[Hub]/) : Traits : Hypothyroidism/myxoedema (self-reported) :

chr8:8,092,025-12,973,575

Best TWAS P=4.08e-16 · Best GWAS P=1.62e-18 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CTSB 0.13 0.10 enet 14 0.09 1.4e-11 5.1 5.2 1.5e-07 -0.45 0.99 0.01 FALSE
2 CommonMind Brain Pre-frontal Cortex FAM167A 0.09 0.09 lasso 6 0.13 1.4e-15 4.3 5.7 1.0e-08 -0.61 0.35 0.65 FALSE
3 CommonMind Brain Pre-frontal Cortex FAM86B1 0.02 0.02 lasso 3 0.01 1.3e-02 -5.7 -5.5 3.4e-08 0.69 0.02 0.93 FALSE
4 CommonMind Brain Pre-frontal Cortex FAM90A25P 0.11 0.08 lasso 3 0.08 1.4e-09 -5.7 -5.6 2.0e-08 0.65 0.02 0.98 FALSE
5 GTEx Adipose Subcutaneous ERI1 0.05 0.00 enet 10 0.00 5.5e-01 -4.2 5.7 9.6e-09 -0.66 0.26 0.25 FALSE
6 GTEx Adipose Subcutaneous FAM85A 0.06 0.06 enet 10 0.07 3.3e-06 5.7 -5.3 9.0e-08 0.55 0.02 0.97 FALSE
7 GTEx Adipose Visceral Omentum FAM86B3P 0.23 0.07 enet 20 0.14 6.4e-08 -8.0 -6.1 9.1e-10 0.71 0.34 0.65 FALSE
8 GTEx Adrenal Gland AF131215.2 0.20 0.16 enet 12 0.13 2.2e-05 -5.3 -5.3 8.9e-08 0.68 0.61 0.38 FALSE
9 GTEx Adrenal Gland AF131215.9 0.18 0.16 lasso 10 0.18 3.5e-07 -5.3 -5.4 7.0e-08 0.70 0.79 0.19 FALSE
10 GTEx Artery Aorta ERI1 0.11 0.08 lasso 5 0.10 5.1e-06 -4.9 6.2 6.9e-10 -0.69 0.77 0.18 FALSE
11 GTEx Artery Aorta FAM85A 0.11 0.06 enet 19 0.06 3.4e-04 5.7 -5.8 6.7e-09 0.66 0.03 0.96 FALSE
12 GTEx Artery Coronary AC087269.1 0.20 0.02 enet 29 0.02 8.7e-02 -4.7 6.6 3.9e-11 -0.58 0.05 0.67 FALSE
13 GTEx Artery Tibial ERI1 0.05 0.02 lasso 7 0.01 3.2e-02 -6.0 6.2 5.2e-10 -0.74 0.06 0.89 FALSE
14 GTEx Brain Cerebellar Hemisphere FAM86B3P 0.28 0.27 lasso 8 0.28 5.4e-08 -8.1 7.4 1.1e-13 -0.83 0.12 0.87 FALSE
15 GTEx Brain Cerebellum FAM86B3P 0.19 0.14 lasso 5 0.16 1.8e-05 -6.6 7.4 1.6e-13 -0.85 0.10 0.89 FALSE
16 GTEx Brain Cortex FAM86B3P 0.14 0.05 enet 9 0.07 5.1e-03 -6.5 6.2 4.6e-10 -0.80 0.03 0.86 FALSE
17 GTEx Brain Frontal Cortex BA9 FAM86B3P 0.16 0.13 enet 27 0.10 1.1e-03 -6.9 6.7 2.7e-11 -0.72 0.16 0.62 FALSE
18 GTEx Brain Nucleus accumbens basal ganglia CTSB 0.41 0.08 enet 21 0.13 1.9e-04 4.5 5.2 1.9e-07 -0.44 0.10 0.24 FALSE
19 GTEx Cells Transformed fibroblasts ERI1 0.34 0.35 lasso 7 0.35 1.9e-27 -4.9 5.6 2.4e-08 -0.66 1.00 0.00 FALSE
20 GTEx Cells Transformed fibroblasts FAM86B3P 0.23 0.33 lasso 11 0.38 8.4e-30 -6.1 -6.8 1.1e-11 0.82 0.99 0.01 FALSE
21 GTEx Colon Sigmoid AF131215.2 0.10 0.00 enet 7 0.02 5.0e-02 -5.6 -5.9 4.3e-09 0.71 0.05 0.82 FALSE
22 GTEx Colon Transverse FAM86B3P 0.13 0.04 lasso 8 0.04 4.4e-03 -6.6 -6.8 1.2e-11 0.78 0.18 0.36 FALSE
23 GTEx Esophagus Gastroesophageal Junction AF131215.2 0.13 0.06 enet 10 0.11 6.4e-05 -5.0 -5.7 1.3e-08 0.67 0.47 0.19 FALSE
24 GTEx Esophagus Mucosa FAM86B3P 0.22 0.17 lasso 8 0.19 1.7e-12 -6.1 -7.0 1.8e-12 0.80 0.98 0.02 FALSE
25 GTEx Esophagus Mucosa AF131215.2 0.15 0.14 enet 15 0.18 4.3e-12 3.9 -5.2 2.7e-07 0.68 0.44 0.56 FALSE
26 GTEx Esophagus Mucosa AF131215.9 0.18 0.16 lasso 14 0.19 1.6e-12 -5.5 -5.2 1.6e-07 0.69 0.67 0.33 FALSE
27 GTEx Esophagus Muscularis ERI1 0.12 0.09 enet 13 0.08 7.7e-06 -4.5 5.8 7.3e-09 -0.74 0.50 0.50 FALSE
28 GTEx Esophagus Muscularis AF131215.9 0.14 0.17 enet 16 0.17 1.6e-10 4.4 -5.2 1.9e-07 0.67 0.69 0.31 FALSE
29 GTEx Heart Atrial Appendage AF131215.2 0.39 0.13 enet 26 0.21 6.6e-10 3.9 -5.3 9.3e-08 0.63 0.22 0.78 FALSE
30 GTEx Lung ERI1 0.13 0.07 lasso 6 0.09 2.7e-07 5.1 5.8 5.3e-09 -0.69 0.28 0.71 FALSE
31 GTEx Muscle Skeletal MFHAS1 0.07 0.04 lasso 4 0.04 1.4e-04 -4.0 -5.4 6.1e-08 0.71 0.68 0.24 FALSE
32 GTEx Nerve Tibial ERI1 0.07 0.01 enet 16 0.01 4.2e-02 4.1 6.0 2.4e-09 -0.72 0.11 0.71 FALSE
33 GTEx Pancreas ERI1 0.08 0.00 enet 16 0.04 6.6e-03 -4.6 6.1 1.3e-09 -0.64 0.14 0.39 FALSE
34 GTEx Pancreas AF131215.9 0.25 0.24 enet 14 0.22 1.0e-09 -5.2 -5.1 2.8e-07 0.67 0.92 0.08 FALSE
35 GTEx Pituitary FAM86B3P 0.13 0.15 lasso 4 0.13 3.5e-04 4.9 6.0 1.6e-09 -0.71 0.19 0.37 FALSE
36 GTEx Skin Sun Exposed Lower leg AF131215.9 0.19 0.17 enet 29 0.21 3.9e-17 4.4 -5.1 2.9e-07 0.66 1.00 0.00 FALSE
37 GTEx Small Intestine Terminal Ileum AF131215.9 0.14 0.11 enet 16 0.06 1.6e-02 4.7 -5.7 1.4e-08 0.60 0.15 0.31 FALSE
38 GTEx Testis FAM86B3P 0.15 0.14 lasso 7 0.13 2.2e-06 -6.5 7.0 2.1e-12 -0.78 0.21 0.79 FALSE
39 GTEx Thyroid SGK223 0.19 0.35 enet 16 0.36 1.1e-28 -8.7 8.1 4.1e-16 -0.95 0.00 1.00 TRUE
40 GTEx Uterus AF131215.2 0.17 0.07 enet 13 0.09 7.1e-03 -5.3 -5.8 8.1e-09 0.71 0.09 0.69 FALSE
41 GTEx Vagina AF131215.9 0.21 0.11 lasso 9 0.08 6.3e-03 -4.9 -5.2 1.6e-07 0.67 0.09 0.82 FALSE
42 NTR Blood MFHAS1 0.02 0.01 blup 759 0.01 2.9e-04 -6.1 -6.3 2.6e-10 0.72 0.82 0.16 FALSE
43 NTR Blood MSRA 0.02 0.01 blup 833 0.01 2.3e-05 -5.1 5.4 7.0e-08 -0.68 0.13 0.87 FALSE
44 ROSMAP Brain Pre-frontal Cortex FAM167A 0.12 0.03 bslmm 620 0.08 1.3e-10 -4.1 5.6 1.9e-08 -0.63 0.25 0.75 FALSE
45 ROSMAP Brain Pre-frontal Cortex XKR6 0.11 0.10 enet 23 0.13 1.2e-16 5.1 -5.7 1.2e-08 0.68 0.96 0.04 FALSE
46 ROSMAP Brain Pre-frontal Cortex FAM86B3P 0.19 0.27 bslmm 331 0.27 5.6e-35 -6.5 6.3 3.9e-10 -0.65 1.00 0.00 FALSE
47 ROSMAP Brain Pre-frontal Cortex FAM66A 0.23 0.26 enet 29 0.30 4.7e-39 -5.8 -5.4 7.7e-08 0.64 0.01 0.99 FALSE
48 ROSMAP Brain Pre-frontal Cortex RP11-62H7.2 0.36 0.35 enet 35 0.39 1.7e-53 -3.9 -5.5 4.6e-08 0.64 1.00 0.00 FALSE
49 ROSMAP Brain Pre-frontal Cortex FAM85B 0.16 0.23 enet 18 0.22 1.8e-28 -6.1 6.8 9.3e-12 -0.79 1.00 0.00 FALSE
50 ROSMAP Brain Pre-frontal Cortex AF131215.3 0.08 0.10 lasso 7 0.12 8.3e-16 -5.5 -5.2 1.8e-07 0.70 0.93 0.07 FALSE
51 ROSMAP Brain Pre-frontal Cortex RP11-481A20.11 0.06 0.04 blup 286 0.04 2.2e-06 -5.7 -5.8 7.9e-09 0.66 0.56 0.44 FALSE
52 ROSMAP Brain Pre-frontal Cortex FAM85A 0.11 0.07 enet 23 0.11 4.3e-14 -5.8 -5.4 7.3e-08 0.66 0.02 0.98 FALSE
53 The Cancer Genome Atlas Bladder Urothelial Carcinoma FLJ10661 0.10 0.16 lasso 1 0.15 6.1e-13 -6.6 -6.6 4.3e-11 0.74 0.03 0.97 FALSE
54 The Cancer Genome Atlas Breast Invasive Carcinoma AMAC1L2 0.03 0.01 enet 6 0.02 1.7e-05 5.3 5.2 2.5e-07 -0.61 0.01 0.98 FALSE
55 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma FLJ10661 0.33 0.09 blup 42 0.09 3.7e-05 -6.6 -5.5 4.1e-08 0.60 0.05 0.87 FALSE
56 The Cancer Genome Atlas Colon Adenocarcinoma FAM86B1 0.08 0.00 lasso 6 0.00 2.0e-01 5.9 6.0 1.9e-09 -0.56 0.01 0.70 FALSE
57 The Cancer Genome Atlas Colon Adenocarcinoma FLJ10661 0.15 0.26 lasso 4 0.23 3.0e-13 -6.6 -6.6 3.5e-11 0.76 0.04 0.96 FALSE
58 The Cancer Genome Atlas Esophageal Carcinoma FLJ10661 0.20 0.23 lasso 2 0.23 5.6e-08 -6.9 -6.8 9.0e-12 0.74 0.00 1.00 FALSE
59 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FLJ10661 0.07 0.14 lasso 3 0.14 3.7e-15 -6.6 -6.7 2.2e-11 0.75 0.02 0.98 FALSE
60 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FLJ10661 0.07 0.01 lasso 4 0.03 1.6e-04 -2.3 -5.4 5.6e-08 0.58 0.04 0.31 FALSE
61 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FLJ10661 0.07 0.02 blup 42 0.04 2.9e-03 -5.6 -7.0 2.1e-12 0.75 0.03 0.72 FALSE
62 The Cancer Genome Atlas Brain Lower Grade Glioma FLJ10661 0.21 0.26 lasso 9 0.30 2.3e-34 -6.1 6.4 1.5e-10 -0.77 0.08 0.92 FALSE
63 The Cancer Genome Atlas Liver Hepatocellular Carcinoma FLJ10661 0.09 0.07 blup 41 0.07 3.6e-04 4.9 -6.0 2.3e-09 0.71 0.01 0.90 FALSE
64 The Cancer Genome Atlas Lung Adenocarcinoma ERI1 0.06 0.04 blup 72 0.04 1.5e-05 -6.1 5.2 2.3e-07 -0.60 0.00 1.00 FALSE
65 The Cancer Genome Atlas Lung Adenocarcinoma FLJ10661 0.06 0.05 lasso 3 0.04 2.4e-05 -5.6 -5.6 2.0e-08 0.71 0.12 0.85 FALSE
66 The Cancer Genome Atlas Lung Squamous Cell Carcinoma AMAC1L2 0.03 0.03 blup 55 0.04 3.0e-05 -5.0 5.4 7.6e-08 -0.64 0.03 0.96 FALSE
67 The Cancer Genome Atlas Lung Squamous Cell Carcinoma FLJ10661 0.12 0.09 lasso 4 0.08 4.7e-09 -6.1 -5.8 7.1e-09 0.69 0.15 0.85 FALSE
68 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma FLJ10661 0.11 0.06 enet 5 0.07 2.3e-05 -6.6 -6.4 1.3e-10 0.70 0.00 0.97 FALSE
69 The Cancer Genome Atlas Pancreatic Adenocarcinoma FAM167A 0.09 0.05 lasso 4 0.08 3.0e-04 -4.8 -6.0 2.7e-09 0.52 0.02 0.66 FALSE
70 The Cancer Genome Atlas Pancreatic Adenocarcinoma FLJ10661 0.17 0.11 enet 10 0.16 3.3e-07 4.6 -5.7 1.1e-08 0.67 0.03 0.96 FALSE
71 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma FAM167A 0.29 0.24 lasso 2 0.27 3.5e-11 -5.3 -5.3 9.1e-08 0.53 0.06 0.94 FALSE
72 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma FLJ10661 0.25 0.18 lasso 4 0.16 4.2e-07 -6.9 7.1 9.4e-13 -0.76 0.00 1.00 FALSE
73 The Cancer Genome Atlas Soft Tissue Sarcoma FLJ10661 0.12 0.00 blup 42 0.00 6.9e-01 -6.6 -7.5 6.0e-14 0.64 0.01 0.59 FALSE
74 The Cancer Genome Atlas Stomach Adenocarcinoma FLJ10661 0.08 0.05 blup 42 0.07 9.3e-06 -5.6 -6.8 1.2e-11 0.75 0.03 0.97 FALSE
75 The Cancer Genome Atlas Testicular Germ Cell Tumors FLJ10661 0.24 0.36 enet 8 0.35 4.1e-13 -6.6 -6.5 8.9e-11 0.75 0.04 0.96 FALSE
76 The Cancer Genome Atlas Testicular Germ Cell Tumors ZNF705D 0.23 0.20 lasso 3 0.24 4.7e-09 -5.8 5.5 2.9e-08 -0.58 0.00 1.00 FALSE
77 The Cancer Genome Atlas Thyroid Carcinoma SGK223 0.16 0.20 enet 14 0.22 6.1e-21 5.0 6.5 6.3e-11 -0.77 0.88 0.12 FALSE