Hub : Traits :

Deep venous thrombosis (DVT) (self-reported)

72 significantly associated models · 26 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	168375973	170514229	7	6	2.4e-17	7.3e-166	1.1e-82	51	ATP1B1 C1orf112 NME7 SLC19A2
2	4	154758667	156166231	3	1	6.7e-17	2.4e-18	5.6e-04	84	PLRG1
3	4	186328499	187829016	3	3	3.3e-15	1.9e-23	3.7e-04	87	CYP4V2 F11
4	9	135521303	137552398	9	3	1.4e-69	8.4e-64	7.8e-01	100	ABO SARDH VAV2
5	10	70516744	71966819	1	1	5.5e-10	5.6e-10	1.0e+00	100	TSPAN15
6	20	32898339	34562581	3	1	2.7e-09	3.9e-09	2.3e-02	85	EIF6

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Blood clot in the leg (DVT)	46.65	12	12	26.7	1	9.7e-22	ABO ATP1B1 C1orf112 CYP4V2 EIF6 F11 NME7 PLRG1 SARDH SLC19A2 TSPAN15 VAV2
Allergy	3.82	3	1	2.2	0	1.0e+00	ABO EIF6 SARDH
Coronary Artery Disease (CAD)	3.81	1	1	2.2	0	1.0e+00	ABO
Medication: Aspirin	3.62	2	0	0.0	0	1.0e+00	ABO NME7
LDL Cholesterol	3.54	1	1	2.2	0	1.0e+00	ABO
Sitting height	3.12	1	1	2.2	0	1.0e+00	EIF6
Medication: Aspirin	3.05	1	0	0.0	0	1.0e+00	NME7
Father's age at death	2.77	2	0	0.0	0	1.0e+00	ABO NME7
Trunk predicted mass	2.73	2	2	4.4	0	1.0e+00	ABO EIF6
Trunk fat-free mass	2.70	2	2	4.4	0	1.0e+00	ABO EIF6
Angina	2.68	1	0	0.0	0	1.0e+00	NME7
Ovarian Cancer	2.60	1	0	0.0	0	1.0e+00	ABO
Mother's age at death	2.56	1	0	0.0	0	1.0e+00	ABO
Frequency of tiredness / lethargy in last 2 weeks	2.53	1	0	0.0	0	1.0e+00	NME7
Standing height	2.53	2	1	2.2	0	1.0e+00	EIF6 PLRG1
Height	2.44	3	1	2.2	0	1.0e+00	ABO EIF6 PLRG1
Arm fat-free mass (right)	2.44	2	2	4.4	0	1.0e+00	ABO EIF6
Arm predicted mass (right)	2.44	2	2	4.4	0	1.0e+00	ABO EIF6
Illnesses of father: Heart disease	2.42	1	0	0.0	0	1.0e+00	ABO
Arm predicted mass (left)	2.39	2	2	4.4	0	1.0e+00	ABO EIF6
Arm fat-free mass (left)	2.36	2	2	4.4	0	1.0e+00	ABO EIF6
Medication: Atorvastatin	2.35	1	0	0.0	0	1.0e+00	ABO
Alcohol drinker status: Previous	2.34	1	0	0.0	0	1.0e+00	NME7
Peak expiratory flow (PEF)	2.26	2	1	2.2	0	1.0e+00	ABO EIF6
Whole body fat-free mass	2.26	1	1	2.2	0	1.0e+00	EIF6
High cholesterol (Self-reported)	2.26	1	1	2.2	0	1.0e+00	ABO
Whole body water mass	2.24	1	1	2.2	0	1.0e+00	EIF6
Hand grip strength (right)	2.18	2	1	2.2	0	1.0e+00	ABO EIF6
Blood White Count	2.15	2	2	4.4	0	1.0e+00	ABO SARDH
Cholesterol lowering medication	2.14	1	1	2.2	0	1.0e+00	ABO
Heart disease (mother)	2.09	1	0	0.0	0	1.0e+00	ABO
Blood Red Count	2.02	3	2	4.4	0	1.0e+00	ABO ATP1B1 SARDH
Basal metabolic rate	1.92	1	1	2.2	0	1.0e+00	EIF6
Ever had bowel cancer screening	1.90	1	0	0.0	0	1.0e+00	ABO
Primary Biliary Cirrhosis	1.89	1	0	0.0	0	1.0e+00	ATP1B1
Ulcerative Colitis	1.89	1	0	0.0	0	1.0e+00	EIF6
Hand grip strength (left)	1.83	2	1	2.2	0	1.0e+00	ABO EIF6
Number of self-reported non-cancer illnesses	1.83	2	0	0.0	0	1.0e+00	ATP1B1 NME7
Medication: Cholesterol lowering	1.80	1	0	0.0	0	1.0e+00	ABO
Impedance of arm (left)	1.76	2	1	2.2	0	1.0e+00	ABO VAV2
Leg fat-free mass (right)	1.76	1	1	2.2	0	1.0e+00	EIF6
Allergy or Eczema	1.75	1	1	2.2	0	1.0e+00	ABO
Leg predicted mass (right)	1.75	1	1	2.2	0	1.0e+00	EIF6
Leg fat-free mass (left)	1.73	1	1	2.2	0	1.0e+00	EIF6
Leg predicted mass (left)	1.73	1	1	2.2	0	1.0e+00	EIF6
Ulcerative Colitis (UC)	1.69	1	0	0.0	0	1.0e+00	EIF6
High blood pressure	1.65	1	1	2.2	0	1.0e+00	ABO
Impedance of arm (right)	1.63	1	1	2.2	0	1.0e+00	ABO
Medication for pain relief, constipation, heartburn	1.60	1	0	0.0	0	1.0e+00	NME7
Medication: Simvastatin	1.52	1	0	0.0	0	1.0e+00	ABO
Lung FEV1/FVC ratio	1.51	3	1	2.2	0	1.0e+00	ABO EIF6 NME7
Hypertension (Self-reported)	1.49	1	1	2.2	0	1.0e+00	ABO
Smoking status: Current	1.48	1	0	0.0	0	1.0e+00	SLC19A2
Age at last live birth	1.47	1	0	0.0	0	1.0e+00	VAV2
Diastolic blood pressure, automated reading	1.42	1	1	2.2	0	1.0e+00	ABO
Systolic Blood Pressure	1.39	3	1	2.2	0	1.0e+00	ABO ATP1B1 NME7
Reaction Time	1.38	1	0	0.0	0	1.0e+00	EIF6
Hayfever, allergic rhinitis or eczema	1.38	1	0	0.0	0	1.0e+00	ABO
Forced expiratory volume in 1-second (FEV1), predicted	1.38	1	1	2.2	0	1.0e+00	EIF6
Comparative height size at age 10	1.34	1	1	2.2	0	1.0e+00	EIF6
Vascular/heart problems diagnosed by doctor	1.34	1	0	0.0	0	1.0e+00	ABO
Tanning	1.31	1	1	2.2	0	1.0e+00	EIF6
Forced expiratory volume in 1-second (FEV1), Best measure	1.30	2	0	0.0	0	1.0e+00	ABO EIF6
Ever used hormone-replacement therapy (HRT)	1.26	1	0	0.0	0	1.0e+00	C1orf112
Qualifications: College or University degree	1.24	1	0	0.0	0	1.0e+00	EIF6
Alcohol intake frequency.	1.20	1	0	0.0	0	1.0e+00	NME7
Arm fat percentage (left)	1.18	1	1	2.2	0	1.0e+00	ABO
Medication: Blood pressure	1.17	1	0	0.0	0	1.0e+00	ATP1B1
Medication: Metformin	1.16	1	0	0.0	0	1.0e+00	ABO
Arm fat percentage (right)	1.16	1	1	2.2	0	1.0e+00	ABO
Mouth/teeth dental problems: Bleeding gums	1.12	1	0	0.0	0	1.0e+00	EIF6
Heel T-Score	1.11	2	1	2.2	0	1.0e+00	ABO CYP4V2
Blood Eosinophil Count	1.06	3	1	2.2	0	1.0e+00	ABO SARDH VAV2
Forced expiratory volume in 1-second (FEV1)	1.06	2	0	0.0	0	1.0e+00	ABO EIF6
Systolic blood pressure, automated reading	0.98	1	0	0.0	0	1.0e+00	ATP1B1
Age when periods started (menarche)	0.94	1	0	0.0	0	1.0e+00	EIF6
Forced vital capacity (FVC), Best measure	0.92	1	0	0.0	0	1.0e+00	EIF6
Weight	0.82	1	1	2.2	0	1.0e+00	EIF6
Heel bone mineral density (BMD) T-score, automated (left)	0.81	1	0	0.0	0	1.0e+00	ABO
Trunk fat percentage	0.79	1	1	2.2	0	1.0e+00	ABO
Forced vital capacity (FVC)	0.79	2	0	0.0	0	1.0e+00	ABO EIF6
Pulse rate, automated reading	0.76	1	0	0.0	0	1.0e+00	ABO
Impedance of leg (left)	0.74	1	0	0.0	0	1.0e+00	EIF6
Impedance of whole body	0.72	2	0	0.0	0	1.0e+00	ABO EIF6
Body fat percentage	0.71	1	0	0.0	0	1.0e+00	ABO
Heel bone mineral density (BMD) T-score, automated (right)	0.69	1	0	0.0	0	1.0e+00	ABO
Lung FVC	0.66	2	0	0.0	0	1.0e+00	ABO EIF6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.66	1	0	0.0	0	1.0e+00	ABO
Impedance of leg (right)	0.62	1	0	0.0	0	1.0e+00	EIF6
Blood Platelet Count	0.60	3	0	0.0	0	1.0e+00	ATP1B1 CYP4V2 TSPAN15
Leg fat percentage (right)	0.58	1	0	0.0	0	1.0e+00	EIF6
Arm fat mass (right)	0.55	1	0	0.0	0	1.0e+00	ABO
Arm fat mass (left)	0.55	1	0	0.0	0	1.0e+00	ABO
Leg fat percentage (left)	0.53	1	0	0.0	0	1.0e+00	EIF6
Trunk fat mass	0.49	1	0	0.0	0	1.0e+00	ABO
Hair Pigment	0.43	1	1	2.2	0	1.0e+00	EIF6

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
The Cancer Genome Atlas	Rectum Adenocarcinoma	1	0.145	1.7
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.146	1.6
The Cancer Genome Atlas	Glioblastoma Multiforme	2	0.196	1.6
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.187	1.6
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.5
The Cancer Genome Atlas	Soft Tissue Sarcoma	1	0.094	1.5
GTEx	Brain Caudate basal ganglia	1	0.109	1.4
GTEx	Brain Hypothalamus	0	0.000	1.4
GTEx	Breast Mammary Tissue	2	0.101	1.4
GTEx	Pancreas	1	0.061	1.4
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
GTEx	Uterus	1	0.176	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	1	0.049	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.4
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	2	0.119	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	1	0.034	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Artery Tibial	2	0.053	1.3
GTEx	Brain Cerebellum	1	0.050	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	1	0.024	1.3
GTEx	Colon Transverse	1	0.048	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	2	0.060	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Atrial Appendage	1	0.063	1.3
GTEx	Lung	1	0.035	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Nerve Tibial	1	0.023	1.3
GTEx	Pituitary	1	0.090	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.3
GTEx	Skin Sun Exposed Lower leg	1	0.027	1.3
GTEx	Spleen	2	0.142	1.3
GTEx	Stomach	1	0.069	1.3
GTEx	Testis	1	0.032	1.3
GTEx	Vagina	1	0.157	1.3
METSIM	Adipose	4	0.087	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	2	0.097	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	2	0.073	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	5	0.122	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	2	0.046	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	4	0.160	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	2	0.039	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	1	0.197	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Thyroid	1	0.025	1.2
GTEx	Whole Blood	1	0.050	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	1	0.023	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.1