Hub : Traits :

Angina (self-reported)

54 significantly associated models · 17 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	109098737	110517617	3	1	3.3e-13	3.9e-13	2.2e-01	97	SORT1
2	1	222133118	223529093	1	1	9.5e-08	1.8e-06	7.6e-01	100	RP11-378J18.8
3	6	12020241	13990267	2	1	2.0e-08	1.9e-08	1.1e-01	92	PHACTR1
4	6	133961374	134468561	1	1	6.4e-09	3.1e-07	7.8e-01	100	TCF21
5	6	160071844	161571560	2	2	6.6e-09	9.1e-17	1.3e-08	53	SLC22A1 SLC22A3
6	8	19547307	20071503	1	1	2.9e-07	1.4e-07	4.0e-02	85	LPL
7	9	21303958	22819407	2	2	3.2e-22	8.6e-34	7.5e-14	62	CDKN2B CDKN2B-AS1
8	15	77888924	79802863	4	2	3.3e-11	1.9e-10	2.4e-01	97	ADAMTS7
9	15	90730363	92135418	1	1	7.6e-12	1.2e-08	3.8e-01	98	FES

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
LDL Cholesterol	43.11	1	1	2.2	0.00	1.0e+00	SORT1
Angina	32.99	11	10	22.2	1.00	5.9e-17	ADAMTS7 CDKN2B CDKN2B-AS1 FES LPL PHACTR1 RP11-378J18.8 SLC22A1 SLC22A3 SORT1 TCF21
Coronary Artery Disease (CAD)	30.37	7	5	11.1	0.99	1.8e-06	ADAMTS7 CDKN2B CDKN2B-AS1 LPL PHACTR1 SLC22A3 TCF21
Illnesses of father: Heart disease	29.23	11	8	17.8	0.99	4.0e-10	ADAMTS7 CDKN2B CDKN2B-AS1 FES LPL PHACTR1 RP11-378J18.8 SLC22A1 SLC22A3 SORT1 TCF21
Triglycerides	27.11	1	1	2.2	0.00	1.0e+00	LPL
HDL Cholesterol	26.28	2	2	4.4	0.00	1.0e+00	LPL SORT1
Heart attack/myocardial infarction (self-reported)	25.82	10	8	17.8	0.98	3.2e-07	CDKN2B CDKN2B-AS1 FES LPL PHACTR1 RP11-378J18.8 SLC22A1 SLC22A3 SORT1 TCF21
Heart attack	25.57	10	8	17.8	0.98	2.5e-07	CDKN2B CDKN2B-AS1 FES LPL PHACTR1 RP11-378J18.8 SLC22A1 SLC22A3 SORT1 TCF21
Medication: Cholesterol lowering	24.43	9	4	8.9	0.90	8.2e-04	CDKN2B CDKN2B-AS1 FES LPL RP11-378J18.8 SLC22A1 SLC22A3 SORT1 TCF21
High cholesterol (Self-reported)	24.34	6	4	8.9	0.81	5.2e-02	FES LPL RP11-378J18.8 SLC22A1 SLC22A3 SORT1
Medication: Atorvastatin	18.35	6	3	6.7	0.96	2.3e-03	CDKN2B CDKN2B-AS1 LPL SLC22A1 SLC22A3 SORT1
Medication: Aspirin	16.44	8	5	11.1	0.99	2.6e-06	CDKN2B CDKN2B-AS1 FES LPL SLC22A1 SLC22A3 SORT1 TCF21
Heart disease (mother)	16.14	8	3	6.7	0.96	2.7e-05	ADAMTS7 CDKN2B CDKN2B-AS1 FES PHACTR1 RP11-378J18.8 SLC22A1 SLC22A3
Medication: Simvastatin	15.80	8	3	6.7	0.91	1.6e-03	CDKN2B CDKN2B-AS1 FES LPL RP11-378J18.8 SLC22A1 SLC22A3 SORT1
Medication: Aspirin	15.75	8	5	11.1	0.99	2.2e-06	CDKN2B CDKN2B-AS1 FES LPL SLC22A1 SLC22A3 SORT1 TCF21
Cholesterol lowering medication	13.81	5	3	6.7	0.90	4.0e-02	CDKN2B LPL SLC22A1 SLC22A3 SORT1
Heart disease (siblings)	12.10	7	0	0.0	0.97	2.5e-04	ADAMTS7 CDKN2B-AS1 FES PHACTR1 SLC22A1 SLC22A3 SORT1
Medication for cholesterol, blood pressure or diabetes	11.99	5	2	4.4	-0.96	1.0e-02	FES LPL SLC22A1 SORT1 TCF21
Illnesses of father: None of the above (group 1)	9.91	4	2	4.4	-0.99	1.3e-02	CDKN2B CDKN2B-AS1 FES SLC22A3
Cardiovascular Disease	9.86	6	5	11.1	0.94	4.6e-03	FES LPL SLC22A1 SLC22A3 SORT1 TCF21
Father's age at death	8.49	5	1	2.2	-1.00	2.5e-04	CDKN2B CDKN2B-AS1 FES LPL SORT1
Vascular/heart problems diagnosed by doctor	8.44	3	2	4.4	0.00	1.0e+00	FES SLC22A3 TCF21
Eye problems/disorders: Glaucoma	7.67	2	2	4.4	0.00	1.0e+00	CDKN2B CDKN2B-AS1
Medication: Atenolol	7.58	1	1	2.2	0.00	1.0e+00	FES
High blood pressure (mother)	7.35	2	1	2.2	0.00	1.0e+00	FES PHACTR1
Pack years adult smoking proportion	7.13	1	1	2.2	0.00	1.0e+00	ADAMTS7
Medication: Blood pressure	6.91	3	1	2.2	0.00	1.0e+00	FES SLC22A1 TCF21
Hypertension (Self-reported)	6.87	3	1	2.2	0.00	1.0e+00	FES SLC22A3 TCF21
Systolic Blood Pressure	6.61	6	3	6.7	0.51	3.0e-01	ADAMTS7 FES PHACTR1 SLC22A1 SLC22A3 TCF21
High blood pressure	6.58	3	1	2.2	0.00	1.0e+00	FES PHACTR1 TCF21
Glaucoma (self-reported)	6.40	2	1	2.2	0.00	1.0e+00	CDKN2B CDKN2B-AS1
Diastolic blood pressure, automated reading	6.37	4	2	4.4	0.97	3.4e-02	ADAMTS7 CDKN2B CDKN2B-AS1 FES
Pack years of smoking	6.31	1	1	2.2	0.00	1.0e+00	ADAMTS7
Medication for cholesterol	6.24	3	2	4.4	0.00	1.0e+00	FES SLC22A3 SORT1
Medication: Blood pressure	5.98	3	1	2.2	0.00	1.0e+00	ADAMTS7 FES SLC22A3
Illnesses of mother	5.59	2	1	2.2	0.00	1.0e+00	CDKN2B FES
Systolic blood pressure, automated reading	5.40	2	1	2.2	0.00	1.0e+00	FES PHACTR1
Medication: Bendroflumethiazide	5.10	3	1	2.2	0.00	1.0e+00	ADAMTS7 FES TCF21
Illnesses of father: High blood pressure	4.98	1	1	2.2	0.00	1.0e+00	FES
Migraine (self-reported)	4.89	1	1	2.2	0.00	1.0e+00	PHACTR1
Chronic bronchitis/emphysema (father)	4.71	1	0	0.0	0.00	1.0e+00	ADAMTS7
Lung cancer (father)	4.66	1	0	0.0	0.00	1.0e+00	ADAMTS7
Number of treatments/medications taken	4.45	3	1	2.2	0.00	1.0e+00	FES LPL SORT1
Medication: Ramipril	4.39	1	0	0.0	0.00	1.0e+00	FES
Medication: Amlodipine	4.30	2	1	2.2	0.00	1.0e+00	FES TCF21
Medication: Ibuprofen	4.30	2	1	2.2	0.00	1.0e+00	PHACTR1 SLC22A3
Headache pain in last month	4.25	2	1	2.2	0.00	1.0e+00	FES PHACTR1
Chest pain or discomfort	4.05	2	0	0.0	0.00	1.0e+00	CDKN2B LPL
Medication: Ibuprofen (e.g. Nurofen)	4.03	2	1	2.2	0.00	1.0e+00	PHACTR1 SLC22A3
Birth weight of first child	3.93	2	1	2.2	0.00	1.0e+00	FES TCF21
Type 2 Diabetes (T2D) (2012)	3.88	1	0	0.0	0.00	1.0e+00	CDKN2B
Pulse rate, automated reading	3.46	3	1	2.2	0.00	1.0e+00	RP11-378J18.8 SORT1 TCF21
Illnesses of siblings	3.45	1	1	2.2	0.00	1.0e+00	FES
Pulse wave Arterial Stiffness index	3.34	2	0	0.0	0.00	1.0e+00	FES PHACTR1
High blood pressure (siblings)	3.34	1	1	2.2	0.00	1.0e+00	FES
Pulse wave peak to peak time	3.33	2	0	0.0	0.00	1.0e+00	FES PHACTR1
Medication for pain relief, constipation, heartburn	3.27	2	0	0.0	0.00	1.0e+00	PHACTR1 SORT1
Bipolar Disorder or Schizophrenia	3.11	1	1	2.2	0.00	1.0e+00	FES
Basal cell carcinoma (self-reported)	3.07	1	0	0.0	0.00	1.0e+00	CDKN2B
Schizophrenia (2018)	3.02	1	1	2.2	0.00	1.0e+00	FES
Pulse rate	2.97	2	1	2.2	0.00	1.0e+00	SLC22A1 TCF21
Schizophrenia (2014)	2.94	1	1	2.2	0.00	1.0e+00	FES
Mineral and other dietary supplements	2.73	1	0	0.0	0.00	1.0e+00	FES
Breast cancer (self-reported)	2.73	1	0	0.0	0.00	1.0e+00	CDKN2B
Chronic bronchitis/emphysema (mother)	2.72	1	0	0.0	0.00	1.0e+00	ADAMTS7
Medication: Metformin	2.63	2	0	0.0	0.00	1.0e+00	CDKN2B LPL
Smoking Status	2.52	1	0	0.0	0.00	1.0e+00	FES
Risk taking	2.40	1	0	0.0	0.00	1.0e+00	FES
Breast Cancer	2.39	3	0	0.0	0.00	1.0e+00	CDKN2B CDKN2B-AS1 FES
Supplements: Fish oil (including cod liver oil)	2.39	1	0	0.0	0.00	1.0e+00	SLC22A3
Waist Hip Ratio (WHR)	2.29	3	1	2.2	0.00	1.0e+00	ADAMTS7 LPL SLC22A3
Type 2 Diabetes (T2D) (2018)	2.18	1	0	0.0	0.00	1.0e+00	LPL
Multivitamins +/- minerals	2.15	1	0	0.0	0.00	1.0e+00	ADAMTS7
Had menopause	2.13	1	0	0.0	0.00	1.0e+00	LPL
Past tobacco smoking	2.07	1	0	0.0	0.00	1.0e+00	CDKN2B-AS1
Mother's age at death	2.03	1	0	0.0	0.00	1.0e+00	SLC22A1
Alcohol usually taken with meals	1.97	1	0	0.0	0.00	1.0e+00	FES
Birth weight	1.97	1	1	2.2	0.00	1.0e+00	FES
Age started oral contraceptive pill	1.95	1	0	0.0	0.00	1.0e+00	FES
Medication: Lisinopril	1.92	1	0	0.0	0.00	1.0e+00	FES
Medication: Paracetamol	1.89	1	1	2.2	0.00	1.0e+00	PHACTR1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.86	1	0	0.0	0.00	1.0e+00	ADAMTS7
Sensitivity / hurt feelings	1.84	1	1	2.2	0.00	1.0e+00	FES
Ever smoked	1.83	1	0	0.0	0.00	1.0e+00	FES
Handedness (chirality/laterality): Left-handed	1.72	1	0	0.0	0.00	1.0e+00	FES
Hand grip strength (left)	1.70	2	0	0.0	0.00	1.0e+00	FES PHACTR1
Diabetes diagnosed by doctor	1.70	1	0	0.0	0.00	1.0e+00	SLC22A3
Smoking status: Previous	1.68	1	0	0.0	0.00	1.0e+00	CDKN2B-AS1
Breastfed as a baby	1.67	1	0	0.0	0.00	1.0e+00	FES
Long-standing illness, disability or infirmity	1.61	1	0	0.0	0.00	1.0e+00	CDKN2B
Peak expiratory flow (PEF)	1.58	1	1	2.2	0.00	1.0e+00	TCF21
Bipolar Disorder (2018)	1.56	1	0	0.0	0.00	1.0e+00	FES
Alcohol intake frequency.	1.54	1	0	0.0	0.00	1.0e+00	PHACTR1
Medication: Paracetamol	1.52	1	0	0.0	0.00	1.0e+00	PHACTR1
Number of incorrect matches in round	1.47	1	0	0.0	0.00	1.0e+00	FES
Knee pain experienced in last month	1.46	1	0	0.0	0.00	1.0e+00	PHACTR1
Mean time to correctly identify matches	1.43	1	0	0.0	0.00	1.0e+00	FES
Pain experienced in last month	1.43	1	0	0.0	0.00	1.0e+00	PHACTR1
Neuroticism (Nagel 2018)	1.40	2	0	0.0	0.00	1.0e+00	FES SLC22A1
Respiratory disease	1.37	1	0	0.0	0.00	1.0e+00	FES
Allergy	1.36	1	0	0.0	0.00	1.0e+00	FES
Hayfever, allergic rhinitis or eczema	1.35	1	0	0.0	0.00	1.0e+00	FES
Neuroticism	1.32	1	0	0.0	0.00	1.0e+00	SLC22A1
Hand grip strength (right)	1.31	1	0	0.0	0.00	1.0e+00	PHACTR1
Impedance of leg (right)	1.29	1	1	2.2	0.00	1.0e+00	FES
Allergy or Eczema	1.23	1	0	0.0	0.00	1.0e+00	FES
Arm fat percentage (right)	1.22	1	0	0.0	0.00	1.0e+00	SLC22A3
Hip circumference	1.22	2	1	2.2	0.00	1.0e+00	ADAMTS7 SLC22A3
Medication: Omeprazole (e.g. Zanprol)	1.20	1	0	0.0	0.00	1.0e+00	TCF21
Impedance of leg (left)	1.19	2	1	2.2	0.00	1.0e+00	FES LPL
Hair/balding pattern: Pattern 4	1.17	1	0	0.0	0.00	1.0e+00	FES
Lung FEV1/FVC ratio	1.11	3	0	0.0	0.00	1.0e+00	RP11-378J18.8 SORT1 TCF21
Arm fat mass (left)	1.09	1	0	0.0	0.00	1.0e+00	SLC22A3
Blood White Count	1.08	2	1	2.2	0.00	1.0e+00	CDKN2B FES
Arm fat mass (right)	1.08	1	0	0.0	0.00	1.0e+00	SLC22A3
Leg predicted mass (right)	1.08	3	0	0.0	0.00	1.0e+00	FES SLC22A3 SORT1
Trunk fat mass	1.07	1	0	0.0	0.00	1.0e+00	SLC22A3
Leg fat-free mass (right)	1.06	3	0	0.0	0.00	1.0e+00	FES SLC22A3 SORT1
Whole body fat mass	1.05	1	0	0.0	0.00	1.0e+00	SLC22A3
Leg fat-free mass (left)	1.03	2	0	0.0	0.00	1.0e+00	FES SLC22A3
Leg predicted mass (left)	1.03	2	0	0.0	0.00	1.0e+00	FES SLC22A3
Worry (Nagel 2018)	1.02	1	0	0.0	0.00	1.0e+00	SLC22A1
Trunk fat percentage	0.99	1	0	0.0	0.00	1.0e+00	SLC22A3
Comparative height size at age 10	0.99	3	0	0.0	0.00	1.0e+00	FES SLC22A3 SORT1
Body fat percentage	0.98	1	0	0.0	0.00	1.0e+00	SLC22A3
Asthma (self-reported)	0.97	1	0	0.0	0.00	1.0e+00	FES
Weight	0.95	1	0	0.0	0.00	1.0e+00	SLC22A3
Basal metabolic rate	0.94	3	0	0.0	0.00	1.0e+00	FES SLC22A3 SORT1
Asthma	0.93	1	0	0.0	0.00	1.0e+00	FES
Whole body fat-free mass	0.93	3	0	0.0	0.00	1.0e+00	FES SLC22A3 SORT1
BMI	0.92	2	0	0.0	0.00	1.0e+00	LPL SLC22A3
Lung FVC	0.91	1	1	2.2	0.00	1.0e+00	TCF21
Trunk fat-free mass	0.91	2	0	0.0	0.00	1.0e+00	SLC22A3 SORT1
Whole body water mass	0.90	3	0	0.0	0.00	1.0e+00	FES SLC22A3 SORT1
Trunk predicted mass	0.89	2	0	0.0	0.00	1.0e+00	SLC22A3 SORT1
Leg fat mass (right)	0.85	1	0	0.0	0.00	1.0e+00	SLC22A3
Blood Platelet Count	0.83	4	1	2.2	0.72	1.7e-01	ADAMTS7 CDKN2B LPL SLC22A3
Sitting height	0.82	3	0	0.0	0.00	1.0e+00	ADAMTS7 FES SLC22A3
Height	0.78	4	3	6.7	-1.00	4.5e-03	FES LPL SLC22A3 SORT1
Arm predicted mass (left)	0.78	2	0	0.0	0.00	1.0e+00	SLC22A3 SORT1
Forced vital capacity (FVC), Best measure	0.76	1	0	0.0	0.00	1.0e+00	TCF21
Arm predicted mass (right)	0.75	2	0	0.0	0.00	1.0e+00	SLC22A3 SORT1
Leg fat mass (left)	0.75	1	0	0.0	0.00	1.0e+00	SLC22A3
Standing height	0.73	2	2	4.4	0.00	1.0e+00	SLC22A3 SORT1
Arm fat-free mass (left)	0.73	2	0	0.0	0.00	1.0e+00	SLC22A3 SORT1
Arm fat-free mass (right)	0.72	2	0	0.0	0.00	1.0e+00	SLC22A3 SORT1
Impedance of arm (right)	0.63	1	0	0.0	0.00	1.0e+00	CDKN2B
Blood Eosinophil Count	0.54	1	0	0.0	0.00	1.0e+00	LPL
Blood Red Count	0.49	2	0	0.0	0.00	1.0e+00	FES TCF21
Hair Pigment	0.48	4	3	6.7	-0.79	2.1e-01	ADAMTS7 CDKN2B CDKN2B-AS1 FES
Heel T-Score	0.35	1	0	0.0	0.00	1.0e+00	SORT1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adrenal Gland	0	0.000	1.4
GTEx	Artery Aorta	2	0.067	1.4
GTEx	Artery Tibial	3	0.080	1.4
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Brain Frontal Cortex BA9	0	0.000	1.4
GTEx	Cells EBV-transformed lymphocytes	1	0.070	1.4
GTEx	Colon Transverse	1	0.048	1.4
GTEx	Liver	1	0.139	1.4
GTEx	Skin Sun Exposed Lower leg	1	0.027	1.4
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
GTEx	Vagina	0	0.000	1.4
CommonMind	Brain Pre-frontal Cortex	4	0.074	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	2	0.182	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	2	0.097	1.4
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	2	0.098	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	2	0.181	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.040	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	2	0.119	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adipose Visceral Omentum	1	0.049	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	1	0.067	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	1	0.160	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	1	0.024	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	1	0.030	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Lung	1	0.035	1.3
GTEx	Muscle Skeletal	1	0.035	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Spleen	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	1	0.025	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Whole Blood	1	0.050	1.3
METSIM	Adipose	1	0.022	1.3
NTR	Blood	0	0.000	1.3
ROSMAP	Brain Pre-frontal Cortex	2	0.046	1.3
YFS	Blood	1	0.022	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	2	0.121	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	4	0.091	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	2	0.049	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	2	0.126	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	1	0.022	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.3
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2