[Hub]/) : Traits : Hypothyroidism/myxoedema (self-reported) :

chr6:166,651,581-167,841,508

Best TWAS P=6.83e-25 · Best GWAS P=3.9e-24 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous AL133458.1 0.11 0.02 enet 18 0.01 2.5e-02 7.45 -7.1 9.3e-13 0.55 0.25 0.35 FALSE
2 GTEx Brain Cerebellar Hemisphere AL133458.1 0.29 0.00 enet 19 0.00 3.6e-01 -8.99 -9.5 1.7e-21 0.83 0.02 0.90 FALSE
3 GTEx Brain Cerebellum AL133458.1 0.42 0.32 lasso 6 0.31 1.0e-09 -10.10 -10.0 9.8e-24 0.94 0.00 1.00 FALSE
4 GTEx Cells Transformed fibroblasts RNASET2 0.29 0.30 enet 31 0.29 1.0e-21 -8.97 9.0 2.2e-19 -0.73 1.00 0.00 FALSE
5 GTEx Cells Transformed fibroblasts AL133458.1 0.16 0.14 enet 13 0.14 1.7e-10 -8.97 8.1 7.0e-16 -0.73 0.99 0.01 FALSE
6 GTEx Colon Transverse RNASET2 0.21 0.02 enet 18 0.07 3.1e-04 -2.95 -5.9 4.2e-09 0.56 0.03 0.79 FALSE
7 GTEx Esophagus Mucosa RNASET2 0.29 0.31 lasso 9 0.32 1.6e-21 -10.10 -10.3 6.8e-25 0.97 0.00 1.00 TRUE
8 GTEx Esophagus Mucosa AL133458.1 0.15 0.01 enet 12 0.02 1.3e-02 -8.84 -8.5 1.6e-17 0.70 0.03 0.90 FALSE
9 GTEx Esophagus Mucosa FGFR1OP 0.10 0.07 lasso 4 0.03 4.4e-03 8.32 8.4 6.4e-17 -0.67 0.28 0.43 FALSE
10 GTEx Lung RNASET2 0.21 0.13 lasso 10 0.13 4.0e-10 -8.98 -9.7 2.3e-22 0.85 0.24 0.76 FALSE
11 GTEx Lung AL133458.1 0.17 0.09 lasso 5 0.12 3.9e-09 -6.22 -8.6 1.3e-17 0.72 0.90 0.10 FALSE
12 GTEx Nerve Tibial RNASET2 0.19 0.07 lasso 8 0.09 4.4e-07 7.45 -8.3 1.5e-16 0.69 0.29 0.70 FALSE
13 GTEx Skin Not Sun Exposed Suprapubic RNASET2 0.14 0.07 enet 25 0.08 3.6e-05 8.53 -8.0 1.0e-15 0.65 0.08 0.91 FALSE
14 GTEx Skin Not Sun Exposed Suprapubic AL133458.1 0.13 0.05 lasso 2 0.01 5.4e-02 7.45 -7.5 9.1e-14 0.55 0.10 0.72 FALSE
15 GTEx Skin Sun Exposed Lower leg RNASET2 0.32 0.23 enet 48 0.24 3.3e-20 -8.97 -9.6 1.1e-21 0.86 0.32 0.68 FALSE
16 GTEx Skin Sun Exposed Lower leg AL133458.1 0.13 0.08 enet 10 0.03 1.0e-03 -8.98 -9.7 4.0e-22 0.80 0.13 0.87 FALSE
17 GTEx Stomach RNASET2 0.22 0.12 lasso 6 0.16 6.5e-08 -8.09 -9.1 1.3e-19 0.89 0.00 0.99 FALSE
18 GTEx Thyroid RNASET2 0.16 0.06 enet 33 0.04 3.8e-04 8.30 -7.9 3.2e-15 0.60 0.87 0.10 FALSE
19 GTEx Thyroid AL133458.1 0.09 0.07 lasso 5 0.07 2.9e-06 -6.22 -7.0 2.5e-12 0.50 0.98 0.00 FALSE
20 GTEx Whole Blood RNASET2 0.20 0.18 enet 23 0.18 3.4e-16 -8.98 -9.9 2.5e-23 0.85 0.98 0.02 FALSE
21 GTEx Whole Blood AL133458.1 0.20 0.14 enet 7 0.18 1.4e-16 -8.84 -9.3 2.0e-20 0.80 1.00 0.00 FALSE
22 METSIM Adipose CCR6 0.06 0.02 lasso 3 0.04 5.6e-07 6.72 6.2 5.4e-10 -0.45 0.93 0.01 FALSE
23 METSIM Adipose FGFR1OP 0.05 0.00 blup 606 0.02 1.5e-03 0.94 6.7 1.8e-11 -0.57 0.06 0.84 FALSE
24 METSIM Adipose RNASET2 0.09 0.09 lasso 4 0.12 8.7e-18 -8.98 -9.7 3.0e-22 0.86 0.14 0.86 FALSE
25 NTR Blood RNASET2 0.28 0.42 lasso 13 0.43 5.3e-155 -8.99 -9.5 1.5e-21 0.84 1.00 0.00 FALSE
26 YFS Blood RNASET2 0.45 0.60 enet 24 0.61 1.8e-260 -8.98 -9.1 8.1e-20 0.83 1.00 0.00 FALSE
27 The Cancer Genome Atlas Bladder Urothelial Carcinoma RNASET2 0.08 0.05 enet 12 0.07 2.0e-06 -10.13 -9.4 4.4e-21 0.86 0.00 1.00 FALSE
28 The Cancer Genome Atlas Breast Invasive Carcinoma RNASET2 0.07 0.05 lasso 4 0.04 5.1e-09 -10.10 -10.1 8.5e-24 1.00 0.00 1.00 FALSE
29 The Cancer Genome Atlas Colon Adenocarcinoma RNASET2 0.12 0.05 enet 7 0.08 2.4e-05 -10.08 -7.2 4.5e-13 0.83 0.00 0.98 FALSE
30 The Cancer Genome Atlas Esophageal Carcinoma RNASET2 0.17 0.11 lasso 3 0.09 8.7e-04 -10.10 -10.2 1.7e-24 0.97 0.01 0.98 FALSE
31 The Cancer Genome Atlas Glioblastoma Multiforme GPR31 0.17 0.06 enet 10 0.09 1.3e-03 -4.82 5.6 2.0e-08 -0.29 0.02 0.21 FALSE
32 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma RNASET2 0.09 0.08 lasso 2 0.08 2.9e-09 -10.13 -10.1 4.7e-24 1.00 0.00 1.00 FALSE
33 The Cancer Genome Atlas Brain Lower Grade Glioma RNASET2 0.05 0.03 lasso 3 0.03 9.2e-05 -8.99 -10.2 2.7e-24 0.92 0.00 0.99 FALSE
34 The Cancer Genome Atlas Lung Adenocarcinoma RNASET2 0.06 0.04 lasso 2 0.03 2.6e-04 -10.13 -10.1 8.8e-24 1.00 0.00 0.99 FALSE
35 The Cancer Genome Atlas Lung Squamous Cell Carcinoma RNASET2 0.13 0.09 lasso 9 0.10 1.4e-11 -10.08 -9.8 6.5e-23 0.93 0.00 1.00 FALSE
36 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma RNASET2 0.08 0.00 enet 8 0.01 6.5e-02 -2.98 -7.9 3.2e-15 0.73 0.01 0.70 FALSE
37 The Cancer Genome Atlas Prostate Adenocarcinoma RNASET2 0.24 0.15 lasso 3 0.14 5.6e-15 -10.08 -9.8 8.5e-23 0.96 0.00 1.00 FALSE
38 The Cancer Genome Atlas Rectum Adenocarcinoma RNASET2 0.14 0.19 lasso 3 0.15 2.1e-04 -10.08 -10.1 6.4e-24 0.99 0.00 0.93 FALSE