Hub : Genes

ZNF652

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1380	0.0400	1.9e-05	0.143	NA	0.144	NA	0.154	7.1e-11	NA	6.6e-11	NA	1.2e-11
2	GTEx	Testis	0.2330	0.0730	2.7e-04	0.190	NA	0.170	NA	0.189	7.8e-09	NA	5.3e-08	NA	8.5e-09
3	METSIM	Adipose	0.0469	0.0160	5.9e-05	0.028	0.031	0.041	0.032	0.049	3.5e-05	1.6e-05	6.8e-07	1.2e-05	6.2e-08
4	YFS	Blood	0.0244	0.0092	9.9e-04	0.023	0.008	0.018	0.017	0.021	3.7e-08	6.5e-04	8.5e-07	1.9e-06	1.3e-07
5	TCGA	Colon Adenocarcinoma	0.0850	0.0520	3.4e-03	0.007	0.035	0.052	NA	0.034	1.2e-01	4.3e-03	5.5e-04	NA	4.7e-03
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0312	0.0171	6.5e-04	0.029	0.022	0.029	NA	0.028	3.0e-04	1.3e-03	2.6e-04	NA	3.4e-04
7	TCGA	Brain Lower Grade Glioma	0.0618	0.0379	1.4e-04	0.034	0.020	0.012	NA	0.021	8.7e-05	2.4e-03	1.5e-02	NA	1.6e-03
8	TCGA	Lung Adenocarcinoma	0.0536	0.0323	1.7e-04	0.019	0.019	0.015	NA	0.014	2.5e-03	2.5e-03	6.2e-03	NA	7.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	2.7	4.3	11.4	-1.6	3.4	-2.4	-1.8	-2.0	-1.7	-1.0	-1.9
Bipolar Disorder or Schizophrenia	1.0	2.4	5.4	-1.4	2.3	-1.7	-1.5	-1.1	-1.4	-0.7	-1.8
Depressed Affect (Nagel 2018)	0.4	0.8	2.0	-1.1	1.3	-0.5	-1.4	-0.7	-0.6	-0.7	-0.6
Depression (Nagel 2018)	2.7	4.1	6.3	-2.5	1.9	-1.1	-2.5	-1.6	-2.2	-1.9	-2.1
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.6	0.9	0.0	1.0	0.0	1.6	1.3	1.1	1.3
Neuroticism (Nagel 2018)	0.1	0.2	0.9	0.1	0.3	0.0	0.2	0.4	-0.7	-1.0	-0.5
Schizophrenia (2018)	0.1	0.2	0.5	-0.5	0.3	-0.2	-0.5	0.2	-0.4	-0.1	-0.7
Schizophrenia vs Biploar Disorder	0.1	0.2	0.5	0.2	-0.2	-0.0	0.4	0.7	0.2	0.5	-0.5
Worry (Nagel 2018)	0.3	0.6	1.9	0.1	0.3	-0.0	0.4	0.3	-1.4	-1.3	-0.9
Alzheimer’s Disease (in mother)	0.9	1.0	3.2	-0.1	-1.8	0.5	0.8	-0.6	-0.9	-1.5	-0.8
Alzheimer’s Disease (in father)	1.4	1.5	3.0	-1.0	0.9	-1.2	-0.3	-0.5	-1.7	-1.5	-1.7
Alzheimer’s Disease (including proxy)	2.9	4.2	11.9	-1.2	-1.1	-1.1	0.3	-1.6	-2.9	-3.5	-2.6
Crohns Disease (2017)	0.5	1.1	2.9	0.3	1.3	-1.2	1.0	0.5	-1.7	-0.7	-1.0
Irritable Bowel Disease (IBD)	0.2	0.6	1.5	1.2	0.7	-0.2	1.2	0.6	-0.4	0.5	-0.5
Ulcerative Colitis (UC)	0.8	1.5	3.4	1.8	-0.7	1.0	1.1	1.0	1.3	1.6	0.6
Major Depression (MDD)	2.4	2.9	6.4	-1.4	2.5	-2.2	-1.0	-1.5	-1.6	-1.5	-1.4
Reaction Time	3.1	5.9	11.6	-1.7	1.3	-2.4	-0.9	-1.9	-3.4	-3.0	-3.4
Verbal and Numeric Reasoning (VNR)	0.9	2.2	4.2	1.6	-0.6	1.1	1.0	1.6	1.7	1.7	2.0
Breast Cancer	2.1	5.2	11.1	3.1	-1.8	1.5	3.3	2.4	1.7	1.5	2.0
Ovarian Cancer	0.8	1.1	4.5	1.6	0.5	0.6	2.1	0.5	-0.6	-0.3	-0.5
Prostate Cancer	0.9	1.2	7.6	1.0	2.8	-0.7	0.4	0.5	-0.2	0.4	-0.5
Age at First Birth	5.3	7.7	15.2	2.3	-0.6	2.6	1.1	2.4	3.8	3.5	3.9
Bipolar Disorder (2011)	3.0	2.9	5.4	-1.4	2.2	-1.1	-1.4	-2.3	-1.6	-1.4	-1.8
Body Mass Index (BMI) (2010)	0.5	0.6	2.4	0.6	0.2	-0.4	1.6	0.6	-0.8	-0.1	-1.0
Coronary Artery Disease (CAD)	5.1	6.1	9.1	-2.3	1.0	-2.8	-2.3	-2.2	-2.6	-3.0	-3.0
Crohns Disease (2012)	1.6	2.5	5.0	-1.5	1.9	-2.1	-0.5	-0.7	-2.2	-1.5	-1.5
Mean Putamen Volume	2.4	2.7	6.3	1.0	-1.7	1.6	0.6	2.0	1.9	1.1	2.5
Fasting Glucose	1.3	1.6	4.4	2.1	0.1	0.8	2.0	1.4	1.0	0.4	0.8
HbA1C	0.7	0.8	2.5	0.6	-1.1	1.6	0.9	0.0	0.5	0.7	0.9
HDL Cholesterol	1.9	3.2	6.4	1.6	0.2	1.3	0.6	1.6	2.5	2.4	2.5
LDL Cholesterol	3.4	5.3	8.1	-2.8	1.0	-1.5	-2.4	-2.6	-2.6	-2.8	-2.0
Lupus	1.7	2.5	6.5	1.0	-1.7	2.6	0.5	1.7	1.6	1.1	1.7
Neuroticism (2016)	1.4	2.0	4.0	1.6	-0.2	1.4	1.0	2.0	1.4	1.7	1.2
Primary Biliary Cirrhosis	0.6	0.9	4.8	-0.2	2.2	-0.8	-1.1	0.1	-0.0	0.6	0.3
Rheumatoid Arthritis	0.3	0.4	1.1	-0.2	0.8	-0.1	-1.1	-0.1	0.7	0.4	0.7
Schizophrenia (2014)	0.5	1.1	3.3	-0.8	1.4	-1.1	-0.4	-0.1	-1.2	-0.7	-1.8
Triglycerides	7.0	11.5	16.1	-3.3	3.5	-2.9	-2.8	-3.7	-4.0	-3.1	-3.6
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.9	-1.4	0.3	-0.2	-1.0	0.0	-0.9	-0.9	-0.9
Ulcerative Colitis	0.7	1.1	2.2	1.5	-0.6	0.8	1.1	0.9	1.2	1.3	0.5
Blood Eosinophil Count	14.3	110.3	176.9	-6.9	11.3	-11.5	-4.7	-10.7	-12.6	-10.1	-13.3
Blood Platelet Count	0.7	8.5	22.6	-3.7	1.2	-1.1	-3.3	-4.8	-2.2	-2.1	-3.0
Blood Red Count	0.5	4.7	12.4	0.6	0.2	-1.3	1.9	-1.0	-3.5	-2.6	-3.5
Blood White Count	2.0	14.5	35.4	-4.0	0.0	-2.0	-2.9	-6.0	-3.9	-4.2	-4.5
Heel T-Score	0.1	1.1	4.0	-1.6	-0.9	0.4	-2.0	-1.1	0.2	-0.4	-0.0
BMI	0.9	5.2	14.8	-1.5	-0.8	-1.0	0.7	-1.8	-3.1	-3.1	-3.9
Height	3.2	61.3	151.3	3.8	-1.5	6.1	-1.5	5.8	12.3	10.9	11.4
Waist Hip Ratio (WHR)	4.1	18.4	35.0	-5.9	3.4	-3.5	-5.9	-4.6	-3.2	-3.5	-3.1
Systolic Blood Pressure	2.5	12.4	28.8	-1.4	1.1	-2.8	-0.0	-4.5	-4.8	-4.1	-5.4
Smoking Status	5.7	13.6	21.8	-2.9	3.1	-4.4	-2.1	-2.7	-4.5	-4.1	-4.7
Allergy or Eczema	7.6	20.1	41.6	-2.2	3.9	-3.8	-0.3	-3.2	-6.5	-5.9	-6.3
Cardiovascular Disease	10.1	33.5	74.5	-3.5	2.9	-5.6	-1.1	-6.2	-7.7	-6.4	-8.6
Hypothyroidism (self reported)	0.8	1.8	4.5	0.1	0.5	-1.2	1.1	0.1	-2.1	-1.8	-2.1
Respiratory disease	12.3	27.4	51.4	-2.7	5.0	-5.0	-1.0	-5.6	-6.8	-5.7	-7.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.0	0.4	-0.7	0.6	0.2	1.0	0.3	0.4	0.2
Lung FEV1/FVC ratio	6.3	31.9	59.0	3.5	-3.5	5.9	0.9	6.8	6.9	6.6	7.7
Lung FVC	0.9	4.6	11.6	-0.4	-0.3	-2.0	0.9	-1.4	-3.2	-3.4	-2.8
Neuroticism	0.5	1.3	2.9	-1.0	0.9	-0.3	-0.7	-0.6	-1.5	-1.7	-1.5
Chronotype (morning person)	0.5	1.3	3.1	-1.4	1.0	-1.6	-1.8	-0.7	-0.4	-0.5	-0.8
Hair Pigment	0.0	1.2	2.7	0.8	1.0	0.1	-0.0	1.6	1.4	1.0	1.4
Tanning	0.0	0.3	1.4	0.1	1.2	-0.6	-0.2	-0.5	-0.1	0.1	-0.6
Hand grip strength (left)	0.2	0.5	1.3	1.0	0.2	-0.7	0.9	1.2	-0.4	-0.2	-0.5
Number of treatments/medications taken	9.8	17.7	30.5	-3.3	2.9	-3.4	-2.4	-5.0	-5.1	-4.8	-5.5
Average weekly spirits intake	0.5	0.7	1.5	1.1	-1.1	0.5	1.2	1.0	0.3	0.3	0.1
Sensitivity / hurt feelings	0.7	1.2	3.2	-1.3	0.7	-0.3	-0.9	-0.9	-1.3	-1.8	-1.1
Frequency of depressed mood in last 2 weeks	3.4	4.8	6.4	-2.5	2.1	-0.9	-2.4	-1.9	-2.4	-2.4	-2.4
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.3	-0.2	0.3	0.1	-0.2	-0.3	-0.3	-0.4
Relative age of first facial hair	0.3	0.7	1.4	-0.2	0.3	0.8	-1.2	1.1	0.8	0.4	1.2
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.8	-1.5	-0.2	0.3	-1.7	-1.3	-0.7	-1.1	-0.9
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.4	0.4	0.2	0.1	0.2	-0.5	-0.3	-0.5
Ever had hysterectomy (womb removed)	0.8	0.9	2.1	0.9	0.1	1.1	-0.0	0.8	1.4	0.7	1.3
Systolic blood pressure, automated reading	1.0	2.8	6.2	-1.0	0.1	-0.8	-0.1	-2.4	-2.3	-1.8	-2.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.3	-0.8	0.8	0.4	-1.1	-0.3	-0.4	-0.5	-0.6
Angina	9.5	12.5	28.8	-1.4	1.1	-3.7	0.1	-2.1	-5.1	-4.9	-5.4
Medication for hormone replacement therapy	0.2	0.2	0.7	-0.5	0.1	-0.1	-0.9	0.6	0.3	0.1	0.1
Vitamin and mineral supplements	1.0	1.3	2.0	-1.4	1.0	-1.1	-1.1	-1.2	-1.2	-0.9	-1.3
Supplements: Zinc	0.7	0.8	1.9	1.1	-1.4	0.8	1.2	0.6	0.6	0.4	0.5
Medication: Co-codamol	0.2	0.3	1.1	0.3	0.1	-0.1	0.5	1.1	-0.7	-0.3	-0.1
Medication: Metformin	0.3	0.4	1.5	-0.6	-0.7	1.2	-0.6	0.2	-0.5	-0.3	-0.5
Diabetes (father)	0.9	1.1	2.4	-1.1	-1.1	-0.2	-0.3	-1.1	-1.2	-1.2	-1.5
Diabetes (mother)	0.5	0.6	1.4	-0.8	1.2	-0.5	-1.0	0.6	0.7	0.7	0.3
Severe depression (siblings)	0.2	0.3	0.4	-0.6	0.6	-0.5	-0.6	-0.6	-0.1	-0.3	0.3
Pack years adult smoking proportion	2.0	3.1	8.6	-0.3	0.2	-0.7	0.7	-0.7	-2.8	-2.9	-2.6
Impedance of leg (right)	7.8	37.7	89.0	2.9	-1.9	5.2	-1.2	4.4	9.2	8.3	9.4
Leg fat-free mass (left)	0.4	2.2	7.4	-1.0	0.2	-1.2	-0.0	-1.1	-1.8	-1.9	-2.7
Trunk fat percentage	1.8	7.1	16.5	-0.9	-1.5	3.4	-2.3	1.0	4.1	3.2	3.0
Hand grip strength (right)	0.1	0.2	0.4	0.3	0.3	-0.6	0.4	0.5	-0.3	-0.2	-0.4
Townsend deprivation index at recruitment	1.1	1.6	3.8	0.1	0.7	-1.7	0.2	0.7	-1.6	-1.4	-2.0
Current tobacco smoking	2.7	4.4	9.9	-1.0	1.4	-1.9	-0.1	-2.1	-3.1	-2.1	-3.1
Average weekly fortified wine intake	0.8	0.9	2.0	-1.2	-1.4	-0.1	-0.7	-1.4	-0.6	-1.0	-0.1
Maternal smoking around birth	1.0	1.5	3.6	-1.5	0.4	-0.4	-1.9	-1.7	-0.8	-1.1	-0.7
Fed-up feelings	0.4	0.7	1.7	-0.8	-0.7	1.3	-1.3	0.5	0.8	-0.0	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	3.8	-1.4	1.6	-0.9	-1.9	-0.5	-1.5	-1.6	-1.9
Relative age voice broke	1.2	1.8	6.6	-1.9	1.5	-0.4	-2.6	-0.8	-0.2	-0.9	0.2
Taking other prescription medications	12.2	18.8	35.2	-3.5	2.5	-3.6	-2.0	-4.3	-5.6	-5.4	-5.9
Age when periods started (menarche)	3.0	7.2	14.6	0.6	-3.8	3.7	-0.1	1.3	3.1	2.2	3.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.1	0.6	-0.6	1.0	1.0	0.5	0.7	0.4	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	4.5	0.3	-2.1	1.2	0.3	-0.4	1.5	0.8	1.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.1	0.4	-0.9	1.1	0.1	0.6	1.6	1.1	1.8
Qualifications: CSEs or equivalent	0.5	0.6	2.1	0.1	1.4	-1.1	-0.7	-0.6	0.3	0.9	0.3
Serious illness, injury or assault to yourself	0.8	0.9	1.6	-1.0	0.8	-0.3	-1.3	-0.9	-1.0	-0.8	-1.2
High blood pressure	8.5	23.7	47.5	-3.8	3.0	-4.3	-1.8	-5.5	-6.3	-5.2	-6.9
Hayfever, allergic rhinitis or eczema	7.7	16.7	32.8	-2.3	3.3	-3.5	-0.7	-3.4	-5.7	-5.4	-5.6
Multivitamins +/- minerals	0.2	0.2	0.6	0.8	0.3	-0.4	0.7	0.3	-0.2	0.3	-0.1
Stomach or abdominal pain in last month	0.1	0.1	0.5	-0.0	0.1	-0.7	-0.3	0.2	-0.1	-0.1	-0.3
Supplements: Glucosamine	0.8	1.0	1.8	0.8	-0.9	1.4	1.0	0.9	1.0	0.8	1.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.5	-0.2	1.2	-0.4	-0.5	0.9	-0.0	0.7	-0.4
Medication: Atenolol	4.1	5.1	9.7	-1.5	1.8	-1.9	-1.1	-2.6	-2.8	-2.4	-3.1
Medication: Levothyroxine sodium	0.8	1.4	3.5	-0.4	1.2	-0.6	-0.3	-0.0	-1.9	-1.5	-1.8
Sitting height	2.4	17.3	37.5	3.4	-2.2	3.6	1.6	3.4	6.1	5.3	5.5
Chronic bronchitis/emphysema (father)	0.4	0.5	1.4	-0.7	0.7	-0.4	-0.6	-1.2	-0.7	-0.6	-0.8
High blood pressure (mother)	2.9	4.1	8.8	-1.5	1.8	-1.9	-0.8	-1.7	-2.5	-2.2	-3.0
Body mass index (BMI)	0.9	3.8	9.7	-2.1	-0.4	-0.5	-0.9	-1.7	-2.4	-2.5	-3.1
Impedance of leg (left)	7.8	37.8	91.8	2.5	-2.2	5.3	-1.6	4.2	9.3	8.1	9.6
Leg predicted mass (left)	0.4	2.3	7.3	-1.1	0.2	-1.2	-0.0	-1.2	-1.8	-1.9	-2.7
Trunk fat mass	1.1	4.6	11.4	-0.8	-1.5	2.7	-1.9	0.8	3.4	2.5	2.2
Waist circumference	1.3	4.7	10.3	-3.2	0.2	-0.6	-2.5	-2.5	-1.8	-2.2	-2.5
Number of incorrect matches in round	0.2	0.4	1.5	-0.1	1.2	-1.1	-0.0	0.3	-0.3	-0.1	-0.6
Past tobacco smoking	6.4	11.8	15.6	3.7	-2.5	3.9	3.1	2.7	3.6	3.8	3.9
Alcohol usually taken with meals	5.6	9.0	15.5	2.3	-1.6	3.5	0.9	3.2	3.9	3.7	3.5
Nervous feelings	0.6	1.1	3.2	-0.3	1.2	-0.3	0.3	-0.5	-1.8	-1.4	-1.4
Frequency of tenseness / restlessness in last 2 weeks	1.9	3.0	4.9	-1.8	1.9	-0.7	-1.4	-0.9	-2.2	-2.2	-2.1
Hearing difficulty/problems with background noise	1.6	2.6	5.7	-2.2	0.2	-0.6	-1.2	-1.0	-2.1	-2.4	-1.9
Hair/balding pattern: Pattern 2	0.6	0.8	1.4	1.0	1.2	-0.1	0.8	0.5	-1.2	-0.9	-1.0
Had menopause	0.2	0.2	0.5	0.5	-0.1	0.7	0.2	0.6	0.4	0.4	0.5
Had other major operations	1.0	1.2	3.3	-1.4	0.0	-0.9	-1.8	-0.8	-0.8	-1.1	-1.1
Forced vital capacity (FVC)	0.2	0.6	1.2	1.1	-0.4	-0.2	0.6	1.0	0.9	0.3	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.1	-0.4	-1.4	0.8	-1.0	-0.9	1.8	1.1	1.5
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	2.8	-1.1	1.7	-1.6	-1.3	-0.5	-1.5	-1.6	-1.2
Qualifications: None of the above	1.8	3.8	6.4	-2.5	-0.1	-1.8	-1.7	-2.0	-2.2	-2.5	-1.6
Financial difficulties in last 2 years	5.1	6.8	11.7	-2.3	1.9	-2.9	-1.2	-1.8	-3.4	-3.3	-3.2
Mouth/teeth dental problems	0.5	0.8	2.1	-0.1	0.6	-0.1	-0.5	0.5	1.3	1.2	1.4
Heart attack	9.6	12.3	26.0	-2.0	2.1	-3.2	-0.6	-2.7	-4.8	-4.7	-5.1
Allergy	13.5	31.0	57.3	3.4	-4.0	5.1	1.3	5.4	7.5	7.0	7.6
Pain all over the body in last month	0.2	0.2	0.5	0.5	0.1	0.1	0.7	0.6	-0.1	0.4	0.6
Diabetes (self-reported)	0.1	0.2	0.5	-0.0	0.3	0.7	-0.3	0.7	-0.3	-0.1	-0.2
Hayfever/allergic rhinitis (self-reported)	3.6	4.8	8.6	-1.9	1.6	-2.2	-0.8	-2.0	-2.8	-2.9	-2.5
Medication: Ramipril	4.0	5.1	13.3	-0.8	0.6	-2.3	0.2	-1.7	-3.2	-2.9	-3.7
Medication: Simvastatin	2.2	3.2	6.4	-1.6	0.4	-1.2	-0.9	-1.5	-2.3	-2.5	-2.5
Fluid intelligence score	1.3	2.7	4.5	1.9	-0.6	1.2	1.2	1.9	1.8	1.8	2.1
Illnesses of siblings	3.3	4.7	10.8	1.5	-0.6	2.4	0.5	1.8	2.8	2.7	3.3
Neuroticism score	0.9	1.9	3.6	-1.6	1.1	-0.3	-1.3	-0.8	-1.6	-1.9	-1.6
Weight	0.2	0.8	1.6	-0.7	-1.1	1.3	-0.9	0.3	1.3	0.6	0.3
Impedance of arm (right)	6.0	27.8	62.9	2.0	-1.8	5.3	-1.1	3.1	7.9	7.1	7.9
Arm fat percentage (right)	0.3	1.3	2.9	-1.7	-1.0	1.6	-1.6	-0.7	0.6	0.1	-0.2
Trunk fat-free mass	0.1	0.4	1.2	0.3	-0.1	-0.9	0.7	0.1	-0.5	-0.8	-1.1
Hip circumference	0.2	1.0	3.2	-0.2	-1.7	1.8	-0.2	0.6	1.2	0.6	0.1
Time employed in main current job	0.9	1.0	2.8	1.2	-1.2	0.4	1.7	0.9	0.2	0.6	0.9
Alcohol intake versus 10 years previously	0.5	0.7	1.7	-1.3	-0.3	-0.1	-1.1	-0.4	-0.7	-1.2	-0.7
Father’s age at death	1.0	1.4	3.7	-1.0	-1.9	1.8	-0.8	-0.2	1.0	0.3	1.1
Worrier / anxious feelings	0.3	0.5	1.5	0.3	-0.8	0.9	0.5	1.2	-0.4	-0.6	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.3	-1.2	0.3	-0.1	-1.5	-0.8	-1.0	-1.5	-1.4
Falls in the last year	0.2	0.3	0.7	0.3	-0.9	0.7	0.7	0.1	0.5	0.1	0.3
Hair/balding pattern: Pattern 3	0.2	0.3	1.1	-0.7	-1.0	0.3	0.2	-0.7	-0.3	-0.3	-0.5
Number of live births	3.8	5.4	10.2	-2.3	1.4	-1.8	-1.4	-1.9	-2.9	-3.2	-3.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	4.8	1.2	-1.3	0.8	0.6	2.2	1.8	1.2	2.1
Pulse rate	0.4	0.7	2.1	0.5	-1.4	0.7	1.5	0.5	-0.4	-0.3	0.2
Happiness	0.4	0.4	2.2	0.2	1.5	0.6	-0.1	0.6	-0.4	-0.1	-0.7
Noisy workplace	0.2	0.2	0.5	-0.5	-0.4	-0.4	-0.3	-0.7	-0.0	-0.7	-0.2
Qualifications: A levels/AS levels or equivalent	0.9	1.9	5.2	1.0	0.2	1.1	0.3	1.3	2.0	2.3	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.7	3.0	-1.1	1.1	-1.5	-0.6	-0.7	-1.7	-1.5	-1.6
Mouth/teeth dental problems: Dentures	0.5	0.8	2.5	-0.2	1.3	-1.6	0.4	0.7	-1.0	-0.5	-0.8
Asthma	15.4	30.4	59.1	-3.3	4.3	-5.1	-1.6	-5.9	-7.2	-6.3	-7.7
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	1.0	0.0	1.0	0.2	-0.4	0.2	0.4	0.2	0.2
Medication: Cholesterol lowering	2.0	3.1	7.3	-1.2	0.6	-1.2	-0.0	-1.7	-2.6	-2.1	-2.7
Depression (self-reported)	0.2	0.3	0.5	-0.5	0.2	0.4	-0.5	-0.6	-0.6	-0.7	-0.3
Medication: Lansoprazole	1.0	1.1	2.9	-0.9	0.4	-1.0	-0.4	-0.6	-1.3	-1.3	-1.7
Prospective memory result	1.3	1.6	2.3	1.5	-0.6	1.5	1.4	1.2	1.4	1.1	1.1
Lung cancer (father)	0.3	0.4	1.7	-0.2	1.3	-0.7	-0.7	-0.3	0.1	0.1	-0.2
Illnesses of mother	4.7	5.9	13.2	2.0	-1.5	1.6	0.8	1.6	3.2	3.3	3.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.0	0.7	-0.6	0.3	0.1	1.7	1.4	1.0	1.7
Pulse wave Arterial Stiffness index	1.1	1.3	3.3	0.6	-0.9	1.0	0.4	0.6	1.5	1.5	1.8
Impedance of arm (left)	6.2	28.9	67.3	2.2	-1.3	4.8	-1.4	3.3	8.2	7.4	8.1
Arm fat mass (right)	0.2	0.8	2.1	-1.5	-0.8	1.1	-1.3	-0.5	0.3	-0.1	-0.5
Trunk predicted mass	0.1	0.4	0.9	0.4	-0.3	-0.7	0.8	0.1	-0.4	-0.7	-1.0
Standing height	2.6	25.4	63.7	2.6	-1.2	3.6	-0.6	3.8	8.0	7.0	7.4
Length of working week for main job	0.5	0.5	1.1	0.5	0.7	0.9	-0.1	-0.2	0.6	1.0	0.9
Exposure to tobacco smoke at home	3.4	3.9	5.4	-1.8	2.3	-2.1	-2.0	-1.9	-1.9	-1.6	-2.1
Breastfed as a baby	0.3	0.3	1.4	0.4	1.2	-0.6	0.1	-0.2	-0.8	-0.4	-0.3
Tense / ‘highly strung’	1.3	2.1	5.3	-0.2	2.3	-1.1	0.2	-1.1	-1.9	-1.2	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.2	0.2	0.8	0.0	0.6	-0.6	-0.7	-0.3
Hair/balding pattern: Pattern 4	0.1	0.1	0.4	-0.6	-0.5	0.1	-0.4	0.3	0.1	-0.3	-0.2
Birth weight of first child	1.6	2.9	6.7	0.8	-1.2	2.3	-0.1	1.1	2.6	2.0	1.9
Peak expiratory flow (PEF)	0.1	0.2	0.8	0.1	-0.7	0.2	-0.3	0.4	0.2	0.2	0.9
Pulse wave reflection index	0.3	0.3	1.1	0.2	1.0	0.4	-0.1	0.2	0.6	0.9	0.5
Ever highly irritable/argumentative for 2 days	1.9	2.3	4.1	-1.6	1.2	-0.9	-1.4	-0.7	-2.0	-1.8	-2.0
Loud music exposure frequency	0.7	0.8	1.9	0.8	1.1	-1.4	0.4	-0.0	-0.9	-0.7	-1.0
Qualifications: O levels/GCSEs or equivalent	1.0	1.7	4.2	0.9	0.0	0.9	0.2	0.9	2.1	1.9	1.7
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.6	0.1	-0.8	0.6	-0.0	-0.3	0.2	0.0	-0.2
Blood clot in the leg (DVT)	0.3	0.3	1.2	-0.6	-0.5	0.2	-0.8	-1.1	0.1	-0.2	-0.3
Medication: Paracetamol	1.4	2.3	5.9	-1.1	2.4	-1.1	-1.8	-1.9	-1.0	-1.2	-1.1
Headache pain in last month	4.0	6.9	11.9	-1.1	3.4	-2.3	-0.9	-2.8	-3.2	-2.5	-3.4
Medication for cholesterol, blood pressure or diabetes	5.5	9.1	23.3	1.8	-1.4	2.5	0.3	2.8	4.3	3.4	4.8
Glaucoma (self-reported)	0.4	0.5	1.9	-0.2	-1.2	1.4	0.1	0.6	0.6	0.1	0.2
Gout (self-reported)	2.3	3.2	4.4	-1.9	1.3	-1.8	-1.3	-1.7	-2.1	-2.0	-2.0
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	6.1	-0.8	1.0	-1.3	0.2	-0.4	-2.5	-2.2	-2.3
Medication: Amlodipine	0.4	0.6	1.4	-0.6	-0.7	-0.4	0.3	-1.0	-0.8	-0.9	-1.2
Medication: Ventolin 100micrograms inhaler	9.0	11.5	22.1	-1.4	2.2	-3.9	-0.0	-3.5	-4.4	-4.0	-4.7
Birth weight	0.5	1.0	3.3	0.3	1.1	-0.3	-0.3	1.8	1.2	0.8	1.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.4	-1.0	1.0	-0.8	-1.0	-0.8	-1.4	-1.8	-1.5
High blood pressure (siblings)	1.9	2.7	7.3	-0.2	0.2	-1.0	0.8	-1.0	-2.5	-2.3	-2.7
Forced vital capacity (FVC), Best measure	0.1	0.2	0.9	0.4	0.2	-0.9	0.2	0.4	0.1	-0.2	0.3
Body fat percentage	1.2	4.7	10.2	-1.1	-1.4	2.9	-2.2	0.6	3.2	2.5	2.2
Leg fat percentage (right)	0.7	2.5	5.4	-1.1	-1.0	2.3	-1.9	0.3	2.1	1.6	1.5
Arm fat-free mass (right)	0.1	0.7	2.4	-0.2	-0.2	-1.1	0.4	-0.2	-0.8	-1.0	-1.5
Exposure to tobacco smoke outside home	3.8	5.1	6.6	-2.2	1.9	-2.1	-2.6	-2.4	-2.2	-2.3	-2.2
Comparative body size at age 10	6.9	19.1	40.7	-2.4	3.4	-4.4	-0.4	-3.5	-6.1	-5.2	-6.4
Number of full brothers	0.1	0.1	0.2	0.2	-0.2	0.1	0.4	0.5	-0.0	-0.1	-0.1
Worry too long after embarrassment	0.3	0.5	1.6	-0.7	0.9	-0.2	-0.2	-0.2	-0.7	-1.3	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	5.4	-1.2	2.3	-0.9	-1.3	-1.7	-1.7	-1.4	-1.7
Wheeze or whistling in the chest in last year	5.7	10.2	18.6	-1.6	2.3	-3.4	-0.4	-3.4	-4.0	-3.9	-4.3
Number of children fathered	0.1	0.1	0.6	-0.1	0.3	-0.8	-0.6	0.0	0.1	-0.2	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.1	0.9	-0.7	-0.0	1.1	1.4	1.1	0.8	1.5
Age at first live birth	2.8	5.0	6.6	2.0	-1.9	2.4	1.2	2.6	2.6	2.4	2.5
Pulse wave peak to peak time	0.7	0.8	2.1	-0.5	0.8	-0.9	-0.4	-0.4	-1.1	-1.1	-1.5
Health satisfaction	0.7	0.9	2.8	-0.3	-0.1	-0.4	-0.0	-1.7	-1.0	-1.2	-1.2
Shortness of breath walking on level ground	2.2	2.6	5.3	-1.9	0.1	-0.9	-1.5	-1.6	-1.6	-2.3	-1.9
Qualifications: College or University degree	1.5	4.7	7.3	1.9	-1.4	2.6	1.1	2.7	2.7	2.1	2.4
Eye problems/disorders: None of the above	3.5	4.0	9.5	-0.2	2.2	-3.1	0.3	-2.1	-2.3	-1.7	-2.2
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.3	0.6	-0.6	-0.3	1.1	0.9	-1.1	-1.0	-1.5
Emphysema/chronic bronchitis	1.0	1.1	3.2	0.6	-0.2	-0.4	1.4	0.4	-1.3	-1.3	-1.8
Medication for pain relief, constipation, heartburn	2.2	3.7	8.9	0.8	-3.0	1.9	1.2	1.7	1.9	1.6	2.5
Neck or shoulder pain in last month	1.5	2.1	3.3	-0.9	0.9	-1.5	-0.8	-1.8	-1.6	-1.7	-1.8
Medication: Blood pressure	8.0	14.2	33.7	-2.5	1.1	-3.0	-0.7	-3.5	-5.3	-4.7	-5.8
Angina (self-reported)	8.1	10.6	24.9	-1.1	0.9	-3.3	0.4	-1.8	-4.8	-4.6	-5.0
Migraine (self-reported)	0.4	0.5	2.8	0.4	1.7	-0.4	0.1	-0.2	-0.5	-0.3	-0.8
Medication: Ibuprofen	0.2	0.3	1.9	-0.2	1.4	-0.0	-0.4	-0.0	0.0	0.0	-0.3
Medication: Allopurinol	1.6	2.2	4.6	-1.4	1.1	-1.3	-0.8	-0.6	-2.1	-1.9	-1.9
Medication: Omeprazole	1.7	2.0	3.9	-1.4	1.3	-0.9	-1.7	-0.6	-1.5	-1.5	-2.0
Medication: Seretide 50 evohaler	9.7	11.2	19.7	-2.8	2.8	-3.1	-1.6	-3.5	-4.2	-3.5	-4.4
Mean time to correctly identify matches	3.1	5.9	10.6	-1.9	2.0	-2.5	-1.0	-1.9	-3.3	-2.8	-3.2
Heart disease (mother)	0.7	0.8	2.0	-0.3	0.3	-0.4	0.0	-0.4	-1.4	-1.4	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.2	4.7	-1.6	0.8	-1.6	-0.4	-1.1	-2.2	-1.7	-1.6
Whole body fat mass	0.5	2.3	4.9	-1.1	-1.3	2.0	-1.7	0.3	2.2	1.5	1.1
Leg fat mass (right)	0.3	1.0	2.2	-1.1	-1.0	1.5	-1.2	-0.0	1.1	0.7	0.2
Arm predicted mass (right)	0.1	0.8	2.7	-0.3	-0.1	-1.0	0.2	-0.2	-0.9	-1.1	-1.6
Pulse rate, automated reading	1.2	3.8	6.4	1.1	-1.3	2.4	1.1	2.2	2.1	2.1	2.5
Alcohol intake frequency.	0.5	1.2	2.6	-0.9	-0.0	0.3	-1.1	-1.6	-1.4	-1.1	-1.4
Comparative height size at age 10	1.0	5.6	14.3	2.3	1.4	0.3	1.2	2.5	3.2	3.8	2.3
Number of full sisters	4.7	5.7	12.3	-1.5	0.6	-2.6	-0.7	-1.5	-3.5	-3.4	-3.1
Suffer from ‘nerves’	0.2	0.4	0.9	-0.7	0.1	0.5	-0.8	0.1	-0.9	-0.9	-0.3
Overall health rating	7.7	16.5	32.8	-3.0	2.0	-3.2	-1.8	-3.7	-5.7	-5.2	-5.7
Chest pain or discomfort	2.6	3.8	8.6	-0.2	1.0	-1.7	0.7	-1.6	-2.9	-2.5	-2.9
Had major operations	7.3	8.5	20.3	-1.6	1.8	-3.0	-0.8	-1.8	-3.8	-3.9	-4.5
Age at last live birth	0.6	0.9	1.7	-0.9	0.5	-0.7	-0.8	-0.6	-1.1	-1.3	-1.2
Family relationship satisfaction	2.5	3.0	6.4	-0.9	2.2	-1.0	-0.3	-1.1	-2.4	-2.0	-2.5
Leg pain on walking	1.0	1.3	3.2	-1.4	-0.3	-0.7	-1.1	-0.9	-1.1	-1.8	-1.2
Qualifications: NVQ or HND or HNC or equivalent	2.9	3.5	6.9	-1.8	2.6	-1.7	-2.0	-1.9	-1.7	-1.4	-1.6
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.0	-1.4	0.0	-0.6	-1.4	-1.2	-1.0	-0.9	-1.1
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	6.0	1.2	-0.6	1.8	0.2	0.8	2.4	2.1	2.3
Medication: Aspirin	3.6	4.8	10.1	-1.8	1.5	-1.9	-1.0	-1.6	-2.9	-2.7	-3.2
Supplements: Vitamin C	0.8	1.0	2.1	0.4	-1.3	1.0	0.8	1.1	1.0	0.3	1.4
Knee pain experienced in last month	1.2	1.9	4.0	-1.8	-0.5	-0.5	-1.8	-1.5	-0.9	-2.0	-0.9
Hypertension (Self-reported)	7.8	21.8	44.7	-3.6	2.7	-4.1	-1.8	-5.3	-6.0	-5.0	-6.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.9	-1.2	1.0	-0.4	-1.1	-1.4	-0.9	-0.7	-0.6
Illnesses of father: Heart disease	1.9	2.6	5.5	-1.4	-0.3	-0.8	-0.2	-1.6	-2.3	-2.1	-2.2
Illnesses of siblings: Diabetes	0.7	0.8	2.3	-1.5	-0.7	-0.9	-0.9	-0.8	-0.6	-1.0	-0.5
Smoking status: Previous	3.2	4.7	8.3	-2.4	1.3	-2.9	-2.3	-1.3	-2.0	-2.4	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.3	10.6	1.4	-0.8	1.4	0.4	1.1	3.3	3.0	3.0
Whole body fat-free mass	0.2	0.9	3.2	-0.2	-0.0	-1.0	0.5	-0.4	-1.0	-1.2	-1.8
Leg fat-free mass (right)	0.5	2.7	8.4	-1.0	0.2	-1.3	0.0	-1.3	-2.0	-2.2	-2.9
Arm fat percentage (left)	0.3	1.2	3.1	-1.6	-0.9	1.4	-1.8	-0.6	0.7	0.2	-0.1
Average weekly red wine intake	0.9	1.3	3.3	0.4	0.1	1.1	-0.4	0.4	1.7	1.8	1.5
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.2	-0.4	-1.1	1.4	-1.1	-0.4	1.5	1.1	1.1
Mood swings	0.4	0.8	1.5	-0.7	1.1	-0.7	-0.4	-0.5	-1.0	-1.1	-1.2
Loneliness, isolation	2.1	2.9	5.3	-0.8	2.3	-2.0	-0.5	-0.3	-2.3	-2.0	-1.9
Long-standing illness, disability or infirmity	6.1	9.4	21.2	-1.6	1.1	-2.3	-0.8	-3.3	-4.1	-4.0	-4.6
Ever had bowel cancer screening	0.4	0.5	1.5	-0.0	0.7	-1.2	-0.0	-0.3	-0.9	-0.6	-0.8
Diabetes diagnosed by doctor	0.1	0.2	0.7	-0.2	0.2	0.8	-0.6	0.8	-0.1	0.2	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	5.2	5.6	9.4	-1.8	1.9	-2.5	-1.2	-2.0	-3.1	-2.8	-3.0
Friendships satisfaction	0.3	0.4	0.9	0.5	0.4	0.9	0.9	-0.4	-0.5	0.0	-0.5
Qualifications: nursing, teaching	0.9	1.4	3.0	-0.6	-1.4	1.4	-1.1	0.4	1.7	1.3	0.9
Commuting to job workplace: Walk	1.7	1.8	4.9	-1.3	2.2	-1.5	-0.9	-1.8	-0.7	-0.7	-0.7
Eye problems/disorders: Cataract	1.1	1.3	2.5	0.1	-1.0	1.3	-0.6	0.8	1.6	1.2	1.6
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	4.5	-1.2	-1.0	0.5	-0.9	-2.1	-1.6	-1.8	-1.4
Medication for cholesterol	4.3	6.5	11.2	2.4	-1.5	2.2	1.9	2.8	2.9	2.8	3.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	3.3	1.8	-1.0	1.2	1.4	1.5	1.3	1.0	1.0
Back pain experienced in last month	0.5	0.7	1.2	-0.8	1.1	-0.8	-1.0	-1.1	-0.3	-0.8	-0.1
Mineral and other dietary supplements	4.5	6.1	9.3	-2.2	2.4	-2.9	-1.7	-2.0	-3.0	-2.6	-2.7
Breast cancer (self-reported)	0.8	0.9	4.3	1.1	-2.1	0.1	0.9	1.1	0.4	-0.2	0.3
Asthma (self-reported)	14.6	29.2	58.2	-2.9	4.4	-5.1	-1.2	-5.6	-7.1	-6.2	-7.6
Osteoporosis (self-reported)	1.7	2.1	4.6	0.6	-1.8	1.7	-0.0	0.6	1.9	1.3	2.2
Osteoarthritis (self-reported)	0.1	0.1	0.6	0.3	0.4	-0.8	0.2	-0.1	0.1	-0.1	0.2
Medication: Aspirin	3.5	4.6	9.4	-1.8	1.6	-1.8	-1.1	-1.6	-2.8	-2.7	-3.1
Medication: Gliclazide	1.1	1.2	3.7	-1.7	0.5	-0.3	-1.9	-0.3	-1.0	-1.0	-0.9
Illnesses of father: None of the above (group 1)	1.7	2.1	4.8	1.3	0.3	0.9	-0.1	2.2	1.6	1.6	2.1
Smoking status: Current	2.5	4.0	8.3	-1.2	1.4	-1.8	-0.4	-2.1	-2.9	-2.0	-2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.7	0.0	-0.6	-0.6	0.2	0.4	-0.8	-0.9	-0.2
Whole body water mass	0.2	0.9	3.2	-0.1	-0.2	-0.9	0.6	-0.3	-1.1	-1.3	-1.8
Leg predicted mass (right)	0.5	2.7	8.5	-1.0	0.2	-1.3	0.0	-1.2	-2.0	-2.2	-2.9
Arm fat mass (left)	0.2	0.8	1.9	-1.4	-0.7	1.1	-1.4	-0.5	0.5	0.1	-0.5
Number of self-reported non-cancer illnesses	11.4	19.8	35.5	-3.1	3.1	-4.1	-1.7	-4.9	-5.8	-5.1	-6.0
Average weekly champagne plus white wine intake	0.8	1.1	2.4	0.7	-1.3	1.0	0.6	0.8	1.1	0.7	1.5
Miserableness	0.4	0.8	1.9	-1.4	-0.1	0.3	-1.2	-0.7	-0.6	-1.0	-0.7
Guilty feelings	0.2	0.3	1.3	-0.2	-0.4	0.9	-0.2	1.2	0.3	-0.2	0.2
Wears glasses or contact lenses	0.4	0.4	2.1	-0.2	1.5	-0.8	-0.5	-0.4	-0.4	-0.1	0.1
Ever taken oral contraceptive pill	0.2	0.2	0.3	-0.5	-0.0	-0.0	-0.6	-0.6	-0.3	-0.5	-0.4
Hearing aid user	0.0	0.1	0.2	0.1	0.2	-0.1	0.2	0.4	0.1	0.4	-0.0
Mother’s age at death	2.4	3.0	6.6	1.2	-0.2	1.8	1.3	2.1	1.8	2.6	1.8
Financial situation satisfaction	0.8	1.0	2.3	0.8	1.1	-0.2	1.2	-0.3	-1.3	-0.9	-1.5
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.4	-0.4	0.2	-0.1	-0.3	-1.2	-0.5	-0.3	-0.9
Commuting to job workplace: Public transport	0.2	0.3	0.8	-0.7	0.7	-0.0	-0.9	-0.6	-0.1	-0.2	0.1
Eye problems/disorders: Glaucoma	1.3	1.6	3.6	0.6	-1.7	1.9	0.8	1.0	1.4	1.0	1.2
Medication: Blood pressure	4.2	8.0	15.6	-2.1	2.0	-2.1	-1.2	-3.5	-3.5	-3.2	-4.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.6	0.6	-0.6	1.6	0.4	0.3	0.2	0.7	-0.1
Supplements: Fish oil (including cod liver oil)	2.6	3.4	6.7	1.7	-1.6	2.1	0.8	0.9	2.6	1.9	2.3
High cholesterol (Self-reported)	1.2	2.2	3.5	-1.0	1.8	-1.9	-0.6	-1.3	-1.7	-1.1	-1.9
Medication: Bendroflumethiazide	3.3	5.0	9.5	-1.5	0.8	-2.3	-0.5	-2.5	-3.0	-2.6	-3.1
Medication: Paracetamol	1.6	2.5	5.8	-1.3	2.4	-1.0	-2.0	-1.8	-1.1	-1.2	-1.3
Medication: Lisinopril	3.7	4.8	8.8	-2.5	1.9	-1.3	-2.1	-3.0	-2.1	-1.9	-2.3
Medication: Atorvastatin	4.0	4.9	10.0	-1.7	1.8	-2.2	-0.6	-2.1	-3.0	-2.1	-3.2
Illnesses of father: High blood pressure	1.4	1.7	3.3	-0.8	1.4	-1.6	-0.1	-1.8	-1.2	-0.9	-1.6
Alcohol drinker status: Never	0.4	0.5	1.5	-0.1	-0.8	-0.5	0.4	-1.2	-0.9	-0.7	-0.3
Ever smoked	5.3	9.3	14.2	-2.8	2.6	-3.4	-2.3	-2.4	-3.5	-3.3	-3.8
Basal metabolic rate	0.1	0.4	1.7	-0.3	-0.3	-0.4	0.2	-0.2	-0.4	-0.8	-1.3
Leg fat percentage (left)	0.7	2.5	4.8	-1.3	-1.1	2.2	-2.1	0.1	2.0	1.4	1.4
Arm fat-free mass (left)	0.1	0.4	1.2	0.1	-0.9	-0.1	0.8	0.2	-0.4	-0.6	-1.1
Number of operations (self-reported)	5.1	7.6	13.6	-2.7	1.3	-2.7	-1.8	-2.1	-3.3	-3.7	-3.6
Average weekly beer plus cider intake	0.5	0.7	2.1	-0.8	1.5	-0.5	-1.1	-1.0	0.3	0.5	-0.2
Irritability	0.3	0.4	1.9	0.7	-0.4	0.7	1.4	0.4	-0.1	-0.4	-0.1
Risk taking	0.0	0.0	0.1	-0.1	0.1	0.1	0.1	0.1	0.2	0.2	0.1
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.9	0.1	-0.2	0.7	-0.1	0.4	0.9	0.6	0.5
Fractured/broken bones in last 5 years	0.7	0.9	2.3	0.3	-1.1	1.5	0.4	1.1	1.0	0.7	0.9
Age started oral contraceptive pill	5.4	6.7	14.3	1.6	-1.3	2.7	0.3	1.8	3.6	3.4	3.8
Diastolic blood pressure, automated reading	5.1	15.8	30.1	-2.9	1.7	-2.9	-1.0	-4.7	-5.4	-4.9	-5.5
Ever depressed for a whole week	2.7	3.4	4.8	-1.8	1.8	-2.0	-1.6	-1.4	-1.9	-1.8	-2.2
Unable to work because of sickness or disability	1.1	1.5	3.2	-1.1	0.6	-0.3	-0.6	-1.0	-1.8	-1.8	-1.6
Commuting to job workplace: Cycle	0.2	0.3	1.3	0.2	-1.1	0.2	0.6	-0.0	0.2	-0.2	0.6
Myopia	1.8	2.5	5.0	0.9	-0.6	1.7	-0.4	1.8	2.1	1.8	2.2
Vascular/heart problems diagnosed by doctor	11.7	31.9	64.2	4.3	-3.4	5.2	2.0	6.0	7.3	6.4	8.0
Cholesterol lowering medication	4.3	6.3	9.5	-2.7	1.3	-2.1	-2.1	-2.2	-3.1	-3.1	-3.0
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	4.6	-1.1	1.7	-1.3	-1.3	-0.4	-1.8	-1.4	-2.1
Pain experienced in last month	2.0	3.4	6.9	1.3	-0.5	1.6	0.6	2.5	2.2	2.6	2.1
Supplements: Calcium	0.1	0.2	0.7	0.2	-0.8	0.4	0.4	0.1	-0.1	-0.3	-0.3
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	0.2	0.6	-0.2	-0.6	-0.1	0.5	0.5	0.7
Heart attack/myocardial infarction (self-reported)	9.7	12.6	26.1	-2.0	2.4	-3.4	-0.6	-2.8	-4.8	-4.7	-5.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.7	-0.9	0.0	-0.3	-1.1	-1.3	-0.2	-0.4	-0.6
Heart disease (siblings)	1.6	1.9	3.3	-1.0	1.4	-1.5	-0.9	-1.2	-1.8	-1.3	-1.8
Alcohol drinker status: Previous	0.3	0.3	1.0	0.2	-0.9	1.0	0.1	-0.4	0.1	-0.5	-0.1
Pack years of smoking	1.8	2.6	7.1	-0.4	0.2	-0.5	0.4	-0.8	-2.5	-2.7	-2.5
Impedance of whole body	7.8	39.5	91.7	2.5	-1.7	5.5	-1.8	4.1	9.6	8.6	9.6
Leg fat mass (left)	0.3	1.0	1.9	-1.3	-1.2	1.3	-1.4	-0.1	1.1	0.4	0.1
Arm predicted mass (left)	0.0	0.3	0.9	0.1	-0.5	-0.1	0.6	0.3	-0.2	-0.5	-0.9