Best TWAS P=3.31e-15 · Best GWAS P=1.92e-23 conditioned to 0.000371
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Caudate basal ganglia | CYP4V2 | 0.37 | 0.17 | enet | 24 | 0.19 | 4.0e-06 | -5.95 | -7.4 | 1.8e-13 | -0.41 | 0.21 | 0.33 | FALSE |
| 2 | GTEx | Brain Cerebellum | CYP4V2 | 0.44 | 0.31 | lasso | 3 | 0.31 | 7.4e-10 | -5.95 | -5.9 | 4.1e-09 | -0.28 | 0.88 | 0.03 | FALSE |
| 3 | GTEx | Colon Transverse | CYP4V2 | 0.29 | 0.23 | lasso | 6 | 0.22 | 5.8e-11 | -5.95 | -5.5 | 3.4e-08 | -0.31 | 1.00 | 0.00 | TRUE |
| 4 | GTEx | Heart Atrial Appendage | FAM149A | 0.36 | 0.03 | enet | 22 | 0.02 | 4.3e-02 | 0.19 | 5.3 | 1.1e-07 | 0.17 | 0.16 | 0.04 | FALSE |
| 5 | GTEx | Nerve Tibial | CYP4V2 | 0.22 | 0.05 | lasso | 6 | 0.09 | 1.3e-06 | -1.75 | -6.9 | 5.6e-12 | -0.40 | 0.91 | 0.06 | FALSE |
| 6 | GTEx | Pancreas | CYP4V2 | 0.31 | 0.27 | enet | 15 | 0.28 | 2.0e-12 | -5.75 | -5.1 | 3.0e-07 | -0.23 | 1.00 | 0.00 | TRUE |
| 7 | GTEx | Pituitary | CYP4V2 | 0.61 | 0.34 | lasso | 6 | 0.44 | 2.6e-12 | -3.23 | -5.3 | 1.4e-07 | -0.28 | 0.98 | 0.00 | FALSE |
| 8 | GTEx | Spleen | CYP4V2 | 0.55 | 0.30 | lasso | 6 | 0.25 | 5.2e-07 | -5.95 | -6.1 | 1.0e-09 | -0.31 | 0.54 | 0.03 | FALSE |
| 9 | GTEx | Thyroid | CYP4V2 | 0.54 | 0.29 | lasso | 6 | 0.44 | 1.2e-36 | -5.95 | -6.1 | 1.3e-09 | -0.35 | 1.00 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | F11 | 0.05 | 0.03 | enet | 9 | 0.04 | 1.8e-05 | -5.55 | -7.9 | 3.3e-15 | -0.56 | 0.07 | 0.90 | TRUE |