[Hub]/) : Traits : Hypothyroidism/myxoedema (self-reported) : ← →

chr8:60,736,025-62,220,903

Best TWAS P=2.55e-08 · Best GWAS P=3.91e-08 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	RAB2A	0.13	0.19	lasso	3	0.19	1.7e-10	5.3	5.3	1.4e-07	0.96	0.03	0.97	FALSE
2	GTEx	Artery Tibial	RAB2A	0.10	0.14	lasso	6	0.12	2.9e-09	5.3	5.4	7.1e-08	0.96	0.04	0.96	FALSE
3	GTEx	Cells EBV-transformed lymphocytes	RAB2A	0.26	0.15	enet	22	0.14	2.7e-05	5.3	5.6	2.6e-08	0.97	0.02	0.98	TRUE
4	GTEx	Cells Transformed fibroblasts	RAB2A	0.35	0.21	lasso	9	0.24	2.5e-18	5.3	5.5	4.6e-08	0.95	0.02	0.98	FALSE
5	GTEx	Esophagus Muscularis	RAB2A	0.21	0.16	lasso	5	0.12	1.2e-07	5.3	5.2	2.4e-07	0.95	0.03	0.97	FALSE
6	GTEx	Lung	RAB2A	0.06	0.03	lasso	6	0.02	9.1e-03	5.4	5.5	5.1e-08	0.98	0.02	0.96	FALSE
7	GTEx	Nerve Tibial	RAB2A	0.10	0.02	lasso	6	0.02	1.4e-02	5.4	5.2	1.7e-07	0.97	0.02	0.96	FALSE
8	GTEx	Skin Sun Exposed Lower leg	RAB2A	0.08	0.09	lasso	2	0.06	1.0e-05	5.3	5.3	1.1e-07	0.97	0.03	0.97	FALSE
9	GTEx	Spleen	RAB2A	0.32	0.19	lasso	4	0.16	7.9e-05	5.2	5.5	3.6e-08	0.96	0.03	0.94	FALSE
10	GTEx	Thyroid	RAB2A	0.06	0.04	enet	8	0.04	9.5e-04	5.5	5.5	3.8e-08	0.99	0.02	0.97	FALSE
11	METSIM	Adipose	RAB2A	0.09	0.10	lasso	8	0.09	9.3e-14	5.4	5.5	4.5e-08	0.98	0.02	0.98	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	RAB2A	0.01	0.02	lasso	3	0.01	7.5e-04	5.4	5.5	4.8e-08	0.98	0.02	0.96	FALSE
13	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAB2A	0.03	0.02	blup	53	0.03	3.0e-04	5.5	5.2	1.9e-07	0.95	0.02	0.97	FALSE
14	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RAB2A	0.10	0.06	blup	51	0.07	3.4e-04	5.4	5.5	3.1e-08	0.97	0.02	0.95	FALSE
15	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RAB2A	0.07	0.06	blup	51	0.06	2.5e-07	5.5	5.2	2.5e-07	0.95	0.02	0.98	FALSE
16	The Cancer Genome Atlas	Stomach Adenocarcinoma	RAB2A	0.04	0.04	blup	51	0.04	5.3e-04	5.5	5.4	5.4e-08	0.97	0.02	0.96	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	RAB2A	0.06	0.03	blup	53	0.05	6.1e-06	3.1	5.5	4.5e-08	0.93	0.02	0.98	FALSE