TWAS hub - S100A11

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.3730	0.0900	4.5e-05	0.265	NA	0.219	NA	0.225	3.2e-09	NA	1.0e-07	NA	6.8e-08
2	GTEx	Colon Sigmoid	0.1750	0.0720	3.5e-03	0.128	NA	0.112	NA	0.141	2.8e-05	NA	9.3e-05	NA	1.1e-05
3	GTEx	Esophagus Gastroesophageal Junction	0.1950	0.0890	7.3e-03	0.121	NA	0.110	NA	0.115	3.8e-05	NA	8.6e-05	NA	5.9e-05
4	YFS	Blood	0.0489	0.0147	2.1e-07	0.028	0.023	0.035	0.032	0.031	1.0e-09	3.5e-08	9.6e-12	1.3e-10	1.5e-10
5	TCGA	Thyroid Carcinoma	0.0450	0.0270	3.3e-03	0.009	0.023	0.000	NA	0.009	3.8e-02	2.2e-03	2.8e-01	NA	3.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Hair/balding pattern: Pattern 4	6.8	16.5	50.0	-0.8	-4.9	-7.1	-2.8	0.5
Respiratory disease	5.4	12.0	52.1	-1.0	7.2	2.3	1.4	-0.2
Asthma	5.4	10.7	44.2	-1.3	6.7	2.5	0.9	-0.7
Asthma (self-reported)	5.4	10.7	43.7	-1.2	6.6	2.5	1.0	-0.9
Allergy or Eczema	4.6	12.0	41.0	0.1	6.4	3.8	2.2	0.2
Hayfever, allergic rhinitis or eczema	4.3	9.3	26.6	-0.1	5.2	4.1	1.6	-0.4
Hair/balding pattern: Pattern 2	4.1	5.2	18.5	1.1	1.8	4.3	1.6	-0.5
Pack years adult smoking proportion	3.8	5.8	12.6	3.0	-0.6	-1.0	2.5	3.5
Pack years of smoking	3.8	5.6	12.8	2.8	-0.3	-1.4	2.2	3.6
Medication for hormone replacement therapy	3.5	3.9	5.8	2.1	1.3	1.9	2.4	2.0
Allergy	3.5	8.2	28.8	-0.1	-5.4	-3.0	-1.8	0.1
Length of working week for main job	3.1	3.4	8.6	-2.3	-0.7	-0.8	-2.9	-1.3
Hair/balding pattern: Pattern 3	2.9	4.3	16.5	-0.9	-0.8	-4.1	-1.8	-0.4
Number of self-reported non-cancer illnesses	2.7	4.7	11.0	1.2	2.5	3.3	2.2	0.0
Time employed in main current job	2.6	3.0	9.3	0.5	-3.1	-1.8	-0.9	1.1
Serious illness, injury or assault to yourself	2.4	2.9	6.0	2.4	0.6	-0.2	2.0	2.1
Qualifications: None of the above	2.4	5.2	12.7	2.4	1.4	-1.2	2.1	3.6
Medication: Ventolin 100micrograms inhaler	2.4	3.0	7.3	-0.5	2.6	2.7	0.8	-0.2
Mean Putamen Volume	2.3	2.6	3.8	-1.8	-0.1	1.8	-1.7	-1.9
Suffer from ‘nerves’	2.3	3.6	7.2	2.7	-0.0	-0.6	2.3	2.3
Alzheimer’s Disease (in mother)	2.2	2.6	5.9	1.5	0.5	-1.8	1.1	2.4
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	4.4	-2.1	0.8	-0.0	-1.7	-1.9
Angina (self-reported)	2.0	2.6	5.3	2.0	0.4	-1.0	1.7	2.3
Angina	1.9	2.5	5.5	2.0	0.1	-0.9	1.5	2.3
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	8.5	-1.8	1.9	2.1	-0.2	-2.9
Financial situation satisfaction	1.9	2.4	4.2	1.3	1.4	1.7	2.0	1.1
Hearing difficulty/problems with background noise	1.8	2.8	4.5	1.8	-1.8	-1.4	1.2	2.1
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.2	9.1	-2.6	0.9	1.0	-1.8	-3.0
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	3.3	1.5	1.6	1.3	1.8	1.5
Emphysema/chronic bronchitis	1.8	2.0	2.7	1.2	1.6	1.5	1.2	1.6
Migraine (self-reported)	1.8	2.2	3.6	-1.9	1.1	1.1	-1.4	-1.7
Commuting to job workplace: Cycle	1.8	2.2	4.5	1.6	-0.6	2.1	1.8	0.8
Sitting height	1.7	12.1	21.9	-4.5	-1.2	1.5	-3.8	-4.7
Wheeze or whistling in the chest in last year	1.7	3.1	14.1	-0.7	3.8	0.4	0.7	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.7	1.9	6.3	-1.3	0.6	1.1	-0.2	-2.5
Alcohol drinker status: Previous	1.7	1.9	4.7	-1.3	2.2	0.3	-0.6	-1.6
Fasting Glucose	1.6	1.9	4.0	0.1	-1.3	-1.0	-2.0	-1.7
Past tobacco smoking	1.6	2.9	6.0	2.3	-0.6	0.3	1.6	2.4
Pain all over the body in last month	1.6	1.8	3.0	-1.6	-0.4	1.4	-1.1	-1.7
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	3.1	-1.3	1.5	-1.5	-1.8	-0.5
Smoking status: Previous	1.6	2.3	4.2	-2.0	0.6	-0.5	-1.7	-2.0
Medication for cholesterol	1.6	2.4	4.3	-1.8	-1.9	-0.5	-2.1	-1.0
Diastolic blood pressure, automated reading	1.6	4.9	9.1	-2.1	-3.0	-1.3	-2.3	-1.9
Worry too long after embarrassment	1.5	2.6	4.0	2.0	-2.0	1.0	1.3	1.6
Relative age of first facial hair	1.4	3.0	9.3	0.3	1.9	3.1	1.3	-0.3
Medication: Metformin	1.4	2.0	4.1	-1.4	-1.3	-0.2	-1.4	-2.0
Relative age voice broke	1.4	2.2	5.1	-0.2	2.3	2.2	-0.0	-1.0
Supplements: Glucosamine	1.4	1.8	4.2	-0.9	1.2	2.1	-0.5	-1.5
Medication: Paracetamol	1.4	2.3	4.6	0.2	2.1	1.9	1.7	-0.4
Arm fat-free mass (right)	1.4	7.1	13.0	-3.3	-2.0	-0.4	-3.6	-2.7
Neck or shoulder pain in last month	1.4	2.0	4.0	2.0	0.8	0.9	1.6	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	6.0	0.6	2.4	-0.1	1.0	1.1
Arm predicted mass (right)	1.4	6.9	11.8	-3.3	-2.1	-0.3	-3.4	-2.7
Osteoporosis (self-reported)	1.4	1.7	2.6	-1.4	-0.9	-1.2	-1.4	-1.6
Eye problems/disorders: Glaucoma	1.4	1.6	3.3	-1.4	-0.4	-0.1	-1.8	-1.6
Medication: Paracetamol	1.4	2.1	5.8	-0.3	2.4	1.7	1.2	-0.5
Depression (Nagel 2018)	1.3	1.9	3.5	1.4	-1.9	-0.5	0.6	1.8
Alzheimer’s Disease (in father)	1.3	1.4	2.1	-1.4	1.4	0.1	-0.8	-1.4
Ulcerative Colitis	1.3	1.9	4.8	-0.4	0.2	2.2	-0.3	-2.1
Leg fat-free mass (left)	1.3	6.7	10.6	-3.2	-2.7	-0.7	-3.3	-2.3
Leg predicted mass (left)	1.3	6.7	10.6	-3.2	-2.6	-0.7	-3.2	-2.3
Medication: Ibuprofen	1.3	1.5	3.0	-1.3	-0.3	1.4	-0.9	-1.7
Medication: Atorvastatin	1.3	1.6	2.7	-0.6	-1.5	-1.5	-1.6	-0.7
Arm fat-free mass (left)	1.3	6.8	12.2	-3.2	-2.1	-0.5	-3.5	-2.7
Ever depressed for a whole week	1.3	1.6	1.8	-1.3	-1.3	-1.1	-1.4	-1.2
Basal cell carcinoma (self-reported)	1.3	1.5	4.6	-1.3	2.1	-0.6	-0.7	-0.7
Arm predicted mass (left)	1.3	6.7	11.4	-3.1	-2.3	-0.5	-3.4	-2.5
Medication: Levothyroxine sodium	1.2	2.1	5.0	0.1	2.2	2.1	0.7	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.0	-1.2	-0.3	1.5	-0.9	-1.7
Exposure to tobacco smoke at home	1.2	1.3	2.8	0.5	-1.4	-1.7	-0.3	1.2
Whole body fat-free mass	1.2	6.9	11.6	-3.3	-2.1	-0.2	-3.4	-2.8
Ever had bowel cancer screening	1.2	1.4	3.6	1.4	0.1	-0.3	1.2	1.9
Whole body water mass	1.2	6.9	11.6	-3.3	-2.1	-0.1	-3.4	-2.7
Leg predicted mass (right)	1.2	6.2	9.3	-3.0	-2.6	-0.6	-3.0	-2.2
Supplements: Fish oil (including cod liver oil)	1.2	1.5	5.3	-1.2	2.3	0.6	-0.4	-0.5
Supplements: Zinc	1.1	1.2	1.6	1.3	1.1	0.8	1.1	1.0
Average weekly fortified wine intake	1.1	1.3	4.1	0.8	-1.4	2.0	0.3	0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	4.7	-1.9	-0.1	0.4	-1.9	-2.2
Impedance of leg (left)	1.1	5.3	17.3	0.6	4.2	1.4	2.6	-0.3
Had other major operations	1.1	1.3	4.6	-1.2	-0.1	-2.1	-0.5	0.1
Trunk fat-free mass	1.1	6.4	10.0	-3.1	-1.7	0.5	-3.2	-3.0
Trunk predicted mass	1.1	6.2	9.7	-3.1	-1.7	0.4	-3.1	-3.0
Glaucoma (self-reported)	1.1	1.3	2.9	-1.4	0.1	0.1	-1.3	-1.7
Heart disease (mother)	1.1	1.4	2.7	1.6	-1.1	1.0	0.5	1.3
Illnesses of siblings: Diabetes	1.1	1.4	2.9	1.7	-1.1	-0.7	0.7	1.4
Leg fat-free mass (right)	1.1	6.1	9.3	-3.0	-2.5	-0.7	-3.0	-2.2
Back pain experienced in last month	1.1	1.6	3.8	1.2	1.9	0.5	1.4	0.8
Average weekly champagne plus white wine intake	1.1	1.5	3.2	-0.1	1.8	1.6	1.1	-0.8
Ever taken oral contraceptive pill	1.1	1.2	3.0	0.9	-0.3	-1.7	1.0	1.1
Basal metabolic rate	1.1	6.3	10.7	-3.3	-2.0	-0.3	-3.2	-2.5
Major Depression (MDD)	1.0	1.3	1.7	-1.3	-1.0	-1.1	-0.8	-1.3
Neuroticism (2016)	1.0	1.5	4.8	0.8	-2.2	1.1	0.4	0.8
Type 2 Diabetes (T2D) (2018)	1.0	1.9	3.3	-1.7	-1.1	0.0	-1.4	-1.8
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.7	0.0	1.9	1.1	0.3	1.1
Impedance of leg (right)	1.0	4.7	15.7	0.3	4.0	1.5	2.3	-0.5
Hand grip strength (right)	1.0	2.8	7.3	-2.7	1.6	0.0	-1.6	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	3.1	1.3	0.3	0.5	1.4	1.8
Medication: Atenolol	1.0	1.2	3.2	1.8	-1.2	0.1	1.0	0.6
Diabetes (self-reported)	1.0	1.5	3.1	-1.0	-1.4	-0.4	-1.2	-1.8
Prospective memory result	1.0	1.2	5.6	0.1	-0.4	-2.4	0.1	0.7
Standing height	1.0	10.1	21.5	-4.6	0.4	1.7	-2.8	-4.3
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	3.4	1.8	0.9	1.8	1.6	0.4
Qualifications: College or University degree	1.0	3.1	7.1	0.0	-2.7	2.5	-0.2	-1.4
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.6	0.3	-1.9	-1.4	-0.5	0.5
Medication: Aspirin	1.0	1.4	5.4	-0.7	0.5	-2.3	-0.9	-0.1
Average weekly red wine intake	1.0	1.5	4.4	0.2	-2.1	-1.6	-0.1	0.7
Mineral and other dietary supplements	1.0	1.3	2.0	1.4	-1.1	-0.7	1.1	1.3
Osteoarthritis (self-reported)	1.0	1.3	6.0	0.6	-0.0	2.4	0.3	0.2
Medication: Aspirin	1.0	1.2	5.3	-0.3	0.4	-2.3	-0.5	0.6
Fractured/broken bones in last 5 years	1.0	1.3	2.2	1.1	0.9	1.0	1.2	1.5
HDL Cholesterol	0.9	1.5	4.1	2.0	-0.1	0.2	1.5	1.1
Diabetes (mother)	0.9	1.2	4.3	-0.4	0.1	-2.1	-1.1	-0.5
Taking other prescription medications	0.9	1.4	4.4	0.4	1.4	2.1	0.9	-0.1
Mouth/teeth dental problems	0.9	1.4	2.5	1.6	0.2	1.0	1.2	1.4
Impedance of arm (right)	0.9	4.0	12.2	0.4	3.5	0.9	2.6	0.3
Worrier / anxious feelings	0.9	1.6	3.0	1.7	0.1	1.1	1.4	1.4
Medication: Lansoprazole	0.9	1.0	2.8	0.5	0.7	1.7	1.0	0.5
Ever highly irritable/argumentative for 2 days	0.9	1.1	4.4	-0.9	-0.1	-2.1	-0.1	0.2
High blood pressure (siblings)	0.9	1.3	3.0	-0.7	0.1	1.7	-1.0	-1.5
Mouth/teeth dental problems: Loose teeth	0.9	1.0	3.1	-0.9	1.7	-0.3	-0.8	-0.7
Medication: Seretide 50 evohaler	0.9	1.0	2.3	0.7	0.8	0.9	1.5	0.9
Pulse rate, automated reading	0.9	2.9	6.9	-2.0	-0.9	-0.2	-2.6	-1.6
Comparative height size at age 10	0.9	4.9	11.3	-3.4	-0.3	1.1	-2.2	-2.7
Commuting to job workplace: Walk	0.9	0.9	1.9	-0.9	0.8	1.0	-0.3	-1.4
Guilty feelings	0.9	1.3	3.7	-1.3	-0.9	0.2	-1.9	-0.6
Wears glasses or contact lenses	0.9	1.1	2.0	1.4	-0.4	1.4	0.5	1.1
Commuting to job workplace: Public transport	0.9	1.0	4.7	0.1	-2.2	-0.5	-0.4	-0.1
Medication: Bendroflumethiazide	0.9	1.4	2.6	-1.5	0.5	-0.2	-1.3	-1.6
Body Mass Index (BMI) (2010)	0.8	1.1	3.5	-0.4	1.2	-1.9	0.1	0.4
Height	0.8	15.0	27.1	-5.2	0.7	3.9	-2.9	-4.9
Hypothyroidism (self reported)	0.8	1.9	3.2	1.8	1.7	0.6	1.6	0.5
Lung FEV1/FVC ratio	0.8	4.2	7.5	-2.2	-1.3	-1.7	-2.7	-2.1
Hand grip strength (left)	0.8	2.1	5.5	-1.9	2.3	0.3	-1.0	-0.5
Number of treatments/medications taken	0.8	1.5	3.1	0.7	1.6	1.8	1.1	0.1
Systolic blood pressure, automated reading	0.8	2.5	4.5	-1.2	-1.6	-2.1	-1.6	-1.1
Current tobacco smoking	0.8	1.3	3.2	0.8	0.7	-0.9	1.2	1.8
Stomach or abdominal pain in last month	0.8	1.0	2.4	-0.8	-1.1	-0.6	-1.5	-0.6
Chronic bronchitis/emphysema (father)	0.8	1.0	1.7	0.4	1.3	1.3	0.6	1.1
Weight	0.8	4.1	8.7	-2.9	-1.7	-0.7	-2.5	-1.4
Father’s age at death	0.8	1.1	2.6	-1.1	0.7	1.6	-0.5	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	3.5	1.3	-0.8	0.2	0.9	1.9
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.5	-1.6	-2.1	1.2	-1.4	-1.6
Blood clot in the leg (DVT)	0.8	1.0	3.5	-0.8	-0.3	-1.9	-0.9	-0.1
Chronic bronchitis/emphysema (mother)	0.8	1.0	1.8	0.7	0.9	-0.6	1.3	1.2
Number of full brothers	0.8	1.0	4.3	-0.2	2.1	0.4	0.5	-0.6
Had major operations	0.8	1.0	2.0	-1.2	1.0	-0.4	-1.4	0.5
Diabetes diagnosed by doctor	0.8	1.4	1.8	-0.9	-1.3	-1.2	-1.0	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.2	-1.0	-0.8	-0.1	-0.6	-1.5
Hearing aid user	0.8	0.9	3.1	-0.2	-0.3	1.8	0.4	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	1.6	1.2	-0.8	-0.9	1.0	0.9
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	4.1	-0.6	-0.4	-2.0	-0.8	-0.0
Age at First Birth	0.7	1.0	2.5	0.7	1.6	-0.9	1.0	0.1
Lupus	0.7	1.1	1.4	1.1	-1.2	-1.1	0.9	0.9
Lung FVC	0.7	3.3	7.2	1.6	-2.7	0.9	1.0	2.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.8	3.6	0.2	0.2	1.9	0.6	-0.4
Age when periods started (menarche)	0.7	1.7	3.6	1.6	0.4	-1.0	1.1	1.9
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.9	0.2	-1.2	-1.7	-0.1	1.1
Fluid intelligence score	0.7	1.4	4.4	0.1	-2.1	1.6	-0.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.2	-0.8	-0.5	1.8	-0.1	-0.4
Medication: Cholesterol lowering	0.7	1.2	2.9	1.7	0.0	0.4	1.3	1.0
Illnesses of mother	0.7	0.8	1.4	-1.2	-1.0	0.5	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	3.7	-1.6	-1.9	0.7	-1.3	-1.6
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.5	-1.1	-0.3	0.7	-0.4	-1.9
Pulse wave peak to peak time	0.7	0.8	3.6	-0.0	-1.9	0.1	-0.1	-0.5
Chest pain or discomfort	0.7	1.0	2.5	0.9	-1.0	0.0	0.9	1.6
Age at last live birth	0.7	1.0	3.3	-0.7	-1.8	-0.0	-0.5	-1.0
Breast cancer (self-reported)	0.7	0.8	3.2	0.2	-1.8	0.1	-0.6	0.8
Illnesses of father: None of the above (group 1)	0.7	0.9	1.5	-1.2	-0.1	-0.7	-1.2	-1.1
High cholesterol (Self-reported)	0.7	1.2	2.0	1.4	0.8	1.4	1.0	0.7
Alcohol drinker status: Never	0.7	0.9	2.5	1.0	-0.5	-0.8	0.2	1.6
Ever smoked	0.7	1.3	2.8	-1.7	0.6	-0.3	-1.0	-1.4
Impedance of whole body	0.7	3.3	10.7	0.2	3.3	0.8	2.3	-0.1
Alzheimer’s Disease (including proxy)	0.6	0.8	1.8	0.5	0.8	-1.3	0.5	1.1
Ulcerative Colitis (UC)	0.6	1.1	2.6	0.6	0.6	1.6	0.4	-1.4
Ovarian Cancer	0.6	0.9	1.8	-1.2	0.2	0.4	-0.9	-1.4
LDL Cholesterol	0.6	0.9	3.4	0.5	-1.9	-0.9	0.2	0.0
Blood Platelet Count	0.6	7.1	14.4	-3.0	-1.1	-2.7	-3.8	-2.0
Heel T-Score	0.6	4.7	7.9	-2.6	-1.5	-1.3	-2.8	-2.2
Waist Hip Ratio (WHR)	0.6	2.5	8.7	-1.2	3.0	-0.5	-0.5	-1.5
Maternal smoking around birth	0.6	0.8	2.5	-1.1	1.6	-0.6	-0.1	-0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.7	0.5	1.3	0.2	0.5	1.1
Forced vital capacity (FVC)	0.6	2.5	4.7	-1.6	-1.5	2.2	-0.8	-1.5
Pulse wave Arterial Stiffness index	0.6	0.7	3.6	-0.2	1.9	-0.1	-0.0	0.2
Impedance of arm (left)	0.6	2.7	9.5	-0.4	3.1	0.4	1.9	0.1
Breastfed as a baby	0.6	0.7	2.0	0.1	-0.7	-1.4	0.7	0.8
Pulse wave reflection index	0.6	0.8	2.2	-1.2	1.5	-0.1	-0.6	-0.1
Eye problems/disorders: None of the above	0.6	0.7	1.7	0.5	1.0	0.6	1.3	0.5
Medication: Omeprazole	0.6	0.7	1.5	0.8	-1.2	-1.0	0.3	0.4
Loneliness, isolation	0.6	0.8	3.3	0.1	-1.8	-0.0	-0.6	0.7
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.2	-0.7	-0.8	0.2	-1.5	-0.3
Number of operations (self-reported)	0.6	0.8	1.1	-1.1	1.0	-1.1	-0.7	0.7
Depressed Affect (Nagel 2018)	0.5	1.1	2.4	0.4	-1.5	-0.7	-0.3	1.5
Bipolar Disorder (2011)	0.5	0.5	1.6	-1.3	0.0	0.5	-0.4	-0.6
Hearing difficulty/problems: Yes	0.5	0.8	2.6	0.7	-0.8	0.2	0.3	1.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.2	-1.0	0.6	-0.4	-1.1	0.2
Financial difficulties in last 2 years	0.5	0.7	2.8	0.1	1.7	0.1	0.7	0.1
Medication: Simvastatin	0.5	0.7	2.2	0.6	1.5	0.4	0.9	0.3
Alcohol intake versus 10 years previously	0.5	0.7	1.8	-0.9	0.2	0.6	-1.3	-0.8
Falls in the last year	0.5	0.7	3.4	-0.1	-1.8	0.1	-0.3	0.3
Noisy workplace	0.5	0.6	1.4	-0.5	1.2	0.7	0.7	-0.5
Peak expiratory flow (PEF)	0.5	1.2	2.4	-1.0	-1.6	0.6	-1.1	-1.1
Loud music exposure frequency	0.5	0.5	0.9	-1.0	0.3	0.7	-0.9	-0.5
Headache pain in last month	0.5	0.9	1.9	-1.3	0.2	-0.7	-1.4	-0.6
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.9	-1.4	0.4	-0.8	-0.9	-0.5
Medication: Amlodipine	0.5	0.7	2.2	-0.0	-1.5	0.2	-0.2	-1.0
Illnesses of father: Heart disease	0.5	0.7	1.6	1.3	-1.0	0.2	1.0	0.3
Medication: Gliclazide	0.5	0.5	1.0	-0.8	-0.1	-1.0	-0.3	-0.9
Smoking status: Current	0.5	0.8	1.4	0.3	0.8	-1.0	0.9	1.2
Risk taking	0.5	0.7	2.2	-0.2	-1.5	-1.0	-0.1	-0.5
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.0	1.0	0.3	0.7	0.5	1.0
Neuroticism (Nagel 2018)	0.4	0.8	2.6	0.6	-1.6	0.5	-0.2	1.0
Schizophrenia (2018)	0.4	0.9	1.9	0.4	-1.4	-1.3	-0.5	0.7
Worry (Nagel 2018)	0.4	0.8	2.0	1.0	-0.7	1.4	0.7	0.5
Reaction Time	0.4	0.7	1.9	0.4	-0.2	1.3	0.1	-1.4
Breast Cancer	0.4	0.9	2.9	0.0	-1.7	-0.0	-1.2	0.1
Coronary Artery Disease (CAD)	0.4	0.5	1.1	-0.7	-0.3	-0.8	-0.4	-1.1
Crohns Disease (2012)	0.4	0.6	1.3	0.6	1.1	0.4	1.2	-0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.7	-0.5	-0.2	-1.3	0.0	0.1
Blood White Count	0.4	3.2	6.8	-2.0	0.4	-2.6	-2.0	-1.1
Systolic Blood Pressure	0.4	2.0	3.5	-0.9	-1.6	-1.4	-1.9	-1.0
Sensitivity / hurt feelings	0.4	0.7	1.7	1.3	-0.6	0.3	0.8	0.8
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.0	0.8	-0.6	-0.6	0.7	1.0
Ever had hysterectomy (womb removed)	0.4	0.5	1.3	-1.1	0.6	0.4	-0.5	-0.5
Medication: Co-codamol	0.4	0.4	1.9	0.2	0.1	-1.4	-0.2	0.3
Diabetes (father)	0.4	0.5	1.3	-0.6	-0.6	0.5	-0.5	-1.1
Severe depression (siblings)	0.4	0.4	0.8	-0.7	-0.6	0.1	-0.6	-0.9
Townsend deprivation index at recruitment	0.4	0.5	1.8	-0.7	1.3	-0.3	-0.4	-0.3
Qualifications: CSEs or equivalent	0.4	0.5	1.6	-0.6	1.2	-0.4	-0.5	-0.6
Multivitamins +/- minerals	0.4	0.5	1.4	-0.6	1.2	-0.2	-0.9	-0.4
Body mass index (BMI)	0.4	1.7	3.6	-0.8	-1.9	-1.4	-1.2	0.6
Alcohol usually taken with meals	0.4	0.6	2.3	0.1	-1.5	0.5	-0.5	-0.3
Nervous feelings	0.4	0.8	1.8	1.4	-1.1	0.9	0.4	0.2
Hip circumference	0.4	1.8	6.9	-0.8	-2.6	-0.6	-0.9	0.4
Pulse rate	0.4	0.7	1.5	-0.3	-1.2	0.5	-0.8	-1.1
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.1	-0.3	-1.1	1.4	0.5	-1.1
Lung cancer (father)	0.4	0.5	0.7	-0.7	0.4	-0.9	-0.8	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.0	0.9	0.3	1.0	1.0	0.3
Forced vital capacity (FVC), Best measure	0.4	1.6	2.1	-1.5	-1.3	1.4	-0.5	-1.4
Comparative body size at age 10	0.4	1.0	4.0	0.1	-2.0	-0.4	-0.7	-0.3
Number of full sisters	0.4	0.4	1.0	0.6	-0.0	-1.0	0.3	0.8
Overall health rating	0.4	0.9	1.7	0.4	0.9	-1.3	0.5	1.3
Long-standing illness, disability or infirmity	0.4	0.6	1.8	-0.1	1.0	1.4	0.2	-0.4
Friendships satisfaction	0.4	0.5	1.1	-0.6	-1.1	0.5	-0.6	-0.6
Eye problems/disorders: Cataract	0.4	0.5	1.4	0.3	1.2	0.5	0.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.8	0.6	-1.7	0.8	0.2	0.8
Arm fat mass (left)	0.4	1.7	3.3	-1.8	-1.4	-1.2	-1.4	-0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.6	-0.3	0.4	-1.3	-0.1	0.7
Average weekly beer plus cider intake	0.4	0.5	2.2	0.0	1.5	-0.5	0.2	0.5
Irritability	0.4	0.6	1.2	-0.5	-1.1	-0.5	-1.0	-0.7
Prostate Cancer	0.3	0.5	1.2	-0.2	0.5	1.1	0.6	-0.8
Schizophrenia (2014)	0.3	0.7	2.8	0.6	-1.7	-0.4	-0.3	0.6
Blood Red Count	0.3	2.6	12.2	-0.3	3.5	0.4	0.4	0.7
Neuroticism	0.3	0.7	1.7	0.8	-1.3	0.1	0.5	1.0
Average weekly spirits intake	0.3	0.4	1.7	-0.3	0.0	-1.3	-0.4	-0.0
Vitamin and mineral supplements	0.3	0.4	1.8	0.2	-1.4	-0.4	0.3	0.2
Fed-up feelings	0.3	0.6	1.2	0.6	-0.9	-0.5	0.4	1.1
Trunk fat mass	0.3	1.1	3.7	-1.9	-0.0	-1.0	-0.9	-0.1
Number of incorrect matches in round	0.3	0.4	0.9	0.9	0.6	-0.1	0.5	0.9
Neuroticism score	0.3	0.6	1.1	1.1	-0.9	-0.1	0.6	0.9
Number of live births	0.3	0.5	1.4	0.5	0.5	-0.6	1.2	0.4
Happiness	0.3	0.4	1.0	-0.3	1.0	-0.7	-0.2	0.7
Arm fat mass (right)	0.3	1.2	2.2	-1.5	-1.1	-1.2	-1.1	-0.0
Birth weight of first child	0.3	0.6	1.4	-0.4	0.3	1.2	-0.0	-1.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	-0.4	-0.1	0.4	-0.6	-1.1
Exposure to tobacco smoke outside home	0.3	0.4	1.3	-0.6	-0.1	-0.3	-1.1	-0.2
Health satisfaction	0.3	0.4	1.1	0.5	-0.2	-1.1	0.4	0.6
Shortness of breath walking on level ground	0.3	0.4	1.5	-0.0	0.7	1.2	0.0	0.1
Medication for pain relief, constipation, heartburn	0.3	0.6	1.7	0.4	-0.8	-0.5	-0.5	1.3
Medication: Allopurinol	0.3	0.4	1.0	-0.2	-1.0	0.8	-0.0	-0.4
Mean time to correctly identify matches	0.3	0.5	1.1	1.0	0.4	1.0	0.5	0.0
Whole body fat mass	0.3	1.1	3.1	-1.8	-0.5	-0.9	-1.1	-0.2
Leg fat mass (right)	0.3	1.3	2.7	-1.6	-0.9	-1.0	-1.3	-0.2
Alcohol intake frequency.	0.3	0.6	2.0	-0.7	0.2	-0.8	-1.4	0.0
Leg pain on walking	0.3	0.3	1.1	-0.3	0.6	1.1	-0.2	-0.2
Supplements: Vitamin C	0.3	0.3	0.5	0.4	0.7	0.7	0.6	-0.1
Knee pain experienced in last month	0.3	0.5	2.1	0.0	-0.2	-1.4	-0.4	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	0.0	-0.6	-0.9	0.6	-0.5
Miserableness	0.3	0.6	1.5	0.5	-0.5	-0.8	-0.4	1.2
Mother’s age at death	0.3	0.3	0.9	-0.7	0.9	0.5	0.1	-0.3
Medication: Blood pressure	0.3	0.6	1.6	0.0	1.3	-0.8	0.3	-0.8
Illnesses of father: High blood pressure	0.3	0.3	0.7	0.4	0.9	-0.0	0.7	-0.5
Unable to work because of sickness or disability	0.3	0.3	0.5	0.7	-0.4	0.7	0.5	0.6
Myopia	0.3	0.4	0.9	0.3	-0.8	-0.6	0.2	0.9
Cholesterol lowering medication	0.3	0.5	1.6	-0.5	1.2	-0.2	-0.2	-0.6
Supplements: Calcium	0.3	0.3	0.9	0.6	1.0	0.1	0.1	-0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.8	0.5	0.4	0.7	0.9	-0.3
Leg fat mass (left)	0.3	1.2	2.4	-1.5	-0.9	-1.0	-1.2	-0.0
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.2	0.5	-0.2	1.5	0.8	-0.5
Crohns Disease (2017)	0.2	0.5	1.1	1.1	-0.1	-0.8	0.9	-0.0
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	0.9	0.3	0.5	0.7	-0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.7	0.2	-0.7	1.3	0.1	-0.4
HbA1C	0.2	0.2	0.8	-0.2	-0.1	0.9	-0.1	0.3
Primary Biliary Cirrhosis	0.2	0.2	0.4	0.4	-0.6	-0.5	0.4	0.4
Rheumatoid Arthritis	0.2	0.3	0.6	0.3	0.7	0.6	0.7	-0.0
Triglycerides	0.2	0.3	0.7	-0.8	-0.5	-0.4	-0.4	0.4
BMI	0.2	1.2	2.7	-0.6	-1.6	-1.6	-0.8	0.1
Smoking Status	0.2	0.5	1.3	-1.2	0.8	-0.2	-0.4	-0.8
Cardiovascular Disease	0.2	0.7	2.7	0.1	0.4	1.6	-0.1	-0.9
Hair Pigment	0.2	4.9	10.4	-2.1	-0.7	3.2	-1.5	-2.6
Trunk fat percentage	0.2	0.8	1.7	-1.3	0.5	-1.2	-0.1	0.6
Waist circumference	0.2	0.8	1.3	-1.0	-0.9	-1.1	-1.0	0.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.7	-0.6	-0.8	-0.5	-0.3	-0.3
Heart attack	0.2	0.3	0.8	0.7	0.2	0.5	0.9	-0.0
Illnesses of siblings	0.2	0.2	0.7	-0.1	-0.6	-0.9	0.1	0.2
Arm fat percentage (right)	0.2	0.7	1.8	-0.5	-0.5	-1.4	-0.0	1.0
Depression (self-reported)	0.2	0.2	0.5	0.4	-0.6	-0.0	0.4	0.7
Tense / ‘highly strung’	0.2	0.3	0.6	-0.5	-0.4	0.5	-0.8	-0.4
Gout (self-reported)	0.2	0.3	1.0	0.1	-0.7	1.0	0.4	-0.1
Birth weight	0.2	0.5	1.8	-0.5	-1.4	-0.1	-0.4	0.3
Body fat percentage	0.2	0.7	1.7	-1.1	0.4	-1.3	-0.1	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.0	-0.4	-0.7	0.0	0.8
Age at first live birth	0.2	0.4	1.9	-0.2	-1.4	0.1	0.3	-0.4
Medication: Blood pressure	0.2	0.4	1.0	0.4	-1.0	0.6	0.3	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.2	0.7	0.5	-0.4	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.1	0.2	0.1	1.1	0.3	0.1
Arm fat percentage (left)	0.2	0.7	1.9	-0.7	-0.5	-1.4	-0.1	1.0
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	-0.2	0.6	-0.7	-0.4	-0.2
Mood swings	0.2	0.3	0.9	0.4	-1.0	-0.1	-0.0	0.7
Qualifications: nursing, teaching	0.2	0.4	1.6	0.2	-1.3	-0.3	0.2	0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	-0.4	0.8	-0.3	0.3	-0.5
Medication: Lisinopril	0.2	0.2	0.9	0.0	-1.0	-0.3	-0.1	-0.1
Age started oral contraceptive pill	0.2	0.2	0.7	0.1	0.2	0.9	-0.4	0.3
Bipolar Disorder (2018)	0.1	0.2	0.4	0.1	0.6	0.4	0.6	-0.5
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	0.4	-0.7	-0.7	-0.1	0.3
Schizophrenia vs Biploar Disorder	0.1	0.1	0.5	0.1	0.0	0.7	0.2	0.3
Blood Eosinophil Count	0.1	0.8	3.0	-0.7	0.6	-0.5	-1.7	0.3
Chronotype (morning person)	0.1	0.2	0.4	0.3	0.3	-0.3	0.5	-0.6
Tanning	0.1	1.5	2.7	1.6	1.1	0.7	1.2	1.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.4	0.6	0.6	-0.0	-0.2	0.0
High blood pressure	0.1	0.3	0.7	0.1	-0.4	0.8	0.2	-0.8
High blood pressure (mother)	0.1	0.1	0.4	0.3	0.3	0.2	0.3	-0.6
Had menopause	0.1	0.2	0.4	0.3	-0.6	0.4	-0.4	0.2
Medication: Ramipril	0.1	0.1	0.3	-0.1	0.2	-0.5	-0.2	-0.5
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	-0.4	0.6	-0.7	0.2	0.2
Leg fat percentage (right)	0.1	0.5	1.2	-0.7	0.1	-1.1	-0.1	0.8
Number of children fathered	0.1	0.1	0.1	0.2	-0.4	0.1	-0.2	0.3
Family relationship satisfaction	0.1	0.2	0.4	-0.6	-0.3	-0.6	-0.4	0.1
Hypertension (Self-reported)	0.1	0.2	0.3	0.5	-0.6	0.5	0.2	-0.2
Leg fat percentage (left)	0.1	0.5	1.5	-0.7	0.2	-1.2	-0.0	0.8
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	-0.1	-0.1	-0.7	-0.2	0.6
Pain experienced in last month	0.1	0.2	0.7	0.6	-0.1	-0.2	0.8	0.2
Heart disease (siblings)	0.0	0.1	0.1	0.2	0.4	0.0	0.0	0.3

Hub : Genes

S100A11

Models

Trait associations