Best TWAS P=4.64e-12 · Best GWAS P=1.85e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | S100A11 | 0.18 | 0.13 | lasso | 3 | 0.14 | 1.1e-05 | 6.0 | 6.6 | 3.8e-11 | 0.28 | 0.21 | 0.05 | TRUE |
| 2 | GTEx | Colon Sigmoid | TDRKH | 0.28 | 0.20 | enet | 16 | 0.17 | 1.2e-06 | -3.1 | -5.4 | 6.0e-08 | -0.35 | 0.87 | 0.06 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LINGO4 | 0.15 | 0.03 | lasso | 4 | 0.05 | 8.9e-10 | 7.4 | 5.5 | 3.7e-08 | 0.88 | 0.00 | 1.00 | TRUE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | LINGO4 | 0.29 | 0.07 | enet | 15 | 0.07 | 8.3e-05 | 7.4 | 6.8 | 1.2e-11 | 0.76 | 0.00 | 0.98 | TRUE |
| 5 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LINGO4 | 0.22 | 0.06 | enet | 13 | 0.06 | 3.3e-07 | 7.4 | 5.7 | 1.1e-08 | 0.91 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | LINGO4 | 0.20 | 0.07 | lasso | 4 | 0.07 | 3.7e-08 | 7.4 | 6.9 | 5.3e-12 | 0.99 | 0.00 | 1.00 | TRUE |
| 7 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LINGO4 | 0.32 | 0.09 | lasso | 8 | 0.13 | 3.3e-06 | 7.4 | 6.9 | 4.6e-12 | 0.80 | 0.00 | 0.99 | TRUE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LINGO4 | 0.53 | 0.20 | lasso | 4 | 0.23 | 1.1e-23 | 7.4 | 6.1 | 1.4e-09 | 0.93 | 0.00 | 1.00 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | LINGO4 | 0.43 | 0.15 | lasso | 7 | 0.20 | 2.3e-19 | 7.4 | 5.4 | 7.9e-08 | 0.87 | 0.00 | 1.00 | FALSE |