Best TWAS P=2.7e-13 · Best GWAS P=6.11e-17 conditioned to 0.0386
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | UBAC2 | 0.09 | 0.06 | lasso | 3 | 0.04 | 1.5e-05 | -7.2 | 7.3 | 2.7e-13 | -0.59 | 0.78 | 0.21 | TRUE |
| 2 | GTEx | Breast Mammary Tissue (Male) | DOCK9-AS2 | 0.21 | 0.00 | lasso | 5 | -0.01 | 5.2e-01 | -7.2 | -7.1 | 1.8e-12 | 0.51 | 0.07 | 0.06 | FALSE |
| 3 | YFS | Blood | UBAC2 | 0.06 | 0.03 | bslmm | 612 | 0.05 | 2.1e-15 | 4.3 | -6.4 | 1.8e-10 | 0.56 | 0.97 | 0.03 | TRUE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TM9SF2 | 0.02 | 0.00 | blup | 93 | 0.01 | 4.6e-04 | -4.9 | -5.2 | 2.1e-07 | 0.20 | 0.01 | 0.68 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | UBAC2 | 0.05 | 0.00 | blup | 118 | 0.02 | 2.8e-04 | -0.3 | -6.9 | 4.4e-12 | 0.49 | 0.15 | 0.18 | TRUE |