Best TWAS P=2.39e-14 · Best GWAS P=5.92e-16 conditioned to 0.00299
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | METSIM | Adipose | ZNF652 | 0.05 | 0.03 | lasso | 8 | 0.05 | 6.2e-08 | -3.5 | -5.1 | 2.8e-07 | -0.69 | 0.68 | 0.32 | FALSE |
2 | YFS | Blood | GNGT2 | 0.13 | 0.13 | lasso | 5 | 0.12 | 1.1e-38 | 4.8 | 5.2 | 2.1e-07 | 0.76 | 1.00 | 0.00 | FALSE |
3 | The Cancer Genome Atlas | Colon Adenocarcinoma | ZNF652 | 0.09 | 0.01 | enet | 12 | 0.05 | 5.5e-04 | 6.7 | -5.6 | 2.2e-08 | -0.55 | 0.02 | 0.40 | FALSE |
4 | The Cancer Genome Atlas | Glioblastoma Multiforme | GNGT2 | 0.22 | 0.00 | blup | 47 | 0.00 | 3.1e-01 | 4.8 | 5.4 | 6.7e-08 | 0.76 | 0.01 | 0.12 | FALSE |
5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GNGT2 | 0.09 | 0.07 | blup | 48 | 0.06 | 2.7e-07 | 4.8 | 5.1 | 2.9e-07 | 0.72 | 0.16 | 0.83 | FALSE |
6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZNF652 | 0.03 | 0.03 | enet | 5 | 0.03 | 2.6e-04 | 6.7 | -7.1 | 1.5e-12 | -0.90 | 0.02 | 0.96 | FALSE |
7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ZNF652 | 0.06 | 0.03 | lasso | 4 | 0.02 | 1.6e-03 | 6.8 | -6.2 | 7.3e-10 | -0.76 | 0.18 | 0.61 | FALSE |
8 | The Cancer Genome Atlas | Lung Adenocarcinoma | ZNF652 | 0.05 | 0.02 | blup | 55 | 0.02 | 2.5e-03 | 8.1 | -7.6 | 2.4e-14 | -0.87 | 0.01 | 0.98 | TRUE |