5.4e-14 6.2e-11 2.8e-17 4.2e-15 5.0e-16
2 GTEx Brain Cerebellar Hemisphere 0.2620 0.0930 3.7e-03 0.085 NA 0.110 NA 0.102 3.5e-03 NA 9.3e-04 NA 1.4e-03
3 GTEx Brain Cerebellum 0.3030 0.0940 2.5e-04 0.168 NA 0.105 NA 0.169 1.1e-05 NA 5.2e-04 NA 1.1e-05
4 GTEx Cells EBV-transformed lymphocytes 0.4160 0.1190 3.3e-03 0.072 NA 0.055 NA 0.064 2.4e-03 NA 7.1e-03 NA 4.0e-03
5 GTEx Skin Sun Exposed Lower leg 0.0870 0.0330 1.7e-03 0.033 NA 0.024 NA 0.030 8.8e-04 NA 3.8e-03 NA 1.5e-03
6 TCGA Lung Adenocarcinoma 0.0352 0.0230 2.7e-03 0.010 0.028 0.017 NA 0.017 2.3e-02 2.7e-04 4.2e-03 NA 3.5e-03
7 TCGA Prostate Adenocarcinoma 0.0380 0.0247 1.4e-03 0.031 0.021 0.021 NA 0.026 2.9e-04 2.7e-03 2.6e-03 NA 9.5e-04
8 TCGA Thyroid Carcinoma 0.0640 0.0310 3.0e-06 0.057 0.060 0.044 NA 0.054 2.8e-06 1.6e-06 4.0e-05 NA 5.6e-06
9 TCGA Uterine Corpus Endometrial Carcinoma 0.2180 0.0870 1.5e-04 0.130 0.122 0.171 NA 0.163 1.8e-04 2.8e-04 1.7e-05 NA 2.7e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.3 0.4 1.3 -0.6 -0.7 -0.7 -0.2 -0.1 -1.1 0.0 -0.3 -1.0
Bipolar Disorder or Schizophrenia 1.3 3.1 5.7 -2.0 -2.1 -2.2 2.4 -0.8 -1.8 -1.7 -0.6 1.2
Depressed Affect (Nagel 2018) 1.3 2.7 8.9 0.3 -0.4 0.0 0.9 2.3 0.3 1.3 2.6 3.0
Depression (Nagel 2018) 0.4 0.6 1.2 -0.6 -1.0 -0.5 0.7 0.8 -0.5 0.4 1.1 0.9
Intelligence (Savage-Jansen 2018) 1.1 3.5 17.7 -0.8 -0.6 -0.7 -0.6 -1.9 -1.2 -0.6 -2.5 -4.2
Neuroticism (Nagel 2018) 0.8 1.9 7.8 0.7 0.3 0.6 0.1 1.5 0.4 1.8 1.7 2.8
Schizophrenia (2018) 2.2 4.5 11.5 -2.1 -2.2 -2.3 3.4 -1.0 -1.4 -2.4 -0.5 2.4
Schizophrenia vs Biploar Disorder 0.3 0.4 1.2 0.2 -0.5 -0.1 1.1 -0.3 0.4 -1.0 0.0 0.7
Worry (Nagel 2018) 2.9 6.1 11.3 2.3 2.0 2.4 -1.5 2.2 1.9 3.4 2.7 3.2
Alzheimer’s Disease (in mother) 1.3 1.6 3.0 -1.6 -1.7 -1.6 1.5 -0.6 -1.2 -1.2 -0.3 0.1
Alzheimer’s Disease (in father) 2.3 2.5 5.0 -1.6 -1.5 -1.8 0.8 -0.9 -2.2 -1.3 -1.7 -1.7
Alzheimer’s Disease (including proxy) 1.2 1.7 3.2 -1.6 -1.6 -1.7 1.2 -0.6 -1.8 -1.2 -0.7 -0.6
Crohns Disease (2017) 0.2 0.5 1.3 1.1 1.1 0.9 -0.7 0.6 0.3 0.3 0.3 0.0
Irritable Bowel Disease (IBD) 0.9 2.1 5.6 2.2 2.4 1.9 -1.5 0.4 1.0 1.1 -0.1 0.2
Ulcerative Colitis (UC) 0.9 1.7 4.5 1.9 2.1 1.7 -0.5 -0.3 0.9 0.7 -0.6 1.4
Major Depression (MDD) 0.4 0.4 0.7 -0.6 -0.8 -0.8 0.8 0.6 -0.7 -0.7 0.3 0.3
Reaction Time 0.2 0.3 1.5 -0.3 0.1 -0.3 0.4 -1.2 -0.2 -0.3 -0.5 0.7
Verbal and Numeric Reasoning (VNR) 1.0 2.3 12.2 -0.0 0.5 0.1 -1.2 -1.3 -1.0 0.3 -1.9 -3.5
Breast Cancer 2.6 6.2 15.7 2.5 1.9 2.5 -1.1 2.5 4.0 1.4 3.3 1.9
Ovarian Cancer 1.0 1.4 3.1 1.8 1.2 1.4 -1.4 0.2 1.7 0.9 0.4 0.0
Prostate Cancer 1.0 1.4 4.3 0.9 0.5 0.8 -0.5 2.1 1.1 1.1 1.9 0.0
Age at First Birth 0.1 0.2 0.8 0.5 0.5 0.6 -0.9 0.3 0.3 0.0 0.0 -0.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 2.2 3.0 5.5 -2.1 -1.5 -1.7 1.5 -2.2 -2.0 0.0 -2.3 -1.1
Coronary Artery Disease (CAD) 0.4 0.4 2.1 0.5 0.4 0.5 -0.4 1.4 -0.7 0.0 0.7 -0.2
Crohns Disease (2012) 0.2 0.4 1.1 0.2 0.3 0.2 -0.3 1.0 -0.7 1.1 0.5 -0.5
Mean Putamen Volume 0.8 0.9 1.6 1.0 0.9 0.8 -0.3 0.9 0.8 1.0 1.1 1.3
Fasting Glucose 1.1 1.3 2.6 1.5 1.3 1.5 -1.6 1.4 0.4 0.0 0.7 -0.3
HbA1C 0.1 0.1 0.2 0.3 -0.1 0.2 -0.3 0.5 -0.4 0.0 -0.2 -0.5
HDL Cholesterol 1.7 2.8 6.0 -2.0 -2.1 -1.8 1.6 -2.4 -1.2 0.0 -1.9 0.3
LDL Cholesterol 4.1 6.4 11.6 3.4 3.2 3.0 -3.2 2.5 2.3 0.0 2.1 0.6
Lupus 0.8 1.3 2.3 -1.5 -1.5 -1.4 1.3 -0.3 -0.8 -1.4 -0.1 0.6
Neuroticism (2016) 0.8 1.1 3.1 0.7 0.3 0.5 0.1 1.8 0.3 1.5 1.7 0.7
Primary Biliary Cirrhosis 1.0 1.5 3.3 0.8 0.8 1.0 -0.1 1.5 1.4 0.2 1.7 1.8
Rheumatoid Arthritis 4.2 5.7 10.5 -3.1 -2.5 -2.9 2.1 -1.9 -1.9 -3.2 -1.8 -1.4
Schizophrenia (2014) 1.5 3.4 6.6 -2.0 -2.0 -1.9 2.6 -1.0 -1.3 -2.1 -0.7 2.1
Triglycerides 1.7 2.8 5.2 1.9 2.1 2.1 -2.3 1.9 1.3 0.0 1.3 -0.3
Type 2 Diabetes (T2D) (2012) 0.4 0.5 2.0 0.6 1.0 0.7 -1.4 0.6 -0.4 0.0 0.1 -0.4
Ulcerative Colitis 0.8 1.2 2.5 1.4 1.6 1.3 -1.5 -0.0 0.4 1.5 -0.5 0.5
Blood Eosinophil Count 1.1 8.7 22.4 3.0 3.4 2.7 -2.3 4.7 1.0 3.3 3.2 0.8
Blood Platelet Count 1.8 20.7 36.1 4.4 5.0 4.2 -5.4 4.4 1.2 6.0 1.5 -6.0
Blood Red Count 0.3 3.3 15.4 0.8 1.2 1.1 0.5 -2.7 1.8 -0.2 -0.8 3.9
Blood White Count 0.7 5.5 13.8 2.0 2.7 2.2 -2.3 3.7 0.6 3.0 2.2 0.2
Heel T-Score 0.1 1.0 2.2 -0.7 -1.3 -1.3 1.5 0.7 -0.5 -1.3 0.8 -0.5
BMI 3.2 18.3 26.4 -5.0 -4.7 -5.1 4.1 -4.7 -4.6 -3.7 -4.0 -1.2
Height 0.3 5.6 15.9 -1.4 -0.9 -1.4 1.6 -3.2 -1.9 -3.1 -4.0 -1.7
Waist Hip Ratio (WHR) 1.6 7.0 14.8 2.1 1.8 2.4 -1.2 3.8 2.6 2.4 3.9 2.6
Systolic Blood Pressure 6.2 31.1 51.7 5.7 5.4 5.8 -5.7 7.2 5.2 6.0 6.1 0.5
Smoking Status 0.8 2.0 5.7 -1.7 -2.4 -2.0 1.4 0.1 -1.7 -0.8 0.1 -0.0
Allergy or Eczema 0.7 1.8 3.5 -1.2 -1.0 -1.4 1.1 -1.3 -1.9 -0.8 -1.5 -1.6
Cardiovascular Disease 6.0 19.7 41.9 4.4 4.2 4.3 -3.9 6.5 4.2 4.5 5.1 -0.7
Hypothyroidism (self reported) 4.5 10.2 25.3 -3.7 -5.0 -4.2 4.6 -1.6 -1.7 -2.9 -0.1 1.0
Respiratory disease 6.3 14.0 22.6 -4.8 -4.2 -4.3 4.3 -4.0 -2.9 -4.1 -2.6 0.4
Type 2 Diabetes (T2D) (2018) 0.8 1.4 5.2 -1.1 -1.3 -1.5 2.3 0.4 -1.0 -1.0 0.5 0.2
Lung FEV1/FVC ratio 0.2 0.8 1.5 -0.5 -0.4 -1.1 1.2 1.1 -1.2 -0.2 0.9 -0.9
Lung FVC 1.2 6.3 9.8 -2.8 -2.8 -2.7 1.7 -3.1 -2.2 -3.0 -2.6 0.1
Neuroticism 1.6 4.0 10.7 1.1 0.5 0.8 0.4 2.6 1.1 2.1 3.2 3.3
Chronotype (morning person) 2.8 6.6 12.2 3.0 3.1 3.2 -3.5 2.2 2.2 2.3 1.1 -1.4
Hair Pigment 0.5 13.5 27.1 4.1 4.4 4.5 -5.2 3.4 3.0 3.4 1.7 -1.9
Tanning 0.1 1.4 4.2 -0.6 -0.7 -1.1 1.0 -2.0 -0.9 -1.4 -1.6 0.0
Hand grip strength (left) 0.4 1.2 2.3 1.0 1.3 1.0 -1.0 1.5 1.0 0.4 0.6 -1.5
Number of treatments/medications taken 0.6 1.1 2.1 -1.1 -1.4 -1.5 0.8 0.6 -1.4 -0.1 0.4 -1.2
Average weekly spirits intake 0.6 0.7 1.9 1.0 0.3 0.9 -1.4 -0.5 0.9 -0.1 -0.8 -1.0
Sensitivity / hurt feelings 0.3 0.5 2.5 -0.3 -0.3 -0.4 0.3 1.6 -0.2 0.3 1.3 0.2
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.5 0.3 0.1 0.4 -0.4 1.2 -0.0 1.1 1.0 1.1
Hearing difficulty/problems: Yes 0.8 1.2 4.9 0.2 0.5 0.5 -1.6 0.8 -0.1 1.4 0.2 -2.2
Relative age of first facial hair 0.3 0.6 1.3 -0.2 -0.8 -0.6 1.2 1.0 -0.1 -0.6 0.9 -0.7
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 3.8 -2.0 -1.8 -1.6 1.3 -1.4 -0.8 -1.7 -1.1 -0.9
Ever used hormone-replacement therapy (HRT) 1.1 1.4 5.1 0.6 -0.1 0.3 -0.7 2.3 0.7 1.0 2.2 0.4
Ever had hysterectomy (womb removed) 0.6 0.7 2.1 -0.5 -0.8 -0.6 1.2 -0.7 -0.4 -1.5 -0.6 0.3
Systolic blood pressure, automated reading 1.8 5.2 12.4 2.1 1.9 2.1 -1.9 3.5 1.7 2.5 3.0 0.5
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 3.0 -1.5 -1.4 -1.5 1.7 -0.4 -0.4 -1.4 -0.1 0.0
Angina 0.7 0.9 2.0 -1.4 -1.3 -1.3 0.3 0.2 -0.8 -0.5 -0.1 -1.3
Medication for hormone replacement therapy 0.6 0.7 1.8 -0.6 -0.9 -1.3 1.0 0.7 -1.4 -0.1 0.2 -0.2
Vitamin and mineral supplements 0.2 0.3 0.7 0.4 0.3 0.4 0.4 0.5 0.7 -0.8 0.5 0.4
Supplements: Zinc 0.3 0.3 1.2 0.1 -0.5 -0.2 0.0 -0.2 0.8 -0.4 0.5 1.1
Medication: Co-codamol 2.2 2.5 6.0 -1.9 -1.9 -2.1 2.4 -0.0 -1.1 -1.7 0.4 0.8
Medication: Metformin 0.4 0.5 2.7 -0.5 -0.5 -0.8 1.6 0.4 -0.5 -0.5 0.1 -0.3
Diabetes (father) 1.2 1.5 3.5 0.7 0.7 1.1 -0.9 0.9 1.6 1.1 1.5 1.9
Diabetes (mother) 0.0 0.1 0.2 -0.5 0.2 -0.0 -0.0 -0.0 -0.4 -0.1 -0.2 -0.2
Severe depression (siblings) 2.0 2.2 3.3 -1.8 -1.6 -1.8 1.8 -1.4 -1.2 -1.3 -1.1 -1.3
Pack years adult smoking proportion 3.1 4.7 8.6 -2.4 -2.7 -2.1 2.5 -1.9 -1.1 -2.9 -1.3 1.8
Impedance of leg (right) 1.5 7.1 10.7 2.9 1.8 2.8 -2.1 3.0 3.3 3.2 3.2 0.2
Leg fat-free mass (left) 2.7 14.1 26.9 -3.7 -2.8 -3.6 2.4 -4.5 -4.3 -3.9 -5.2 -2.1
Trunk fat percentage 4.8 19.2 25.1 -5.0 -4.7 -5.0 3.6 -4.8 -5.0 -3.8 -4.6 -2.0
Hand grip strength (right) 0.2 0.6 2.0 0.8 0.9 0.6 -0.7 1.0 0.5 0.2 0.2 -1.4
Townsend deprivation index at recruitment 0.5 0.7 1.2 1.1 1.1 1.1 -0.6 0.2 0.7 0.8 0.2 1.1
Current tobacco smoking 1.2 1.9 4.0 -1.4 -1.9 -1.8 2.0 0.5 -1.1 -1.4 0.6 -0.4
Average weekly fortified wine intake 0.5 0.6 2.8 -0.7 -0.5 -0.4 -0.2 -1.7 -0.2 -0.5 -1.1 0.3
Maternal smoking around birth 2.5 3.6 8.5 -1.6 -1.9 -1.7 2.2 -2.9 -1.8 -1.5 -2.3 0.3
Fed-up feelings 1.4 2.6 6.4 1.0 0.3 0.7 0.2 2.5 0.5 1.9 2.5 2.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.8 -0.1 -0.2 -0.1 0.2 0.9 -0.3 0.3 0.7 0.3
Relative age voice broke 0.4 0.6 1.6 -0.7 -0.2 -1.0 0.9 0.2 -1.0 -0.4 -0.1 -1.3
Taking other prescription medications 1.4 2.2 4.5 -1.7 -2.0 -2.1 0.7 -0.6 -1.7 -0.5 -0.5 -2.1
Age when periods started (menarche) 0.1 0.1 0.5 -0.1 -0.2 0.3 -0.7 -0.2 0.3 0.6 -0.0 -0.2
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.3 -0.0 -0.6 -0.1 0.2 -0.4 0.3 -0.3 -0.1 0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.8 4.6 -2.0 -2.2 -2.1 2.0 -0.9 -1.5 -2.0 -0.5 -0.8
Tinnitus: Yes, but not now, but have in the past 3.1 3.3 6.2 -2.5 -2.4 -2.3 1.9 -0.7 -1.5 -2.1 -0.5 -1.2
Qualifications: CSEs or equivalent 2.7 3.6 5.9 2.4 1.9 2.4 -2.1 1.6 2.3 1.3 1.3 1.4
Serious illness, injury or assault to yourself 0.7 0.8 1.9 -0.9 -0.5 -0.3 -0.1 -1.2 -0.9 -0.4 -1.4 -1.4
High blood pressure 5.4 15.1 29.4 4.0 3.8 3.9 -3.7 5.4 3.5 4.1 4.3 -0.6
Hayfever, allergic rhinitis or eczema 2.3 4.9 7.0 -2.5 -2.1 -2.6 1.6 -2.3 -2.3 -1.9 -1.9 -2.5
Multivitamins +/- minerals 0.2 0.2 0.7 -0.2 -0.0 -0.3 -0.6 -0.4 -0.3 0.5 -0.6 -0.8
Stomach or abdominal pain in last month 0.4 0.5 1.5 0.2 -0.7 0.3 -0.4 1.2 0.4 0.4 0.9 -1.0
Supplements: Glucosamine 0.4 0.5 3.2 0.8 0.4 0.3 -0.1 0.3 0.2 -0.2 0.4 1.8
Diverticular disease/diverticulitis (self-reported) 0.1 0.2 0.5 -0.1 -0.7 -0.4 -0.0 0.5 -0.4 0.2 0.5 -0.4
Medication: Atenolol 4.7 5.9 12.9 2.1 2.2 2.0 -2.0 3.6 1.6 3.1 3.1 0.3
Medication: Levothyroxine sodium 2.9 4.8 13.8 -2.5 -3.7 -3.0 3.3 -0.1 -0.9 -1.2 1.2 0.6
Sitting height 0.2 1.3 2.9 1.1 1.6 0.9 -1.4 -1.0 -0.1 -0.1 -1.7 -1.2
Chronic bronchitis/emphysema (father) 0.5 0.6 3.4 -0.4 -0.4 -0.2 0.9 -0.1 0.6 -0.3 0.6 1.9
High blood pressure (mother) 2.3 3.2 7.2 1.8 1.7 1.9 -2.4 2.7 0.7 1.9 1.5 -0.5
Body mass index (BMI) 3.7 15.6 22.7 -4.7 -4.1 -4.6 3.2 -3.9 -4.8 -3.3 -4.1 -2.2
Impedance of leg (left) 1.4 7.0 12.8 2.7 1.7 2.6 -1.8 3.4 3.1 3.0 3.6 0.6
Leg predicted mass (left) 2.7 14.3 26.8 -3.7 -2.8 -3.7 2.5 -4.5 -4.4 -4.0 -5.2 -2.2
Trunk fat mass 4.8 20.5 26.4 -5.1 -4.6 -5.0 3.6 -4.9 -5.1 -4.2 -4.9 -2.4
Waist circumference 3.0 10.9 16.7 -4.1 -3.8 -4.0 3.2 -2.9 -3.5 -3.2 -2.7 -1.3
Number of incorrect matches in round 2.0 3.3 4.6 2.1 2.1 2.1 -1.6 2.0 1.8 1.6 1.8 0.6
Past tobacco smoking 0.2 0.4 0.9 0.5 0.6 0.4 0.5 0.1 0.9 -0.6 0.3 -1.0
Alcohol usually taken with meals 0.6 1.0 6.2 0.4 0.7 0.5 0.8 0.7 0.5 -0.3 0.9 2.5
Nervous feelings 2.6 4.9 12.1 2.1 1.9 2.3 -1.8 1.5 1.7 2.7 1.7 3.5
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 1.2 0.3 0.3 0.4 0.3 1.1 0.3 0.8 1.0 0.0
Hearing difficulty/problems with background noise 0.6 1.0 2.4 -0.8 -1.1 -0.8 1.2 -0.6 -0.5 -1.5 -0.2 1.5
Hair/balding pattern: Pattern 2 0.7 0.8 5.2 0.1 -0.1 0.2 0.8 0.1 1.0 0.0 0.7 2.3
Had menopause 0.1 0.2 0.6 -0.3 -0.8 -0.7 0.1 0.1 0.0 -0.3 0.3 -0.1
Had other major operations 0.1 0.2 0.5 0.0 0.1 -0.2 0.0 0.7 0.0 -0.0 0.6 -0.7
Forced vital capacity (FVC) 1.1 4.4 9.9 -1.6 -1.7 -1.7 0.9 -3.1 -1.3 -2.9 -3.0 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.5 3.6 -1.3 -1.6 -1.5 1.6 -0.2 -0.6 -1.9 0.2 0.0
Ever unenthusiastic/disinterested for a whole week 3.8 4.7 7.5 2.0 1.8 2.1 -2.1 2.6 2.0 2.7 2.7 0.3
Qualifications: None of the above 0.2 0.3 1.3 0.3 0.5 0.6 -0.5 -0.1 0.3 0.9 0.2 1.1
Financial difficulties in last 2 years 1.7 2.3 9.0 -1.2 -0.9 -1.2 0.6 -1.1 -1.7 -0.4 -1.8 -3.0
Mouth/teeth dental problems 0.3 0.5 1.2 0.6 0.5 0.9 -1.1 -0.2 1.1 0.1 -0.5 -0.3
Heart attack 1.3 1.7 4.5 0.9 1.0 0.9 -1.3 2.1 0.3 1.9 1.6 -0.3
Allergy 5.3 12.1 17.4 4.2 3.8 4.2 -3.2 3.9 3.1 3.6 3.0 1.6
Pain all over the body in last month 2.9 3.1 7.3 -1.6 -2.7 -2.0 2.4 -0.8 -0.6 -2.2 0.1 1.5
Diabetes (self-reported) 1.5 2.4 7.7 -1.7 -1.6 -2.1 2.8 -0.5 -0.9 -1.5 -0.0 -0.4
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.5 -0.8 -0.8 -1.0 0.4 0.2 -0.5 -0.4 0.2 -1.2
Medication: Ramipril 0.2 0.2 0.9 0.2 0.4 0.4 -0.3 0.4 -0.3 0.7 -0.3 -0.9
Medication: Simvastatin 3.3 4.9 11.6 2.2 2.2 2.1 -0.9 3.4 1.9 1.8 2.9 1.3
Fluid intelligence score 0.5 1.0 3.7 -0.1 0.3 -0.1 -0.7 -1.2 -0.8 -0.4 -1.6 -1.9
Illnesses of siblings 2.2 3.1 6.2 -1.4 -1.2 -1.4 1.6 -2.4 -1.0 -2.1 -2.5 -1.7
Neuroticism score 2.4 5.0 10.3 1.8 1.4 1.6 -0.5 2.8 1.8 2.4 3.2 3.1
Weight 3.4 16.6 22.7 -4.4 -3.8 -4.4 3.1 -4.3 -4.7 -3.9 -4.8 -2.8
Impedance of arm (right) 0.1 0.6 2.9 0.3 -0.4 0.3 0.1 -0.8 1.0 -0.3 0.4 1.7
Arm fat percentage (right) 5.7 22.6 30.6 -5.5 -5.1 -5.4 4.2 -5.1 -5.4 -4.4 -4.8 -1.7
Trunk fat-free mass 0.6 3.3 7.9 -1.5 -0.8 -1.5 0.8 -1.8 -2.2 -1.9 -2.8 -2.0
Hip circumference 5.5 23.5 29.9 -5.2 -5.0 -5.3 3.7 -5.3 -5.2 -4.7 -5.5 -3.3
Time employed in main current job 1.1 1.3 3.6 -1.7 -1.9 -1.3 0.7 -0.1 -0.2 -1.7 0.1 -0.3
Alcohol intake versus 10 years previously 3.2 4.9 13.3 1.5 0.9 1.2 -0.6 3.6 1.6 1.5 3.5 2.8
Father’s age at death 0.6 0.8 1.8 -0.5 -0.7 -0.6 1.1 -1.4 0.1 -1.1 -0.5 1.2
Worrier / anxious feelings 2.4 4.6 8.9 2.3 1.8 2.1 -0.5 2.3 1.8 2.3 2.4 3.0
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 2.0 -1.4 -1.4 -1.3 1.2 0.5 -1.2 -0.3 0.5 0.3
Falls in the last year 0.7 0.9 2.4 -1.2 -1.0 -1.1 -0.1 -0.5 -1.6 -0.2 -0.9 -1.0
Hair/balding pattern: Pattern 3 1.1 1.6 6.5 -0.7 -0.3 -1.0 0.2 -0.5 -2.1 0.1 -1.3 -2.5
Number of live births 1.6 2.2 6.5 -1.8 -1.3 -1.6 0.8 -1.7 -0.5 -2.5 -1.2 -0.9
Forced expiratory volume in 1-second (FEV1) 1.3 4.4 8.6 -1.8 -1.7 -1.9 1.3 -2.9 -1.6 -2.8 -2.9 -1.1
Pulse rate 0.4 0.6 3.1 -0.2 0.6 -0.2 -0.4 0.9 -1.1 -0.0 -0.2 -1.8
Happiness 0.8 1.0 3.5 0.1 -0.1 -0.0 -0.6 1.9 -0.2 1.3 1.7 0.8
Noisy workplace 0.3 0.4 1.1 -0.7 -0.6 -0.7 -0.1 0.8 -0.5 -0.3 -0.0 -1.0
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.6 -0.6 0.1 -0.4 -0.2 -0.8 -0.3 -0.6 -0.7 -0.8
Serious illness, injury or assault of a close relative in last 2 years 3.3 3.8 6.6 -2.1 -1.6 -2.0 1.3 -2.6 -1.9 -2.1 -2.4 -0.3
Mouth/teeth dental problems: Dentures 0.1 0.1 0.6 -0.2 -0.2 -0.2 0.0 0.2 -0.3 0.3 0.5 -0.8
Asthma 4.6 9.1 14.4 -3.6 -3.0 -3.2 3.5 -3.8 -2.5 -3.0 -2.8 -0.1
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.7 4.7 -1.5 -1.1 -1.6 1.6 0.4 -2.2 -0.4 -0.3 -1.1
Medication: Cholesterol lowering 1.6 2.5 7.0 1.7 1.8 1.7 -1.1 2.6 0.8 1.6 1.5 -0.4
Depression (self-reported) 0.3 0.4 1.0 -0.6 -0.9 -0.8 0.1 -0.1 -1.0 -0.5 -0.3 -0.0
Medication: Lansoprazole 0.8 0.9 1.4 -0.9 -1.0 -0.9 0.7 -0.8 -1.1 -0.9 -1.2 -1.0
Prospective memory result 3.0 3.7 4.9 1.9 2.1 1.9 -2.1 1.8 1.9 2.2 1.9 1.4
Lung cancer (father) 0.7 0.8 4.0 0.5 -0.1 0.5 0.3 0.7 1.1 -0.3 1.1 2.0
Illnesses of mother 0.9 1.1 2.2 -1.0 -1.0 -1.2 0.9 -1.5 -0.7 -0.9 -1.2 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.6 9.9 -2.0 -2.1 -2.3 1.9 -3.1 -2.0 -3.1 -3.0 -0.8
Pulse wave Arterial Stiffness index 0.2 0.3 1.7 -0.3 -0.0 -0.4 -0.3 0.4 -0.1 -0.2 0.3 -1.3
Impedance of arm (left) 0.1 0.3 1.5 0.3 -0.3 0.2 0.1 -1.2 0.6 -0.1 -0.3 0.9
Arm fat mass (right) 5.0 20.4 28.1 -5.1 -4.4 -5.0 3.5 -5.0 -5.3 -4.1 -5.1 -2.6
Trunk predicted mass 0.5 3.1 7.7 -1.4 -0.7 -1.4 0.7 -1.7 -2.1 -1.8 -2.8 -2.0
Standing height 0.1 1.1 3.5 0.4 0.7 0.3 -0.3 -1.1 -0.1 -1.2 -1.9 -1.6
Length of working week for main job 0.8 0.9 2.8 -0.8 -1.0 -1.0 1.3 -0.3 0.0 -1.7 -0.1 -0.8
Exposure to tobacco smoke at home 0.3 0.3 1.6 -0.2 -0.5 -0.2 0.2 1.2 -0.0 0.3 0.7 -0.7
Breastfed as a baby 0.4 0.5 1.0 0.5 0.4 0.6 -0.5 0.8 0.9 0.8 1.0 0.4
Tense / ‘highly strung’ 0.6 1.0 2.4 0.9 0.2 0.9 -0.5 0.3 1.1 1.5 1.1 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.5 -0.6 -1.1 -0.7 1.2 -0.2 0.3 -0.9 0.4 0.9
Hair/balding pattern: Pattern 4 2.4 5.8 11.0 2.4 2.4 2.3 -1.8 3.3 2.4 1.8 3.2 1.3
Birth weight of first child 2.7 4.9 7.4 2.7 2.6 2.7 -2.1 1.7 2.5 2.4 1.8 0.3
Peak expiratory flow (PEF) 1.1 2.5 5.1 -1.6 -1.7 -1.6 1.4 -1.8 -0.9 -2.2 -1.5 -0.9
Pulse wave reflection index 0.1 0.1 0.4 -0.4 -0.3 -0.3 -0.1 -0.2 0.3 -0.1 0.2 -0.6
Ever highly irritable/argumentative for 2 days 0.4 0.4 2.9 -0.3 -0.1 -0.1 -0.2 -0.4 0.0 0.7 -0.0 -1.7
Loud music exposure frequency 1.6 1.8 3.6 1.2 0.8 1.2 -1.2 1.9 0.9 1.9 1.6 -0.4
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 2.8 -0.3 0.7 0.1 -1.1 -1.1 -0.3 -0.3 -1.7 -1.6
Mouth/teeth dental problems: Bleeding gums 1.6 2.1 6.2 -1.6 -1.5 -1.6 2.5 -0.3 -1.6 -1.2 -0.1 1.0
Blood clot in the leg (DVT) 6.1 7.8 14.5 -3.3 -3.8 -3.4 3.1 -1.8 -2.1 -3.5 -1.0 1.7
Medication: Paracetamol 0.3 0.5 1.4 0.4 -0.3 -0.0 -0.5 1.1 -0.5 0.9 0.5 -1.2
Headache pain in last month 0.5 0.8 4.3 0.2 0.7 0.1 -0.8 -0.1 -0.9 0.6 -0.9 -2.1
Medication for cholesterol, blood pressure or diabetes 2.2 3.6 10.3 -1.9 -1.7 -1.8 0.7 -3.2 -1.5 -1.8 -2.5 -0.7
Glaucoma (self-reported) 1.1 1.3 2.9 1.5 1.7 1.5 -1.0 1.3 0.7 0.6 0.5 -0.4
Gout (self-reported) 0.6 0.9 4.4 0.5 -0.1 0.6 -0.4 -0.1 1.4 -0.3 0.7 2.1
Hypothyroidism/myxoedema (self-reported) 3.2 6.2 17.0 -2.9 -4.1 -3.5 3.4 -1.0 -1.2 -1.9 0.4 0.3
Medication: Amlodipine 2.8 3.9 13.7 1.2 0.5 0.7 0.5 3.3 1.7 0.7 3.7 2.1
Medication: Ventolin 100micrograms inhaler 1.5 1.9 3.8 -1.2 -1.5 -1.4 0.9 -1.9 -1.2 -1.4 -1.8 -0.2
Birth weight 0.1 0.2 0.4 -0.5 -0.3 -0.3 0.1 -0.5 0.0 -0.6 -0.4 -0.4
Chronic bronchitis/emphysema (mother) 0.5 0.6 4.3 -0.5 -0.5 -0.4 0.4 -0.1 -0.6 0.1 -0.5 -2.1
High blood pressure (siblings) 4.0 5.7 10.2 2.1 1.8 2.1 -2.1 2.9 1.7 2.5 3.2 2.7
Forced vital capacity (FVC), Best measure 1.3 4.7 9.1 -1.7 -1.9 -1.9 1.5 -3.0 -1.7 -3.0 -2.9 -0.6
Body fat percentage 5.0 19.6 27.2 -5.2 -4.9 -5.1 3.8 -4.6 -5.0 -3.8 -4.4 -2.2
Leg fat percentage (right) 4.1 14.9 22.2 -4.7 -4.6 -4.6 3.3 -3.4 -4.5 -2.8 -3.4 -2.7
Arm fat-free mass (right) 1.2 6.0 11.0 -2.5 -1.6 -2.4 1.4 -2.4 -2.9 -2.5 -3.3 -2.5
Exposure to tobacco smoke outside home 0.7 0.9 3.0 -0.9 -1.1 -0.8 0.6 0.4 0.3 -1.2 0.9 1.7
Comparative body size at age 10 0.6 1.7 4.4 -0.9 -1.2 -0.9 2.1 0.1 -0.0 -1.9 0.5 2.0
Number of full brothers 2.1 2.7 10.2 -0.5 0.0 -0.6 -0.7 -1.1 -2.3 0.6 -2.4 -3.2
Worry too long after embarrassment 0.6 1.0 3.1 -0.6 -0.4 -0.5 0.6 -1.8 -0.4 -0.8 -1.5 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.0 0.1 -0.8 -0.4 0.7 0.5 0.7 -0.5 1.0 -0.4
Wheeze or whistling in the chest in last year 3.5 6.3 12.1 -3.2 -3.5 -3.0 3.3 -1.9 -1.3 -2.9 -0.6 0.8
Number of children fathered 3.1 3.5 4.8 -2.1 -2.0 -2.0 1.1 -1.8 -2.2 -1.9 -2.0 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 1.8 1.3 1.0 1.2 -1.2 1.2 1.2 0.8 1.1 1.0
Age at first live birth 0.2 0.4 0.6 0.8 0.8 0.8 -0.7 0.5 0.6 0.5 0.2 -0.1
Pulse wave peak to peak time 0.3 0.3 1.8 0.6 0.3 0.6 0.1 -0.4 0.3 0.3 -0.3 1.3
Health satisfaction 1.8 2.4 7.2 -2.3 -2.7 -2.1 1.0 0.5 -1.4 -0.4 0.8 -0.9
Shortness of breath walking on level ground 1.0 1.1 3.0 -1.3 -1.7 -1.4 1.2 -0.2 -1.3 -0.1 -0.1 -0.6
Qualifications: College or University degree 0.2 0.5 2.6 -0.4 -0.5 -0.7 0.9 0.0 0.1 -1.6 0.1 0.4
Eye problems/disorders: None of the above 0.8 0.9 2.0 0.9 0.8 1.0 -1.4 -1.1 0.4 0.8 -1.2 0.1
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.2 -0.9 -0.8 -0.7 0.9 0.6 -0.5 0.1 1.0 1.1
Emphysema/chronic bronchitis 1.3 1.5 2.7 -1.1 -1.1 -0.7 1.1 -1.6 -0.1 -1.4 -1.4 1.5
Medication for pain relief, constipation, heartburn 0.5 0.9 2.1 0.1 0.3 0.6 -0.3 -1.4 1.5 -1.2 -0.6 1.2
Neck or shoulder pain in last month 0.4 0.5 1.1 -0.5 -0.4 -0.5 0.9 1.1 -0.8 -0.1 0.6 1.0
Medication: Blood pressure 2.1 3.7 9.0 1.8 1.8 1.7 -0.9 3.0 1.6 2.0 2.6 0.9
Angina (self-reported) 0.6 0.8 2.1 -1.4 -1.3 -1.2 0.3 0.0 -0.8 -0.4 -0.1 -1.1
Migraine (self-reported) 1.4 1.7 4.9 0.8 1.2 0.8 -2.1 -0.3 0.1 1.3 -1.1 -2.2
Medication: Ibuprofen 2.5 3.0 6.7 -2.1 -2.0 -2.3 2.0 -0.1 -2.6 -1.0 -0.5 -1.3
Medication: Allopurinol 1.1 1.5 5.2 1.3 1.1 1.3 -1.2 -0.3 1.4 0.0 0.2 2.3
Medication: Omeprazole 0.7 0.8 2.9 -0.8 -0.9 -1.0 -0.0 -0.3 -1.7 -0.1 -0.7 -1.1
Medication: Seretide 50 evohaler 3.8 4.4 6.9 -2.6 -2.3 -2.6 1.9 -1.8 -2.5 -2.2 -1.5 -0.4
Mean time to correctly identify matches 0.1 0.3 1.1 0.5 1.0 0.5 -0.4 -0.5 -0.1 0.7 -0.2 0.1
Heart disease (mother) 0.5 0.6 1.8 0.8 1.2 0.7 -0.5 0.7 -0.4 1.3 0.2 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.0 2.4 7.3 -1.4 -0.9 -1.2 1.0 -1.3 -1.7 -1.0 -1.9 -2.7
Whole body fat mass 4.4 18.3 24.8 -4.9 -4.3 -4.8 3.3 -4.6 -5.0 -3.8 -4.7 -2.4
Leg fat mass (right) 5.1 19.7 26.7 -5.1 -4.7 -5.1 3.6 -4.4 -5.2 -3.7 -4.6 -2.9
Arm predicted mass (right) 1.3 6.7 12.7 -2.5 -1.8 -2.5 1.4 -2.5 -3.1 -2.5 -3.6 -2.8
Pulse rate, automated reading 0.5 1.6 5.9 0.3 0.9 0.2 -1.4 2.1 -0.6 0.5 0.4 -2.4
Alcohol intake frequency. 0.7 1.7 4.1 1.2 1.7 1.2 -1.4 1.4 0.5 2.0 1.2 0.1
Comparative height size at age 10 0.3 1.7 7.0 -0.5 -0.0 -0.5 0.3 -1.7 -1.4 -1.3 -2.6 -0.9
Number of full sisters 0.6 0.7 3.1 -0.9 -0.6 -0.5 0.3 -1.8 -0.6 -0.3 -1.3 0.3
Suffer from ‘nerves’ 3.9 6.1 13.0 2.3 2.2 2.3 -2.5 2.9 1.6 3.6 2.7 1.4
Overall health rating 1.0 2.2 8.8 0.2 -0.5 -0.0 0.1 2.8 0.6 1.2 3.0 1.0
Chest pain or discomfort 0.3 0.5 1.4 -0.9 -0.7 -0.7 -0.2 -0.1 -1.1 -0.2 -0.4 -1.2
Had major operations 0.5 0.6 1.6 0.7 1.1 1.0 -1.3 -0.1 0.8 0.1 -0.2 0.5
Age at last live birth 0.3 0.4 1.3 0.6 0.6 0.7 -1.2 0.0 0.9 0.0 -0.2 -0.7
Family relationship satisfaction 1.3 1.6 5.4 0.5 -0.0 0.6 -1.3 2.3 1.1 1.2 2.1 0.2
Leg pain on walking 1.8 2.2 8.8 0.1 0.0 0.1 -0.3 3.0 0.8 1.2 3.0 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 2.0 0.4 0.5 0.4 -0.7 0.6 0.3 1.4 0.5 -0.9
Commuting to job workplace: Car/motor vehicle 4.2 4.8 8.4 -2.8 -2.9 -2.8 2.8 -0.5 -1.3 -2.0 -0.0 -2.2
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.6 0.9 0.8 0.6 -0.3 1.3 0.7 0.4 1.1 0.5
Medication: Aspirin 0.6 0.8 2.2 0.8 0.4 0.5 -0.3 1.5 0.7 1.2 1.4 0.1
Supplements: Vitamin C 0.3 0.4 1.4 0.3 0.7 0.5 -0.5 -0.7 -0.2 0.7 -0.3 1.2
Knee pain experienced in last month 1.0 1.5 5.5 0.6 0.7 0.3 0.2 2.3 0.5 1.2 2.3 0.8
Hypertension (Self-reported) 5.1 14.1 29.9 3.6 3.4 3.5 -3.5 5.5 3.4 3.9 4.5 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 2.4 -1.4 -0.5 -1.0 -0.8 -1.3 -1.5 -0.4 -1.5 -1.5
Illnesses of father: Heart disease 0.5 0.6 2.2 0.1 0.4 0.2 -0.3 1.2 -0.9 1.5 0.6 -0.6
Illnesses of siblings: Diabetes 0.3 0.3 1.5 -0.6 -0.3 -0.4 -0.1 -0.0 -1.2 0.4 -0.4 -0.7
Smoking status: Previous 0.2 0.4 2.0 0.1 0.1 0.3 -1.4 0.3 -0.2 0.9 -0.1 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 7.8 -0.3 0.3 -0.2 0.4 -2.0 -1.2 -0.9 -2.8 -1.6
Whole body fat-free mass 1.2 7.0 14.1 -2.5 -1.7 -2.5 1.5 -2.9 -3.1 -2.9 -3.8 -2.1
Leg fat-free mass (right) 2.4 12.9 23.1 -3.6 -2.7 -3.5 2.5 -4.2 -4.1 -4.0 -4.8 -1.9
Arm fat percentage (left) 5.9 23.5 31.2 -5.5 -5.0 -5.4 4.1 -5.4 -5.6 -4.3 -5.1 -2.2
Average weekly red wine intake 1.8 2.6 7.1 -1.4 -0.4 -1.2 1.6 -2.7 -1.3 -1.7 -2.3 0.7
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.4 -0.6 -0.4 -0.6 0.4 0.2 -0.6 -0.2 0.3 0.6
Mood swings 1.6 2.8 10.1 1.0 0.4 1.0 0.5 1.8 1.1 1.9 2.2 3.2
Loneliness, isolation 3.1 4.2 10.8 1.7 1.2 1.6 -0.7 3.3 1.7 1.7 3.1 2.1
Long-standing illness, disability or infirmity 1.3 2.0 3.8 -1.9 -1.9 -1.9 1.1 -1.1 -1.2 -1.1 -0.8 -1.1
Ever had bowel cancer screening 1.7 1.9 4.1 1.3 0.5 1.1 -0.8 2.0 1.2 1.6 2.0 1.4
Diabetes diagnosed by doctor 0.7 1.1 4.6 -1.1 -0.8 -1.3 2.1 -0.3 -0.8 -1.0 -0.1 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 2.4 -1.0 -1.6 -1.1 0.4 0.1 -0.5 -0.8 0.3 -0.5
Friendships satisfaction 0.3 0.3 0.8 -0.3 -0.5 -0.4 -0.6 0.9 -0.0 0.4 0.8 0.8
Qualifications: nursing, teaching 1.1 1.6 2.8 -1.7 -1.6 -1.6 0.8 -1.2 -1.2 -1.1 -0.9 -1.2
Commuting to job workplace: Walk 3.1 3.4 6.1 2.0 1.8 1.8 -1.5 1.9 1.7 1.1 1.9 2.5
Eye problems/disorders: Cataract 0.6 0.7 1.9 -0.6 -0.6 -0.7 1.4 0.8 -0.4 -1.0 1.0 0.5
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.0 1.0 1.2 0.9 -1.3 0.4 0.3 1.4 0.4 0.4
Medication for cholesterol 1.6 2.5 8.7 -1.1 -0.8 -0.8 0.6 -3.0 -0.9 -1.9 -2.5 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.8 3.3 -1.5 -1.7 -1.8 1.6 -0.5 -0.7 -1.8 0.2 1.1
Back pain experienced in last month 0.3 0.4 2.2 -0.1 -0.2 -0.1 -0.8 0.5 -0.6 0.3 -0.1 -1.5
Mineral and other dietary supplements 0.8 1.1 2.3 -1.1 -0.6 -0.7 0.9 -1.2 -1.0 -0.7 -1.5 -1.5
Breast cancer (self-reported) 2.3 2.8 6.2 1.7 2.2 2.1 -2.5 -0.2 1.3 1.5 -0.5 -1.5
Asthma (self-reported) 5.2 10.3 17.6 -3.8 -3.1 -3.4 3.5 -4.2 -2.7 -3.2 -3.1 -0.1
Osteoporosis (self-reported) 1.7 2.1 7.2 -0.6 0.4 -0.4 -0.9 -1.4 -1.7 0.5 -2.2 -2.7
Osteoarthritis (self-reported) 1.3 1.7 6.5 0.9 0.1 0.3 0.7 1.8 1.4 0.2 2.5 1.6
Medication: Aspirin 0.4 0.5 1.4 0.6 0.4 0.3 -0.2 1.2 0.5 1.0 1.2 0.0
Medication: Gliclazide 0.4 0.4 0.9 0.5 0.9 0.6 -0.3 0.9 0.1 0.9 0.3 -0.8
Illnesses of father: None of the above (group 1) 0.4 0.5 1.3 0.4 0.5 0.5 -0.8 -1.0 0.3 -0.3 -1.1 -0.8
Smoking status: Current 1.0 1.6 3.7 -1.2 -1.7 -1.7 1.9 0.7 -1.2 -1.1 0.7 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.9 4.1 10.1 -1.7 -1.4 -1.8 1.7 -3.2 -1.8 -2.3 -2.6 -0.6
Whole body water mass 1.2 7.1 14.2 -2.5 -1.7 -2.5 1.5 -2.8 -3.2 -2.9 -3.8 -2.2
Leg predicted mass (right) 2.4 13.0 23.6 -3.6 -2.7 -3.5 2.4 -4.2 -4.1 -4.1 -4.9 -1.9
Arm fat mass (left) 5.1 21.1 29.4 -5.1 -4.4 -5.0 3.5 -5.2 -5.4 -4.1 -5.3 -2.6
Number of self-reported non-cancer illnesses 0.3 0.5 1.9 0.1 0.0 -0.0 -0.3 1.3 0.5 0.7 1.4 -0.0
Average weekly champagne plus white wine intake 0.3 0.4 2.1 0.2 0.2 0.3 0.6 0.2 0.7 -0.3 0.3 1.4
Miserableness 0.5 0.9 4.0 0.2 -0.3 0.2 0.1 1.3 0.3 0.7 1.4 2.0
Guilty feelings 0.1 0.1 0.4 0.4 -0.0 0.2 -0.1 0.3 0.5 0.3 0.5 0.6
Wears glasses or contact lenses 0.3 0.4 1.7 -0.1 -0.3 -0.2 0.3 0.9 0.8 -0.4 1.3 0.1
Ever taken oral contraceptive pill 0.1 0.1 0.3 0.1 -0.1 0.3 -0.3 0.5 0.3 0.5 0.1 -0.3
Hearing aid user 0.3 0.4 1.1 -1.0 -0.4 -0.7 -0.1 -0.1 -0.8 0.1 -0.4 -1.1
Mother’s age at death 0.1 0.1 0.5 -0.1 -0.5 -0.2 0.1 -0.1 0.4 -0.7 0.1 -0.2
Financial situation satisfaction 0.9 1.1 1.7 -1.2 -1.1 -1.2 -0.3 1.1 -1.3 0.9 0.8 -1.3
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.5 -0.6 -0.5 -0.6 0.3 -1.2 -0.7 -0.5 -1.6 -0.5
Commuting to job workplace: Public transport 0.1 0.2 0.6 0.2 -0.1 -0.1 -0.6 0.2 0.3 -0.0 0.4 0.8
Eye problems/disorders: Glaucoma 1.0 1.2 2.3 1.4 1.2 1.2 -1.2 1.5 0.8 0.8 1.0 -0.2
Medication: Blood pressure 1.2 2.3 5.7 0.9 0.8 0.8 -1.4 2.4 0.3 1.9 1.7 -2.0
Pain type(s) experienced in last month: Hip pain 0.4 0.6 2.4 -0.0 0.0 -0.1 0.6 1.6 0.3 0.3 1.4 0.5
Supplements: Fish oil (including cod liver oil) 0.9 1.2 2.2 1.0 0.5 0.7 -0.9 1.4 1.0 0.7 1.5 1.5
High cholesterol (Self-reported) 12.5 22.2 30.4 5.2 5.2 5.1 -4.2 5.5 4.6 4.5 4.8 2.5
Medication: Bendroflumethiazide 1.7 2.6 5.5 1.3 1.5 1.3 -2.1 1.9 1.0 2.3 1.9 0.3
Medication: Paracetamol 0.6 1.0 2.5 0.3 -0.4 -0.1 -0.6 1.6 -0.7 1.3 0.9 -1.6
Medication: Lisinopril 1.8 2.3 4.7 1.2 0.9 1.4 -1.2 2.2 1.8 1.5 2.1 0.6
Medication: Atorvastatin 1.7 2.2 5.3 1.3 1.4 1.4 -1.0 2.3 0.9 1.8 1.8 0.5
Illnesses of father: High blood pressure 0.5 0.6 2.2 0.2 0.0 -0.1 -0.1 1.5 -0.3 0.8 1.1 -0.9
Alcohol drinker status: Never 0.8 0.9 2.5 -1.3 -1.1 -1.0 0.5 -1.6 -0.2 -1.0 -0.7 0.3
Ever smoked 0.3 0.5 2.0 -0.9 -0.6 -0.6 -0.2 -0.4 -0.9 0.0 -0.3 1.4
Basal metabolic rate 1.8 9.8 18.2 -3.1 -2.3 -3.1 1.9 -3.4 -3.7 -3.3 -4.3 -2.5
Leg fat percentage (left) 4.4 15.9 24.9 -5.0 -4.9 -4.9 3.6 -3.2 -4.7 -3.1 -3.2 -2.3
Arm fat-free mass (left) 1.1 5.3 10.4 -2.3 -1.4 -2.2 1.2 -2.2 -2.9 -2.3 -3.2 -2.4
Number of operations (self-reported) 1.4 2.1 3.8 -1.6 -1.1 -1.7 0.8 -1.3 -1.6 -1.3 -1.3 -2.0
Average weekly beer plus cider intake 0.5 0.7 3.5 0.3 0.2 0.4 -0.3 0.7 0.3 1.0 0.9 1.9
Irritability 0.3 0.5 1.2 -0.4 -0.7 -0.7 1.0 0.5 -1.1 0.9 0.4 0.6
Risk taking 1.0 1.5 5.0 -1.1 -1.4 -1.4 2.2 -0.6 -0.6 -1.6 -0.4 -0.3
Ever had prostate specific antigen (PSA) test 0.2 0.2 1.5 -0.4 -0.0 -0.1 -0.3 -0.3 -0.4 0.1 -0.4 -1.2
Fractured/broken bones in last 5 years 0.4 0.5 0.9 -0.9 -0.8 -0.9 0.6 -0.6 -0.6 -0.9 -0.5 0.4
Age started oral contraceptive pill 0.2 0.3 1.0 -0.4 -0.1 -0.8 1.0 -0.3 -0.6 -0.4 -0.1 0.4
Diastolic blood pressure, automated reading 1.3 4.0 12.4 1.8 1.3 1.7 -2.0 3.5 1.2 2.2 2.3 -0.2
Ever depressed for a whole week 1.9 2.4 6.7 1.1 0.8 1.1 -0.7 1.6 1.9 1.3 2.6 1.9
Unable to work because of sickness or disability 2.1 2.7 6.0 -2.0 -2.5 -1.9 2.0 -1.0 -1.3 -1.6 -0.6 0.9
Commuting to job workplace: Cycle 0.4 0.5 2.0 0.0 0.3 0.3 -0.4 -1.4 -0.3 -0.0 -1.4 -0.0
Myopia 0.8 1.2 3.6 1.1 1.5 1.5 -1.0 0.9 0.3 1.9 0.2 -0.1
Vascular/heart problems diagnosed by doctor 4.3 11.6 23.2 -3.4 -3.3 -3.3 3.4 -4.8 -2.7 -3.8 -3.7 0.9
Cholesterol lowering medication 3.5 5.2 11.9 2.0 1.8 1.8 -0.6 3.2 2.6 1.7 3.5 1.9
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 2.0 -0.4 -0.5 -0.5 -0.3 -0.1 -1.1 0.1 -0.7 -1.4
Pain experienced in last month 0.3 0.6 2.0 -0.8 -0.4 -0.5 0.5 -1.4 -0.2 -0.8 -1.1 -0.1
Supplements: Calcium 0.6 0.6 2.7 -0.5 -0.3 -0.4 -0.2 -1.6 -0.1 -0.8 -1.3 0.0
Basal cell carcinoma (self-reported) 1.5 1.7 5.5 -1.4 -0.7 -1.3 0.9 -0.9 -2.3 -0.9 -1.8 -0.8
Heart attack/myocardial infarction (self-reported) 2.0 2.6 6.6 1.2 1.4 1.2 -1.6 2.6 0.5 2.2 1.9 -0.7
Deep venous thrombosis (DVT) (self-reported) 6.2 7.9 15.4 -3.3 -3.9 -3.4 3.1 -1.8 -2.1 -3.6 -1.0 1.7
Heart disease (siblings) 2.3 2.8 7.8 1.7 1.8 1.5 -1.8 2.0 -0.0 2.8 1.1 -0.3
Alcohol drinker status: Previous 0.7 0.8 2.2 1.0 1.3 1.1 -0.6 0.6 0.2 1.5 0.3 0.5
Pack years of smoking 3.0 4.3 7.4 -2.3 -2.7 -2.1 2.4 -1.7 -1.1 -2.7 -1.1 2.0
Impedance of whole body 0.3 1.7 4.1 1.5 0.7 1.4 -0.9 0.7 2.0 1.3 1.4 1.0
Leg fat mass (left) 5.2 20.4 28.0 -5.3 -4.8 -5.2 3.8 -4.4 -5.2 -4.0 -4.5 -2.6
Arm predicted mass (left) 1.1 5.7 10.6 -2.5 -1.6 -2.4 1.3 -2.2 -3.1 -2.4 -3.2 -2.1