Best TWAS P=1.36e-69 · Best GWAS P=8.42e-64 conditioned to 0.776
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | CACFD1 | 0.10 | 0.03 | lasso | 4 | 0.03 | 1.7e-03 | -2.02 | 7.5 | 8.6e-14 | 0.40 | 0.13 | 0.35 | FALSE |
2 | GTEx | Breast Mammary Tissue | VAV2 | 0.38 | 0.11 | lasso | 10 | 0.18 | 1.2e-09 | -0.68 | 6.7 | 1.7e-11 | 0.38 | 0.45 | 0.50 | FALSE |
3 | GTEx | Breast Mammary Tissue | AL590710.1 | 0.31 | 0.11 | lasso | 7 | 0.12 | 1.3e-06 | -1.29 | 7.4 | 1.2e-13 | 0.36 | 0.11 | 0.81 | FALSE |
4 | GTEx | Spleen | SARDH | 0.40 | -0.01 | enet | 49 | 0.10 | 1.3e-03 | 1.38 | 5.6 | 1.7e-08 | 0.17 | 0.07 | 0.08 | TRUE |
5 | GTEx | Testis | CACFD1 | 0.26 | 0.05 | enet | 25 | 0.10 | 5.3e-05 | 11.34 | 6.5 | 9.9e-11 | 0.23 | 0.31 | 0.14 | FALSE |
6 | GTEx | Uterus | SURF1 | 0.40 | 0.05 | enet | 18 | 0.08 | 9.2e-03 | 8.30 | -6.8 | 7.7e-12 | -0.21 | 0.07 | 0.12 | FALSE |
7 | METSIM | Adipose | C9orf96 | 0.07 | 0.01 | blup | 605 | 0.03 | 7.8e-05 | -0.98 | 8.0 | 1.2e-15 | 0.38 | 0.09 | 0.29 | FALSE |
8 | METSIM | Adipose | VAV2 | 0.09 | 0.03 | bslmm | 690 | 0.03 | 2.9e-05 | -3.27 | -5.4 | 8.2e-08 | -0.07 | 0.18 | 0.03 | TRUE |
9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ABO | 0.08 | 0.01 | blup | 43 | 0.07 | 7.9e-07 | 16.11 | 12.5 | 5.3e-36 | 0.77 | 0.01 | 0.98 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ABO | 0.07 | 0.08 | lasso | 3 | 0.08 | 5.0e-16 | 16.11 | 16.1 | 1.7e-58 | 0.94 | 0.39 | 0.61 | FALSE |
11 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | ABO | 0.11 | 0.05 | blup | 43 | 0.12 | 1.2e-06 | -6.82 | 13.3 | 2.8e-40 | 0.77 | 0.02 | 0.97 | FALSE |
12 | The Cancer Genome Atlas | Colon Adenocarcinoma | ABO | 0.27 | 0.31 | blup | 43 | 0.33 | 2.1e-19 | 16.18 | 16.4 | 3.0e-60 | 0.87 | 0.01 | 0.99 | FALSE |
13 | The Cancer Genome Atlas | Esophageal Carcinoma | ABO | 0.27 | 0.13 | lasso | 2 | 0.11 | 1.8e-04 | 16.18 | 16.1 | 1.3e-58 | 0.93 | 0.02 | 0.96 | FALSE |
14 | The Cancer Genome Atlas | Glioblastoma Multiforme | ABO | 0.18 | 0.01 | blup | 42 | 0.07 | 3.0e-03 | 16.18 | 14.9 | 3.3e-50 | 0.84 | 0.00 | 0.74 | FALSE |
15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ABO | 0.11 | 0.08 | blup | 43 | 0.12 | 2.5e-13 | 16.18 | 14.8 | 1.1e-49 | 0.78 | 0.01 | 0.99 | FALSE |
16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ABO | 0.20 | 0.19 | blup | 43 | 0.33 | 3.0e-38 | -6.79 | 12.2 | 2.4e-34 | 0.79 | 0.58 | 0.42 | FALSE |
17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C9orf7 | 0.09 | 0.00 | blup | 21 | 0.03 | 2.2e-04 | -2.60 | 6.0 | 2.0e-09 | 0.28 | 0.01 | 0.03 | FALSE |
18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | REXO4 | 0.04 | 0.01 | lasso | 4 | 0.02 | 1.4e-03 | -0.85 | -7.1 | 1.5e-12 | -0.30 | 0.01 | 0.84 | FALSE |
19 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ABO | 0.31 | 0.38 | lasso | 5 | 0.42 | 3.1e-26 | 16.81 | 16.2 | 4.3e-59 | 0.97 | 0.00 | 1.00 | FALSE |
20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ABO | 0.26 | 0.23 | enet | 10 | 0.26 | 6.0e-29 | 16.11 | 16.7 | 3.0e-62 | 0.88 | 0.94 | 0.06 | FALSE |
21 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABO | 0.23 | 0.23 | lasso | 2 | 0.24 | 2.2e-11 | 16.81 | 16.8 | 1.3e-63 | 0.99 | 0.00 | 1.00 | FALSE |
22 | The Cancer Genome Atlas | Lung Adenocarcinoma | ABO | 0.21 | 0.25 | lasso | 5 | 0.25 | 2.1e-29 | 16.11 | 16.5 | 1.8e-61 | 0.97 | 0.02 | 0.98 | FALSE |
23 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ABO | 0.08 | 0.06 | blup | 43 | 0.09 | 1.7e-10 | 16.11 | 13.8 | 3.1e-43 | 0.89 | 0.00 | 1.00 | FALSE |
24 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ABO | 0.28 | 0.22 | lasso | 8 | 0.22 | 1.2e-14 | 16.11 | 16.3 | 5.0e-60 | 0.94 | 0.01 | 0.99 | FALSE |
25 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ABO | 0.23 | 0.21 | lasso | 5 | 0.20 | 6.7e-09 | 16.81 | 16.3 | 1.5e-59 | 0.95 | 0.00 | 1.00 | FALSE |
26 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ABO | 0.23 | 0.23 | lasso | 3 | 0.23 | 2.0e-09 | 16.18 | 16.1 | 3.3e-58 | 0.95 | 0.01 | 0.99 | FALSE |
27 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ABO | 0.18 | 0.15 | blup | 43 | 0.21 | 3.4e-21 | 16.81 | 12.6 | 2.8e-36 | 0.84 | 0.00 | 1.00 | FALSE |
28 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ABO | 0.48 | 0.23 | enet | 10 | 0.27 | 4.7e-07 | 16.86 | 17.6 | 1.4e-69 | 0.89 | 0.00 | 0.98 | TRUE |
29 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ABO | 0.32 | 0.18 | enet | 10 | 0.20 | 2.3e-12 | 16.11 | 14.6 | 3.4e-48 | 0.85 | 0.01 | 0.99 | FALSE |
30 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | ABO | 0.38 | 0.11 | blup | 43 | 0.15 | 9.6e-05 | 7.71 | 13.4 | 3.3e-41 | 0.76 | 0.02 | 0.86 | FALSE |
31 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ABO | 0.20 | 0.10 | blup | 42 | 0.18 | 5.8e-13 | 16.11 | 15.6 | 1.6e-54 | 0.83 | 0.01 | 0.99 | FALSE |
32 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ABO | 0.41 | 0.17 | enet | 12 | 0.25 | 3.0e-09 | -9.58 | 13.1 | 3.0e-39 | 0.87 | 0.09 | 0.90 | FALSE |
33 | The Cancer Genome Atlas | Thyroid Carcinoma | ABO | 0.44 | 0.57 | enet | 18 | 0.60 | 1.9e-73 | 16.11 | 16.2 | 7.7e-59 | 0.97 | 0.00 | 1.00 | FALSE |
34 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | ABO | 0.23 | 0.07 | blup | 44 | 0.12 | 4.3e-04 | 16.81 | 10.0 | 1.5e-23 | 0.64 | 0.00 | 0.78 | FALSE |