Hub : Traits :

Deep venous thrombosis (DVT) (self-reported)

72 significantly associated models · 26 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 168375973 170514229 7 6 2.4e-17 7.3e-166 1.1e-82 51 ATP1B1 C1orf112 NME7 SLC19A2
2 4 154758667 156166231 3 1 6.7e-17 2.4e-18 5.6e-04 84 PLRG1
3 4 186328499 187829016 3 3 3.3e-15 1.9e-23 3.7e-04 87 CYP4V2 F11
4 9 135521303 137552398 9 3 1.4e-69 8.4e-64 7.8e-01 100 ABO SARDH VAV2
5 10 70516744 71966819 1 1 5.5e-10 5.6e-10 1.0e+00 100 TSPAN15
6 20 32898339 34562581 3 1 2.7e-09 3.9e-09 2.3e-02 85 EIF6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Ulcerative Colitis (UC) 1.69 1 0 0.0 0 1.0e+00 EIF6
Reaction Time 1.38 1 0 0.0 0 1.0e+00 EIF6
Ovarian Cancer 2.60 1 0 0.0 0 1.0e+00 ABO
Coronary Artery Disease (CAD) 3.81 1 1 2.2 0 1.0e+00 ABO
LDL Cholesterol 3.54 1 1 2.2 0 1.0e+00 ABO
Primary Biliary Cirrhosis 1.89 1 0 0.0 0 1.0e+00 ATP1B1
Ulcerative Colitis 1.89 1 0 0.0 0 1.0e+00 EIF6
Blood Eosinophil Count 1.06 3 1 2.2 0 1.0e+00 ABO SARDH VAV2
Blood Platelet Count 0.60 3 0 0.0 0 1.0e+00 ATP1B1 CYP4V2 TSPAN15
Blood Red Count 2.02 3 2 4.4 0 1.0e+00 ABO ATP1B1 SARDH
Blood White Count 2.15 2 2 4.4 0 1.0e+00 ABO SARDH
Heel T-Score 1.11 2 1 2.2 0 1.0e+00 ABO CYP4V2
Height 2.44 3 1 2.2 0 1.0e+00 ABO EIF6 PLRG1
Systolic Blood Pressure 1.39 3 1 2.2 0 1.0e+00 ABO ATP1B1 NME7
Allergy or Eczema 1.75 1 1 2.2 0 1.0e+00 ABO
Lung FEV1/FVC ratio 1.51 3 1 2.2 0 1.0e+00 ABO EIF6 NME7
Lung FVC 0.66 2 0 0.0 0 1.0e+00 ABO EIF6
Hair Pigment 0.43 1 1 2.2 0 1.0e+00 EIF6
Tanning 1.31 1 1 2.2 0 1.0e+00 EIF6
Hand grip strength (left) 1.83 2 1 2.2 0 1.0e+00 ABO EIF6
Ever used hormone-replacement therapy (HRT) 1.26 1 0 0.0 0 1.0e+00 C1orf112
Systolic blood pressure, automated reading 0.98 1 0 0.0 0 1.0e+00 ATP1B1
Angina 2.68 1 0 0.0 0 1.0e+00 NME7
Medication: Metformin 1.16 1 0 0.0 0 1.0e+00 ABO
Impedance of leg (right) 0.62 1 0 0.0 0 1.0e+00 EIF6
Leg fat-free mass (left) 1.73 1 1 2.2 0 1.0e+00 EIF6
Trunk fat percentage 0.79 1 1 2.2 0 1.0e+00 ABO
Hand grip strength (right) 2.18 2 1 2.2 0 1.0e+00 ABO EIF6
Age when periods started (menarche) 0.94 1 0 0.0 0 1.0e+00 EIF6
Heel bone mineral density (BMD) T-score, automated (left) 0.81 1 0 0.0 0 1.0e+00 ABO
High blood pressure 1.65 1 1 2.2 0 1.0e+00 ABO
Hayfever, allergic rhinitis or eczema 1.38 1 0 0.0 0 1.0e+00 ABO
Sitting height 3.12 1 1 2.2 0 1.0e+00 EIF6
Impedance of leg (left) 0.74 1 0 0.0 0 1.0e+00 EIF6
Leg predicted mass (left) 1.73 1 1 2.2 0 1.0e+00 EIF6
Trunk fat mass 0.49 1 0 0.0 0 1.0e+00 ABO
Forced vital capacity (FVC) 0.79 2 0 0.0 0 1.0e+00 ABO EIF6
Heel bone mineral density (BMD) T-score, automated (right) 0.69 1 0 0.0 0 1.0e+00 ABO
Allergy 3.82 3 1 2.2 0 1.0e+00 ABO EIF6 SARDH
Medication: Simvastatin 1.52 1 0 0.0 0 1.0e+00 ABO
Weight 0.82 1 1 2.2 0 1.0e+00 EIF6
Impedance of arm (right) 1.63 1 1 2.2 0 1.0e+00 ABO
Arm fat percentage (right) 1.16 1 1 2.2 0 1.0e+00 ABO
Trunk fat-free mass 2.70 2 2 4.4 0 1.0e+00 ABO EIF6
Father's age at death 2.77 2 0 0.0 0 1.0e+00 ABO NME7
Frequency of tiredness / lethargy in last 2 weeks 2.53 1 0 0.0 0 1.0e+00 NME7
Forced expiratory volume in 1-second (FEV1) 1.06 2 0 0.0 0 1.0e+00 ABO EIF6
Medication: Cholesterol lowering 1.80 1 0 0.0 0 1.0e+00 ABO
Forced expiratory volume in 1-second (FEV1), Best measure 1.30 2 0 0.0 0 1.0e+00 ABO EIF6
Impedance of arm (left) 1.76 2 1 2.2 0 1.0e+00 ABO VAV2
Arm fat mass (right) 0.55 1 0 0.0 0 1.0e+00 ABO
Trunk predicted mass 2.73 2 2 4.4 0 1.0e+00 ABO EIF6
Standing height 2.53 2 1 2.2 0 1.0e+00 EIF6 PLRG1
Peak expiratory flow (PEF) 2.26 2 1 2.2 0 1.0e+00 ABO EIF6
Mouth/teeth dental problems: Bleeding gums 1.12 1 0 0.0 0 1.0e+00 EIF6
Blood clot in the leg (DVT) 46.65 12 12 26.7 1 9.7e-22 ABO ATP1B1 C1orf112 CYP4V2 EIF6 F11 NME7 PLRG1 SARDH SLC19A2 TSPAN15 VAV2
Forced vital capacity (FVC), Best measure 0.92 1 0 0.0 0 1.0e+00 EIF6
Body fat percentage 0.71 1 0 0.0 0 1.0e+00 ABO
Leg fat percentage (right) 0.58 1 0 0.0 0 1.0e+00 EIF6
Arm fat-free mass (right) 2.44 2 2 4.4 0 1.0e+00 ABO EIF6
Qualifications: College or University degree 1.24 1 0 0.0 0 1.0e+00 EIF6
Medication for pain relief, constipation, heartburn 1.60 1 0 0.0 0 1.0e+00 NME7
Heart disease (mother) 2.09 1 0 0.0 0 1.0e+00 ABO
Arm predicted mass (right) 2.44 2 2 4.4 0 1.0e+00 ABO EIF6
Pulse rate, automated reading 0.76 1 0 0.0 0 1.0e+00 ABO
Alcohol intake frequency. 1.20 1 0 0.0 0 1.0e+00 NME7
Comparative height size at age 10 1.34 1 1 2.2 0 1.0e+00 EIF6
Age at last live birth 1.47 1 0 0.0 0 1.0e+00 VAV2
Medication: Aspirin 3.62 2 0 0.0 0 1.0e+00 ABO NME7
Hypertension (Self-reported) 1.49 1 1 2.2 0 1.0e+00 ABO
Illnesses of father: Heart disease 2.42 1 0 0.0 0 1.0e+00 ABO
Forced expiratory volume in 1-second (FEV1), predicted 1.38 1 1 2.2 0 1.0e+00 EIF6
Whole body fat-free mass 2.26 1 1 2.2 0 1.0e+00 EIF6
Leg fat-free mass (right) 1.76 1 1 2.2 0 1.0e+00 EIF6
Arm fat percentage (left) 1.18 1 1 2.2 0 1.0e+00 ABO
Ever had bowel cancer screening 1.90 1 0 0.0 0 1.0e+00 ABO
Medication: Aspirin 3.05 1 0 0.0 0 1.0e+00 NME7
Smoking status: Current 1.48 1 0 0.0 0 1.0e+00 SLC19A2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.66 1 0 0.0 0 1.0e+00 ABO
Whole body water mass 2.24 1 1 2.2 0 1.0e+00 EIF6
Leg predicted mass (right) 1.75 1 1 2.2 0 1.0e+00 EIF6
Arm fat mass (left) 0.55 1 0 0.0 0 1.0e+00 ABO
Number of self-reported non-cancer illnesses 1.83 2 0 0.0 0 1.0e+00 ATP1B1 NME7
Mother's age at death 2.56 1 0 0.0 0 1.0e+00 ABO
Medication: Blood pressure 1.17 1 0 0.0 0 1.0e+00 ATP1B1
High cholesterol (Self-reported) 2.26 1 1 2.2 0 1.0e+00 ABO
Medication: Atorvastatin 2.35 1 0 0.0 0 1.0e+00 ABO
Basal metabolic rate 1.92 1 1 2.2 0 1.0e+00 EIF6
Leg fat percentage (left) 0.53 1 0 0.0 0 1.0e+00 EIF6
Arm fat-free mass (left) 2.36 2 2 4.4 0 1.0e+00 ABO EIF6
Diastolic blood pressure, automated reading 1.42 1 1 2.2 0 1.0e+00 ABO
Vascular/heart problems diagnosed by doctor 1.34 1 0 0.0 0 1.0e+00 ABO
Cholesterol lowering medication 2.14 1 1 2.2 0 1.0e+00 ABO
Alcohol drinker status: Previous 2.34 1 0 0.0 0 1.0e+00 NME7
Impedance of whole body 0.72 2 0 0.0 0 1.0e+00 ABO EIF6
Arm predicted mass (left) 2.39 2 2 4.4 0 1.0e+00 ABO EIF6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 1 0.034 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 2 0.053 1.3
GTEx Brain Caudate basal ganglia 1 0.109 1.4
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 1 0.050 1.3
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.4
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 2 0.101 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.1
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 1 0.024 1.3
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 1 0.048 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 2 0.060 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 1 0.063 1.3
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.2
GTEx Lung 1 0.035 1.3
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 1 0.023 1.3
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 1 0.061 1.4
GTEx Pituitary 1 0.090 1.3
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 1 0.041 1.3
GTEx Skin Sun Exposed Lower leg 1 0.027 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 2 0.142 1.3
GTEx Stomach 1 0.069 1.3
GTEx Testis 1 0.032 1.3
GTEx Thyroid 1 0.025 1.2
GTEx Uterus 1 0.176 1.4
GTEx Vagina 1 0.157 1.3
GTEx Whole Blood 1 0.050 1.2
METSIM Adipose 4 0.087 1.3
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 1 0.023 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 2 0.037 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 2 0.045 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 2 0.097 1.3
The Cancer Genome Atlas Esophageal Carcinoma 1 0.146 1.6
The Cancer Genome Atlas Glioblastoma Multiforme 2 0.196 1.6
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 2 0.073 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 5 0.122 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 1 0.049 1.4
The Cancer Genome Atlas Brain Lower Grade Glioma 2 0.046 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.5
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 4 0.160 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.063 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 1 0.060 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.4
The Cancer Genome Atlas Prostate Adenocarcinoma 2 0.043 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 1 0.145 1.7
The Cancer Genome Atlas Soft Tissue Sarcoma 1 0.094 1.5
The Cancer Genome Atlas Skin Cutaneous Melanoma 1 0.187 1.6
The Cancer Genome Atlas Stomach Adenocarcinoma 2 0.119 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.4
The Cancer Genome Atlas Thyroid Carcinoma 2 0.039 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 1 0.197 1.3