[Hub]/) : Traits : Hypothyroidism/myxoedema (self-reported) : ← →

chr8:8,092,025-12,973,575

Best TWAS P=4.08e-16 · Best GWAS P=1.62e-18 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CTSB	0.13	0.10	enet	14	0.09	1.4e-11	5.1	5.2	1.5e-07	-0.45	0.99	0.01	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAM167A	0.09	0.09	lasso	6	0.13	1.4e-15	4.3	5.7	1.0e-08	-0.61	0.35	0.65	FALSE
3	CommonMind	Brain Pre-frontal Cortex	FAM86B1	0.02	0.02	lasso	3	0.01	1.3e-02	-5.7	-5.5	3.4e-08	0.69	0.02	0.93	FALSE
4	CommonMind	Brain Pre-frontal Cortex	FAM90A25P	0.11	0.08	lasso	3	0.08	1.4e-09	-5.7	-5.6	2.0e-08	0.65	0.02	0.98	FALSE
5	GTEx	Adipose Subcutaneous	ERI1	0.05	0.00	enet	10	0.00	5.5e-01	-4.2	5.7	9.6e-09	-0.66	0.26	0.25	FALSE
6	GTEx	Adipose Subcutaneous	FAM85A	0.06	0.06	enet	10	0.07	3.3e-06	5.7	-5.3	9.0e-08	0.55	0.02	0.97	FALSE
7	GTEx	Adipose Visceral Omentum	FAM86B3P	0.23	0.07	enet	20	0.14	6.4e-08	-8.0	-6.1	9.1e-10	0.71	0.34	0.65	FALSE
8	GTEx	Adrenal Gland	AF131215.2	0.20	0.16	enet	12	0.13	2.2e-05	-5.3	-5.3	8.9e-08	0.68	0.61	0.38	FALSE
9	GTEx	Adrenal Gland	AF131215.9	0.18	0.16	lasso	10	0.18	3.5e-07	-5.3	-5.4	7.0e-08	0.70	0.79	0.19	FALSE
10	GTEx	Artery Aorta	ERI1	0.11	0.08	lasso	5	0.10	5.1e-06	-4.9	6.2	6.9e-10	-0.69	0.77	0.18	FALSE
11	GTEx	Artery Aorta	FAM85A	0.11	0.06	enet	19	0.06	3.4e-04	5.7	-5.8	6.7e-09	0.66	0.03	0.96	FALSE
12	GTEx	Artery Coronary	AC087269.1	0.20	0.02	enet	29	0.02	8.7e-02	-4.7	6.6	3.9e-11	-0.58	0.05	0.67	FALSE
13	GTEx	Artery Tibial	ERI1	0.05	0.02	lasso	7	0.01	3.2e-02	-6.0	6.2	5.2e-10	-0.74	0.06	0.89	FALSE
14	GTEx	Brain Cerebellar Hemisphere	FAM86B3P	0.28	0.27	lasso	8	0.28	5.4e-08	-8.1	7.4	1.1e-13	-0.83	0.12	0.87	FALSE
15	GTEx	Brain Cerebellum	FAM86B3P	0.19	0.14	lasso	5	0.16	1.8e-05	-6.6	7.4	1.6e-13	-0.85	0.10	0.89	FALSE
16	GTEx	Brain Cortex	FAM86B3P	0.14	0.05	enet	9	0.07	5.1e-03	-6.5	6.2	4.6e-10	-0.80	0.03	0.86	FALSE
17	GTEx	Brain Frontal Cortex BA9	FAM86B3P	0.16	0.13	enet	27	0.10	1.1e-03	-6.9	6.7	2.7e-11	-0.72	0.16	0.62	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	CTSB	0.41	0.08	enet	21	0.13	1.9e-04	4.5	5.2	1.9e-07	-0.44	0.10	0.24	FALSE
19	GTEx	Cells Transformed fibroblasts	ERI1	0.34	0.35	lasso	7	0.35	1.9e-27	-4.9	5.6	2.4e-08	-0.66	1.00	0.00	FALSE
20	GTEx	Cells Transformed fibroblasts	FAM86B3P	0.23	0.33	lasso	11	0.38	8.4e-30	-6.1	-6.8	1.1e-11	0.82	0.99	0.01	FALSE
21	GTEx	Colon Sigmoid	AF131215.2	0.10	0.00	enet	7	0.02	5.0e-02	-5.6	-5.9	4.3e-09	0.71	0.05	0.82	FALSE
22	GTEx	Colon Transverse	FAM86B3P	0.13	0.04	lasso	8	0.04	4.4e-03	-6.6	-6.8	1.2e-11	0.78	0.18	0.36	FALSE
23	GTEx	Esophagus Gastroesophageal Junction	AF131215.2	0.13	0.06	enet	10	0.11	6.4e-05	-5.0	-5.7	1.3e-08	0.67	0.47	0.19	FALSE
24	GTEx	Esophagus Mucosa	FAM86B3P	0.22	0.17	lasso	8	0.19	1.7e-12	-6.1	-7.0	1.8e-12	0.80	0.98	0.02	FALSE
25	GTEx	Esophagus Mucosa	AF131215.2	0.15	0.14	enet	15	0.18	4.3e-12	3.9	-5.2	2.7e-07	0.68	0.44	0.56	FALSE
26	GTEx	Esophagus Mucosa	AF131215.9	0.18	0.16	lasso	14	0.19	1.6e-12	-5.5	-5.2	1.6e-07	0.69	0.67	0.33	FALSE
27	GTEx	Esophagus Muscularis	ERI1	0.12	0.09	enet	13	0.08	7.7e-06	-4.5	5.8	7.3e-09	-0.74	0.50	0.50	FALSE
28	GTEx	Esophagus Muscularis	AF131215.9	0.14	0.17	enet	16	0.17	1.6e-10	4.4	-5.2	1.9e-07	0.67	0.69	0.31	FALSE
29	GTEx	Heart Atrial Appendage	AF131215.2	0.39	0.13	enet	26	0.21	6.6e-10	3.9	-5.3	9.3e-08	0.63	0.22	0.78	FALSE
30	GTEx	Lung	ERI1	0.13	0.07	lasso	6	0.09	2.7e-07	5.1	5.8	5.3e-09	-0.69	0.28	0.71	FALSE
31	GTEx	Muscle Skeletal	MFHAS1	0.07	0.04	lasso	4	0.04	1.4e-04	-4.0	-5.4	6.1e-08	0.71	0.68	0.24	FALSE
32	GTEx	Nerve Tibial	ERI1	0.07	0.01	enet	16	0.01	4.2e-02	4.1	6.0	2.4e-09	-0.72	0.11	0.71	FALSE
33	GTEx	Pancreas	ERI1	0.08	0.00	enet	16	0.04	6.6e-03	-4.6	6.1	1.3e-09	-0.64	0.14	0.39	FALSE
34	GTEx	Pancreas	AF131215.9	0.25	0.24	enet	14	0.22	1.0e-09	-5.2	-5.1	2.8e-07	0.67	0.92	0.08	FALSE
35	GTEx	Pituitary	FAM86B3P	0.13	0.15	lasso	4	0.13	3.5e-04	4.9	6.0	1.6e-09	-0.71	0.19	0.37	FALSE
36	GTEx	Skin Sun Exposed Lower leg	AF131215.9	0.19	0.17	enet	29	0.21	3.9e-17	4.4	-5.1	2.9e-07	0.66	1.00	0.00	FALSE
37	GTEx	Small Intestine Terminal Ileum	AF131215.9	0.14	0.11	enet	16	0.06	1.6e-02	4.7	-5.7	1.4e-08	0.60	0.15	0.31	FALSE
38	GTEx	Testis	FAM86B3P	0.15	0.14	lasso	7	0.13	2.2e-06	-6.5	7.0	2.1e-12	-0.78	0.21	0.79	FALSE
39	GTEx	Thyroid	SGK223	0.19	0.35	enet	16	0.36	1.1e-28	-8.7	8.1	4.1e-16	-0.95	0.00	1.00	TRUE
40	GTEx	Uterus	AF131215.2	0.17	0.07	enet	13	0.09	7.1e-03	-5.3	-5.8	8.1e-09	0.71	0.09	0.69	FALSE
41	GTEx	Vagina	AF131215.9	0.21	0.11	lasso	9	0.08	6.3e-03	-4.9	-5.2	1.6e-07	0.67	0.09	0.82	FALSE
42	NTR	Blood	MFHAS1	0.02	0.01	blup	759	0.01	2.9e-04	-6.1	-6.3	2.6e-10	0.72	0.82	0.16	FALSE
43	NTR	Blood	MSRA	0.02	0.01	blup	833	0.01	2.3e-05	-5.1	5.4	7.0e-08	-0.68	0.13	0.87	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	FAM167A	0.12	0.03	bslmm	620	0.08	1.3e-10	-4.1	5.6	1.9e-08	-0.63	0.25	0.75	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	XKR6	0.11	0.10	enet	23	0.13	1.2e-16	5.1	-5.7	1.2e-08	0.68	0.96	0.04	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	FAM86B3P	0.19	0.27	bslmm	331	0.27	5.6e-35	-6.5	6.3	3.9e-10	-0.65	1.00	0.00	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	FAM66A	0.23	0.26	enet	29	0.30	4.7e-39	-5.8	-5.4	7.7e-08	0.64	0.01	0.99	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	RP11-62H7.2	0.36	0.35	enet	35	0.39	1.7e-53	-3.9	-5.5	4.6e-08	0.64	1.00	0.00	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	FAM85B	0.16	0.23	enet	18	0.22	1.8e-28	-6.1	6.8	9.3e-12	-0.79	1.00	0.00	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	AF131215.3	0.08	0.10	lasso	7	0.12	8.3e-16	-5.5	-5.2	1.8e-07	0.70	0.93	0.07	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	RP11-481A20.11	0.06	0.04	blup	286	0.04	2.2e-06	-5.7	-5.8	7.9e-09	0.66	0.56	0.44	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	FAM85A	0.11	0.07	enet	23	0.11	4.3e-14	-5.8	-5.4	7.3e-08	0.66	0.02	0.98	FALSE
53	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FLJ10661	0.10	0.16	lasso	1	0.15	6.1e-13	-6.6	-6.6	4.3e-11	0.74	0.03	0.97	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	AMAC1L2	0.03	0.01	enet	6	0.02	1.7e-05	5.3	5.2	2.5e-07	-0.61	0.01	0.98	FALSE
55	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FLJ10661	0.33	0.09	blup	42	0.09	3.7e-05	-6.6	-5.5	4.1e-08	0.60	0.05	0.87	FALSE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	FAM86B1	0.08	0.00	lasso	6	0.00	2.0e-01	5.9	6.0	1.9e-09	-0.56	0.01	0.70	FALSE
57	The Cancer Genome Atlas	Colon Adenocarcinoma	FLJ10661	0.15	0.26	lasso	4	0.23	3.0e-13	-6.6	-6.6	3.5e-11	0.76	0.04	0.96	FALSE
58	The Cancer Genome Atlas	Esophageal Carcinoma	FLJ10661	0.20	0.23	lasso	2	0.23	5.6e-08	-6.9	-6.8	9.0e-12	0.74	0.00	1.00	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FLJ10661	0.07	0.14	lasso	3	0.14	3.7e-15	-6.6	-6.7	2.2e-11	0.75	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FLJ10661	0.07	0.01	lasso	4	0.03	1.6e-04	-2.3	-5.4	5.6e-08	0.58	0.04	0.31	FALSE
61	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLJ10661	0.07	0.02	blup	42	0.04	2.9e-03	-5.6	-7.0	2.1e-12	0.75	0.03	0.72	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLJ10661	0.21	0.26	lasso	9	0.30	2.3e-34	-6.1	6.4	1.5e-10	-0.77	0.08	0.92	FALSE
63	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FLJ10661	0.09	0.07	blup	41	0.07	3.6e-04	4.9	-6.0	2.3e-09	0.71	0.01	0.90	FALSE
64	The Cancer Genome Atlas	Lung Adenocarcinoma	ERI1	0.06	0.04	blup	72	0.04	1.5e-05	-6.1	5.2	2.3e-07	-0.60	0.00	1.00	FALSE
65	The Cancer Genome Atlas	Lung Adenocarcinoma	FLJ10661	0.06	0.05	lasso	3	0.04	2.4e-05	-5.6	-5.6	2.0e-08	0.71	0.12	0.85	FALSE
66	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AMAC1L2	0.03	0.03	blup	55	0.04	3.0e-05	-5.0	5.4	7.6e-08	-0.64	0.03	0.96	FALSE
67	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FLJ10661	0.12	0.09	lasso	4	0.08	4.7e-09	-6.1	-5.8	7.1e-09	0.69	0.15	0.85	FALSE
68	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FLJ10661	0.11	0.06	enet	5	0.07	2.3e-05	-6.6	-6.4	1.3e-10	0.70	0.00	0.97	FALSE
69	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FAM167A	0.09	0.05	lasso	4	0.08	3.0e-04	-4.8	-6.0	2.7e-09	0.52	0.02	0.66	FALSE
70	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FLJ10661	0.17	0.11	enet	10	0.16	3.3e-07	4.6	-5.7	1.1e-08	0.67	0.03	0.96	FALSE
71	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FAM167A	0.29	0.24	lasso	2	0.27	3.5e-11	-5.3	-5.3	9.1e-08	0.53	0.06	0.94	FALSE
72	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FLJ10661	0.25	0.18	lasso	4	0.16	4.2e-07	-6.9	7.1	9.4e-13	-0.76	0.00	1.00	FALSE
73	The Cancer Genome Atlas	Soft Tissue Sarcoma	FLJ10661	0.12	0.00	blup	42	0.00	6.9e-01	-6.6	-7.5	6.0e-14	0.64	0.01	0.59	FALSE
74	The Cancer Genome Atlas	Stomach Adenocarcinoma	FLJ10661	0.08	0.05	blup	42	0.07	9.3e-06	-5.6	-6.8	1.2e-11	0.75	0.03	0.97	FALSE
75	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FLJ10661	0.24	0.36	enet	8	0.35	4.1e-13	-6.6	-6.5	8.9e-11	0.75	0.04	0.96	FALSE
76	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ZNF705D	0.23	0.20	lasso	3	0.24	4.7e-09	-5.8	5.5	2.9e-08	-0.58	0.00	1.00	FALSE
77	The Cancer Genome Atlas	Thyroid Carcinoma	SGK223	0.16	0.20	enet	14	0.22	6.1e-21	5.0	6.5	6.3e-11	-0.77	0.88	0.12	FALSE