Best TWAS P=6.83e-25 · Best GWAS P=3.9e-24 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | AL133458.1 | 0.11 | 0.02 | enet | 18 | 0.01 | 2.5e-02 | 7.45 | -7.1 | 9.3e-13 | 0.55 | 0.25 | 0.35 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | AL133458.1 | 0.29 | 0.00 | enet | 19 | 0.00 | 3.6e-01 | -8.99 | -9.5 | 1.7e-21 | 0.83 | 0.02 | 0.90 | FALSE |
| 3 | GTEx | Brain Cerebellum | AL133458.1 | 0.42 | 0.32 | lasso | 6 | 0.31 | 1.0e-09 | -10.10 | -10.0 | 9.8e-24 | 0.94 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | RNASET2 | 0.29 | 0.30 | enet | 31 | 0.29 | 1.0e-21 | -8.97 | 9.0 | 2.2e-19 | -0.73 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | AL133458.1 | 0.16 | 0.14 | enet | 13 | 0.14 | 1.7e-10 | -8.97 | 8.1 | 7.0e-16 | -0.73 | 0.99 | 0.01 | FALSE |
| 6 | GTEx | Colon Transverse | RNASET2 | 0.21 | 0.02 | enet | 18 | 0.07 | 3.1e-04 | -2.95 | -5.9 | 4.2e-09 | 0.56 | 0.03 | 0.79 | FALSE |
| 7 | GTEx | Esophagus Mucosa | RNASET2 | 0.29 | 0.31 | lasso | 9 | 0.32 | 1.6e-21 | -10.10 | -10.3 | 6.8e-25 | 0.97 | 0.00 | 1.00 | TRUE |
| 8 | GTEx | Esophagus Mucosa | AL133458.1 | 0.15 | 0.01 | enet | 12 | 0.02 | 1.3e-02 | -8.84 | -8.5 | 1.6e-17 | 0.70 | 0.03 | 0.90 | FALSE |
| 9 | GTEx | Esophagus Mucosa | FGFR1OP | 0.10 | 0.07 | lasso | 4 | 0.03 | 4.4e-03 | 8.32 | 8.4 | 6.4e-17 | -0.67 | 0.28 | 0.43 | FALSE |
| 10 | GTEx | Lung | RNASET2 | 0.21 | 0.13 | lasso | 10 | 0.13 | 4.0e-10 | -8.98 | -9.7 | 2.3e-22 | 0.85 | 0.24 | 0.76 | FALSE |
| 11 | GTEx | Lung | AL133458.1 | 0.17 | 0.09 | lasso | 5 | 0.12 | 3.9e-09 | -6.22 | -8.6 | 1.3e-17 | 0.72 | 0.90 | 0.10 | FALSE |
| 12 | GTEx | Nerve Tibial | RNASET2 | 0.19 | 0.07 | lasso | 8 | 0.09 | 4.4e-07 | 7.45 | -8.3 | 1.5e-16 | 0.69 | 0.29 | 0.70 | FALSE |
| 13 | GTEx | Skin Not Sun Exposed Suprapubic | RNASET2 | 0.14 | 0.07 | enet | 25 | 0.08 | 3.6e-05 | 8.53 | -8.0 | 1.0e-15 | 0.65 | 0.08 | 0.91 | FALSE |
| 14 | GTEx | Skin Not Sun Exposed Suprapubic | AL133458.1 | 0.13 | 0.05 | lasso | 2 | 0.01 | 5.4e-02 | 7.45 | -7.5 | 9.1e-14 | 0.55 | 0.10 | 0.72 | FALSE |
| 15 | GTEx | Skin Sun Exposed Lower leg | RNASET2 | 0.32 | 0.23 | enet | 48 | 0.24 | 3.3e-20 | -8.97 | -9.6 | 1.1e-21 | 0.86 | 0.32 | 0.68 | FALSE |
| 16 | GTEx | Skin Sun Exposed Lower leg | AL133458.1 | 0.13 | 0.08 | enet | 10 | 0.03 | 1.0e-03 | -8.98 | -9.7 | 4.0e-22 | 0.80 | 0.13 | 0.87 | FALSE |
| 17 | GTEx | Stomach | RNASET2 | 0.22 | 0.12 | lasso | 6 | 0.16 | 6.5e-08 | -8.09 | -9.1 | 1.3e-19 | 0.89 | 0.00 | 0.99 | FALSE |
| 18 | GTEx | Thyroid | RNASET2 | 0.16 | 0.06 | enet | 33 | 0.04 | 3.8e-04 | 8.30 | -7.9 | 3.2e-15 | 0.60 | 0.87 | 0.10 | FALSE |
| 19 | GTEx | Thyroid | AL133458.1 | 0.09 | 0.07 | lasso | 5 | 0.07 | 2.9e-06 | -6.22 | -7.0 | 2.5e-12 | 0.50 | 0.98 | 0.00 | FALSE |
| 20 | GTEx | Whole Blood | RNASET2 | 0.20 | 0.18 | enet | 23 | 0.18 | 3.4e-16 | -8.98 | -9.9 | 2.5e-23 | 0.85 | 0.98 | 0.02 | FALSE |
| 21 | GTEx | Whole Blood | AL133458.1 | 0.20 | 0.14 | enet | 7 | 0.18 | 1.4e-16 | -8.84 | -9.3 | 2.0e-20 | 0.80 | 1.00 | 0.00 | FALSE |
| 22 | METSIM | Adipose | CCR6 | 0.06 | 0.02 | lasso | 3 | 0.04 | 5.6e-07 | 6.72 | 6.2 | 5.4e-10 | -0.45 | 0.93 | 0.01 | FALSE |
| 23 | METSIM | Adipose | FGFR1OP | 0.05 | 0.00 | blup | 606 | 0.02 | 1.5e-03 | 0.94 | 6.7 | 1.8e-11 | -0.57 | 0.06 | 0.84 | FALSE |
| 24 | METSIM | Adipose | RNASET2 | 0.09 | 0.09 | lasso | 4 | 0.12 | 8.7e-18 | -8.98 | -9.7 | 3.0e-22 | 0.86 | 0.14 | 0.86 | FALSE |
| 25 | NTR | Blood | RNASET2 | 0.28 | 0.42 | lasso | 13 | 0.43 | 5.3e-155 | -8.99 | -9.5 | 1.5e-21 | 0.84 | 1.00 | 0.00 | FALSE |
| 26 | YFS | Blood | RNASET2 | 0.45 | 0.60 | enet | 24 | 0.61 | 1.8e-260 | -8.98 | -9.1 | 8.1e-20 | 0.83 | 1.00 | 0.00 | FALSE |
| 27 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RNASET2 | 0.08 | 0.05 | enet | 12 | 0.07 | 2.0e-06 | -10.13 | -9.4 | 4.4e-21 | 0.86 | 0.00 | 1.00 | FALSE |
| 28 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RNASET2 | 0.07 | 0.05 | lasso | 4 | 0.04 | 5.1e-09 | -10.10 | -10.1 | 8.5e-24 | 1.00 | 0.00 | 1.00 | FALSE |
| 29 | The Cancer Genome Atlas | Colon Adenocarcinoma | RNASET2 | 0.12 | 0.05 | enet | 7 | 0.08 | 2.4e-05 | -10.08 | -7.2 | 4.5e-13 | 0.83 | 0.00 | 0.98 | FALSE |
| 30 | The Cancer Genome Atlas | Esophageal Carcinoma | RNASET2 | 0.17 | 0.11 | lasso | 3 | 0.09 | 8.7e-04 | -10.10 | -10.2 | 1.7e-24 | 0.97 | 0.01 | 0.98 | FALSE |
| 31 | The Cancer Genome Atlas | Glioblastoma Multiforme | GPR31 | 0.17 | 0.06 | enet | 10 | 0.09 | 1.3e-03 | -4.82 | 5.6 | 2.0e-08 | -0.29 | 0.02 | 0.21 | FALSE |
| 32 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RNASET2 | 0.09 | 0.08 | lasso | 2 | 0.08 | 2.9e-09 | -10.13 | -10.1 | 4.7e-24 | 1.00 | 0.00 | 1.00 | FALSE |
| 33 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RNASET2 | 0.05 | 0.03 | lasso | 3 | 0.03 | 9.2e-05 | -8.99 | -10.2 | 2.7e-24 | 0.92 | 0.00 | 0.99 | FALSE |
| 34 | The Cancer Genome Atlas | Lung Adenocarcinoma | RNASET2 | 0.06 | 0.04 | lasso | 2 | 0.03 | 2.6e-04 | -10.13 | -10.1 | 8.8e-24 | 1.00 | 0.00 | 0.99 | FALSE |
| 35 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RNASET2 | 0.13 | 0.09 | lasso | 9 | 0.10 | 1.4e-11 | -10.08 | -9.8 | 6.5e-23 | 0.93 | 0.00 | 1.00 | FALSE |
| 36 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RNASET2 | 0.08 | 0.00 | enet | 8 | 0.01 | 6.5e-02 | -2.98 | -7.9 | 3.2e-15 | 0.73 | 0.01 | 0.70 | FALSE |
| 37 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RNASET2 | 0.24 | 0.15 | lasso | 3 | 0.14 | 5.6e-15 | -10.08 | -9.8 | 8.5e-23 | 0.96 | 0.00 | 1.00 | FALSE |
| 38 | The Cancer Genome Atlas | Rectum Adenocarcinoma | RNASET2 | 0.14 | 0.19 | lasso | 3 | 0.15 | 2.1e-04 | -10.08 | -10.1 | 6.4e-24 | 0.99 | 0.00 | 0.93 | FALSE |