Best TWAS P=7.61e-09 · Best GWAS P=1.02e-09 conditioned to 0.0401
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | DMWD | 0.28 | 0.19 | lasso | 3 | 0.15 | 1.2e-08 | -5.7 | 5.6 | 2.1e-08 | -0.94 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Tibial | DMWD | 0.22 | 0.17 | lasso | 8 | 0.16 | 6.8e-13 | -5.7 | 5.8 | 8.3e-09 | -0.96 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Artery Tibial | AC074212.6 | 0.14 | 0.04 | lasso | 5 | 0.06 | 2.4e-05 | -5.9 | 5.3 | 9.9e-08 | -0.87 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Muscle Skeletal | DMWD | 0.06 | 0.01 | lasso | 6 | 0.01 | 1.9e-02 | -5.7 | 5.8 | 7.6e-09 | -0.91 | 0.01 | 0.97 | TRUE |
| 5 | GTEx | Thyroid | AC074212.6 | 0.08 | 0.10 | lasso | 2 | 0.09 | 1.8e-07 | -5.7 | 5.7 | 1.1e-08 | -0.95 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SIX5 | 0.05 | 0.05 | lasso | 8 | 0.03 | 7.6e-03 | -5.8 | -5.6 | 2.0e-08 | 0.98 | 0.01 | 0.94 | FALSE |