Best TWAS P=3.29e-11 · Best GWAS P=1.85e-10 conditioned to 0.238
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | ADAMTS7 | 0.13 | 0.07 | lasso | 4 | 0.06 | 9.2e-06 | -5.7 | -6.1 | 8.8e-10 | 0.68 | 0.05 | 0.95 | TRUE |
| 2 | GTEx | Brain Putamen basal ganglia | RP11-762H8.1 | 0.29 | 0.07 | lasso | 4 | 0.02 | 1.1e-01 | 5.6 | 5.1 | 2.7e-07 | -0.42 | 0.06 | 0.13 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | ADAMTS7 | 0.32 | 0.11 | lasso | 5 | 0.17 | 2.8e-06 | 5.5 | 6.6 | 3.3e-11 | -0.47 | 0.16 | 0.74 | TRUE |
| 4 | GTEx | Colon Transverse | CHRNA5 | 0.18 | 0.14 | lasso | 4 | 0.13 | 9.4e-07 | -5.7 | 5.1 | 2.9e-07 | -0.75 | 0.14 | 0.74 | FALSE |
| 5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | MORF4L1 | 0.04 | 0.03 | lasso | 2 | 0.03 | 5.8e-04 | -5.7 | -6.2 | 6.8e-10 | 0.43 | 0.01 | 0.80 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ADAMTS7 | 0.08 | 0.07 | lasso | 3 | 0.06 | 4.2e-04 | -6.1 | -6.0 | 1.7e-09 | 0.94 | 0.02 | 0.79 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADAMTS7 | 0.08 | 0.07 | lasso | 3 | 0.07 | 4.9e-08 | -5.8 | -6.0 | 2.2e-09 | 0.94 | 0.02 | 0.98 | FALSE |